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Journal Articles

Inhibition of platelet phagocytosis as an in vitro predictor for therapeutic potential of RBC antibodies in murine ITP

Ramsha Khan, Melissa Menard, Chao-Ching Jen, Xi Chen, Peter A. A. Norris, Alan H. Lazarus

Blood (2020) 135 (26): 2420–2424.

https://doi.org/10.1182/blood.2019003646

Published: 2020

Includes: Supplemental data

Journal Articles

Opsonization, inflammation, and RBC alloimmunization

Laura Cooling

Blood (2020) 135 (22): 1923–1924.

https://doi.org/10.1182/blood.2020005971

Published: 2020

Journal Articles

Inhibition of Complement C1s with Sutimlimab in Patients with Cold Agglutinin Disease (CAD): Results from the Phase 3 Cardinal Study

Alexander Röth, Wilma Barcellini, Shirley D'Sa, Yoshitaka Miyakawa, Catherine M Broome, Marc Michel, David J. Kuter, Bernd Jilma, Tor Henrik Anderson Tvedt, Stella Lin, Xiaoyu Jiang, Caroline Reuter, William Hobbs, Sigbjørn Berentsen

Blood (2019) 134 (Supplement_2): LBA-2.

https://doi.org/10.1182/blood-2019-132490

Published: 2019

Journal Articles

Symptomatic Bilirubin Gallstones in Patients with PNH Treated with Eculizumab

David J. Araten, MD, H. Leon Pachter, Robert J Dring, Elliot Newman, Steven M Cohen

Blood (2019) 134 (Supplement_1): 4795.

https://doi.org/10.1182/blood-2019-124571

Published: 2019

Journal Articles

Targeted Inhibition of CD47-Sirp Alpha Requires Fc-Fc Gamma Receptor Interactions to Maximize Phagocytosis in T-Cell Lymphomas

Salvia Jain, MD, Alexandria Van Scoyk, Elizabeth A Morgan, MD, Andrew Matthews, MD, Kristen E. Stevenson, MS, Gail Newton, PhD, Anu K Autio, PhD, Marisa O. Peluso, MS, Rachel W O'Connor, BS, Alison M. Paterson, PhD, Pamela M. Holland, PhD, Francis W Luscinskas, PhD, David M Weinstock, MD

Blood (2018) 132 (Supplement 1): 339.

https://doi.org/10.1182/blood-2018-99-112986

Published: 2018

Journal Articles

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Peter A. A. Norris, BSc, George B. Segel, MD, Ulrich J Sachs, MD PhD, Behnaz Bayat, PhD, Gestur Vidarsson, PhD, Rick Kapur, MDPhDMSc, Christine M. Cserti-Gazdewich, BSc, MD FRCPC, Jeannie Callum, MD, Yulia Lin, MD FRCPC, Richard Burack, MD PhD, John W Semple, PhD, Alan H Lazarus, PhD

Blood (2018) 132 (Supplement 1): 129.

https://doi.org/10.1182/blood-2018-99-117650

Published: 2018

Journal Articles

Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization

Anno Saris, Bert Tomson, Anneke Brand, Arend Mulder, Frans H. Claas, Jos Lorinser, John Scharenberg, S. Marieke van Ham, Anja ten Brinke, Jaap Jan Zwaginga, Pieter F. van der Meer

Blood (2018) 131 (1): 144–152.

https://doi.org/10.1182/blood-2017-07-799270

Published: 2018

Includes: Supplemental data

Journal Articles

Long Term Efficacy, Safety and PK/PD Profile of the Anti-C1s Antibody (BIVV009) in Primary Cold Agglutinin Disease Patients

Ulrich Jaeger, MD, Shirley D'Sa, MD FRCP, FRCPath, Christian Schoergenhofer, MD, Johann Bartko, MD, Christian Sillaber, MD, Petra Jilma-Stohlawetz, MD, Michael Fillitz, MD, Thomas Schenk, MD, Gary Patou, MD, Sandip Panicker, PhD, Graham C Parry, PhD, James C Gilbert, MD, Bernd Jilma, MD

Blood (2017) 130 (Supplement 1): 703.

