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Journal Articles

A Novel 10-Fluorochrome Multiparameter Flow Cytometry (MFC) Panel for Precise Plasma Cell (PC) and MRD Assessment in Clinical Routine of Multiple Myeloma (MM) Patients and throughout the Disease Course

Veronika Riebl, Sandra M. Woerner, Dagmar Wider, Marie Follo, Stefan J. Mueller, Cornelius Miething, Mihaela Zlei, Justus Duyster, MD, Ralph Wäsch, MD, Monika Engelhardt, MD

Blood (2019) 134 (Supplement_1): 1789.

https://doi.org/10.1182/blood-2019-124680

Published: 2019

Journal Articles

Minimal Residual Disease (MRD) Analysis Using Multiparametric Flow Cytometry (MFC) and Identification of Differences in Subpopulations Using Next Generation Sequencing (NGS) in the Bone Marrow (BM) of Multiple Myeloma (MM) Patients (pts)

Sandra M. Dold, MSc, BSc, Veronika Riebl, Dagmar Wider, Marie Follo, PhD, Stefan J. Mueller, Ingrid Bartsch, Milena Pantic, PhD, Cornelius Miething, MD, Chrissoula Kiote-Schmidt, K. Martin Kortüm, MD, Mihaela Zlei, Abdel Kareem Azab, PhD, Mascha Binder, MD, Justyna Rawluk, Justus Duyster, Prof., Robert Zeiser, MD, Ralph Wäsch, MD, Monika Engelhardt, MD

Blood (2018) 132 (Supplement 1): 3222.

https://doi.org/10.1182/blood-2018-99-112489

Published: 2018

Journal Articles

Epigenetic Modifications of the Bone Marrow (BM) Niche in Multiple Myeloma (MM) - a Three-Dimensional (3D) in Vitro Approach

Stefan J. Müller, PharmD, Dagmar Wider, Andreas R. Thomsen, MD, Marie Follo, PhD, Johannes M. Waldschmidt, MD, Gabriele Ihorst, Sandra M. Dold, MSc, Julia Felthaus, Johanna Senger, PhD, Julia Schüler, DVM, Justus Duyster, Abdel Kareem Azab, PhD, Martin J. Hug, PhD, Manfred Jung, PhD, Ralph Wäsch, MD, Monika Engelhardt

Blood (2017) 130 (Supplement 1): 1793.

https://doi.org/10.1182/blood.V130.Suppl_1.1793.1793

Published: 2017

Journal Articles

PIM1-Mediated CXCR4 Phosphorylation: A Potentially Class-Distinct Therapeutic Target of Next Generation Proteasome Inhibitors in Multiple Myeloma

Johannes M. Waldschmidt, MD, Dagmar Wider, Stefan J. Müller, Dipl.-Pharm., Anna Simon, Sarah Decker, PhD, Marie Follo, PhD, Justus Duyster, MD PhD, Ralph Wäsch, MD, Monika Engelhardt, MD PhD

Blood (2016) 128 (22): 2774.

https://doi.org/10.1182/blood.V128.22.2774.2774

Published: 2016

Journal Articles

Testing Novel Anti - Multiple Myeloma (MM) Agents in a Suitable Three-Dimensional (3D) Co-Culture Platform

Stefan J. Müller, Dipl.-Pharm., Johannes M. Waldschmidt, MD, Johanna Senger, PhD, Dagmar Wider, Andreas R. Thomsen, MD, Gabriele Ihorst, PhD, Justus Duyster, MD, Martin J. Hug, PhD, Manfred Jung, PhD, Ralph Wäsch, MD, Monika Engelhardt, MD PhD

Blood (2016) 128 (22): 2109.

https://doi.org/10.1182/blood.V128.22.2109.2109

Published: 2016

Journal Articles

The APC/C Coactivator Cdh1 Controls Self-Renewal and Differentiation of Human and Murine HSPCs

Daniel Ewerth, Stefanie Kreutmair, Andrea Schmidts, Marie Follo, PhD, Dagmar Wider, Julia B. Schueler, DVM, PhD, Julia Felthaus, Justus Duyster, MD, Anna Lena Illert, MD, Monika Engelhardt, MD PhD, Wäsch Ralph, MD

