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Journal Articles

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Etienne De Braekeleer, PhD MSc, Joanne Hsu, BS, Celine Hervieu, MSc, Konstantinos Tzelepis, PhD, Stefano Indraccolo, MD, Alan J. Warren, PhD FRCP, FRCPath, Irmela Jeremias, MD PhD, David Fernandez Antoran, PhD, Phil H Jones, PhD, Margaret A. Goodell, PhD, George S. Vassiliou

Blood (2018) 132 (Supplement 1): 2615.

https://doi.org/10.1182/blood-2018-99-118827

Published: 2018

Journal Articles

Defective Rab1b Related Megakaryocytic ER-to-Golgi Transport in RUNX1 Haplodeficiency

Gauthami S. Jalagadugula, PhD, Lawrence E. Goldfinger, PhD, Guangfen Mao, MD, Angara Koneti Rao, MD

Blood (2017) 130 (Supplement 1): 2333.

https://doi.org/10.1182/blood.V130.Suppl_1.2333.2333

Published: 2017

Journal Articles

Microrna-15a-5p Regulates Multiple Components of GPVI-Mediated Platelet and Megakaryocyte Activation Pathway

Indranil Basak, PhD, Seema Bhatlekar, PhD MBA, Robert A. Campbell, PhD, Ahmed Chahdi, Xianguo Kong, MD PhD, Lin Ma, Matthew T. Rondina, MD, Andrew S. Weyrich, PhD, Leonard C. Edelstein, PhD, Paul F. Bray, MD

Blood (2017) 130 (Supplement 1): 1021.

https://doi.org/10.1182/blood.V130.Suppl_1.1021.1021

Published: 2017

Journal Articles

Integrative Genomic Analysis of Adult Mixed Phenotype Acute Leukemia (MPAL)

Koichi Takahashi, MD, Feng Wang, PhD, Kiyomi Morita, MD, Yuanqing Yan, Keyur Patel, MD PhD, Carlos E. Bueso-Ramos, MD PhD, Curtis Gumbs, Jianhua Zhang, Steven Kornblau, MD, Courtney D. DiNardo, MDMSc, Farhad Ravandi, MBBS, Guillermo Garcia-Manero, MD, Elias J. Jabbour, MD, Michael Andreeff, MD PhD, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, Andrew Futreal, PhD

Blood (2017) 130 (Supplement 1): 3904.

https://doi.org/10.1182/blood.V130.Suppl_1.3904.3904

Published: 2017

Journal Articles

Gene Expression Profiling Identifies Distinct Signatures for Dysplastic and Proliferative Chronic Myelomonocytic Leukemia

Mrinal M Patnaik, MBBS, Daniela Barraco, MD, Terra L. Lasho, PhD, Ezequiel Tolosa, PhD, Luciana L. Almada, PhD, Jaime I Davila, PhD, Christy Finke, BS, Curtis A. Hanson, MD, Rhett P. Ketterling, MD, Éric Solary, MD PhD, Nathalie M. Droin, PhD, Naseema Gangat, MBBS, Aref Al-Kali, MD, Martin E. Fernandez-Zapico, MD, Ayalew Tefferi, MD

Blood (2016) 128 (22): 110.

https://doi.org/10.1182/blood.V128.22.110.110

Published: 2016

Journal Articles

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome

Blood (2016) 127 (26): 3387–3397.

https://doi.org/10.1182/blood-2016-02-699843

Published: 2016

Includes: Supplemental data

Journal Articles

Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function

Cameron McDonald-Hyman, BA, Govindarajan Thangavelu, PhD, James Muller, Guoan Zhang, PhD, Sudha Kumari, PhD, Asim Saha, PhD, Brent H. Koehn, PhD, Jason S. Mitchell, PhD, Brian T Fife, PhD, Jonathan S. Serody, MD, Mark J. Osborn, PhD, Keli L. Hippen, PhD, Ameeta Kelekar, PhD, David H. Munn, MD, Amnon Altman, PhD, Thomas A. Neubert, PhD, Michael L. Dustin, PhD, Bruce R. Blazar, MD

Blood (2015) 126 (23): 849.

https://doi.org/10.1182/blood.V126.23.849.849

Published: 2015

Journal Articles

Genes Associated with Alloimmunization to Blood Group Antigens in Sickle Cell Disease

Jacqueline N. Milton, PhD, Allison E. Ashley-Koch, PhD, Melanie E. Garrett, MS, Karen L. Soldano, B.S., Eugene P. Orringer, MD, Paola Sebastiani, PhD, Daniel A. Dworkis, MD PhD, Karen Quillen, MD MPH, Martin H. Steinberg, MD, Marilyn J. Telen, MD

