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Journal Articles

The Exosomal Transfer of Acid Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

Inge Oudaert, MSc, Sylvia Faict, MSc, Ludovic D'Auria, PhD, Jonas Dehairs, PhD, Ken Maes, Philip Vlummens, MD, Lotte Jacobs, BSc, Kim De Veirman, Elke De Bruyne, PhD, Karel Fostier, MD, Isabelle Vande Broek, MD PhD, Rik Schots, Karin Vanderkerken, PhD, Johannes V. Swinnen, PhD, Eline Menu, PhD

Blood (2019) 134 (Supplement_1): 3058.

https://doi.org/10.1182/blood-2019-122857

Published: 2019

Journal Articles

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Jue Wang, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 1103.

https://doi.org/10.1182/blood-2019-125933

Published: 2019

Journal Articles

Secreted Factors Determine Resistance to Idelalisib in Marginal Zone Lymphoma Models of Resistance

Alberto J Arribas, Sara Napoli, Eugenio Gaudio, PhD, Luciano Cascione, PhD, Alessandra Di Veroli, Chiara Tarantelli, PhD, Filippo Spriano, Antonella Zucchetto, Francesca Maria Rossi, PhD, Andrea Rinaldi, Anastasios Stathis, MD, Georg Stuessi, MD, Valter Gattei, MD, Gabriele Cruciani, Emanuele Zucca, MD, Davide Rossi, MD PhD, Francesco Bertoni, MD

Blood (2019) 134 (Supplement_1): 2569.

https://doi.org/10.1182/blood-2019-124299

Published: 2019

Journal Articles

Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity

Jue Wang, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2019) 134 (7): 645–655.

https://doi.org/10.1182/blood.2019001400

Published: 2019

Includes: Supplemental data

Journal Articles

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Blood (2018) 132 (Supplement 1): 2748.

https://doi.org/10.1182/blood-2018-99-118183

Published: 2018

Journal Articles

Metabolomic Profile in Patients with Autoimmune Hemolytic Anemia

Iara Baldim Rabelo, MD PhD, Akemi Kuroda Chiba, Pharmacist, MS, Elyse Moritz, Pharmacist, PhD, Melca Oliveira Barros, MD PhD, Ismael Dale Cotrim Guerreiro Silva, MD PhD, Jose Orlando Bordin, MD PhD, Maria de Lourdes Chauffaille, MD PhD, Mihoko Yamamoto, MD PhD, Celso Arrais, MD PhD

Blood (2018) 132 (Supplement 1): 3622.

https://doi.org/10.1182/blood-2018-99-116275

Published: 2018

Journal Articles

High Glutathione and NAD(P)H Levels, and Increased Protein Folding Capacity Are Involved in Mediating Proteasome Inhibitor-Resistance in Multiple Myeloma

Lenka Besse, Andrej Besse, Marianne Kraus, Jürgen Bader, Christoph Driessen, MD

Blood (2017) 130 (Supplement 1): 1258.

https://doi.org/10.1182/blood.V130.Suppl_1.1258.1258

Published: 2017

Journal Articles

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

Jue Wang, PhD, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 16.

https://doi.org/10.1182/blood.V128.22.16.16

Published: 2016

Journal Articles

The Cell Surface NADH Oxidase ENOX2 Is Highly Expressed in Chronic Myeloid Leukemia (CML): a Redox Protein As a Secreted Surrogate Biomarker and Druggable Target

Seda Baykal, Maud Voldoire, MD, Christophe Desterke, Nathalie Sorel, Hyacinthe Atchroue Johnson Ansah, Agnes Guerci-Bresler, MD, Jean-Claude Chomel, PharmD PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD, PhD

Blood (2016) 128 (22): 3059.

https://doi.org/10.1182/blood.V128.22.3059.3059

Published: 2016

Journal Articles

Marqibo®, Vincristine Sulfate Liposome Injection, for the Treatment of Advanced, Relapsed or Refractory Philadelphia Chromosome-Negative (Ph-) Acute Lymphoblastic Leukemia (ALL) in an Adolescent Young Adult (AYA) Population