Blood (2016) 128 (22): 2650.

https://doi.org/10.1182/blood.V128.22.2650.2650

Published: 2016

Journal Articles

Self-Renewal and Differentiation in Hematopoietic Stem and Progenitor Cells Is Controlled By the APC/C Coactivator Cdh1

Daniel Ewerth, Stefanie Kreutmair, Birgit Kügelgen, Dagmar Wider, Julia Felthaus, Julia Schüler, DVM, PhD, Andrea Schmidts, Justus Duyster, MD PhD, Anna Lena Illert, Monika Engelhardt, Ralph Wäsch, MD PhD

Blood (2015) 126 (23): 2370.

https://doi.org/10.1182/blood.V126.23.2370.2370

Published: 2015

Journal Articles

Novel Patient Derived Multiple Myeloma Model Reflects Sensitivity Towards Anticancer Treatment in Multiple Myeloma Patients

Julia B. Schueler, DVM, PhD, Dagmar Wider, Kerstin Klingner, Gabrielle Melanie Siegers, PhD, Annette M May, MD, Johannes M. Waldschmidt, MD, Alexander Keller, MD, Justus Duyster, MD, Ralph M. Waesch, MD, Monika Engelhardt, MD

Blood (2015) 126 (23): 3004.

https://doi.org/10.1182/blood.V126.23.3004.3004

Published: 2015

Journal Articles

Results of an Open, Non-Comparative, Phase I/II Investigator Initiated Trial (IIT) in Relapsed or Refractory Multiple Myeloma Patients Using Vorinostat, Bortezomib, Doxorubicin and Dexamethasone (VBDD)

Alexander Keller, MD, Johannes M. Waldschmidt, MD, Dagmar Wider, Dorothee Jakobs, Mandy Möller, Heike Reinhardt, Milena Pantic, PhD, Olga Grishina, MD, Gabriele Ihorst, PhD, Annette M May, MD, Anna Frey, MD, Ulrike Kohlweyer, PhD, Justus Duyster, MD PhD, Manfred Jung, PhD, Monika Engelhardt, MD PhD, Ralph Wäsch, MD PhD

Blood (2015) 126 (23): 4260.

https://doi.org/10.1182/blood.V126.23.4260.4260

Published: 2015

Journal Articles

Mimicking the Myeloma Niche: A 3D Bone-Derived Co-Culture System to Selectively Assess Bystander BMSCs and to Perform High-Throughput Drug Screening in Multiple Myeloma

Johannes M. Waldschmidt, MD, Dagmar Wider, Andreas R. Thomsen, MD, Claudius Klein, Christine Aldrian, Martin Kortuem, MD, Marie Follo, PhD, Julia Schüler, DVM, PhD, Justus Duyster, MD PhD, Monika Engelhardt, MD PhD, Ralph Wäsch, MD PhD

Blood (2015) 126 (23): 1822.

https://doi.org/10.1182/blood.V126.23.1822.1822

Published: 2015

Journal Articles

Investigation of the CXCL12-CXCR4/CXCR7 Axis in Multiple Myeloma (MM): Adhesion Molecules As Novel Targets of the Potent Proteasome Inhibitor Carfilzomib

Anna Simon, Dagmar Wider, Johannes Waldschmidt, MD, Marie Follo, PhD, Sarah Decker, PhD, Ralph Wäsch, MD, Monika Engelhardt, MD

Blood (2014) 124 (21): 927.

https://doi.org/10.1182/blood.V124.21.927.927

Published: 2014

Journal Articles

Bone Marrow Interaction and Multiple Myeloma - Approximating Reality in Novel High-Throughput Multiple Myeloma Coculture Systems

Johannes Waldschmidt, MD, Dagmar Wider, Anna Simon, Andreas R. Thomsen, MD, Christine Aldrian, Marie Follo, PhD, Julia Schüler, Martin Kortum, MD, Ralph Wäsch, MD, Monika Engelhardt, MD

Blood (2014) 124 (21): 2243.

