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Journal Articles

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Asumi Yokota, PhD, Lulu Zhang, PhD, Jianhua Feng, Xiaomin Feng, MD PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD

Blood (2019) 134 (Supplement_1): 1696.

https://doi.org/10.1182/blood-2019-126799

Published: 2019

Journal Articles

Maternal Erythrocyte ENT1-Mediated AMPK Activation and Oxygen Delivery: A Missing Component Counteracting Placental Hypoxia, Dysfunction, and Fetal Growth Restriction

Seisuke Sayama, MD PhD, Anren Song, PhD, Yang Xia, MD PhD

Blood (2019) 134 (Supplement_1): 341.

https://doi.org/10.1182/blood-2019-123053

Published: 2019

Journal Articles

Efficacy of Chemotherapy, Phd-Inhibitor Molidustat or BRD4 Inhibitor JQ1 in Combination with Targeted Inhibition of Mutated IDH1 in Human AML In Vivo

Anuhar Chaturvedi, PhD, Charu Gupta, Stefan Kaulfuss, PhD, Basem Othman, Kerstin Görlich, Renate Schottmann, Olaf Panknin, Markus Wagner, PhD, Arnold Ganser, MD, Michael Jeffers, PhD, Andrea Haegebarth, Michael Heuser, MD

Blood (2019) 134 (Supplement_1): 3933.

https://doi.org/10.1182/blood-2019-124016

Published: 2019

Journal Articles

Roxadustat (FG4592; ASP1517; AZD9941) in the Treatment of Anemia in Patients with Lower Risk Myelodysplastic Syndrome (LR-MDS) and Low Red Blood Cell (RBC) Transfusion Burden (LTB)

David H. Henry, MD, John Glaspy, MD MPH, Rosemary Anne Harrup, MBBS, FRACP, FRCPA, Moshe Mittelman, MD, Amy Zhou, MD, Charles Bradley, PhD, Gopal Saha, MD, Pamela Bartels, Leong Robert, Kin-Hung P Yu, MD

Blood (2019) 134 (Supplement_1): 843.

https://doi.org/10.1182/blood-2019-128714

Published: 2019

Journal Articles

Dimethyl Oxalyl Glycine a Prolyl Hydroxylase Inhibitor Decreases Early Gastrointestinal Gvhd Via Two Independent Pathways of Apoptosis after Allogeneic Hematopoietic Cell Transplantation

Reena Kumari, PhD, Senthilnathan Palaniyandi, PhD, Ethan Strattan, BS, Sabarinath Venniyil Radhakrishnan, MBBS, MD, Gerhard Carl Hildebrandt, MD

Blood (2018) 132 (Supplement 1): 3317.

https://doi.org/10.1182/blood-2018-99-116245

Published: 2018

Journal Articles

Tibetan Enriched PKLR Variant Is Beneficial to High Altitude Adaption By Improving Oxygen Delivery

Jihyun Song, PhD, Virginia Abello, MD, Ricardo Amaru, MD, Adelina Sergueeva, MD, Jainagul Isakova, Penelope A. Kosinski, MS, Brigitte A. van Oirschot, Victor R. Gordeuk, MD, Charles Kung, PhD, Richard van Wijk, PhD, Josef T. Prchal, MD

Blood (2018) 132 (Supplement 1): 1027.

https://doi.org/10.1182/blood-2018-99-117389

Published: 2018

Journal Articles

Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, PhD, Ramya Goparaju, PhD, Razif Gabdoulline, Renate Schottmann, Kerstin Görlich, Arnold Kloos, Felicitas Thol, MD, Robert Geffers, PhD, Dimitrios Mougiakakos, Peter Carmeliet, MD PhD, Arnold Ganser, MD, Michael Heuser, MD

Blood (2018) 132 (Supplement 1): 759.

https://doi.org/10.1182/blood-2018-99-110425

Published: 2018

Journal Articles

Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin

Blood (2018) 131 (12): 1325–1336.

https://doi.org/10.1182/blood-2017-07-794875

Published: 2018

Includes: Supplemental data

Journal Articles

Erythroid and Cardiovascular High Altitude-Selected Haplotypes in Andean Aymaras and Tibetans

Ricardo Amaru, MD, Jihyun Song, PhD, Noel S Reading, Victor R. Gordeuk, MD, Teddy Quispe, Msc, Lorna Moore, PhD, Rasmus Nielsen, PhD, Josef T. Prchal, MD

Blood (2017) 130 (Supplement 1): 2205.

https://doi.org/10.1182/blood.V130.Suppl_1.2205.2205

Published: 2017

Journal Articles

Iron Supplementation: What's New?

