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Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2019) 134 (Supplement_1): 1276.

https://doi.org/10.1182/blood-2019-129011

Published: 2019

Journal Articles

Concurrent FLT3 Inhibitor and PP2A Activating Drug Treatment Induces Synergistic Cytotoxicity in Acute Myeloid Leukemia Cells with FLT3 Internal Tandem Duplication through Proteasomal Degradation of Pim-1 and c-Myc

Mario Scarpa, PhD, Shivani Kapoor, MS, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2018) 132 (Supplement 1): 3951.

https://doi.org/10.1182/blood-2018-99-117609

Published: 2018

Journal Articles

Clinical Significance of Pim-2 , PD-1 and PD-L1 Expressions in Multiple Myeloma

Tingting Zhao, MD, Yu Wu, MD

Blood (2018) 132 (Supplement 1): 4507.

https://doi.org/10.1182/blood-2018-99-112004

Published: 2018

Journal Articles

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

Kshama A. Doshi, PhD, Shivani Kapoor, MS, Ying Zou, MD PhD, Xiang Li, PhD, Mario Scarpa, MS, Nidal Muvarak, PhD, Pratik Nagaria, PhD, Olga Goloubeva, PhD MSc, Adriana E. Tron, PhD, Charles J. Bieberich, PhD, Feyruz V. Rassool, BSc, PhD, Maria R. Baer, MD

Blood (2017) 130 (Supplement 1): 1243.

https://doi.org/10.1182/blood.V130.Suppl_1.1243.1243

Published: 2017

Journal Articles

The Mechanisms of PIM Kinase Inhibitor, SGI-1776 Free Base, in Treating Myeloma-Associated Bone Disease

Qingxiao Chen, MS, Jingsong He, MD, Huiyao Gu, Xi Huang, MD, Jing Chen, MD, Zhang En Fan, Xing Guo, MD, Haimeng Yan, He Huang, MD, Zhen Cai, MD PhD

Blood (2017) 130 (Supplement 1): 3079.

https://doi.org/10.1182/blood.V130.Suppl_1.3079.3079

Published: 2017

Journal Articles

FLT3/ITD Cooperates with Rac1/DOCK2 to Modulate the Sensitivity of Leukemic Cells to Chemotherapeutic Agents Via Regulation of DNA Repair Pathways

Min Wu, PhD, Li Li, PhD, Max Hamaker, BA, Donald Small, MD PhD, Amy S. Duffield, MD PhD

Blood (2016) 128 (22): 2732.

https://doi.org/10.1182/blood.V128.22.2732.2732

Published: 2016

Journal Articles

PIM1-Mediated CXCR4 Phosphorylation: A Potentially Class-Distinct Therapeutic Target of Next Generation Proteasome Inhibitors in Multiple Myeloma

Johannes M. Waldschmidt, MD, Dagmar Wider, Stefan J. Müller, Dipl.-Pharm., Anna Simon, Sarah Decker, PhD, Marie Follo, PhD, Justus Duyster, MD PhD, Ralph Wäsch, MD, Monika Engelhardt, MD PhD

Blood (2016) 128 (22): 2774.

https://doi.org/10.1182/blood.V128.22.2774.2774

Published: 2016

Journal Articles

TET2 Downregulation Promotes AML Cell Proliferation Via Pim-1 Expression

Qingxiao Chen, M.MD, Jingsong He, Xing Guo, M.MD, Jing Chen, M.MD, Xuanru Lin, M.MD, Xi Huang, M.MD, Haimeng Yan, Li Yang, PhD, Yi Li, PhD, Enfan Zhang, M.MD, Yang Yang, PhD, He Huang, MD PhD, Zhen Cai, MD PhD

Blood (2016) 128 (22): 5085.

https://doi.org/10.1182/blood.V128.22.5085.5085

Published: 2016

Journal Articles

Enhance T Cell Immunotherapy By Targeting PIM-2 Kinase

Anusara Daenthanasanmak, PhD, Yongxia Wu, PhD, Supinya Iamsawat, MSc, Hung D Nguyen, PhD, Shikhar Mehrotra, PhD, Andrew Kraft, MD, Xue-Zhong Yu, PhD

