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Journal Articles

PI3Kα/δ Inhibitor, Copanlisib, Inhibits Acute Lymphoblastic Leukemia Cell Growth, Increases Survival and Inhibits CNS Disease Progression in Leukemic Mice

Sarah Ridge, PhD, Hisayuki Yao, PhD, Trevor T Price, PhD, Andrew E Whiteley, PhD, Maegan Burns, Dorothy A. Sipkins, MD

Blood (2019) 134 (Supplement_1): 2758.

https://doi.org/10.1182/blood-2019-132097

Published: 2019

Journal Articles

Evidence of Endothelial Dysfunction and Activation of RhoA/Rho Kinase Pathway in Inflammatory Bowel Disease

Jaime Pereira, MD, Claudia G Saez, PhD, Manuel Alvarez, MD, Felipe Silva, MD, Nixa Olivares, Jose G Valenzuela, Antonia Pastore, Diego Mezzano, MD

Blood (2019) 134 (Supplement_1): 3641.

https://doi.org/10.1182/blood-2019-126033

Published: 2019

Journal Articles

Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Outside-in Signaling through Targeting cAMP/PKA Pathway and Inhibits Atherosclerosis

Yan Yang, MD PhD, Xiaohong Ruby Xu, MD PhD, Heyu Ni, MD MSc, PhD, Liping Ma, MD, Wenhua Ling, Fuli Ya

Blood (2018) 132 (Supplement 1): 2423.

https://doi.org/10.1182/blood-2018-99-120196

Published: 2018

Journal Articles

Acute Lymphoblastic Leukemia Cells Bypass the Blood Brain Barrier to Enter the CNS Via a Neuronal Developmental Pathway

Hisayuki Yao, MD PhD, Matthew Warner, PhD, Trevor Price, PhD, Lindsey Olivere, Gaia Cantelli, PhD, Sarah Ridge, PhD, Brandon Ngo, Surya Ravichandran, Stacey Tannheimer, PhD, Anjen Chenn, MD PhD, Dorothy A. Sipkins, MD

Blood (2017) 130 (Supplement 1): 144.

https://doi.org/10.1182/blood.V130.Suppl_1.144.144

Published: 2017

Journal Articles

PCTP (Phosphatidylcholine Transfer Protein) is Regulated By RUNX1 in Platelets/Megakaryocytes and is Associated with Adverse Cardiovascular Events

Natthapol Songdej, MD MPH, Guangfen Mao, MD, Deepak Voora, MD, Lawrence E. Goldfinger, PhD, Fabiola Del Carpio-Cano, Rachel Myers, Angara Koneti Rao, MBBS

Blood (2016) 128 (22): 365.

https://doi.org/10.1182/blood.V128.22.365.365

Published: 2016

Journal Articles

Transcription Factor RUNX1 Regulates Pctp (Phosphatidylcholine Transfer Protein) in Platelets: A Potential Role in Regulating Platelet Function

Natthapol Songdej, MD MPH, Guangfen Mao, MD, Lawrence E. Goldfinger, PhD, Angara Koneti Rao, MD

Blood (2015) 126 (23): 2247.

https://doi.org/10.1182/blood.V126.23.2247.2247

Published: 2015

Journal Articles

The JAK Inhibitor Ruxolitinib Impairs Dendritic Cell Migration Via Off-Target Inhibition of Rock

Janna Rudolph, Annkristin Heine, MD, Thomas Quast, Waldemar Kolanus, Peter Brossart, MD, Dominik Wolf, MD

Blood (2015) 126 (23): 3423.

https://doi.org/10.1182/blood.V126.23.3423.3423

Published: 2015

Journal Articles

Therapeutic Potential of Beta-Nicotinamide Adenine Dinucleotide to Reverse Endothelial Barrier Dysfunction in Sickle Cell Mouse Model

Nagavedi S Umapathy, PhD, Levi C Makala, DVM, MBA, PhD, Mayuko Takezaki, MS, Betty Pace, MD

Blood (2015) 126 (23): 969.

https://doi.org/10.1182/blood.V126.23.969.969

Published: 2015

Journal Articles

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1

Julien Record, Dessislava Malinova, Helen L. Zenner, Vincent Plagnol, Karolin Nowak, Farhatullah Syed, Gerben Bouma, James Curtis, Kimberly Gilmour, Catherine Cale, Scott Hackett, Guillaume Charras, Dale Moulding, Sergey Nejentsev, Adrian J. Thrasher, Siobhan O. Burns

