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Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

GBT1118 Diminishes Vaso-Occlusion in Sickle Cell Disease Mice

Carsten Alt, PhD, Perry Liu, Chien-Ming Li, PhD, Abel Silva, Peter Rademacher, PhD, Hilary Zou, Mira Patel, PhD, Kobina Dufu, PhD, Donna Oksenberg, PhD, Katalin Kauser, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3516.
https://doi.org/10.1182/blood.V130.Suppl_1.3516.3516
Published: 2017
Journal Articles

Nonconventional Gene Expression within the NF-κb Signaling Pathway Induced By Poly(propylene)Imine Glycodendrimers in Chronic Lymphocytic Leukemia Cells

Ida Franiak-Pietryga, PhD, Kinga Ostrowska, Ms.C., Dietmar Appelhans, PhD, Henryk Maciejewski, PhD, Maria Bryszewska, Professor, Tadeusz Robak, MD PhD, Jacek Trelinski, MD Professor, Maciej Borowiec, Professor
Journal: Blood
Blood (2016) 128 (22): 5595.
https://doi.org/10.1182/blood.V128.22.5595.5595
Published: 2016
Journal Articles

A CD123-Targeting Antibody-Drug Conjugate (ADC), IMGN632, Designed to Eradicate Acute Myeloid Leukemia (AML) Cells While Sparing Normal Bone Marrow Cells

Yelena Kovtun, PhD, Gregory Jones, Charlene Audette, Lauren Harvey, MS, Baudouin Gerard, PhD, Alan Wilhelm, Chen Bai, Sharlene Adams, PhD, Victor S Goldmacher, PhD, Ravi Chari, PhD, Thomas Chittenden, PhD
Journal: Blood
Blood (2016) 128 (22): 768.
https://doi.org/10.1182/blood.V128.22.768.768
Published: 2016
Journal Articles

IMGN779, a CD33-Targeted Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Effector Molecule, Induces DNA Damage, Cell Cycle Arrest, and Apoptosis in AML Cells

Watkins M Krystal, MS, Russell Walker, MS, Nathan Fishkin, PhD, Charlene Audette, Yelena Kovtun, PhD, Angela Romanelli, PhD
Journal: Blood
Blood (2015) 126 (23): 1366.
https://doi.org/10.1182/blood.V126.23.1366.1366
Published: 2015
Journal Articles

The Antibody-Drug Conjugate (ADC) IMGN779 Is Highly Active in Vitro and in Vivo Against Acute Myeloid Leukemia (AML) with FLT3-ITD Mutations

Kathleen R Whiteman, MS, Paul Noordhuis, PhD, Russell Walker, MS, Krystal Watkins, MS, Yelena Kovtun, PhD, Lauren Harvey, BS, Alan Wilhelm, BS, Holly Johnson, BS, Gerrit Jan Schuurhuis, PhD, Gert J Ossenkoppele, MD PhD, Robert J. Lutz, PhD
Journal: Blood
Blood (2014) 124 (21): 2321.
https://doi.org/10.1182/blood.V124.21.2321.2321
Published: 2014
Journal Articles

Nanoparticles – a Novel Approach to Chronic Lymphocytic Leukemia Treatment?

Ida Franiak-Pietryga, PhD, Ewelina Ziolkowska, MSc, Barbara Ziemba, PhD, Dietmar Appelhans, PhD, Brigitte Voit, Prof., Joanna Gora-Tybor, Prof., Tadeusz Robak, Prof., Barbara Klajnert, Prof., Maria Bryszewska, Prof.
Journal: Blood
Blood (2012) 120 (21): 4601.
https://doi.org/10.1182/blood.V120.21.4601.4601
Published: 2012