Blood (2016) 128 (22): 815.

https://doi.org/10.1182/blood.V128.22.815.815

Published: 2016

Journal Articles

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

Patrick R. Baldwin, PhD, Shivani Kapoor, B.S., Karthika Natarajan, PhD, Rossana Trotta, PhD, Adriana Tron, PhD, Dennis Huszar, PhD, Eduardo Davila, PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2016) 128 (22): 35.

https://doi.org/10.1182/blood.V128.22.35.35

Published: 2016

Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Kshama A. Doshi, M.S., Karthika Natarajan, PhD, Feyruz V. Rassool, PhD, Dennis Huszar, PhD, Maria R. Baer, MD

Blood (2015) 126 (23): 1268.

https://doi.org/10.1182/blood.V126.23.1268.1268

Published: 2015

Journal Articles

FLT3-ITD Confers Resistance to Bortezomib By Protecting the mTOR/4EBP1 Pathway through Activation of STAT5 and Induction of Pim-1 Expression

Ayako Nogami, MD PhD, Keigo Okada, MD, Gaku Oshikawa, MD PhD, Shinya Ishida, MD, Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Tetsuya Kurosu, MD PhD, Osamu Miura, MD PhD

Blood (2015) 126 (23): 1270.

https://doi.org/10.1182/blood.V126.23.1270.1270

Published: 2015

Journal Articles

The Dual PIM/PI3-K Inhibitor Ibl-202 Overcomes Microenvironmental Mediated Resistance in Multiple Myeloma and Prevents PIM1 Induced CXCR4 Upregulation

Mairead Reidy, PhD, Marianne VanDijk, PhD, Michael O'Neill, PhD, Michael O'Dwyer, MD FRCPI, FRCPath

Blood (2015) 126 (23): 5350.

https://doi.org/10.1182/blood.V126.23.5350.5350

Published: 2015

Journal Articles

Pim-1, Beyond an Oncogene, in Acute Myeloid Leukemia

Yu Wu, MD & PhD, Ruixue Sun, Master, Yan Lun, MD

Blood (2015) 126 (23): 4979.

https://doi.org/10.1182/blood.V126.23.4979.4979

Published: 2015

Journal Articles

A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity

Ewa Jablonska, PhD, Maciej Szydlowski, PhD, Emilia Bialopiotrowicz, PhD, Przemyslaw Kiliszek, MSc, Tomasz Sewastianik, MSc, Anna Polak, MSc, Krzysztof Warzocha, MD PhD, Wojciech Czardybon, PhD, Michal Galezowski, PhD, Renata Windak, PhD, Aniela Golas, PhD, Krzysztof Brzozka, PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 706.

https://doi.org/10.1182/blood.V126.23.706.706

Published: 2015

Journal Articles

The Role of Tumor Associated Macrophages in Multiple Myeloma and Its Pathophysiological Effect on Myeloma Cells Survival, Apopotosis and Angiogenesis

Yu Wu, MD PhD, Xinyi Chen, Yuhuan Zheng

Blood (2015) 126 (23): 4204.

https://doi.org/10.1182/blood.V126.23.4204.4204

Published: 2015

Journal Articles

Expression of PIM Kinases in Reed-Sternberg Cells Fosters Immune Privilege and Tumor Cell Survival in Classical Hodgkin Lymphoma

Maciej Szydlowski, PhD, Monika Prochorec-Sobieszek, MD PhD, Anna Szumera-Cieckiewicz, MD PhD, Grazyna Hoser, PhD, Ewa Jablonska, PhD, Emilia Bialopiotrowicz, PhD, Przemyslaw Kiliszek, MSc, Tomasz Sewastianik, MSc, Anna Polak, MSc, Wojciech Czardybon, PhD, Michal Galezowski, PhD, Renata Windak, PhD, Krzysztof Brzozka, PhD, Krzysztof Warzocha, MD PhD, Jan Maciej Zaucha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 819.

https://doi.org/10.1182/blood.V126.23.819.819

Published: 2015

Journal Articles

Novel Deletion Mutants in the Juxtamembrane Domain of Fms-like Tyrosine Kinase 3 (FLT3) Induce Transformation By Release from Autoinhibition in AML