Gary J Schiller, MD, Lloyd E. Damon, MD, Wendy Stock, MD, Steven E Coutre, MD, Pamela Hsu, Lucy Prasad, Dan Douer, MD

Blood (2015) 126 (23): 1291.

https://doi.org/10.1182/blood.V126.23.1291.1291

Published: 2015

Journal Articles

Fingolimod Expands Human Umbilical Cord Blood Cells (UCB) in Vitro and Improves Engraftment Rate of Human UCB in Sublethally Irradiated NOD SCID Gamma (NSG) Mice

Basem M. William, MD, Stephen Moreton, Jane Reese, Pingfu Fu, Ph., D., Julia V. Busik, PhD, Marcos de Lima, MD, David N. Wald, MD PhD

Blood (2014) 124 (21): 2413.

https://doi.org/10.1182/blood.V124.21.2413.2413

Published: 2014

Journal Articles

Anemia, Shortened Erythrocyte Lifespan and Stomatocytosis In a Flippase Mutant Mouse Strain

Coupland Lucy, Mehmet Yabas, Deborah Cromer, Markus Winterberg, Narcissus Teoh, Kiaran Kirk, Stefan Broer, Christopher Parish, Anselm Enders

Blood (2013) 122 (21): 2183.

https://doi.org/10.1182/blood.V122.21.2183.2183

Published: 2013

Journal Articles

Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts

Kohji Kasahara, Mizuho Kaneda, Toshiaki Miki, Kazuko Iida, Naoko Sekino-Suzuki, Ikuo Kawashima, Hidenori Suzuki, Motoyuki Shimonaka, Morio Arai, Yoshiko Ohno-Iwashita, Soichi Kojima, Mitsuhiro Abe, Toshihide Kobayashi, Toshiro Okazaki, Masayoshi Souri, Akitada Ichinose, Naomasa Yamamoto

Blood (2013) 122 (19): 3340–3348.

https://doi.org/10.1182/blood-2013-04-491290

Published: 2013

Includes: Supplemental data

Journal Articles

Neurotoxicity Profile of Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) Monotherapy in Adults with Relapsed Acute Lymphoblastic Leukemia and Universal Prior Standard Vincristine Exposure

Steven R. Deitcher, MD, Jeffrey A. Silverman, Ph.D.

Blood (2012) 120 (21): 3568.

https://doi.org/10.1182/blood.V120.21.3568.3568

Published: 2012

Journal Articles

Vincristine Sulfate Liposomes Injection (VSLI, Marqibo): Interim Results From a Phase I Study in Children and Adolescents with Refractory Cancer

Nirali N Shah, MD, Melinda Merchant, MD, PhD, Diane Cole, Kelly Richards, RN, Cindy Delbrook, RN, Brigitte C Widemann, MD, Alan S Wayne, MD

Blood (2012) 120 (21): 1497.

https://doi.org/10.1182/blood.V120.21.1497.1497

Published: 2012

Journal Articles

Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) Facilitates Increased Delivery of Vincristine Sulfate to Target Cancer Tissues.

Jeffrey A. Silverman, Ph.D., Steven R. Deitcher, MD

Blood (2012) 120 (21): 2457.

https://doi.org/10.1182/blood.V120.21.2457.2457

Published: 2012

Journal Articles

Sphingomyelinase-Induced Remodeling of the Erythrocyte Membrane

Sip Dinkla, Katharina Wessels, Wouter P.R. Verdurmen, Irma Joosten, Roland E. Brock, Giel J.C.G.M. Bosman

Blood (2011) 118 (21): 1032.

https://doi.org/10.1182/blood.V118.21.1032.1032

Published: 2011

Journal Articles

Vincristine Sulfate Liposomes Injection (Marqibo ® ) Facilitates Durable Remissions and Potentially Curative Hematopoietic Stem Cell Transplantation in Adults with Advanced, Relapsed and/or Refractory Acute Lymphoblastic Leukemia

Gary J. Schiller, MD, John Lister, MD, Leonard T. Heffner, MD, Stuart L. Goldberg, MD, Lloyd E. Damon, MD, Jeffrey A. Silverman, Ph.D., Steven R. Deitcher, MD

Blood (2011) 118 (21): 4235.

