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Journal Articles

The Effect of the Soluble Guanylate Cyclase Stimulator Olinciguat on Renal Function and Biomarkers of Inflammation and Renal Injury in Sickle Cell Mice

Boris Tchernychev, PhD, Raghunath Ramanarasimhaiah, MD, Guang Liu, PhD, Katherine Hall, PhD, Regina Margaret Graul, PhD, Jaime Masferrer, PhD

Blood (2019) 134 (Supplement_1): 3554.

https://doi.org/10.1182/blood-2019-127361

Published: 2019

Journal Articles

Effects of Targeting the Interleukin-1 Receptor in a Murine Model of Sickle Cell Disease

Jessica Venugopal, PhD, Jintao Wang, PhD, Chiao Guo, Daniel Eitzman, MD

Blood (2019) 134 (Supplement_1): 2259.

https://doi.org/10.1182/blood-2019-128980

Published: 2019

Journal Articles

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Boris Tchernychev, Susanne Feil, Peter Germano, William Warren, Elisabeth Lonie, Robert Feil, Todd G Milne, John Hadcock, Yueh-Tyng Chien, Mark G Currie, Regina Margaret Graul

Blood (2017) 130 (Supplement 1): 447.

https://doi.org/10.1182/blood.V130.Suppl_1.447.447

Published: 2017

Journal Articles

Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice

Kelly Marie Knee, Reema Jasuja, Amey Barakat, John J. Kelly, Joseph C. Nneji, Pratap Singh, Jay M. Janz

Blood (2016) 128 (22): 3644.

https://doi.org/10.1182/blood.V128.22.3644.3644

Published: 2016

Journal Articles

E-Selectin Antagonist GMI-1271 Shows a Favorable Safety, PK and Bleeding Profile in Phase I Studies of Healthy Volunteers

Dana E. Angelini, MD, Sumana Devata, MD, Angela E. Hawley, Susan A. Blackburn, RN, MBA, Satwinder Grewal, Martina V Hemmer, MA, Henry Flanner, MS, William Kramer, PhD, William E Parker, Yu-Ling Li, MS, MD, Daniel Durant Myers, DVM, MPH, James B. Froehlich, MD MPH, John L Magnani, PhD, Helen M. Thackray, MD, Thomas W. Wakefield, MD, Suman L. Sood, MD MSCE

Blood (2016) 128 (22): 3826.

https://doi.org/10.1182/blood.V128.22.3826.3826

Published: 2016

Journal Articles

Increased Levels of Endothelial Dysfunction Markers and Matrix Metalloproteinases in Patients with Severe Post-Thrombotic Syndrome

Luis Fernando Bittar, PhD, Fernanda Andrade Orsi, MD PhD, Kiara Cristina Senger Zapponi, MSc, Bruna Moraes Mazetto, PhD, Erich Vinicius De Paula, Sr., MD PhD, Joyce Maria Annichino-Bizzacchi, MD PhD

Blood (2016) 128 (22): 276.

https://doi.org/10.1182/blood.V128.22.276.276

Published: 2016

Journal Articles

A Phase I/II Study of GMI-1271, a Novel E-Selectin Antagonist, in Combination with Induction Chemotherapy in Relapsed/Refractory and Elderly Previously Untreated Acute Myeloid Leukemia; Results to Date

Daniel J. DeAngelo, MD PhD, Jane L. Liesveld, MD, Brian A Jonas, MD PhD, Michael E O'Dwyer, MD, Dale L. Bixby, MD, John L Magnani, PhD, Helen M. Thackray, MD, Pamela S. Becker, MD PhD

Blood (2016) 128 (22): 4049.

https://doi.org/10.1182/blood.V128.22.4049.4049

Published: 2016

Journal Articles

Simvastatin Reduces Frequency of Vaso-Occlusive Pain in Sickle Cell Disease: A Pilot Efficacy Trial

Carolyn C. Hoppe, MD, Eufemia Jacob, PhD RN, Frans A. Kuypers, PhD, Lori Styles, MD

Blood (2015) 126 (23): 545.

