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Journal Articles

The Immunophilin FKBP12 Inhibits Hepcidin By Modulating BMP Type I-Type II Receptors Interaction and Ligand Responsiveness

Alessandro Dulja, MSc, Alessia Pagani, PhD, Mariateresa Pettinato, Antonella Nai, PhD, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2019) 134 (Supplement_1): 430.

https://doi.org/10.1182/blood-2019-130058

Published: 2019

Journal Articles

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Mariateresa Pettinato, Mariam Aghajan, PhD, Violante Olivari, MSc, Alessandro Dulja, MSc, Antonella Nai, PhD, Jessica Bordini, PhD, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, PhD, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2019) 134 (Supplement_1): 955.

https://doi.org/10.1182/blood-2019-126496

Published: 2019

Journal Articles

Inhibiting the Immunophilin FKBP12: A Potential Therapeutic Approach to Iron Overload/Low Hepcidin Disorders

Mariateresa Pettinato, MSc, Mariam Aghajan, Alessandro Dulja, Antonella Nai, PhD, Violante Olivari, Jessica Bordini, MSc, Alessandro Campanella, PhD, Alessia Pagani, PhD, Shuling Guo, Clara Camaschella, MD, Laura Silvestri, PhD

Blood (2018) 132 (Supplement 1): 2333.

https://doi.org/10.1182/blood-2018-99-118112

Published: 2018

Journal Articles

Novel Insights Into Systemic Iron Regulation

Laura Silvestri, PhD, Alessia Pagani, PhD, Antonella Nai, PhD, Clara Camaschella, MD

Blood (2018) 132 (Supplement 1): SCI-1.

https://doi.org/10.1182/blood-2018-99-109518

Published: 2018

Journal Articles

Differential Expression of Inducible Caspase-9 (iC9) in Allogeneic T Cells Allows Selective Depletion of Activated T Cells Following Exposure to Rimiducid and Permits In Vivo Allodepletion

Xiaoou Zhou, MD PhD, An Lu, Kelly L Sharp, Margie Harris, Madhavi Anumula, MS, J. Bayle, PhD, David M. Spencer, PhD, Aaron Foster, PhD, Joanne Shaw, PhD

Blood (2018) 132 (Supplement 1): 3496.

https://doi.org/10.1182/blood-2018-99-119285

Published: 2018

Journal Articles

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123 + Cancer

J. Henri Bayle, PhD, MyLinh T Duong, PhD, An Lu, Eva Morschl, PhD, Matthew R. Collinson-Pautz, PhD, Kelly L Sharp, Slawomir Szymanski, PhD, Mary E. Brandt, Kevin M. Slawin, MD, Steven Toler, PhD, Eric Yvon, S., Aaron Foster, David M. Spencer

Blood (2017) 130 (Supplement 1): 3184.

https://doi.org/10.1182/blood.V130.Suppl_1.3184.3184

Published: 2017

Journal Articles

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

Silvia Colucci, Alessia Pagani, Mariateresa Pettinato, Irene Artuso, Antonella Nai, Clara Camaschella, Laura Silvestri

Blood (2017) 130 (19): 2111–2120.

https://doi.org/10.1182/blood-2017-04-780692

Published: 2017

Includes: Supplemental data

Journal Articles

Releasing the FKBP12 brake on hepcidin

Nermi L. Parrow, Robert E. Fleming

Blood (2017) 130 (19): 2049–2050.

https://doi.org/10.1182/blood-2017-09-805390

Published: 2017

Journal Articles

A Novel Crosstalk Between Iron Homeostasis and mTOR Mediated By the Immunophilin FKBP12

Laura Silvestri, PhD, Silvia Colucci, Alessia Pagani, PhD, Irene Artuso, BSc, Mariatesera Pettinato, BSc, Antonella Nai, PhD, Clara Camaschella, MD

Blood (2016) 128 (22): 261.

https://doi.org/10.1182/blood.V128.22.261.261

Published: 2016

Journal Articles

Generation of Epstein-Barr virus–specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

Biagio De Angelis, Gianpietro Dotti, Concetta Quintarelli, Leslie E. Huye, Lan Zhang, Ming Zhang, Fabrizio Pane, Helen E. Heslop, Malcolm K. Brenner, Cliona M. Rooney, Barbara Savoldo

Blood (2009) 114 (23): 4784–4791.

https://doi.org/10.1182/blood-2009-07-230482

Published: 2009

Includes: Supplemental data

Journal Articles

Phase I Trial of Lenalidomide and CCI-779 in Patients with Relapsed Multiple Myeloma.

