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Journal Articles

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Kartika Venugopal, MS, Daniil E Shabashvili, PhD, Jianping Li, MD, Luisa M Posada, Richard Lynn Bennett, PhD, Yang Feng, MS, Daphne Dupere Richer, PhD, Alberto Riva, PhD, Santhi Pondugula, PhD, Jonathan E. Bird, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD

Blood (2019) 134 (Supplement_1): 535.

https://doi.org/10.1182/blood-2019-128213

Published: 2019

Journal Articles

Phase I Study of the PTEFb Inhibitor BAY 1251152 in Patients with Acute Myelogenous Leukemia

Michael Byrne, MD, Mark G. Frattini, MD PhD, Oliver G. Ottmann, MD, Ioannis Mantzaris, MD MS, Martin Wermke, MD, Daniel J. Lee, MD, Daniel Morillo, MD, Arne Scholz, PhD, Stuart Ince, PhD, Ray Valencia, MD, Fabricio Souza, MD, Raul Cordoba, MD PhD

Blood (2018) 132 (Supplement 1): 4055.

https://doi.org/10.1182/blood-2018-99-117257

Published: 2018

Journal Articles

hnRNP U and DDX47 Are Novel FANCD2 Interactors That May Help to Resolve R-Loops during Mild Replication Stress

Yusuke Okamoto, MD, Masako Abe, Akiko Itaya, Junya Tomida, Akifumi Takaori-Kondo, MD PhD, Masato Taoka, Toshiaki Isobe, Minoru Takata, MD PhD

Blood (2018) 132 (Supplement 1): 1301.

https://doi.org/10.1182/blood-2018-99-112364

Published: 2018

Journal Articles

Combining Next Generation Proteomics Platforms with Drug Sensitivity Resistance Testing AllowsÂ Identification of Physiologically Distinct Sub-ClonesÂ That Can Inform Therapeutic and Drug Development Strategies

Despina Bazou, BSc, MSc, PhD, Muntasir M Majumder, MSc, BPharm, Ciara Tierney, BSc, Sinead O'Rourke, BSc, Pekka Anttila, MD, Raija Helena Silvennoinen, MD PhD, Caroline A Heckman, PhD, Paul Dowling, BSc, PhD, Peter O'Gorman, MD PhD FRCP, FRCPath

Blood (2018) 132 (Supplement 1): 1901.

https://doi.org/10.1182/blood-2018-99-115910

Published: 2018

Journal Articles

Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, MD PhD, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, MD PhD, Shunya Arai, MD PhD, Hironori Ueno, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Hiroyuki Mano, MDPhD, Mineo Kurokawa, MD PhD

Blood (2017) 130 (Supplement 1): 4238.

https://doi.org/10.1182/blood.V130.Suppl_1.4238.4238

Published: 2017

Journal Articles

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Andrew Volk, PhD, Kaiwei Liang, PhD, Jianyun Zhao, Xinyu Li, Marinka Bulic, Stacy Marshall, Jeffrey W. Taub, MD, Yubin Ge, PhD, Sebastien Malinge, PhD, Elizabeth Bartom, PhD, Ali Shilatifard, PhD, John D. Crispino, PhD

Blood (2017) 130 (Supplement 1): 245.

https://doi.org/10.1182/blood.V130.Suppl_1.245.245

Published: 2017

Journal Articles

Leukemia-Derived Exosomes Induce Paracrine and Autocrine Cell Proliferation in Pediatric ALL

Shabirul Haque, PhD, Sarah Rivkah Vaiselbuh, MD

Blood (2016) 128 (22): 4080.

https://doi.org/10.1182/blood.V128.22.4080.4080

Published: 2016

Journal Articles

SET8 Is a Potential Therapeutic Target in MM

Herviou Laurie, Fanny Izard, Elke De Bruyne, PhD, Eva Desmedt, Anqi Ma, PhD, Jian Jin, PhD, Karin Vanderkerken, PhD, Eric Julien, Jerome Moreaux, PhD

Blood (2016) 128 (22): 4435.