Blood (2015) 126 (13): 1527–1535.

https://doi.org/10.1182/blood-2014-12-611012

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

Integrin α IIb cytoplasmic Tail Is Essential for Integrin Outside-in Signaling and Regulation of in Vivo Thrombosis

Meghna Ulhas Naik, MS, Ulhas P Naik, PhD FAHA

Blood (2014) 124 (21): 4160.

https://doi.org/10.1182/blood.V124.21.4160.4160

Published: 2014

Journal Articles

Fasudil, a Rho-Associated Protein Kinase (ROCK) Inhibitor, Decreases Disease Burden in a Cbl/Cbl-b Deficiency-Driven Murine Model for Myeloproliferative Disorders

Basem M. William, MD, Dan Feng, Wei An, Scott Nadeau, Bhopal Mohapatra, Matt Storck, Hamid Band, MD PhD

Blood (2014) 124 (21): 4569.

https://doi.org/10.1182/blood.V124.21.4569.4569

Published: 2014

Journal Articles

Dasatinib Induced Thrombocytopenia Might Be Due To The Inhibition Of Proplatelet Formation Of Megakaryocytes Via The Pathways Including Rho/Rock and Rac

Kazunori Murai, MD, PhD, Shugo Kowata, MD., Yukiteru Fujishima, MD, Yasuhiko Tsukushi, M.D., Takahiro Mine, MD., Tatsuo Oyake, M.D., Ph.D., Shigeki Ito, M.D., Ph.D., Yoji Ishida, M.D., Ph.D.

Blood (2013) 122 (21): 1071.

https://doi.org/10.1182/blood.V122.21.1071.1071

Published: 2013

Journal Articles

GFI1B Mutation Causes a Platelet Function Defect With Reduced Alpha-Granule Content and Abnormal Aggregation Response

Christopher M Ward, MB, CHB, PhD, Marie-Christine Morel-Kopp, PhD, Qiang Chen, BMed MSc, Hai Po Liang, PhD, Ashley P. Ng, MBBS, BMedSc, PhD, FRACP, FRCPA, Andrew W. Roberts, MBBS, PhD, Melanie Bahlo, PhD, William s Stevenson, MBBS, PhD

Blood (2013) 122 (21): 566.

https://doi.org/10.1182/blood.V122.21.566.566

Published: 2013

Journal Articles

RUNX1 Regulates PLDN (Pallidin) Expression In Platelets: A Potential Mechanism For Dense Granule Deficiency In RUNX1 Haplodeficiency

Guangfen Mao, MD, Chengxiang Fan, MD, PhD, Gauthami Jalagadugula, PhD, Robert Freishtat, MD, A. Koneti Rao, MD

Blood (2013) 122 (21): 567.

https://doi.org/10.1182/blood.V122.21.567.567

Published: 2013

Journal Articles

cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway

Ahmed Aburima, Katie S. Wraith, Zaher Raslan, Robert Law, Simbarashe Magwenzi, Khalid M. Naseem

Blood (2013) 122 (20): 3533–3545.

https://doi.org/10.1182/blood-2013-03-487850

Published: 2013

Includes: Supplemental data

Journal Articles

Novel Putative Polymorphism in SERPINC1 Encoding Antithrombin III Is Implicated in Elevated Estimated Systolic Pulmonary Pressure in Patients with Chuvash Polycythemia.

Victor R. Gordeuk, MD, Xu Zhang, PhD, Wei Zhang, PhD, Shwu-Fan Ma, PhD, Craig Sable, MD, Galina Miasniakova, MD, Adelina Sergueeva, MD, Tatiana Ammosova, PhD, Min Xu, PhD, Sergei Nekhai, PhD, Josef T. Prchal, MD, Michael Wade, MS, Joe GN Garcia, MD, Roberto Machado, MD

Blood (2012) 120 (21): 2869.

https://doi.org/10.1182/blood.V120.21.2869.2869

Published: 2012

Journal Articles

Hyperangiotensinemia Induces Stem Cell/Progenitor Mobilization and De-Adhesion From BM Endothelial Cells Through AT2R Signaling and Inhibition of RhoA Activity

Kyung-Hee Chang, PhD, Ramesh C Nayak, Ph.D., Katie Bezold, Ashley Ficker, Swarnava Roy, PhD, Xuan Zhou, Megan Pirman, Susan Dunn, Yi Zheng, PhD, Punam Malik, MD, Jose A. Cancelas, M.D. PhD

Blood (2012) 120 (21): 3466.

https://doi.org/10.1182/blood.V120.21.3466.3466

Published: 2012

Journal Articles

Cocaine-Induced Endothelial Dysfunction: Role of RhoA/Rho Kinase Pathway Activation.

