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Journal Articles

Tumor-targeted nanoparticles improve the therapeutic index of BCL2 and MCL1 dual inhibition

Neeta Bala Tannan, Mandana T. Manzari, Laurie Herviou, Mariana Da Silva Ferreira, Connor Hagen, Hiroto Kiguchi, Katia Manova-Todorova, Venkatraman Seshan, Elisa de Stanchina, Daniel A. Heller, Anas Younes

Blood (2021) 137 (15): 2057–2069.

https://doi.org/10.1182/blood.2020008017

Published: 2021

Includes: Supplemental data

Journal Articles

Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation

Stavros P. Loukogeorgakis, Camila G. Fachin, Andre I. B. S. Dias, Haiying Li, Li Tang, Aimee G. Kim, Jesse D. Vrecenak, John D. Stratigis, Nicholas J. Ahn, Ilana Nissim, Izhtak Nissim, Antonio F. Moron, Jose L. Martins, William H. Peranteau, Paolo De Coppi, Darrell J. Irvine, Alan W. Flake

Blood (2019) 134 (22): 1983–1995.

https://doi.org/10.1182/blood.2019001037

Published: 2019

Includes: Supplemental data

Journal Articles

The Novel Role That Nrf2 Plays in Erythropoiesis during Aging

Serge Cedrick Toya Mbiandjeu, Alessandro Mattè, BSc,PhD, Enrica Federti, PhD, Massimiliano Perduca, Immacolata Andolfo, Achille Iolascon, MD PhD, Maria Teresa Valenti, PhD, Arianna Pisani, Luca Dalle Carbonare, MD, Pietro Pucci, Angela Amoresano, Mohandas Narla, DSc, Lucia De Franceschi, MD

Blood (2019) 134 (Supplement_1): 3502.

https://doi.org/10.1182/blood-2019-125920

Published: 2019

Journal Articles

Bio-Inspired Functional Lipoprotein-like Nanoparticles (Flip-NPs) Cause Cholesterol Starvation and Ferroptosis in B-Cell Lymphomas: Studies in Cell Lines, Xenograft Models and Primary Patient Samples

Jonathan Rink, PhD, Adam Yuh Lin, MD PhD, Shuo Yang, PhD, Amir Behdad, MD, Reem Karmali, MD, Colby Shad Thaxton, MD PhD, Leo I. Gordon, MD

Blood (2019) 134 (Supplement_1): 2857.

https://doi.org/10.1182/blood-2019-127805

Published: 2019

Journal Articles

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML

Sagarajit Mohanty, MSc, Nidhi Jyotsana, PhD, Amit Sharma, PhD, Basem Othman, Arnold Kloos, PhD, Madhvi Mandhania, MSc, Renate Schottmann, Euan Ramsay, PhD, Hans- Peter Vornlocher, PhD, Arnold Ganser, MD, Felicitas Thol, MD, Michael Heuser, MD

Blood (2019) 134 (Supplement_1): 2545.

https://doi.org/10.1182/blood-2019-123709

Published: 2019

Journal Articles

Dual Inhibition of MCL1 and BCL2 in Lymphoma Using Tumor Targeted Nanoparticles

Neeta Bala Bala, PhD, Mandana Taghizadeh Manzari, PhD, Mariana Da Silva Ferreira, MSc, Zahra Asgari, Connor Hagen, Venkatraman Seshan, PhD, Elisa de Stanchina, Katia Manova-Todorova, Daniel Heller, Anas Younes, MD

Blood (2019) 134 (Supplement_1): 305.

https://doi.org/10.1182/blood-2019-130571

Published: 2019

Journal Articles

A Phase I/II Study of AZD2811 Nanoparticles (NP) As Monotherapy or in Combination in Treatment-Naïve or Relapsed/Refractory AML/MDS Patients Not Eligible for Intensive Induction Therapy

Blood (2019) 134 (Supplement_1): 3919.

https://doi.org/10.1182/blood-2019-130635

Published: 2019

Journal Articles

Nanoparticles Mimicking Platelets and Platelet Cloaking

Liangfang Zhang, PhD

Blood (2019) 134 (Supplement_1): SCI-38.

https://doi.org/10.1182/blood-2019-121082

Published: 2019

Journal Articles

Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects in an Immune Competent Lymphoma Model

Adam Yuh Lin, MD PhD, Jonathan Rink, PhD, Reem Karmali, MD, Colby Shad Thaxton, MD PhD, Leo I. Gordon, MD

Blood (2019) 134 (Supplement_1): 1577.

https://doi.org/10.1182/blood-2019-125308

Published: 2019

Journal Articles

Effective Lipidoid Nanoparticle Delivery In Vivo of siRNA Targeting Kappa Light Chain Production in a Murine Xenograft Model