https://doi.org/10.1182/blood.V130.Suppl_1.703.703

Published: 2017

Journal Articles

The Role of Platelets in the Induction of Alloimmunization after Platelet Transfusion

Anno Saris, MSc, Pieter F. Van Der Meer, PhD, Sander Meijer, PhD, Ivan Peyron, Marieke van Ham, PhD, Anja ten Brinke, PhD, Jaap Jan Zwaginga, MD PhD

Blood (2017) 130 (Supplement 1): 3726.

https://doi.org/10.1182/blood.V130.Suppl_1.3726.3726

Published: 2017

Journal Articles

Platelets from Donors with Consistent Low HLA-B8, B12 or B35 Expression Do Not Undergo Antibody-Mediated Internalization

Anno Saris, MSc, Bert Tomson, PhD, Anneke Brand, PhD, Arend Mulder, PhD, Frans H.J. Claas, PhD, Jos Lorinser, John Scharenberg, PhD, Marieke van Ham, PhD, Anja ten Brinke, PhD, Jaap Jan Zwaginga, MD PhD, Pieter F. Van Der Meer, PhD

Blood (2017) 130 (Supplement 1): 3727.

https://doi.org/10.1182/blood.V130.Suppl_1.3727.3727

Published: 2017

Journal Articles

APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

Federico V Grossi, MDPhD, Pauline Bedwell, Pascal Deschatelets, PhD, Lil Edis, PhD, Cedric G Francois, MDPhD, Patrick J Johnson, PhD, Helen J Richardson, Lisa Tan, Carolina A Vega, Jason Lickliter, MBBS,PhD

Blood (2016) 128 (22): 1251.

https://doi.org/10.1182/blood.V128.22.1251.1251

Published: 2016

Journal Articles

ANX005, an Inhibitory Antibody Against C1q, Blocks Complement Activation Triggered By Cold Agglutinins in Human Disease

Morie A. Gertz, MD MACP, Haiyan Qiu, PhD, Laura Kendall, Mario Saltarelli, MDPhD, Ted Yednock, PhD, Sethu Sankaranarayanan, PhD

Blood (2016) 128 (22): 1265.

https://doi.org/10.1182/blood.V128.22.1265.1265

Published: 2016

Journal Articles

RBC Adhesive Capacity Is Essential for Efficient 'Immune Adherence Clearance' and Provide a Generic Target to Deplete Pathogens from Septic Patients

Djuna Zoe De Back, Elena Kostova, Thomas Klei, Boukje Beuger, Rob van Zwieten, Taco Kuijpers, Nicole Juffermans, Timo van den Berg, Dirk Korte, Marian van Kraaij, Robin van Bruggen

Blood (2016) 128 (22): 1031.

https://doi.org/10.1182/blood.V128.22.1031.1031

Published: 2016

Journal Articles

TNT009 Prevents Erythrocyte C3 Fragment Opsonization and Rescues Reticulocytes from Destruction in Patients with Cold Agglutinin Disease

Sandip Panicker, PhD, Christa Drucker, Sami Hussain, Graham C Parry, PhD, James C Gilbert, MD, Bernd Jilma, MD, Ulrich Jaeger, MD

Blood (2016) 128 (22): 94.

https://doi.org/10.1182/blood.V128.22.94.94

Published: 2016

Journal Articles

Complement Blockade with C1 Esterase Inhibitor in Refractory Immune Thrombocytopenia

Erin Elizabeth Roesch, MD, Catherine Broome, MD

Blood (2015) 126 (23): 2253.

https://doi.org/10.1182/blood.V126.23.2253.2253

Published: 2015

Journal Articles

Engineered Donor Marrow Macrophages Phagocytose Cancer Cells and Aggressively Shrink Solid Tumor Xenografts Compared to Tumor Associated Macrophages

Cory M Alvey, BS Biology and Chemistry, Kyle Spinler, Manu Tewari, PhDBiochemistry, Dennis Discher, PhDCell Membrane Biophysics & Biochemistry

Blood (2015) 126 (23): 2214.