Iain C. Macdougall, MD

Blood (2017) 130 (Supplement 1): SCI-43.

https://doi.org/10.1182/blood.V130.Suppl_1.SCI-43.SCI-43

Published: 2017

Journal Articles

The Role of Egln2/Proline Hydroxylase 1 in Regulation of Cyclin D1 in Mantle Cell Lymphoma

Olga Babosova, M.Sc., Lucie Lanikova, PhD, Katarina Kapralova, MSc, Vladimir Divoky, PhD, Vladimir Korinek, PhD, Josef T. Prchal, MD

Blood (2017) 130 (Supplement 1): 5141.

https://doi.org/10.1182/blood.V130.Suppl_1.5141.5141

Published: 2017

Journal Articles

Let's give BACH2 a breath of fresh air

Francesco Bertoni

Blood (2017) 130 (6): 696–697.

https://doi.org/10.1182/blood-2017-06-790402

Published: 2017

Journal Articles

PPARα Agonists and TGFβ Inhibitors Stimulate Red Blood Cell Production by Enhancing Self-Renewal of BFU-E Erythroid Progenitors

Harvey Lodish, PhD

Blood (2016) 128 (22): SCI-48.

https://doi.org/10.1182/blood.V128.22.SCI-48.SCI-48

Published: 2016

Journal Articles

Extramedullary Erythropoiesis in Spleen of HIF Prolyl 4-Hydroxylase-2 Deficient Mice Is Mediated By Notch Signaling Downregulation

Mikko Myllymäki, MD PhD, Jenni Määttä, MD Cand., Elitsa Dimova, PhD, Valerio Izzi, PhD, Timo Väisänen, PhD, Johanna Myllyharju, Professor, Peppi Koivunen, Professor, Raisa Serpi, PhD

Blood (2016) 128 (22): 2656.

https://doi.org/10.1182/blood.V128.22.2656.2656

Published: 2016

Journal Articles

Inhibition of HIF Prolyl Hydroxylases Mitigate Gut Graft-Versus-Host Disease

Rena Feinman, PhD, Iriana Colorado, MSc, Keyi Wang, MSc, Eugenia Dziopa, MSc, Michael A Flynn, MSc, Kevin Peters, MD, Andrew L. Pecora, MD, Robert Korngold, PhD

Blood (2016) 128 (22): 3349.

https://doi.org/10.1182/blood.V128.22.3349.3349

Published: 2016

Journal Articles

Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes

Andres A. Urrutia, Aqeela Afzal, Jacob Nelson, Olena Davidoff, Kenneth W. Gross, Volker H. Haase

Blood (2016) 128 (21): 2550–2560.

https://doi.org/10.1182/blood-2016-05-713545

Published: 2016

Includes: Supplemental data

Journal Articles

Spectrum of Mutations Associated with Hereditary Erythrocytosis

Jennifer L Oliveira, MD, Lori A Frederick, BS, Lea M Coon, MS, Molly Susan Hein, BS, Mrinal M Patnaik, MBBS, Ayalew Tefferi, MD, Animesh Pardanani, MBBS, PhD, Stefan K Grebe, MD, PhD, David S Viswanatha, MD, James D Hoyer, MD

Blood (2015) 126 (23): 2140.

https://doi.org/10.1182/blood.V126.23.2140.2140

Published: 2015

Journal Articles

Tibetan Gain-of-Function Variant of Prolyl Hydroxylase 2 ( EGLN1) and Selected SNPs of HIF-2-Alpha ( EPAS1) Are Associated with Lower Hemoglobin Values in Tibetans