Nicolas Chatain, PhD, Janine Rossa, Giulia Rossetti, PhD, Rodrigo Casasnovas Perera, PhD, Paolo Carloni, PhD, Torsten Haferlach, MD, Tim H. Brümmendorf, MD, Susanne Schnittger, PhD, Steffen Koschmieder, MD

Blood (2014) 124 (21): 885.

https://doi.org/10.1182/blood.V124.21.885.885

Published: 2014

Journal Articles

Investigation of the CXCL12-CXCR4/CXCR7 Axis in Multiple Myeloma (MM): Adhesion Molecules As Novel Targets of the Potent Proteasome Inhibitor Carfilzomib

Anna Simon, Dagmar Wider, Johannes Waldschmidt, MD, Marie Follo, PhD, Sarah Decker, PhD, Ralph Wäsch, MD, Monika Engelhardt, MD

Blood (2014) 124 (21): 927.

https://doi.org/10.1182/blood.V124.21.927.927

Published: 2014

Journal Articles

Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation

Kristen A McEachern, PhD, Adriana E Tron, PhD, Greg O'Connor, Rachel DuPont, Francis D Gibbons, PhD, Lourdes Pablo, Karthick Vishwanathan, PhD, Patricia McCoon, PhD, Jorge E. Cortes, MD, Daniel J. DeAngelo, MDPhD, Mark D Minden, MDPhD, Geoffrey L. Uy, MD, Frank Neumann, MDPhD, Karen Keating, Dennis Huszar, PhD, J. Elizabeth Pease, PhD, Jeffrey Brown, PhD, J. Carl Barrett, PhD

Blood (2014) 124 (21): 906.

https://doi.org/10.1182/blood.V124.21.906.906

Published: 2014

NARROW

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Concurrent FLT3 Inhibitor and PP2A Activating Drug Treatment Induces Synergistic Cytotoxicity in Acute Myeloid Leukemia Cells with FLT3 Internal Tandem Duplication through Proteasomal Degradation of Pim-1 and c-Myc

Clinical Significance of Pim-2 , PD-1 and PD-L1 Expressions in Multiple Myeloma

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

The Mechanisms of PIM Kinase Inhibitor, SGI-1776 Free Base, in Treating Myeloma-Associated Bone Disease

FLT3/ITD Cooperates with Rac1/DOCK2 to Modulate the Sensitivity of Leukemic Cells to Chemotherapeutic Agents Via Regulation of DNA Repair Pathways

PIM1-Mediated CXCR4 Phosphorylation: A Potentially Class-Distinct Therapeutic Target of Next Generation Proteasome Inhibitors in Multiple Myeloma

TET2 Downregulation Promotes AML Cell Proliferation Via Pim-1 Expression

Enhance T Cell Immunotherapy By Targeting PIM-2 Kinase

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

FLT3-ITD Confers Resistance to Bortezomib By Protecting the mTOR/4EBP1 Pathway through Activation of STAT5 and Induction of Pim-1 Expression

The Dual PIM/PI3-K Inhibitor Ibl-202 Overcomes Microenvironmental Mediated Resistance in Multiple Myeloma and Prevents PIM1 Induced CXCR4 Upregulation

Pim-1, Beyond an Oncogene, in Acute Myeloid Leukemia

A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity

The Role of Tumor Associated Macrophages in Multiple Myeloma and Its Pathophysiological Effect on Myeloma Cells Survival, Apopotosis and Angiogenesis

Expression of PIM Kinases in Reed-Sternberg Cells Fosters Immune Privilege and Tumor Cell Survival in Classical Hodgkin Lymphoma

Novel Deletion Mutants in the Juxtamembrane Domain of Fms-like Tyrosine Kinase 3 (FLT3) Induce Transformation By Release from Autoinhibition in AML

Investigation of the CXCL12-CXCR4/CXCR7 Axis in Multiple Myeloma (MM): Adhesion Molecules As Novel Targets of the Potent Proteasome Inhibitor Carfilzomib

Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation

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American Society of Hematology

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American Society of Hematology

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