https://doi.org/10.1182/blood.V118.21.4235.4235

Published: 2011

Journal Articles

Neurological Toxicity Profile of Weekly Vincristine Sulfate Liposomes Injection (Marqibo ® ) 2.25 mg/m 2 Compared to Historical Standard Vincristine Sulfate 1.4 mg/m 2 , 2 mg, and 4 mg Administered Less Frequently

Lloyd E. Damon, MD, Stuart L. Goldberg, MD, Leonard T. Heffner, MD, John Lister, MD, Gary J. Schiller, MD, Steven R. Deitcher, MD

Blood (2011) 118 (21): 4247.

https://doi.org/10.1182/blood.V118.21.4247.4247

Published: 2011

Journal Articles

Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation.

Subramanian Yegneswaran, PhD, Yajnavalka Banerjee, PhD, Jose A. Fernandez, MD, PhD, Hiroshi Deguchi, MD, PhD, John H. Griffin, PhD

Blood (2010) 116 (21): 1130.

https://doi.org/10.1182/blood.V116.21.1130.1130

Published: 2010

NARROW

The Exosomal Transfer of Acid Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

Alterations in Sphingomyelin Metabolism Influences Tissue Factor Procoagulant Activity and the Release of TF-Positive Microvesicles

Secreted Factors Determine Resistance to Idelalisib in Marginal Zone Lymphoma Models of Resistance

Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity

Biology of Acute Myeloid Leukemia (AML) with Monosomy of Chromosome 7 or Loss of 7q. a Study on 487 Patients Analyzed By Gene Expression Profile (GEP), Single Nucleotide Polymorphism (SNP) Arrays and Metabolomics

Metabolomic Profile in Patients with Autoimmune Hemolytic Anemia

High Glutathione and NAD(P)H Levels, and Increased Protein Folding Capacity Are Involved in Mediating Proteasome Inhibitor-Resistance in Multiple Myeloma

The Role of Sphingomyelin (SM) in Tissue Factor (TF) Encryption: ATP-Induced Activation of Acid Sphingomyelinase in Macrophages Decrypts Tissue Factor By Hydrolysis of SM in the Outer Leaflet

The Cell Surface NADH Oxidase ENOX2 Is Highly Expressed in Chronic Myeloid Leukemia (CML): a Redox Protein As a Secreted Surrogate Biomarker and Druggable Target

Marqibo®, Vincristine Sulfate Liposome Injection, for the Treatment of Advanced, Relapsed or Refractory Philadelphia Chromosome-Negative (Ph-) Acute Lymphoblastic Leukemia (ALL) in an Adolescent Young Adult (AYA) Population

Fingolimod Expands Human Umbilical Cord Blood Cells (UCB) in Vitro and Improves Engraftment Rate of Human UCB in Sublethally Irradiated NOD SCID Gamma (NSG) Mice

Anemia, Shortened Erythrocyte Lifespan and Stomatocytosis In a Flippase Mutant Mouse Strain

Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts

Neurotoxicity Profile of Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) Monotherapy in Adults with Relapsed Acute Lymphoblastic Leukemia and Universal Prior Standard Vincristine Exposure

Vincristine Sulfate Liposomes Injection (VSLI, Marqibo): Interim Results From a Phase I Study in Children and Adolescents with Refractory Cancer

Vincristine Sulfate Liposome Injection (VSLI, Marqibo®) Facilitates Increased Delivery of Vincristine Sulfate to Target Cancer Tissues.

Sphingomyelinase-Induced Remodeling of the Erythrocyte Membrane

Vincristine Sulfate Liposomes Injection (Marqibo ® ) Facilitates Durable Remissions and Potentially Curative Hematopoietic Stem Cell Transplantation in Adults with Advanced, Relapsed and/or Refractory Acute Lymphoblastic Leukemia

Neurological Toxicity Profile of Weekly Vincristine Sulfate Liposomes Injection (Marqibo ® ) 2.25 mg/m 2 Compared to Historical Standard Vincristine Sulfate 1.4 mg/m 2 , 2 mg, and 4 mg Administered Less Frequently

Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation.

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American Society of Hematology

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American Society of Hematology

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