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Journal Articles

Phase 2 Results of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia (AML)

Blood (2019) 134 (Supplement_1): 676.

https://doi.org/10.1182/blood-2019-131055

Published: 2019

Journal Articles

Laminin G Domains of Protein S Bind and Inhibit Fixa

Sabyasachi Chatterjee, PhD MSc, BSc, Amber Sylvain, Undergraduate Student, Satish Pilli, PhD, Whitney Fant, MS, Doerte R. Fricke, MS, Terry Watt, PhD, Rinku Majumder, PhD

Blood (2019) 134 (Supplement_1): 3624.

https://doi.org/10.1182/blood-2019-127112

Published: 2019

Journal Articles

Ribosome Biogenesis Controls Erythroid Differentiation Via a p53-Dependent Transcriptional Checkpoint and Its Limitation By RPS14 Haploinsufficiency Results in Selective Defects in Translation

Ismael Boussaid, PharmD, Salome Le Goff, PhDstudent, Celia Floquet, Post-doc, Anna Raimbault, PharmD, PhD, Charlotte Andrieu-Soler, Emilie-fleur Gautier, PhD, Olivier Kosmider, Isabelle Hatin, PhD, Mohandas Narla, DSc, Eric Soler, PhD, Patrick Mayeux, PhD, Michaela Fontenay, MD PhD

Blood (2017) 130 (Supplement 1): 83.

https://doi.org/10.1182/blood.V130.Suppl_1.83.83

Published: 2017

Journal Articles

CT7001, a Novel Orally Bio-Available CDK7 Inhibitor, Is Highly Active in in-Vitro and in-Vivo Models of AML

Kristopher Clark, PhD, Edward Ainscow, PhD, Adam Peall, Stuart Thomson, PhD, Andrew Leishman, PhD, Sullivan Elaine, PhD, Simak Ali, PhD, Raoul Coombes, MD, Anthony Barrett, PhD, Ash Kumar Bahl, PhD

Blood (2017) 130 (Supplement 1): 2645.

https://doi.org/10.1182/blood.V130.Suppl_1.2645.2645

Published: 2017

Journal Articles

Characterization of the Interactions of Arg-Gly-Asp- and Ala-Gly-Asp-Val-Containing Peptides with the Platelet Integrin αIIbβ3

Rustem I. Litvinov, PhD, Olga Kononova, PhD, Dmitry S. Blokhin, PhD, Vladimir V. Klochkov, PhD, John W. Weisel, Valeri Barsegov, PhD, Joel S. Bennett, MD

Blood (2016) 128 (22): 1350.

https://doi.org/10.1182/blood.V128.22.1350.1350

Published: 2016

Journal Articles

Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

Joseph A. Micucci, PhD, Parvathi Kamath, PhD, Anuja Khan, PhD, Paul E. Bock, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 122.

https://doi.org/10.1182/blood.V126.23.122.122

Published: 2015

Journal Articles

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Mikhail Galkin, PhD, Harlan Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 2267.

https://doi.org/10.1182/blood.V126.23.2267.2267

Published: 2015

Journal Articles

Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4

Martin Kreimann, Sven Brandt, Krystin Krauel, Stephan Block, Christiane A. Helm, Werner Weitschies, Andreas Greinacher, Mihaela Delcea

Blood (2014) 124 (15): 2442–2449.

https://doi.org/10.1182/blood-2014-03-559518

Published: 2014

Includes: Supplemental data

Journal Articles

The Relative Bioavailability, Food Effect and Drug Interaction With Omeprazole Of Momelotinib Tablet Formulation

Yan Xin, PhD, Lixin Shao, MD MS, Wei Deng, PhD, Amanda Shaffer, Pharm D, Dimitrios Stefanidis, PhD, Jeffrey Hemenway, PhD, Xiaoming Li, PhD, Susie Jun, MD, PhD, Srini Ramanathan, PhD