Craig C Hofmeister, M.D., Don Benson, MD, PhD, Yvonne A Efebera, M.D., Sherif Farag, MBBS, PhD, Michael R. Grever

Blood (2009) 114 (22): 2884.

https://doi.org/10.1182/blood.V114.22.2884.2884

Published: 2009

Journal Articles

Generation of Epstein Barr Virus Specific Cytotoxic T Lymphocytes (EBVCTLs) Resistant to the Immunosuppressive Drug Tacrolimus (FK506)

Biagio De Angelis, PhD, Gianpietro Dotti, MD, Concetta Quintarelli, PhD, Leslie E Huye, PhD, Lan Zhang, Ming Zhang, Helen E. Heslop, MD, Malcolm K Brenner, MD, PhD, Cliona M Rooney, PhD, Barbara Savoldo, MD

Blood (2008) 112 (11): 3536.

https://doi.org/10.1182/blood.V112.11.3536.3536

Published: 2008

Journal Articles

A Novel Strategy to Render CTL Resistant to Immunosuppression with Calcineurin Inhibitors

Jennifer Brewin, Karin Straathof, Helen Karlsson, Cristoph Mancao, Barbara Savoldo, Gianpietro Dotti, Martin Pule, Persis Amrolia

Blood (2008) 112 (11): 3897.

https://doi.org/10.1182/blood.V112.11.3897.3897

Published: 2008

Journal Articles

Sirolimus and Tacrolimus without Methotrexate as Graft-vs.-Host Disease Prophylaxis after Matched, Unrelated Peripheral Blood Stem Cell Transplantation: Excellent GVHD Control with Low Transplant-Related Morbidity and Mortality.

Corey Cutler, MD, MPH, FRCP(C), Shuli Li, MS, Haesook T. Kim, PhD, Rebecca Macdonell, Vincent Ho, MD, Edwin Alyea, MD, Stephanie J. Lee, MD, MPH, Robert J. Soiffer, MD, Joseph H. Antin, MD

Blood (2005) 106 (11): 2051.

https://doi.org/10.1182/blood.V106.11.2051.2051

Published: 2005

Journal Articles

Sirolimus and Tacrolimus as Graft-vs.-Host Disease Prophylaxis in Allogeneic Stem Cell Transplantation: The Dana-Farber Cancer Institute Experience.

Corey Cutler, MD MPH FRCPC, Shuli Li, MS, Haesook T. Kim, PhD, Edwin Alyea, MD, Vincent Ho, MD, Stephanie J. Lee, MD MPH, David C. Fisher, MD, Robert Schlossman, MD, David Miklos, MD PhD, Stephen Sonis, DMD DMSc, Robert Soiffer, MD, Joseph H. Antin, MD

Blood (2004) 104 (11): 1227.

https://doi.org/10.1182/blood.V104.11.1227.1227

Published: 2004

Journal Articles

Identification and Characterization of Novel Small-Molecule Inhibitors of the Replication Checkpoint.

James Bradner, M.D., Yong-Son Kim, M.D., Angela Koehler, Ph.D., Masaoki Kawasumi, M.D., Xiaodong Li, Ph.D., Stuart L. Schreiber, Ph.D., Paul Nghiem, M.D., Ph.D.

Blood (2004) 104 (11): 763.

https://doi.org/10.1182/blood.V104.11.763.763

Published: 2004

Journal Articles

Sirolimus, Tacrolimus and Reduced-Dose Methotrexate as Graft Versus Host Disease (GVHD)Prophylaxis after Non-Myeloablative Stem Cell Transplantation: Low Incidence of Acute GVHD Compared with Tacrolimus/Methotrexate or Cyclosporine/Prednisone.

