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Journal Articles

Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies

Aileen Kelly, PhD, Daniel W Robbins, May Tan, Austin Tenn-McClellan, Joel McIntosh, Jeffrey Wu, Zef Konst, Daisuke Kato, Luz Perez, Jennifer Tung, Anna Kolobova, Timothy Ingallinera, Jenny McKinnell, Dahlia Weiss, Mark Noviski, Jordan Ye, Ge Peng, Mario Cardozo, Jeff Mihalic, Steve Basham, Ryan Rountree, Dane E Karr, Neil Bence, Christoph W Zapf, Arthur T Sands
Journal: Blood
Blood (2019) 134 (Supplement_1): 3805.
https://doi.org/10.1182/blood-2019-129262
Published: 2019
Journal Articles

Small Molecule-Induced, Selective STAT3 Degradation Leads to Anti-Tumor Activity in STAT3-Dependent Heme Malignancies

Fred Csibi, Nan Ji, PhD, Bin Yang, Karen Yuan, Michele Mayo, Haojing Rong, PhD, Scott Rusin, Kirti Sharma, Christine Loh, PhD, Henry Li, PhD, Sharon Townson, Jesse Chen, PhD, Hari Kamadurai, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3803.
https://doi.org/10.1182/blood-2019-128981
Published: 2019
Journal Articles

Improved Anti-Leukemic Pre-Clinical Efficacy of a Protac Based MDM2 Degrader in a Large AML Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Megha Ramappan, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2670.
https://doi.org/10.1182/blood-2019-131949
Published: 2019
Journal Articles

AMPK Regulates the Expression of the Fe-S Cluster Assembly Enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis

Ping La, Silvia Pires Lourenco, MSc, Laura Breda, PhD, Stefano Rivella
Journal: Blood
Blood (2018) 132 (Supplement 1): 851.
https://doi.org/10.1182/blood-2018-99-112175
Published: 2018
Journal Articles

Ets1 Enhances Context-Dependent Notch1 Activity in T-Cell Leukemia

Anna McCarter, BS, Ran Yan, Amparo Serna Alarcon, Catherine Chang, Erin Kim, Cher Sha, Yiran Liu, Qing Wang, PhD, Luke F. Peterson, PhD, Rork Kuick, Russell Ryan, MD, Moshe Talpaz, MD, Linda Samuelson, PhD, Michael Ostrowski, PhD, Mark Y Chiang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2595.
https://doi.org/10.1182/blood-2018-99-111376
Published: 2018
Journal Articles

Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma

Joseph Kelleher, PhD, Laurent Audoly, PhD, Veronica Campbell, Jesse Chen, PhD, Nan Ji, PhD, Hari Kamadurai, PhD, Henry Li, PhD, Christine Loh, PhD, Haojing Rong, PhD, Dominico Vigil, PhD, Matt Weiss, PhD, Karen Yuan, Yi Zhang, PhD, Nello Mainolfi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2018-99-120148
Published: 2018
Journal Articles

Differentiation Status Revealed By Shotgun Phosphoproteomics Determines Sensitivity of Primary AML Cells to Kinase Inhibitors

Pedro Casado, PhD, Edmund Wilkes, PhD, Marym M Hadi, Vinothini Rajeeve, PhD, Farideh Miraki-Moud, PhD, Rebecca Pike, PhD, Ana Del Rio-Machin, PhD, Sameena Iqbal, Jude Fitzgibbon, PhD, John Gribben, Pedro R Cutillas, BSc, PhD
Journal: Blood
Blood (2016) 128 (22): 840.
https://doi.org/10.1182/blood.V128.22.840.840
Published: 2016
Journal Articles

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Katherine A Minson, MD, Catherine C Smith, MD, Alisa B. Lee-Sherick, MD, Deborah DeRyckere, PhD, Elisabeth Lasater, PhD, Amanda A. Hill, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Neil P. Shah, MD PhD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3757.
https://doi.org/10.1182/blood.V124.21.3757.3757
Published: 2014
Journal Articles

Cullin-1 Controls The Clinical and Cellular response to Bortezomib Through NF-Kb Pathway Activation In Myeloma

