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Journal Articles

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Justin M Watts, MD, Terrence J Bradley, MD, Amber Thomassen, MA, MSN, Yvonne Trang Dinh, BS, Dalissa Tejera, MSN, Kristen Englund, Sorab Boga, MPH, Randy Astaiza, BS, Charles J Chen, MPH, Malika Abdur-Rahman, BS, MSED, Marinescu Ion, CCRC, FMG, Aymee Perez, PhD, Masoumeh Tayari, PhD, Lluis Morey, PhD, Maria E. Figueroa, MD, Ramin Shiekhattar, PhD, Arthur Zelent, PhD, Ronan Swords, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2721.
https://doi.org/10.1182/blood-2018-99-115411
Published: 2018
Journal Articles

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

Cuong LE, PhD, Greggory Myers, Alawi Habara, MBBS, MSc, David H.K. Chui, MD, Martin H. Steinberg, MD, James Douglas Engel, PhD, Shuaiying Cui, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1066.
https://doi.org/10.1182/blood-2018-99-117675
Published: 2018
Journal Articles

Monoamine Oxidase a (MAO A) Is Expressed Selectively in Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Pei-Chuan Li, PhD, Imran N Siddiqi, MD PhD, Eric Y. Loo, MD, Yinfei Kong, M.S., Wendy Cozen, DO, MPH, Chieh-Hsi Wu, PhD, Jean Chen Shih, PhD
Journal: Blood
Blood (2015) 126 (23): 3864.
https://doi.org/10.1182/blood.V126.23.3864.3864
Published: 2015
Journal Articles

Pharmacological Inhibition or Genetic Knockdown of Kdm1a (Lsd1 or Aof2) Induces Differentiation of MLL Acute Myeloid Leukaemia Stem Cells

William J Harris, BSc, Xu Huang, PhD, James T Lynch, PhD, Tim Somervaille, PhD MRCP FRCPath
Journal: Blood
Blood (2011) 118 (21): 58.
https://doi.org/10.1182/blood.V118.21.58.58
Published: 2011
Journal Articles

HDAC and LSD1 Inhibitors Synergize to Induce Cell Death in Acute Leukemia Cells

Lorimar Ramirez, MD, Melissa Singh, PhD, Joya Chandra, PhD
Journal: Blood
Blood (2011) 118 (21): 1427.
https://doi.org/10.1182/blood.V118.21.1427.1427
Published: 2011
Journal Articles

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

Kevin R. Petrie, PhD, Tino Schenk, PhD, Manuel Boix Chornet, PhD, Louise Howell, John E Dick, PhD, Victor E Marquez, PhD, Laurence J Marton, MD, Patrick M Woster, PhD, Robert A Casero, Jr., PhD, Arthur Zelent, PhD
Journal: Blood
Blood (2009) 114 (22): 1046.
https://doi.org/10.1182/blood.V114.22.1046.1046
Published: 2009