https://doi.org/10.1182/blood.V126.23.545.545

Published: 2015

Journal Articles

PDE-9 Inhibition Combined with Hydroxyurea Is Beneficial in Vaso-Occlusive Crisis in Mouse Model of Sickle Cell Disease

Reema Jasuja, Sunita Patel Hett, Joachim Fruebis, PhD, Debra Pittman

Blood (2014) 124 (21): 2694.

https://doi.org/10.1182/blood.V124.21.2694.2694

Published: 2014

Journal Articles

Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis

Ted Wun, MD, Marilyn J. Telen, MD, Lakshmanan Krishnamurti, MD, Timothy L. McCavit, MD, Laura M DeCastro, MD, Henry Flanner, ME, Frans A. Kuypers, PhD, Sandra K. Larkin, MS, Seungshin Rhee, MS, John L. Magnani, PhD, Helen M. Thackray, MD

Blood (2014) 124 (21): 2704.

https://doi.org/10.1182/blood.V124.21.2704.2704

Published: 2014

Journal Articles

Recombinant Thrombomodurin For The Treatment Of Transplantation-Associated Coagulopathy After Allogeneic Stem Cell Transplantation

Kazuyoshi Ishii, MD, MPH, PhD, Shosaku Nomura, MD, PhD, Tomoki Ito, MD, PhD, Yuta Katayama, MD, PhD, Taiichi Kyo, MD, Shuichi Ota, MD, PhD, Masanori Seki, MD, PhD, Shigeru Chiba, MD, PhD, Yoshinobu Maeda, M.D., Ph.D., Mitsune Tanimoto, MD, PhD, Takayuki Ikezoe, MD. PhD, Hideo Yagi, MD, PhD, Yoji Ishida, M.D., Ph.D., Naohito Fujishima, MD, PhD, Kenichi Sawada, MD, PhD

Blood (2013) 122 (21): 5454.

https://doi.org/10.1182/blood.V122.21.5454.5454

Published: 2013

Journal Articles

MCP-1 and VCAM-1 As Pathological Markers In a Patient With Infection Induced Hemophagocytic Syndrome After Stem Cell Transplantation

Kunio Hayashi, PhD/MD, Kazuhiro Ikegame, PhD/MD, Masafumi Ito, PhD/MD, Shosaku Nomura, PhD/MD

Blood (2013) 122 (21): 5465.

https://doi.org/10.1182/blood.V122.21.5465.5465

Published: 2013

Journal Articles

Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease

Olufolake Adisa, MD, Benjamin Yaw Owusu, B.S., Yijuan Hu, PhD, Samit Ghosh, PhD, Fang Tan, PhD, Frederika Sey, MD, Ivy Ekem, MD, Isaac Quaye, PhD, Solomon F Ofori-Acquah, PhD

Blood (2013) 122 (21): 2235.

https://doi.org/10.1182/blood.V122.21.2235.2235

Published: 2013

Journal Articles

Clinical Characteristics Associated with Survival in Adult Sickle Cell Disease

Hany Elmariah, MD, Melanie E. Garrett, MS, Kenneth I. Ataga, MD, Allison E Ashley-Koch, PhD, Marilyn J. Telen, MD

Blood (2012) 120 (21): 3229.

https://doi.org/10.1182/blood.V120.21.3229.3229

Published: 2012

Journal Articles

Endothelial Glycocalyx Degradation Is Associated with Bleeding, Thrombocytopathy, Endothelial Disruption and Leukocytosis in Acute Myeloid Leukemia.

Anne Mette Larsen, MD, Eva Birgitte Leinøe, MD, PhD, Pär Johansson, MD, DMSc, Henrik Birgens, MD, DMSc, Sisse Rye Ostrowski, MD, PhD, DMSc

Blood (2012) 120 (21): 2173.

https://doi.org/10.1182/blood.V120.21.2173.2173

Published: 2012

Journal Articles

Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State

John L. Magnani, PhD, Frans A Kuypers, PhD, John T. Patton, PhD, Sandra K Larkin, MS, Lori Styles, MD, Laura M DeCastro, MD, Marilyn J. Telen, MD, Ted Wun, MD, Helen Thackray, MD

Blood (2012) 120 (21): 87.

https://doi.org/10.1182/blood.V120.21.87.87

Published: 2012

Journal Articles

Epithelial adhesion molecules can inhibit HIV-1–specific CD8 + T-cell functions

Blood (2011) 117 (19): 5112–5122.

https://doi.org/10.1182/blood-2010-12-321588

Published: 2011

Includes: Supplemental data

Journal Articles

Relationship of Soluble Adhesion Receptors to Red Cell Apoptosis In SCD.