Xun Ma, DMD, MSc, PhD, Ping Zhou, MD PhD, Adin Kugelmass, BSc, Denis Toskic, Melissa Warner, BS, Lisa X. Lee, MD, Teresa Fogaren, NP, Ming Wang, PhD, Yamin Li, Liu Yang, Qiaobing Xu, Raymond Comenzo

Blood (2018) 132 (Supplement 1): 3208.

https://doi.org/10.1182/blood-2018-99-112682

Published: 2018

Journal Articles

A Phase I/II, Open-Label, Multicentre 2-Part Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD2811 Nanoparticle As Monotherapy or in Combination in Treatment-Naïve or Relapsed/Refractory Acute Myeloid Leukaemia/Myelodysplastic Syndrome Patients Not Eligible for Intensive Induction Therapy

William B. Donnellan, MD, Ehab L. Atallah, MD, Adam S. Asch, MD, Manish R Patel, MD, Julie Charlton, Alexander MacDonald, Elena Young, Elizabeth Sainsbury, Donald Strickland, MD, Suzanne Jones, PharmD, Philip Overend, Carrie A. Adelman, Jon Travers, PhD, Simon Smith, PhD, J. Elizabeth Pease, PhD, Wolfram Brugger, MD PhD

Blood (2018) 132 (Supplement 1): 4064.

https://doi.org/10.1182/blood-2018-99-118465

Published: 2018

Journal Articles

Development of Acute Myeloid Leukemia Cell Membrane Coated Nanoparticles (AMCNPs) for Cancer Vaccination Immunotherapy

Daniel T Johnson, Ashley V Kroll, BS, Ronnie H Fang, PhD, Justin Kline, MD, Liangfang Zhang, PhD, Dong-Er Zhang, PhD

Blood (2018) 132 (Supplement 1): 4062.

https://doi.org/10.1182/blood-2018-99-117841

Published: 2018

Journal Articles

Overcoming Drug Resistance in Myeloma By Synchronized Delivery of Therapeutic and Bone Marrow Disrupting Agents By Nanoparticles Targeting Tumor-Associated Endothelium

Cinzia Federico, PhD, Barbara Muz, PhDMSc, Jennifer Sun, BSc, Kinan Alhallak, BSc, Justin King, Daniel R. Kohnen, MBA, Mark A. Fiala, BS, Aldo M. Roccaro, MDPhD, Ravi Vij, MBBS, Abdel Kareem Azab, PhD

Blood (2018) 132 (Supplement 1): 1931.

https://doi.org/10.1182/blood-2018-99-118251

Published: 2018

Journal Articles

Minit-Livin Conjugated to Targeted Nanoparticles Inhibits Tumorigenicity

Ihab Abd Elrahman, BSc, MSc, Taher Nassar, PhD, Noha Khairi, MSc, Riki Perlman, PhD, Simon Benita, PhD, Dina Ben-Yehuda, MD

Blood (2018) 132 (Supplement 1): 4171.

https://doi.org/10.1182/blood-2018-99-118045

Published: 2018

Journal Articles

The Population of Circulating Extracellular Vesicles Dramatically Alters after Very Premature Delivery- a Previously Unrecognised Postnatal Adaptation Process?

Daniel O'Reilly, MBBS, BSc, Karl Egan, PhD, Oscar Burke, BSc, Angharad Griffiths, Elaine Neary, MD, Alfonso Blanco, PhD, Paulina Szklanna, PhD, Patricia Maguire, PhD, Naomi McCallion, Fionnuala Ni Ainle, MD PhD

Blood (2018) 132 (Supplement 1): 1129.

https://doi.org/10.1182/blood-2018-99-113180

Published: 2018

Journal Articles

Bcma Heteroclitic Peptide Encapsulated Nanoparticle Enhances Antigen Stimulatory Capacity and Tumor-Specific CD8 + cytotoxic T Lymphocytes Against Multiple Myeloma

Jooeun Bae, PhD, Parayath Neha, Mansoor Amiji, Nikhil Munshi, MD, Kenneth Anderson, MD

Blood (2018) 132 (Supplement 1): 3195.

https://doi.org/10.1182/blood-2018-99-117292

Published: 2018

Journal Articles

Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled By Functional Lipoprotein Nanoparticles and the B Cell Receptor Inhibitor Ibrutinib: A Therapeutic Strategy Dependent on Cell of Origin (COO)

Jonathan Rink, PhD, Osman Cen, PhD, Kaylin Marie McMahon, PhD, Sol Misener, BS, Shuo Yang, PhD, Colby Shad Thaxton, MD PhD, Leo I. Gordon, MD

Blood (2017) 130 (Supplement 1): 576.