Blood (2013) 122 (21): 5239.

https://doi.org/10.1182/blood.V122.21.5239.5239

Published: 2013

Journal Articles

Coagulopathy In Trauma Patients Is Accompanied By Oxidation Of a Methionine Residue In The αC Domain Of Fibrinogen and Abnormal Fibrin Polymerization

Nathan J White, MD, Yi Wang, Ph.D., Patrick Burney, Xiaoyun Fu, PhD, José A López, Jim Pfaendtner, PhD, Dominic Chung

Blood (2013) 122 (21): 1097.

https://doi.org/10.1182/blood.V122.21.1097.1097

Published: 2013

Journal Articles

Acquisition Of Compound BCR-ABL1 Alleles As A Mechanism Of Resistance To Ponatinib In Chronic Myeloid Leukemia

Don L Gibbons, MD, PhD, Sabrina Pricl, Paola Posocco, PhD, Erik Laurini, PhD, Maurizio Fermeglia, Moshe Talpaz, MD, Jorge E. Cortes, MD, Nicholas J. Donato, PhD, Alfonso Quintas-Cardama, MD

Blood (2013) 122 (21): 853.

https://doi.org/10.1182/blood.V122.21.853.853

Published: 2013

Journal Articles

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

Maurice S. Brozzo, Saša Bjelić, Kaisa Kisko, Thomas Schleier, Veli-Matti Leppänen, Kari Alitalo, Fritz K. Winkler, Kurt Ballmer-Hofer

Blood (2012) 119 (7): 1781–1788.

https://doi.org/10.1182/blood-2011-11-390922

Published: 2012

Includes: Supplemental data

Journal Articles

Nilotinib, in Comparison to Both Dasatinib and Imatinib, Possesses a Greatly Prolonged Residence Time When Bound to the BCR-ABL Kinase SH1 Domain

Paul W. Manley, Ph. D., Sandra W. Cowan-Jacob, Gabriele Fendrich, Wolfgang Jahnke, Doriano Fabbro

Blood (2011) 118 (21): 1674.

https://doi.org/10.1182/blood.V118.21.1674.1674

Published: 2011

Journal Articles

Peptide Nucleic Acid (PNA)-Clamping Competitive PCR: A New Tool for the High Sensitive Detection of JAK2V617F Mutation in Myeloproliferative Neoplasms (MPNs)

Ferdinando Frigeri, MD, PhD, Raffaele Di Francia, PhD, Luigi Petraccone, PhD, Concetta Giancola, PhD, Annunziata Cummaro, PhD, Paolo Danise, MD, Stefania Crisci, PhD, Giancarla Iaccarino, PhD, Rosaria De Filippi, MD, PhD, Emanuela Morelli, MD, Gaetana Capobianco, MD, Francesco Volzone, MD, Alfonso Maria D'Arco, MD, Antonio Pinto, MD

Blood (2011) 118 (21): 5168.

https://doi.org/10.1182/blood.V118.21.5168.5168

Published: 2011

Journal Articles

Novel Solution and Membrane-Based Assays Reveal Lack of Interaction Between Murine FVIIa and Murine EPCR

Giulia Pavani, MS, Paris Margaritis, DPhil

Blood (2011) 118 (21): 531.

https://doi.org/10.1182/blood.V118.21.531.531

Published: 2011

Journal Articles

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Casie Reed, BS, Scott J. Rodig, MD, PhD, Eleni Tholouli, PhD, MRCPath, Vu Ngo, PhD, Jeffery Lorne Kutok, MD, PhD, Suzanne E. Dahlberg, PhD, Lisa A Moreau, PhD, George Vande Woude, PhD, James Christensen, MD, Richard Byers, PhD, MBChB, FRCPath, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD., Ph.D., Thomas Look, MD

Blood (2011) 118 (21): 1405.

https://doi.org/10.1182/blood.V118.21.1405.1405

Published: 2011

Journal Articles

The PLATELET INTEGRIN αIIbβ3 CHANGES FROM A LOWER- to A Higher-AFFINITY STATE DURING INTERACTION with FIBRINOGEN

Rustem I. Litvinov, Ph.D., Valeri Barsegov, Ph.D., Andrey Mekler, John W. Weisel, Ph.D., Joel S. Bennett, M.D.