Charmaine P. Mutucumarana, Catherine Chandler, Marilyn J. Telen, MD, Martha Delahunty, PhD

Blood (2010) 116 (21): 1654.

https://doi.org/10.1182/blood.V116.21.1654.1654

Published: 2010

Journal Articles

A Pilot Study of Tapered Oral Dexamethasone for the Acute Chest Syndrome of Sickle Cell Disease.

Charles T. Quinn, MD, MS, Marie J. Stuart, MD, Karen Kesler, PhD, Kenneth I. Ataga, MD, Winfred C. Wang, MD, Lori Styles, MD, Kim Smith-Whitley, MD, Ted Wun, MD, Suba Krishnan, MD, Frans A. Kuypers, PhD, Yamaja Setty, PhD, Nigel S. Key, MB, ChB, Seungshin Rhee, MS, George R. Buchanan, MD

Blood (2009) 114 (22): 1515.

https://doi.org/10.1182/blood.V114.22.1515.1515

Published: 2009

Journal Articles

Pomalidomide Modifies Sickle Cell Related Organ Damage in Transgenic Mice with Sickle Cell Anemia.

Steffen E. Meiler, MD, Marlene Wade, Laure Moutouh de Parseval, MD, Laura G Corral, Paul S. Swerdlow, MD, Ferdane Kutlar, MD, Abdullah Kutlar

Blood (2009) 114 (22): 904.

https://doi.org/10.1182/blood.V114.22.904.904

Published: 2009

NARROW

The Effect of the Soluble Guanylate Cyclase Stimulator Olinciguat on Renal Function and Biomarkers of Inflammation and Renal Injury in Sickle Cell Mice

Effects of Targeting the Interleukin-1 Receptor in a Murine Model of Sickle Cell Disease

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice

E-Selectin Antagonist GMI-1271 Shows a Favorable Safety, PK and Bleeding Profile in Phase I Studies of Healthy Volunteers

Increased Levels of Endothelial Dysfunction Markers and Matrix Metalloproteinases in Patients with Severe Post-Thrombotic Syndrome

A Phase I/II Study of GMI-1271, a Novel E-Selectin Antagonist, in Combination with Induction Chemotherapy in Relapsed/Refractory and Elderly Previously Untreated Acute Myeloid Leukemia; Results to Date

Simvastatin Reduces Frequency of Vaso-Occlusive Pain in Sickle Cell Disease: A Pilot Efficacy Trial

PDE-9 Inhibition Combined with Hydroxyurea Is Beneficial in Vaso-Occlusive Crisis in Mouse Model of Sickle Cell Disease

Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis

Recombinant Thrombomodurin For The Treatment Of Transplantation-Associated Coagulopathy After Allogeneic Stem Cell Transplantation

MCP-1 and VCAM-1 As Pathological Markers In a Patient With Infection Induced Hemophagocytic Syndrome After Stem Cell Transplantation

Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease

Clinical Characteristics Associated with Survival in Adult Sickle Cell Disease

Endothelial Glycocalyx Degradation Is Associated with Bleeding, Thrombocytopathy, Endothelial Disruption and Leukocytosis in Acute Myeloid Leukemia.

Pan-Selectin Antagonist GMI-1070 Affects Biomarkers of Adhesion, Activation and the Coagulation Cascade in Sickle Cell Adults At Steady State

Epithelial adhesion molecules can inhibit HIV-1–specific CD8 + T-cell functions

Relationship of Soluble Adhesion Receptors to Red Cell Apoptosis In SCD.

A Pilot Study of Tapered Oral Dexamethasone for the Acute Chest Syndrome of Sickle Cell Disease.

Pomalidomide Modifies Sickle Cell Related Organ Damage in Transgenic Mice with Sickle Cell Anemia.

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American Society of Hematology

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American Society of Hematology

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