https://doi.org/10.1182/blood.V128.22.4435.4435

Published: 2016

Journal Articles

Impaired DNA Damage Repair in Severe Congenital Neutropenia Patients

Perihan Mir, Maksim Klimiankou, PhD, Benjamin Dannenmann, Cornelia Zeidler, MD, Klaus Schulze-Osthoff, PhD, Lothar Kanz, MD, Karl Welte, MD, Julia Skokowa, MD PhD

Blood (2016) 128 (22): 1334.

https://doi.org/10.1182/blood.V128.22.1334.1334

Published: 2016

Journal Articles

Chromatin Histone Modifying and DNA Repair Inhibition Enhances the Anti-Myeloma Activity of Melphalan

Maria Gkotzamanidou, Evangelos Terpos, Nikhil C Munshi, MD, Vassilis L. Souliotis, Meletios A Dimopoulos

Blood (2016) 128 (22): 4437.

https://doi.org/10.1182/blood.V128.22.4437.4437

Published: 2016

Journal Articles

Deubiquitylating Enzyme USP1 As Therapeutic Target in Multiple Myeloma

Deepika Sharma Das, PhD, Yan Song, PhD, Arghya Ray, PhD, Mehmet K. Samur, PhD, Nikhil C. Munshi, MD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2016) 128 (22): 3290.

https://doi.org/10.1182/blood.V128.22.3290.3290

Published: 2016

Journal Articles

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Ronan LE Moigne, PhD, Valeria Visconte, PhD, Bartlomiej Przychodzen, MSc, Mark Rolfe, PhD, Stevan Djakovic, PhD, Daniel Anderson, David Wustrow, PhD, Han-Jie Zhou, Steve Wong, PhD, Anjali Advani, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD

Blood (2015) 126 (23): 1350.

https://doi.org/10.1182/blood.V126.23.1350.1350

Published: 2015

Journal Articles

Antagonizing HDAC6 Activity: A New Strategy to Maximize the Anti-Myeloma Effects of BET Inhibition

Jennifer S. Carew, PhD, Claudia M. Espitia, Weiguo Zhao, Valeria Visconte, PhD, Kevin R. Kelly, MD PhD, Steffan T. Nawrocki, PhD

Blood (2015) 126 (23): 3022.

https://doi.org/10.1182/blood.V126.23.3022.3022

Published: 2015

Journal Articles

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Jianhong Lin, MD M.Sc, Chun Yang, MD PhD, Ariel Kwart, B.S., Jianjun Zhao, MD PhD, Mehmet K Samur, PhD, Weihong Zhang, MD, Purushothama Nanjappa, M.S., Teresa Calimeri, MD PhD, Xiubao Ren, MD, Dongdong Ma, MD PhD, Xiaofeng Jiang, MD PhD, Yi Zhou, PhD, Masood Shammas, PhD, Kenneth C. Anderson, MD, Jon C. Aster, MD PhD, Leonard I. Zon, MD, Robert I. Handin, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 1431.

https://doi.org/10.1182/blood.V126.23.1431.1431

Published: 2015

Journal Articles

Targeting Deubiquitylating Enzyme USP1 in Multiple Myeloma

Deepika Sharma Das, PhD, Yan Song, PhD, Arghya Ray, PhD, Paul Richardson, MD, Dharminder Chauhan, PhD, Kenneth C Anderson, MD

Blood (2015) 126 (23): 1813.

https://doi.org/10.1182/blood.V126.23.1813.1813

Published: 2015

Journal Articles

The Suppression of CCL2 Expression Decrease the Proliferation of HL-60 Cells through Downregulation of Cyclin d1 Via Arresting Cells at the G1 Phase

Jin Yang, Dan Hong, Qi Zhou, Jun-jie Fan, Le Li, Jian Pan, Shaoyan Hu, MD PhD

Blood (2015) 126 (23): 4809.