Tsewang Tashi, MD, N. Scott Reading, PhD, Anna Shestakova, MD PhD, Tatiana Burjanivova, PhD, Tanna Uran, MD PhD, Felipe R Lorenzo V, MD, PhD, Hao Hu, PhD, Chad Huff, PhD, Lorna Moore, PhD, Parvaiz Koul, MD, Carl T Wittwer, MD PhD, Victor R. Gordeuk, MD, Re-Li Ge, MD PhD, Josef T. Prchal, MD

Blood (2015) 126 (23): 3332.

https://doi.org/10.1182/blood.V126.23.3332.3332

Published: 2015

Journal Articles

The Effect of IV Iron Therapy on HIF Pathway and HIF Regulated Genes in Elderly Patients with Unexplained Anemia

Levon Katsakhyan, BS, Sabina Swierczek, PhD, Andrew Artz, MD MS, Elizabeth A Price, MD MPH, Stanley L. Schrier, MD, Harvey Jay Cohen, MD, Josef T. Prchal, MD, Victor R. Gordeuk, MD

Blood (2015) 126 (23): 4533.

https://doi.org/10.1182/blood.V126.23.4533.4533

Published: 2015

Journal Articles

Activation of HIF-2a-EPO Axis in Kidney or Liver Is Sufficient to Drive Erythrocytosis in a Novel Inducible HIF-2a Transgenic Mouse Model

Jieyu Wang, MD, Yoshihiro Hayashi, MD PhD, Zefeng Xu, MD, Lingyun Wu, MD PhD, Xiaomei Yan, MD PhD, Theodosia A. Kalfa, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2015) 126 (23): 931.

https://doi.org/10.1182/blood.V126.23.931.931

Published: 2015

NARROW

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Maternal Erythrocyte ENT1-Mediated AMPK Activation and Oxygen Delivery: A Missing Component Counteracting Placental Hypoxia, Dysfunction, and Fetal Growth Restriction

Efficacy of Chemotherapy, Phd-Inhibitor Molidustat or BRD4 Inhibitor JQ1 in Combination with Targeted Inhibition of Mutated IDH1 in Human AML In Vivo

Roxadustat (FG4592; ASP1517; AZD9941) in the Treatment of Anemia in Patients with Lower Risk Myelodysplastic Syndrome (LR-MDS) and Low Red Blood Cell (RBC) Transfusion Burden (LTB)

Dimethyl Oxalyl Glycine a Prolyl Hydroxylase Inhibitor Decreases Early Gastrointestinal Gvhd Via Two Independent Pathways of Apoptosis after Allogeneic Hematopoietic Cell Transplantation

Tibetan Enriched PKLR Variant Is Beneficial to High Altitude Adaption By Improving Oxygen Delivery

Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia

Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin

Erythroid and Cardiovascular High Altitude-Selected Haplotypes in Andean Aymaras and Tibetans

Iron Supplementation: What's New?

The Role of Egln2/Proline Hydroxylase 1 in Regulation of Cyclin D1 in Mantle Cell Lymphoma

Let's give BACH2 a breath of fresh air

PPARα Agonists and TGFβ Inhibitors Stimulate Red Blood Cell Production by Enhancing Self-Renewal of BFU-E Erythroid Progenitors

Extramedullary Erythropoiesis in Spleen of HIF Prolyl 4-Hydroxylase-2 Deficient Mice Is Mediated By Notch Signaling Downregulation

Inhibition of HIF Prolyl Hydroxylases Mitigate Gut Graft-Versus-Host Disease

Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes

Spectrum of Mutations Associated with Hereditary Erythrocytosis

Tibetan Gain-of-Function Variant of Prolyl Hydroxylase 2 ( EGLN1) and Selected SNPs of HIF-2-Alpha ( EPAS1) Are Associated with Lower Hemoglobin Values in Tibetans

The Effect of IV Iron Therapy on HIF Pathway and HIF Regulated Genes in Elderly Patients with Unexplained Anemia

Activation of HIF-2a-EPO Axis in Kidney or Liver Is Sufficient to Drive Erythrocytosis in a Novel Inducible HIF-2a Transgenic Mouse Model

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American Society of Hematology

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American Society of Hematology

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