Blood (2014) 124 (21): 762.

https://doi.org/10.1182/blood.V124.21.762.762

Published: 2014

Journal Articles

Robust Assessment of Genomic Imbalance in Diffuse Large B-Cell Lymphoma Confirms Inferior Outcome Is Associated with Genomic Complexity and Identifies Potential Therapeutic Pathway Targets

Lizalynn Dias, PhD, Venkata Thodima, PhD, Asha Guttapalli, M.S., Geetu Mendiratta, PhD, Sergei I Syrbu, MD, Jane Houldsworth, PhD

Blood (2014) 124 (21): 2993.

https://doi.org/10.1182/blood.V124.21.2993.2993

Published: 2014

Journal Articles

The Transcripts Of Platelet-Endothelial Adhesion Molecules and Inflamatory Chemokine Activation Pathway Molecules Are Hyperexpressed In The Bone Marrow Of Acute Promyelocytic Leukemia Patients Presenting Severe Coagulopathy

Priscila S Scheucher, Ph.D, Guilherme A. dos Santos, M.D., Ph.D, Rodrigo Alexandre Panepucci, PhD, Amelia Goes de Araujo, Roberto P. Falcao, M.D., Ph.D, Eduardo M. Rego, M.D., PhD

Blood (2013) 122 (21): 2574.

https://doi.org/10.1182/blood.V122.21.2574.2574

Published: 2013

Journal Articles

Genetic and Pharmacologic Inhibition of PKCθ and PKCα Prevents Acute Gvhd While Sparing GVL Activity in Mice.

Kelley M.K. Haarberg, Ph.D., Kane Kaosaard, Jun Li, M.D, Jessica Heinrichs, B.S., Crystina Bronk, Alexander M Owyang, Ph.D., Esteban Masuda, Ph.D., Claudio Anasetti, MD, Amer Beg, Ph.D., Xue-Zhong Yu, M.D., M.S.

Blood (2012) 120 (21): 3000.

https://doi.org/10.1182/blood.V120.21.3000.3000

Published: 2012

Journal Articles

Effective Prevention of Acute Graft-Verses-Host Disease by Targeting PKC Alpha and PKC Theta in Mice

Kelley M.K. Haarberg, Ph.D., Crystina Bronk, Dapeng Wang, Ph.D., Amer Beg, Ph.D., Xue-Zhong Yu, M.D., M.S.

Blood (2011) 118 (21): 1898.

https://doi.org/10.1182/blood.V118.21.1898.1898

Published: 2011

Journal Articles

Notch-Mediated Suppression of PKCθ Reduces Reactive Oxygen Species and Promotes Leukemic Stem Cell Activity In T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Vincenzo Giambra, PhD, Oksana Nemirovsky, Sonya Lam, Christopher Jenkins, Carol Wai, Hind Medyouf, PhD, R. Keith Humphries, PhD, Connie J. Eaves, PhD, Andrew P Weng, MD, PhD

Blood (2010) 116 (21): 12.

https://doi.org/10.1182/blood.V116.21.12.12

Published: 2010

Journal Articles

Targeting PKCtheta Inhibits Alloreactivity and Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia and Anti-Infection Activities.

Xue-Zhong Yu, MD, Javier Valenzuela, PhD, Cristina Iclozan, PhD, Mohammad Hossain, PhD, Emily Hopewell, Crystina Bronk, Junmei Wang, Esteban Celis, MD, PhD, Robert Engelman, DVM, Edmund K. Waller, MD, PhD, Bruce R. Blazar, MD, Amer Beg, PhD

Blood (2009) 114 (22): 2458.

https://doi.org/10.1182/blood.V114.22.2458.2458

Published: 2009

Journal Articles

Overexpansion of Th17 and Th1/17 Cells in Patients with Myelodysplastic Syndrome

Elena E. Solomou, MD, PhD, A. Tsanaktsi, MD, V. Fertakis, K. Dallas, S. Karambina, M. Tiniakou, A. Kourakli, I. Micheva, A. P Andonopoulos, MD, FACP, S.N C Liossis, MD, P. Matsouka, MD, Nicholas Zoumbos, MD, PhD

Blood (2008) 112 (11): 2698.

https://doi.org/10.1182/blood.V112.11.2698.2698

Published: 2008

Journal Articles

Impaired Activation of Platelets Lacking Protein Kinase C Theta (PKCΘ) Isoform.

Bela Nagy, MD, Kamala Bhavaraju, MS, Todd Getz, BS, Yamini Saraswathy Bynagari, Soochong Kim, PhD, Satya P. Kunapuli, Ph.D.