https://doi.org/10.1182/blood.V130.Suppl_1.576.576

Published: 2017

Journal Articles

CLL Cell-Derived Exosomes Promote Bone Marrow Fibrosis and Inhibit Normal Hematopoietic Colony Proliferation

Uri Rozovski, MD, David M. Harris, Ping Li, PhD, Zhiming Liu, Taghi Manshouri, Ivo Veletic, MD, Carlos Bueso-Ramos, MD PhD, Preetesh Jain, MBBS,MDDM,PhD, Srdan Verstovsek, MD PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A Thompson, MBBS, Nitin Jain, MD, William G Wierda, MD PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 1728.

https://doi.org/10.1182/blood.V130.Suppl_1.1728.1728

Published: 2017

Journal Articles

Preclinical and Early Phase 1 Clinical Data of AZD2811 Nanoparticle in AML, an Aurora B Kinase Inhibitor

Wolfram Brugger, MDPhD, Susan Ashton, Carrie A. Adelman, Nicolas Floc'h, Paula Taylor, Maureen Hattersley, PhD, Shenghua Wen, Kimberly Maratea, Philip Overend, Steven Fox, Julie Charlton, Simon T Barry, Donald Strickland, MD, Suzanne Jones, PharmD, Howard A. Burris, MD, Carol Greenlees, Alexander MacDonald, J. Elizabeth Pease, PhD, William Donnellan

Blood (2017) 130 (Supplement 1): 1368.

https://doi.org/10.1182/blood.V130.Suppl_1.1368.1368

Published: 2017

Journal Articles

Enhancing Proteasome-Inhibitory Activity and Specificity of Bortezomib By Endocytosis-Mediated Uptake of CD38 Targeted Nanoparticles in Multiple Myeloma

Pilar De La Puente, PhD M.Sc, Abbey Jin, Micah John Luderer, BS, MS, Christopher Egbulefu, Barbara Muz, PhDMSc, Cinzia Federico, PhD, Justin King, Daniel Kohnen, Noha Nabil Salama, PhD, Samuel Achilefu, Ravi Vij, MDMBA, Abdel Kareem Azab, PhD

Blood (2017) 130 (Supplement 1): 1876.

https://doi.org/10.1182/blood.V130.Suppl_1.1876.1876

Published: 2017

NARROW

Tumor-targeted nanoparticles improve the therapeutic index of BCL2 and MCL1 dual inhibition

Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation

The Novel Role That Nrf2 Plays in Erythropoiesis during Aging

Bio-Inspired Functional Lipoprotein-like Nanoparticles (Flip-NPs) Cause Cholesterol Starvation and Ferroptosis in B-Cell Lymphomas: Studies in Cell Lines, Xenograft Models and Primary Patient Samples

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML

Dual Inhibition of MCL1 and BCL2 in Lymphoma Using Tumor Targeted Nanoparticles

A Phase I/II Study of AZD2811 Nanoparticles (NP) As Monotherapy or in Combination in Treatment-Naïve or Relapsed/Refractory AML/MDS Patients Not Eligible for Intensive Induction Therapy

Nanoparticles Mimicking Platelets and Platelet Cloaking

Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects in an Immune Competent Lymphoma Model

Effective Lipidoid Nanoparticle Delivery In Vivo of siRNA Targeting Kappa Light Chain Production in a Murine Xenograft Model

Development of Acute Myeloid Leukemia Cell Membrane Coated Nanoparticles (AMCNPs) for Cancer Vaccination Immunotherapy

Overcoming Drug Resistance in Myeloma By Synchronized Delivery of Therapeutic and Bone Marrow Disrupting Agents By Nanoparticles Targeting Tumor-Associated Endothelium

Minit-Livin Conjugated to Targeted Nanoparticles Inhibits Tumorigenicity

The Population of Circulating Extracellular Vesicles Dramatically Alters after Very Premature Delivery- a Previously Unrecognised Postnatal Adaptation Process?

Bcma Heteroclitic Peptide Encapsulated Nanoparticle Enhances Antigen Stimulatory Capacity and Tumor-Specific CD8 + cytotoxic T Lymphocytes Against Multiple Myeloma

Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled By Functional Lipoprotein Nanoparticles and the B Cell Receptor Inhibitor Ibrutinib: A Therapeutic Strategy Dependent on Cell of Origin (COO)

CLL Cell-Derived Exosomes Promote Bone Marrow Fibrosis and Inhibit Normal Hematopoietic Colony Proliferation

Preclinical and Early Phase 1 Clinical Data of AZD2811 Nanoparticle in AML, an Aurora B Kinase Inhibitor

Enhancing Proteasome-Inhibitory Activity and Specificity of Bortezomib By Endocytosis-Mediated Uptake of CD38 Targeted Nanoparticles in Multiple Myeloma

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American Society of Hematology

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American Society of Hematology

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