https://doi.org/10.1182/blood.V124.21.2243.2243

Published: 2014

Journal Articles

Dissecting Stem Cell Proliferation and Differentiation In Association With The Central Cell Cycle Regulator APC/C Cdh1 In Vitro and In Vivo

Daniel Ewerth, Andrea Schmidts, Birgit Kuegelgen, Dagmar Wider, Julia Schüler, Monika Engelhardt, MD, Ralph M. Waesch, MD

Blood (2013) 122 (21): 2446.

https://doi.org/10.1182/blood.V122.21.2446.2446

Published: 2013

Journal Articles

Targeting The Protective Microenvironment In Multiple Myeloma (MM): An Analysis Of The CXCL12/CXCR4-Axis and Its Inhibitors AMD3100 and Nox-A12 Combined With Antimyeloma Substances, Such As Pomalidomide and Carfilzomib

Anna Simon, Dagmar Wider, Marie Follo, PhD, Johannes Waldschmidt, Martina Kleber, Ralph Waesch, MD, Monika Engelhardt, MD

Blood (2013) 122 (21): 3851.

https://doi.org/10.1182/blood.V122.21.3851.3851

Published: 2013

Journal Articles

Vorinostat (V) In Combination With Bortezomib (B), Doxorubicin (D) and Dexamethasone (D) (VBDD) In Patients With Refractory Or Relapsed Multiple Myeloma: An Interim Phase I/II Analysis

Martina Kleber, Dagmar Wider, Kristina Keller, Barbara Groß, Heike Reinhardt, Dorothee Jakobs, Mandy-Deborah Moeller, Manuela Burbeck, Milena Pantic, Annette May, Manfred Jung, PhD, Ralph Waesch, MD, Monika Engelhardt, MD

Blood (2013) 122 (21): 3202.

https://doi.org/10.1182/blood.V122.21.3202.3202

Published: 2013

Journal Articles

APC/C Cdh1 As a Mediator Of Hematopoietic Differentiation, Self-Renewal and Malignant Transformation

Andrea Schmidts, Daniel Ewerth, Dominik Schnerch, MD, Arunas Kvainickas, Dagmar Wider, Birgit Kügelgen, Heike L. Pahl, PhD, Monika Engelhardt, MD, Ralph Wäsch, MD

Blood (2013) 122 (21): 3676.

https://doi.org/10.1182/blood.V122.21.3676.3676

Published: 2013

Journal Articles

Dissecting Stem Cell Proliferation and Differentiation in Association with the Central Cell Cycle Regulator APC/C Cdh1

Daniel Ewerth, Andrea Schmidts, Birgit Kuegelgen, Dagmar Wider, Julia Schüler, Monika Engelhardt, Ralph Wäsch, MD

Blood (2012) 120 (21): 1236.

https://doi.org/10.1182/blood.V120.21.1236.1236

Published: 2012

Journal Articles

Bone Marrow Interaction in Multiple Myeloma Pathogenesis: Phenotypical Analysis, Kinetics and Novel Therapy Approaches Based On CXCR4 Inhibition.

Johannes Waldschmidt, Dagmar Wider, Marie Follo, PhD, Josefina Udi, MD, Martina Kleber, Joschka Lorenz, Gabriele Ihorst, Ralph Wäsch, Monika Engelhardt

Blood (2012) 120 (21): 2450.

https://doi.org/10.1182/blood.V120.21.2450.2450

Published: 2012

Journal Articles

APC/C Cdh1 Regulates Self-Renewal and Differentiation of Hematopoietic Stem Cells

Andrea Schmidts, Daniel Ewerth, Dagmar Wider, Birgit Kuegelgen, Monika Engelhardt, MD, Ralph Waesch, MD

Blood (2011) 118 (21): 2379.

https://doi.org/10.1182/blood.V118.21.2379.2379

Published: 2011

Journal Articles

Multikinase Inhibitor Sorafenib Induces Apoptosis, CD138-Downregulation, Actin Depolymerization and Inhibition of M210B4-Triggered Chemotaxis in Multiple Myeloma Cell Lines and Synergyzes with Proteasome Inhibitor Bortezomib