Blood (2011) 118 (21): 1130.

https://doi.org/10.1182/blood.V118.21.1130.1130

Published: 2011

Journal Articles

Structural Insights Into How Clotting Proteins with GLA Domains Bind to Membrane Surfaces.

Rebecca L Davis-Harrison, Ph.D., Narjes Tavoosi, Mary Clay, John M Boettcher, Ph.D., Chad M Rienstra, Ph.D, James H. Morrissey, PhD

Blood (2010) 116 (21): 1141.

https://doi.org/10.1182/blood.V116.21.1141.1141

Published: 2010

Journal Articles

Differential Engagement of the Unfolded Protein Response by Human and Porcine Factor VIII

Harrison C. Brown, BBA, Bagirath Gangadharan, MS, Christopher Doering, PhD

Blood (2010) 116 (21): 2224.

https://doi.org/10.1182/blood.V116.21.2224.2224

Published: 2010

Journal Articles

Driving Thrombin From a Protease-Like State to a Zymogen-Like State and Back.

Parvathi Kamath, Ph.D., Sriram Krishnaswamy, PhD

Blood (2009) 114 (22): 852.

https://doi.org/10.1182/blood.V114.22.852.852

Published: 2009

NARROW

Phase 2 Results of APR-246 and Azacitidine (AZA) in Patients with TP53 mutant Myelodysplastic Syndromes (MDS) and Oligoblastic Acute Myeloid Leukemia (AML)

Laminin G Domains of Protein S Bind and Inhibit Fixa

Ribosome Biogenesis Controls Erythroid Differentiation Via a p53-Dependent Transcriptional Checkpoint and Its Limitation By RPS14 Haploinsufficiency Results in Selective Defects in Translation

CT7001, a Novel Orally Bio-Available CDK7 Inhibitor, Is Highly Active in in-Vitro and in-Vivo Models of AML

Characterization of the Interactions of Arg-Gly-Asp- and Ala-Gly-Asp-Val-Containing Peptides with the Platelet Integrin αIIbβ3

Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4

The Relative Bioavailability, Food Effect and Drug Interaction With Omeprazole Of Momelotinib Tablet Formulation

Coagulopathy In Trauma Patients Is Accompanied By Oxidation Of a Methionine Residue In The αC Domain Of Fibrinogen and Abnormal Fibrin Polymerization

Acquisition Of Compound BCR-ABL1 Alleles As A Mechanism Of Resistance To Ponatinib In Chronic Myeloid Leukemia

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

Nilotinib, in Comparison to Both Dasatinib and Imatinib, Possesses a Greatly Prolonged Residence Time When Bound to the BCR-ABL Kinase SH1 Domain

Peptide Nucleic Acid (PNA)-Clamping Competitive PCR: A New Tool for the High Sensitive Detection of JAK2V617F Mutation in Myeloproliferative Neoplasms (MPNs)

Novel Solution and Membrane-Based Assays Reveal Lack of Interaction Between Murine FVIIa and Murine EPCR

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

The PLATELET INTEGRIN αIIbβ3 CHANGES FROM A LOWER- to A Higher-AFFINITY STATE DURING INTERACTION with FIBRINOGEN

Structural Insights Into How Clotting Proteins with GLA Domains Bind to Membrane Surfaces.

Differential Engagement of the Unfolded Protein Response by Human and Porcine Factor VIII

Driving Thrombin From a Protease-Like State to a Zymogen-Like State and Back.

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American Society of Hematology

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American Society of Hematology

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