Jaime Pereira, M.D., Claudia G Saez, Ph.D., Julio Pallavicini, M.D., Karla Pereira-Flores, Camila Mendoza, Romina Hernández, Ph.D., Ulises Novoa, María Paz Ocaranza, Ph.D., Teresa Massardo, M.D., Diego Mezzano, M.D., Jorge Jalil, M.D.

Blood (2012) 120 (21): 2177.

https://doi.org/10.1182/blood.V120.21.2177.2177

Published: 2012

Journal Articles

Thrombocytopenia and Platelet Ultra-Structural Abnormalities Associated with RUNX1 Haploinsufficiency in Monosomy 21 Mosaicism.

Riten Kumar, MD, MSc, Fred Pluthero, PhD, Hilary Christensen, Walter H. Kahr, MD, PhD

Blood (2012) 120 (21): 2190.

https://doi.org/10.1182/blood.V120.21.2190.2190

Published: 2012

Journal Articles

Trypsin Causes Platelet Activation Independently of Known Protease-Activated Receptors

Yingying Mao, Ph.D, Satya P. Kunapuli, PhD

Blood (2011) 118 (21): 2197.

https://doi.org/10.1182/blood.V118.21.2197.2197

Published: 2011

NARROW

PI3Kα/δ Inhibitor, Copanlisib, Inhibits Acute Lymphoblastic Leukemia Cell Growth, Increases Survival and Inhibits CNS Disease Progression in Leukemic Mice

Evidence of Endothelial Dysfunction and Activation of RhoA/Rho Kinase Pathway in Inflammatory Bowel Disease

Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Outside-in Signaling through Targeting cAMP/PKA Pathway and Inhibits Atherosclerosis

Acute Lymphoblastic Leukemia Cells Bypass the Blood Brain Barrier to Enter the CNS Via a Neuronal Developmental Pathway

PCTP (Phosphatidylcholine Transfer Protein) is Regulated By RUNX1 in Platelets/Megakaryocytes and is Associated with Adverse Cardiovascular Events

Transcription Factor RUNX1 Regulates Pctp (Phosphatidylcholine Transfer Protein) in Platelets: A Potential Role in Regulating Platelet Function

The JAK Inhibitor Ruxolitinib Impairs Dendritic Cell Migration Via Off-Target Inhibition of Rock

Therapeutic Potential of Beta-Nicotinamide Adenine Dinucleotide to Reverse Endothelial Barrier Dysfunction in Sickle Cell Mouse Model

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1

Integrin α IIb cytoplasmic Tail Is Essential for Integrin Outside-in Signaling and Regulation of in Vivo Thrombosis

Fasudil, a Rho-Associated Protein Kinase (ROCK) Inhibitor, Decreases Disease Burden in a Cbl/Cbl-b Deficiency-Driven Murine Model for Myeloproliferative Disorders

Dasatinib Induced Thrombocytopenia Might Be Due To The Inhibition Of Proplatelet Formation Of Megakaryocytes Via The Pathways Including Rho/Rock and Rac

GFI1B Mutation Causes a Platelet Function Defect With Reduced Alpha-Granule Content and Abnormal Aggregation Response

RUNX1 Regulates PLDN (Pallidin) Expression In Platelets: A Potential Mechanism For Dense Granule Deficiency In RUNX1 Haplodeficiency

cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway

Novel Putative Polymorphism in SERPINC1 Encoding Antithrombin III Is Implicated in Elevated Estimated Systolic Pulmonary Pressure in Patients with Chuvash Polycythemia.

Hyperangiotensinemia Induces Stem Cell/Progenitor Mobilization and De-Adhesion From BM Endothelial Cells Through AT2R Signaling and Inhibition of RhoA Activity

Cocaine-Induced Endothelial Dysfunction: Role of RhoA/Rho Kinase Pathway Activation.

Thrombocytopenia and Platelet Ultra-Structural Abnormalities Associated with RUNX1 Haploinsufficiency in Monosomy 21 Mosaicism.

Trypsin Causes Platelet Activation Independently of Known Protease-Activated Receptors

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American Society of Hematology

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American Society of Hematology

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