Josefina Udi, MD, Dagmar Wider, Julie Catusse, PhD, Dominik Schnerch, MD, Marie Follo, PhD, Gabriele Ihorst, Ralph Waesch, MD, Monika Engelhardt, MD

Blood (2011) 118 (21): 2380.

https://doi.org/10.1182/blood.V118.21.2380.2380

Published: 2011

NARROW

A Novel 10-Fluorochrome Multiparameter Flow Cytometry (MFC) Panel for Precise Plasma Cell (PC) and MRD Assessment in Clinical Routine of Multiple Myeloma (MM) Patients and throughout the Disease Course

Minimal Residual Disease (MRD) Analysis Using Multiparametric Flow Cytometry (MFC) and Identification of Differences in Subpopulations Using Next Generation Sequencing (NGS) in the Bone Marrow (BM) of Multiple Myeloma (MM) Patients (pts)

Epigenetic Modifications of the Bone Marrow (BM) Niche in Multiple Myeloma (MM) - a Three-Dimensional (3D) in Vitro Approach

PIM1-Mediated CXCR4 Phosphorylation: A Potentially Class-Distinct Therapeutic Target of Next Generation Proteasome Inhibitors in Multiple Myeloma

Testing Novel Anti - Multiple Myeloma (MM) Agents in a Suitable Three-Dimensional (3D) Co-Culture Platform

The APC/C Coactivator Cdh1 Controls Self-Renewal and Differentiation of Human and Murine HSPCs

Self-Renewal and Differentiation in Hematopoietic Stem and Progenitor Cells Is Controlled By the APC/C Coactivator Cdh1

Novel Patient Derived Multiple Myeloma Model Reflects Sensitivity Towards Anticancer Treatment in Multiple Myeloma Patients

Results of an Open, Non-Comparative, Phase I/II Investigator Initiated Trial (IIT) in Relapsed or Refractory Multiple Myeloma Patients Using Vorinostat, Bortezomib, Doxorubicin and Dexamethasone (VBDD)

Mimicking the Myeloma Niche: A 3D Bone-Derived Co-Culture System to Selectively Assess Bystander BMSCs and to Perform High-Throughput Drug Screening in Multiple Myeloma

Investigation of the CXCL12-CXCR4/CXCR7 Axis in Multiple Myeloma (MM): Adhesion Molecules As Novel Targets of the Potent Proteasome Inhibitor Carfilzomib

Bone Marrow Interaction and Multiple Myeloma - Approximating Reality in Novel High-Throughput Multiple Myeloma Coculture Systems

Dissecting Stem Cell Proliferation and Differentiation In Association With The Central Cell Cycle Regulator APC/C Cdh1 In Vitro and In Vivo

Targeting The Protective Microenvironment In Multiple Myeloma (MM): An Analysis Of The CXCL12/CXCR4-Axis and Its Inhibitors AMD3100 and Nox-A12 Combined With Antimyeloma Substances, Such As Pomalidomide and Carfilzomib

Vorinostat (V) In Combination With Bortezomib (B), Doxorubicin (D) and Dexamethasone (D) (VBDD) In Patients With Refractory Or Relapsed Multiple Myeloma: An Interim Phase I/II Analysis

APC/C Cdh1 As a Mediator Of Hematopoietic Differentiation, Self-Renewal and Malignant Transformation

Dissecting Stem Cell Proliferation and Differentiation in Association with the Central Cell Cycle Regulator APC/C Cdh1

Bone Marrow Interaction in Multiple Myeloma Pathogenesis: Phenotypical Analysis, Kinetics and Novel Therapy Approaches Based On CXCR4 Inhibition.

APC/C Cdh1 Regulates Self-Renewal and Differentiation of Hematopoietic Stem Cells

Multikinase Inhibitor Sorafenib Induces Apoptosis, CD138-Downregulation, Actin Depolymerization and Inhibition of M210B4-Triggered Chemotaxis in Multiple Myeloma Cell Lines and Synergyzes with Proteasome Inhibitor Bortezomib

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American Society of Hematology

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American Society of Hematology

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