Blood (2008) 112 (11): 1845.

https://doi.org/10.1182/blood.V112.11.1845.1845

Published: 2008

Journal Articles

Changes in Differential Gene and Protein Expression Patterns during Development of Cord Blood (CB) Versus Adult Peripheral Blood (APB) Monocyte (Mo) into Mature Dendritic Cells (mDC): Insight into Immaturity of CB DC Immunity.

Hong Jiang, PhD, Cheryl Wade-Harris, Megan Lim, MD, PhD, Laxmi Baxi, MD, Mitchell S. Cairo, MD

Blood (2006) 108 (11): 5204.

https://doi.org/10.1182/blood.V108.11.5204.5204

Published: 2006

Journal Articles

T-bet Over-Expression in T Cells from Patients with Aplastic Anemia.

Elena E. Solomou, MD, Keyvan Keyvanfar, Elaine M. Sloand, MD, Barbara Weinstein, Olga Nunez, Neal S. Young, MD

Blood (2005) 106 (11): 832.

https://doi.org/10.1182/blood.V106.11.832.832

Published: 2005

Journal Articles

The Role of the Protein Kinase C (PKC) Family in Glucocorticoid-Induced Apoptosis of Human Leukemic Cells.

Spogmai Komak, BS, Aaron L. Miller, BS, Betty H. Johnson, MS, E. Brad Thompson, MD

Blood (2005) 106 (11): 1214.

https://doi.org/10.1182/blood.V106.11.1214.1214

Published: 2005

Journal Articles

Differential Protein Expression of Zinc Finger Proteins and Cell Cycle Regulators between Lipopolysaccharide (LPS)-Activated Cord Blood (CB) and Adult Peripheral Blood (APB) Dendritic Cells (DC) Derived from Monocytes: Implication of CB Versus APB DC Differential Innate and Adaptive Immunity.

H. Jiang, PhD, M. S. Lim, MD, PhD, K.S.J. Elenitoba-Johnson, MD, C. Wade-Harris, L. Baxi, MD, M. S. Cairo, MD

Blood (2005) 106 (11): 2209.

https://doi.org/10.1182/blood.V106.11.2209.2209

Published: 2005

NARROW

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Defective Rab1b Related Megakaryocytic ER-to-Golgi Transport in RUNX1 Haplodeficiency

Microrna-15a-5p Regulates Multiple Components of GPVI-Mediated Platelet and Megakaryocyte Activation Pathway

Integrative Genomic Analysis of Adult Mixed Phenotype Acute Leukemia (MPAL)

Gene Expression Profiling Identifies Distinct Signatures for Dysplastic and Proliferative Chronic Myelomonocytic Leukemia

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome

Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function

Genes Associated with Alloimmunization to Blood Group Antigens in Sickle Cell Disease

Robust Assessment of Genomic Imbalance in Diffuse Large B-Cell Lymphoma Confirms Inferior Outcome Is Associated with Genomic Complexity and Identifies Potential Therapeutic Pathway Targets

The Transcripts Of Platelet-Endothelial Adhesion Molecules and Inflamatory Chemokine Activation Pathway Molecules Are Hyperexpressed In The Bone Marrow Of Acute Promyelocytic Leukemia Patients Presenting Severe Coagulopathy

Genetic and Pharmacologic Inhibition of PKCθ and PKCα Prevents Acute Gvhd While Sparing GVL Activity in Mice.

Effective Prevention of Acute Graft-Verses-Host Disease by Targeting PKC Alpha and PKC Theta in Mice

Notch-Mediated Suppression of PKCθ Reduces Reactive Oxygen Species and Promotes Leukemic Stem Cell Activity In T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Targeting PKCtheta Inhibits Alloreactivity and Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia and Anti-Infection Activities.

Overexpansion of Th17 and Th1/17 Cells in Patients with Myelodysplastic Syndrome

Impaired Activation of Platelets Lacking Protein Kinase C Theta (PKCΘ) Isoform.

Changes in Differential Gene and Protein Expression Patterns during Development of Cord Blood (CB) Versus Adult Peripheral Blood (APB) Monocyte (Mo) into Mature Dendritic Cells (mDC): Insight into Immaturity of CB DC Immunity.

T-bet Over-Expression in T Cells from Patients with Aplastic Anemia.

The Role of the Protein Kinase C (PKC) Family in Glucocorticoid-Induced Apoptosis of Human Leukemic Cells.

Differential Protein Expression of Zinc Finger Proteins and Cell Cycle Regulators between Lipopolysaccharide (LPS)-Activated Cord Blood (CB) and Adult Peripheral Blood (APB) Dendritic Cells (DC) Derived from Monocytes: Implication of CB Versus APB DC Differential Innate and Adaptive Immunity.

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American Society of Hematology

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American Society of Hematology

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