James Driscoll, MD, PhD, Elias J. Anaissie, MD, Sajjeev Jagannathan, BS
Journal: Blood
Blood (2013) 122 (21): 4445.
https://doi.org/10.1182/blood.V122.21.4445.4445
Published: 2013
Journal Articles

Polymorphism nt7778G/T In Mitochondrial ATP8 Gene Promotes Protective Effect On Reactive Oxygen Species Level In Murine Hematopoietic Cells During Aging

Christin Kretzschmar, Catrin Roolf, Katrin Timmer, Gudrun Knübel, Anett Sekora, Sarah Müller, Markus Tiedge, Simone Baltrusch, Rüdiger Köhling, Saleh Ibrahim, Mathias Freund, Christian Junghanss
Journal: Blood
Blood (2013) 122 (21): 1196.
https://doi.org/10.1182/blood.V122.21.1196.1196
Published: 2013
Journal Articles

A Potential Biomarker Panel of Multiple Myeloma Identified Using Label-Free Mass Spectrometry-Based Quantitative Proteomics

Attaya Suvannasankha, MD, Colin D. Crean, Heather M. Sahm, Rafat Abonour, MD, Sherif Farag, MD, PhD, FRACP, FRCPA, Mu Wang, PhD
Journal: Blood
Blood (2011) 118 (21): 2890.
https://doi.org/10.1182/blood.V118.21.2890.2890
Published: 2011
Journal Articles

Modulation of MicroRNA Expression In Sickle Reticulocytes Is Associated with Hydroxyurea Treatment and Fetal Hemoglobin Induction

Aisha L Walker, PhD, Shirley Steward, Michael Wang, Matthew P Smeltzer, Russell E. Ware, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2650.
https://doi.org/10.1182/blood.V116.21.2650.2650
Published: 2010
Journal Articles

MicroRNAs Characterize Genetic Diversity and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia.

Diana Schotte, Renee X de Menezes, PhD, Farhad Akbari Moqadam, Ellen Lange-Turenhout, Caifu Chen, Ph.D., Rob Pieters, Ph.D., Prof., Monique L. Den Boer, PhD
Journal: Blood
Blood (2009) 114 (22): 89.
https://doi.org/10.1182/blood.V114.22.89.89
Published: 2009
Journal Articles

Primary Waldesntrom Macroglobulinemia Cells Harbor Constitutive Activation of Akt, mTOR, Rictor and Raptor: Rational for Testing a Dual Inhibitor of the PI3K/Akt and mTOR Pathways in This Disease.

Aldo M. Roccaro, MD, PhD, Antonio Sacco, Emanuel N. Husu, Costas M Pitsillides, PhD, Steven Vesole, Abdel Kareem Azab, BPharm, PhD, Feda Azab, BPharm, Molly Melhem, Hai Ngo, Phong Quang, Patricia Maiso, PhD, Judith M. Runnels, PhD, Charles P. Lin, PhD, Kenneth C. Anderson, MD, Irene Ghobrial, M.D.
Journal: Blood
Blood (2009) 114 (22): 3843.
https://doi.org/10.1182/blood.V114.22.3843.3843
Published: 2009
Journal Articles

Differentiation-Stage-Specific Expression of MicroRNAs in B-Lymphocytes and Diffuse Large B-Cell Lymphomas (DLBCL)

Raquel Malumbres, PhD., Robert Tibshirani, PhD., Elena Cubedo, PhD., Kristopher A Sarosiek, BS, Xiaoyu Jiang, PhD., Jose Ruiz, MD, Izidore Lossos, MD
Journal: Blood
Blood (2008) 112 (11): 805.
https://doi.org/10.1182/blood.V112.11.805.805
Published: 2008
Journal Articles

Erythroid Inhibition by AML1-ETO: Repression of GATA-1 Function by a Novel Non-Transcriptional Mechanism Involving Targeted Protein Degradation.

Youngjin Choi, Ph.D., Kamaleldin E. Elagib, M.B.B.S., Ph.D., Adam N. Goldfarb, M.D.
Journal: Blood
Blood (2004) 104 (11): 388.
https://doi.org/10.1182/blood.V104.11.388.388
Published: 2004