Edwin P. Alyea, MD, Shuli Li, MS, Haesook Kim, PhD, Corey Cutler, MD, Vincent Ho, MD, Stephanie J. Lee, MD, John Gribben, MD, PhD, Jerome Ritz, MD, David C. Fisher, MD, Robert J. Soiffer, MD, Joseph H. Antin, MD

Blood (2004) 104 (11): 730.

https://doi.org/10.1182/blood.V104.11.730.730

Published: 2004

Journal Articles

Identification of Common Target Genes of the BCR/ABL and FLT3-ITD Tyrosine Kinases by Microarray Analysis.

Lolita Banerji, Ph.D., Blanca Scheijen, Ph.D., James D. Griffin, MD.

Blood (2004) 104 (11): 3551.

https://doi.org/10.1182/blood.V104.11.3551.3551

Published: 2004

Journal Articles

Cell proliferation through forced engagement of c-Kit and Flt-3

Kevin G. Otto, Liqing Jin, David M. Spencer, C. Anthony Blau

Blood (2001) 97 (11): 3662–3664.

https://doi.org/10.1182/blood.V97.11.3662

Published: 2001

Journal Articles

Pharmacologically regulated cell therapy

Tobias Neff, C. Anthony Blau

Blood (2001) 97 (9): 2535–2540.

https://doi.org/10.1182/blood.V97.9.2535

Published: 2001

NARROW

The Immunophilin FKBP12 Inhibits Hepcidin By Modulating BMP Type I-Type II Receptors Interaction and Ligand Responsiveness

Targeting the BMP Receptor Inhibitor FKBP12 to Upregulate Hepcidin in Wild-Type and Hemojuvelin-Hemochromatosis Models

Inhibiting the Immunophilin FKBP12: A Potential Therapeutic Approach to Iron Overload/Low Hepcidin Disorders

Novel Insights Into Systemic Iron Regulation

Differential Expression of Inducible Caspase-9 (iC9) in Allogeneic T Cells Allows Selective Depletion of Activated T Cells Following Exposure to Rimiducid and Permits In Vivo Allodepletion

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123 + Cancer

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

Releasing the FKBP12 brake on hepcidin

A Novel Crosstalk Between Iron Homeostasis and mTOR Mediated By the Immunophilin FKBP12

Generation of Epstein-Barr virus–specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

Phase I Trial of Lenalidomide and CCI-779 in Patients with Relapsed Multiple Myeloma.

Generation of Epstein Barr Virus Specific Cytotoxic T Lymphocytes (EBVCTLs) Resistant to the Immunosuppressive Drug Tacrolimus (FK506)

A Novel Strategy to Render CTL Resistant to Immunosuppression with Calcineurin Inhibitors

Sirolimus and Tacrolimus without Methotrexate as Graft-vs.-Host Disease Prophylaxis after Matched, Unrelated Peripheral Blood Stem Cell Transplantation: Excellent GVHD Control with Low Transplant-Related Morbidity and Mortality.

Sirolimus and Tacrolimus as Graft-vs.-Host Disease Prophylaxis in Allogeneic Stem Cell Transplantation: The Dana-Farber Cancer Institute Experience.

Identification and Characterization of Novel Small-Molecule Inhibitors of the Replication Checkpoint.

Sirolimus, Tacrolimus and Reduced-Dose Methotrexate as Graft Versus Host Disease (GVHD)Prophylaxis after Non-Myeloablative Stem Cell Transplantation: Low Incidence of Acute GVHD Compared with Tacrolimus/Methotrexate or Cyclosporine/Prednisone.

Identification of Common Target Genes of the BCR/ABL and FLT3-ITD Tyrosine Kinases by Microarray Analysis.

Cell proliferation through forced engagement of c-Kit and Flt-3

Pharmacologically regulated cell therapy

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American Society of Hematology

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American Society of Hematology

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