https://doi.org/10.1182/blood.V126.23.4809.4809

Published: 2015

Journal Articles

The Expression and Effect of B7-H3 in Mantle Cell Lymphoma

Jing Wang, Wei Zhang, Yanfang Wang, Fei Dong, Mingxia Zhu, Wenli Wan, Haisheng Li, Feifei Wu, Xinxing Yan, Xiao-Feng Yang, MD PhD FAHA, Xiaoyan Ke, MD PhD

Blood (2015) 126 (23): 4811.

https://doi.org/10.1182/blood.V126.23.4811.4811

Published: 2015

Journal Articles

B7-H3 Silencing By RNAi Inhibits Tumor Progression and Enhances Chemosensitivity in U937 Cells

Wei Zhang, Jing Wang, Yanfang Wang, Fei Dong, Mingxia Zhu, Wenli Wan, Haishen Li, Feifei Wu, Xinxing Yan, Xiao-Feng Yang, MD PhD FAHA, Xiaoyan Ke, MD PhD

Blood (2015) 126 (23): 4813.

https://doi.org/10.1182/blood.V126.23.4813.4813

Published: 2015

Journal Articles

Metformin Induces p53-Dependent Mitochondrial Stress in Therapy-Sensitive and -Resistant Lymphoma Pre-Clinical Model and Primary Patients Sample with B-Cell Non-Hodgkin Lymphoma (NHL)

Juan J Gu, PhD, Qunling Zhang, MD PhD, Cory Mavis, MSc, Myron S. Czuczman, MD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2015) 126 (23): 4008.

https://doi.org/10.1182/blood.V126.23.4008.4008

Published: 2015

Journal Articles

Examining the Impact of Altered Protein Expression and Ubiquitination Levels on the Development of Resistance to Proteasome Inhibitors Using Proteomics Analysis

Paul Dowling, Kay Reen Ting, Justine Meiller, Shane Kelly, Martin Clynes, Peter O'Gorman

Blood (2015) 126 (23): 4208.

https://doi.org/10.1182/blood.V126.23.4208.4208

Published: 2015

NARROW

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Phase I Study of the PTEFb Inhibitor BAY 1251152 in Patients with Acute Myelogenous Leukemia

hnRNP U and DDX47 Are Novel FANCD2 Interactors That May Help to Resolve R-Loops during Mild Replication Stress

Combining Next Generation Proteomics Platforms with Drug Sensitivity Resistance Testing AllowsÂ Identification of Physiologically Distinct Sub-ClonesÂ That Can Inform Therapeutic and Drug Development Strategies

Human Germline HLTF E259K Mutation Identified in Familial MDS Patients Accumulates DNA Damage through Impaired PCNA Polyubiquitination

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Leukemia-Derived Exosomes Induce Paracrine and Autocrine Cell Proliferation in Pediatric ALL

SET8 Is a Potential Therapeutic Target in MM

Impaired DNA Damage Repair in Severe Congenital Neutropenia Patients

Chromatin Histone Modifying and DNA Repair Inhibition Enhances the Anti-Myeloma Activity of Melphalan

Deubiquitylating Enzyme USP1 As Therapeutic Target in Multiple Myeloma

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Antagonizing HDAC6 Activity: A New Strategy to Maximize the Anti-Myeloma Effects of BET Inhibition

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Targeting Deubiquitylating Enzyme USP1 in Multiple Myeloma

The Suppression of CCL2 Expression Decrease the Proliferation of HL-60 Cells through Downregulation of Cyclin d1 Via Arresting Cells at the G1 Phase

The Expression and Effect of B7-H3 in Mantle Cell Lymphoma

B7-H3 Silencing By RNAi Inhibits Tumor Progression and Enhances Chemosensitivity in U937 Cells

Metformin Induces p53-Dependent Mitochondrial Stress in Therapy-Sensitive and -Resistant Lymphoma Pre-Clinical Model and Primary Patients Sample with B-Cell Non-Hodgkin Lymphoma (NHL)

Examining the Impact of Altered Protein Expression and Ubiquitination Levels on the Development of Resistance to Proteasome Inhibitors Using Proteomics Analysis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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