https://doi.org/10.1182/blood.V126.23.2214.2214

Published: 2015

Journal Articles

Safety and Pharmacokinetics of the Complement Inhibitor TT30 in a Phase I Trial for Untreated PNH Patients

Antonio M Risitano, MD PhD, Michael Storek, Leonardo Sahelijo, MD, Mittie Doyle, Yang Dai, Ilene Ceil Weitz, MD, Judith C.W. Marsh, MD, Modupe Elebute, MBChB, MD, Casey L O'Connell, MD, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Giridharan Ramsingh, MD, Serena Marotta, MD, Andrzej Hellmann, Ante S. Lundberg, MD

Blood (2015) 126 (23): 2137.

https://doi.org/10.1182/blood.V126.23.2137.2137

Published: 2015

Journal Articles

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Marybeth Langer, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Mark K. Coggeshall, Steven DeMarco, PhD, Florea Lupu, PhD

Blood (2015) 126 (23): 765.

https://doi.org/10.1182/blood.V126.23.765.765

Published: 2015

Journal Articles

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

Zhuoer Lin, Christoph Q. Schmidt, Sophia Koutsogiannaki, Patrizia Ricci, Antonio M. Risitano, John D. Lambris, Daniel Ricklin

Blood (2015) 126 (7): 891–894.

https://doi.org/10.1182/blood-2015-02-625871

Published: 2015

Includes: Supplemental data

Journal Articles

Novel Small-Molecule Inhibitors Targeting Complement Factor D for Therapy of Paroxysmal Nocturnal Hemoglobinuria

B. Paul Morgan, PhD, Jane Thanassi, Steven Podos, PhD, Avinash Phadke, PhD, Venkat Gadhachanda, PhD, Godwin Pais, PhD, Akihiro Hashimoto, PhD, Qiuping Wang, PhD, Dawei Chen, PhD, Xiangzhu Wang, PhD, Atul Agarwal, PhD, Milind Deshpande, PhD, Yongqing Huang, PhD, Jason Wiles, PhD, Mingjun Huang, PhD

Blood (2014) 124 (21): 4817.

https://doi.org/10.1182/blood.V124.21.4817.4817

Published: 2014

NARROW

Inhibition of platelet phagocytosis as an in vitro predictor for therapeutic potential of RBC antibodies in murine ITP

Opsonization, inflammation, and RBC alloimmunization

Inhibition of Complement C1s with Sutimlimab in Patients with Cold Agglutinin Disease (CAD): Results from the Phase 3 Cardinal Study

Symptomatic Bilirubin Gallstones in Patients with PNH Treated with Eculizumab

Targeted Inhibition of CD47-Sirp Alpha Requires Fc-Fc Gamma Receptor Interactions to Maximize Phagocytosis in T-Cell Lymphomas

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization

Long Term Efficacy, Safety and PK/PD Profile of the Anti-C1s Antibody (BIVV009) in Primary Cold Agglutinin Disease Patients

The Role of Platelets in the Induction of Alloimmunization after Platelet Transfusion

Platelets from Donors with Consistent Low HLA-B8, B12 or B35 Expression Do Not Undergo Antibody-Mediated Internalization

APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

ANX005, an Inhibitory Antibody Against C1q, Blocks Complement Activation Triggered By Cold Agglutinins in Human Disease

RBC Adhesive Capacity Is Essential for Efficient 'Immune Adherence Clearance' and Provide a Generic Target to Deplete Pathogens from Septic Patients

TNT009 Prevents Erythrocyte C3 Fragment Opsonization and Rescues Reticulocytes from Destruction in Patients with Cold Agglutinin Disease

Complement Blockade with C1 Esterase Inhibitor in Refractory Immune Thrombocytopenia

Engineered Donor Marrow Macrophages Phagocytose Cancer Cells and Aggressively Shrink Solid Tumor Xenografts Compared to Tumor Associated Macrophages

Safety and Pharmacokinetics of the Complement Inhibitor TT30 in a Phase I Trial for Untreated PNH Patients

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

Novel Small-Molecule Inhibitors Targeting Complement Factor D for Therapy of Paroxysmal Nocturnal Hemoglobinuria

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American Society of Hematology

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American Society of Hematology

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