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Journal Articles

The Impact of Chemotherapeutic Agents on Signaling and Epigenetics in Vascular Endothelial Cells

Srila Gopal, MD, Amanda Creech, Adam Officer, Shawn Egri, Desiree Davison, Jacob D Jaffe, PhD, Iris Z Jaffe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1353.
https://doi.org/10.1182/blood.V128.22.1353.1353
Published: 2016
Journal Articles

PDE4 Inhibitors Block TLR7 and TLR9-Driven Signaling, Proliferation and Cytokine Secretion in CLL Cells As Well As Proliferation Driven by Exposure to Apoptotic Cells

Ying Tan, M.D., Ph.D., Amanda A. Watkins, Ian R. Rifkin, M.D., Ph.D., Adam Lerner, MD
Journal: Blood
Blood (2012) 120 (21): 1774.
https://doi.org/10.1182/blood.V120.21.1774.1774
Published: 2012
Journal Articles

PDE4B Modulates Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia

Jun J. Yang, PhD, Shuyu E, PhD, Shuhong Shen, MD, PhD, Deepa Bhojwani, MD, Huining Kang, PhD, Yani Ma, PhD, Jing Chen, MD, PhD, JingYan Tang, MD, Nita L. Seibel, MD, Heng Xu, PhD, Jin Cheng, Laura B. Ramsey, PhD, Kristine Crews, PharmD, W. Paul Bowman, MD, Michael J. Borowitz, MD, PhD, William L. Carroll, MD, Cheryl L. Willman, MD, Sima Jeha, MD, Ching-Hon Pui, MD, Stephen P. Hunger, MD, Mary V. Relling, PharmD, William E. Evans, PharmD
Journal: Blood
Blood (2012) 120 (21): 530.
https://doi.org/10.1182/blood.V120.21.530.530
Published: 2012
Journal Articles

PDE4 Inhibitors Enhance DNA Damage-Induced Apoptosis In CLL

John Meyers, PhD, Adam Lerner, MD
Journal: Blood
Blood (2010) 116 (21): 2902.
https://doi.org/10.1182/blood.V116.21.2902.2902
Published: 2010
Journal Articles

Control of the PI3K/AKT Pathway by Phosphodiesterase 4B Modulates Glucocorticoid Response in B-Cell Lymphomas.

Sang-Woo Kim, PhD, Deepak Rai, PhD, Ricardo C Aguiar, MD, PhD,
Journal: Blood
Blood (2009) 114 (22): 728.
https://doi.org/10.1182/blood.V114.22.728.728
Published: 2009
Journal Articles

Phosphodiesterase-4 Inhibition Reduces Ischemic/Reperfusion Liver Injury in a Mouse Model for Sickle Cell Disease.

Alida Filippini, Giorgio Malpeli, Anne Janin, Orah S Platt, Christhope Leboeuf, Aldo Scarpa, Yves Beuzard, Lucia De Franceschi, MD
Journal: Blood
Blood (2008) 112 (11): 1444.
https://doi.org/10.1182/blood.V112.11.1444.1444
Published: 2008
Journal Articles

Cytotoxicity of the Type 4 Phosphodiesterase Inhibitor CD160130 for Freshly Isolated Human CLL Cells In Vitro.

J. Brice Weinberg, MD, Ning Jiang, MD, Alicia D. Volkheimer, MS, Youwei Chen, MD, Karen M. Bond, BS, Joseph O. Moore, MD, Jon P. Gockerman, MD, Louis F. Diehl, MD, Carlos M. de Castro, MD, David A. Rizzieri, MD, PhD, Marc C. Levesque, MD, PhD, Kenneth Mugridge, PhD, Joe DeAngelo
Journal: Blood
Blood (2007) 110 (11): 3129.
https://doi.org/10.1182/blood.V110.11.3129.3129
Published: 2007
Journal Articles

PDE4 Inhibitors Augment Glucocorticoid Receptor Levels in B-CLL Cells but Not in T Cells, B Cells, Monocytes or Neutrophils.

Adam Lerner, MD, John A. Meyers, BA, Josephine A. Taverna, MD, Anthony Makkinje, PhD
Journal: Blood
Blood (2006) 108 (11): 2608.
https://doi.org/10.1182/blood.V108.11.2608.2608
Published: 2006
Journal Articles

PDE-4 Inhibitor Rolipram Prevents Hypoxia Induced Pulmonary Hypertension in Transgenic Sickle Cell Sad Mice.

Lucia De Franceschi, MD, Giorgio Malpeli, Anne Janin, MD, Aldo Scarpa, MD, Christhophe Leboeuf, Orah Platt, MD, Philippe Leboulch, Emmanuel Payen, Yves Beuzard, MD, Carlo Brugnara, MD
Journal: Blood
Blood (2004) 104 (11): 3577.
https://doi.org/10.1182/blood.V104.11.3577.3577
Published: 2004
Journal Articles

PDE4 Inhibitors Augment Glucocorticoid-Mediated Apoptosis in B-CLL Cells in the Absence of Exogenous Adenylyl Cyclase Stimulation.

Adam Lerner, MD, Hongli Dong, PhD, Lewis Weintraub, MD, Paul M. Epstein, PhD, Sanjay Tiwari, PhD
Journal: Blood
Blood (2004) 104 (11): 4793.
https://doi.org/10.1182/blood.V104.11.4793.4793
Published: 2004
Journal Articles

Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis

Sanjay Tiwari, Kyriacos Felekkis, Eun-Yi Moon, Amanda Flies, David H. Sherr, Adam Lerner
Journal: Blood
Blood (2004) 103 (7): 2661–2667.
https://doi.org/10.1182/blood-2003-06-2154
Published: 2004
Journal Articles

PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A

Eun-Yi Moon, Adam Lerner
Journal: Blood
Blood (2003) 101 (10): 4122–4130.
https://doi.org/10.1182/blood-2002-10-3208
Published: 2003
Journal Articles

Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21 WAF1/CIP1 proteins in human acute lymphoblastic leukemia cells

Ryosuke Ogawa, Michael B. Streiff, Artem Bugayenko, Gregory J. Kato
Journal: Blood
Blood (2002) 99 (9): 3390–3397.
https://doi.org/10.1182/blood.V99.9.3390
Published: 2002
Journal Articles

Type 4 Cyclic Adenosine Monophosphate Phosphodiesterase as a Therapeutic Target in Chronic Lymphocytic Leukemia

Doo Ho Kim, Adam Lerner
Journal: Blood
Blood (1998) 92 (7): 2484–2494.
https://doi.org/10.1182/blood.V92.7.2484
Published: 1998
Journal Articles

Inactivation of Recombinant Monocyte cAMP-Specific Phosphodiesterase by cAMP Analog, 8-[(4-Bromo-2,3-Dioxobutyl)thio]Adenosine 3′,5′-Cyclic Monophosphate

George A. Omburo, Theodore J. Torphy, Gilbert Scott, Susanne Jacobitz, Roberta F. Colman, Robert W. Colman
Journal: Blood
Blood (1997) 89 (3): 1019–1026.
https://doi.org/10.1182/blood.V89.3.1019
Published: 1997