Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 22

Sort by

Sort Order Select

Journal Articles

No Association between Relapse Risk and Thiopurine Methyltransferase Activity By Either Geno- or Phenotype in the NOPHO ALL-2008 Protocol

Stine Nygaard Nielsen, PhD MD, Kathrine Grell, PhD, Jacob Nersting, PhD, Jonas Abrahamsson, MD PhD, Bendik Lund, MD PhD, Jukka A. Kanerva, MD, Ólafur G Jónsson, MD, Goda Vaitkeviciene, MD, Kaie Pruunsild, MD, Malin Lindqvist Appell, Lisa Hjalgrim, PhD, Kjeld Schmiegelow, MD DMSc

Blood (2017) 130 (Supplement 1): 1279.

https://doi.org/10.1182/blood.V130.Suppl_1.1279.1279

Published: 2017

Journal Articles

Thiopurine Methyl Transferase (TPMT) Activity and Erythrocyte Thioguanine Nucleotide Levels Are Reliable Markers of Tolerability to 6-Mercaptopurine in Adult Acute Lymphoblastic Leukemia

Manju Sengar, MD DM, Murari Gurjar, Anand Patil, Vikram Gota, Hasmukh Jain, MDDM, Hari Menon, MD DM, Uma Dangi

Blood (2015) 126 (23): 3761.

https://doi.org/10.1182/blood.V126.23.3761.3761

Published: 2015

Journal Articles

Tolerability of 6-Mercaptopurine (6MP) in Patients with Thiopurine Methyltransferase ( TPMT ) Heterozygosity in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia (ALL)

Chengcheng Liu, Deqing Pei, MS, Cheng Cheng, PhD, Jun J. Yang, PhD, Kristine Crews, PharmD, Wenjian Yang, PhD, Seth E. Karol, MD, Sima Jeha, MD, John T. Sandlund, MD, Raul C Ribeiro, MD, Jeffrey E Rubnitz, MD PhD, Monika L. Metzger, MD MS, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD

Blood (2014) 124 (21): 3722.

https://doi.org/10.1182/blood.V124.21.3722.3722

Published: 2014

Journal Articles

Impact of 6 Mercaptopurine (6MP) Pill-Taking Habits on Adherence, Thioguanine Nucleotide (TGN) Levels and Relapse Risk in Children with Acute Lymphoblastic Leukemia (ALL): Results from a Children’s Oncology Group (COG) Study (AALL03N1)

Lindsey Hageman, Wendy Landier, PhD, R.N., Yanjun Chen, MS, Heeyoung Kim, M.S., Nancy Kornegay, M.S., William E. Evans, PharmD, Bruce C. Bostrom, MD, Jacqueline Casillas, MD, M.S.H.S., David Dickens, MD, Anne Angiolillo, MD, Glen Lew, MD, Kelly Maloney, MD, Leo Mascarenhas, Arthur K. Ritchey, MD, Amanda Termuhlen, MD, William L. Carroll, MD, Mary V. Relling, PharmD, F. Lennie Wong, Smita Bhatia, PhD

Blood (2014) 124 (21): 369.

https://doi.org/10.1182/blood.V124.21.369.369

Published: 2014

Journal Articles

High Intra-Individual Variability In Systemic Exposure To 6 Mercaptopurine (6MP) In Children With Acute Lymphoblastic Leukemia (ALL) Contributes To ALL Relapse: Results From a Children’s Oncology Group (COG) Study (AALL03N1)

Smita Bhatia, Ph.D., Wendy Landier, Ph.D., R.N., Lindsey Hageman, Can-Lan Sun, Heeyoung Kim, M.S., Nancy Kornegay, M.S., William E. Evans, PharmD, Bruce C. Bostrom, MD, Jacqueline Casillas, M.D., M.S.H.S, Anne Angiolillo, MD, Glen Lew, MD, Kelly Maloney, MD, Leo Mascarenhas, Jane Meza, Ph.D., A. Kim Ritchey, MD, Amanda Termuhlen, MD, William L. Carroll, MD, F. Lennie Wong, PhD, Mary V. Relling, PharmD

Blood (2013) 122 (21): 59.

https://doi.org/10.1182/blood.V122.21.59.59

Published: 2013

Journal Articles

Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness

Laura B. Ramsey, PhD, Laura Janke, DVM, PhD, Mathew Edick, PhD, Cheng Cheng, PhD, Richard T Williams, MBBS, PhD, Charles J. Sherr, MD, PhD, William E. Evans, PharmD, Mary V. Relling, PharmD

Blood (2012) 120 (21): 3560.

https://doi.org/10.1182/blood.V120.21.3560.3560

Published: 2012

Journal Articles

Nonadherence to Oral 6-Mercaptopurine (6MP) in a Multi-Ethnic Cohort of Children with Acute Lymphoblastic Leukemia (ALL) and Its Impact On Relapse – a Children's Oncology Group (COG) Study (AALL03N1)

Smita Bhatia, MD, MPH, Wendy Landier, Ph.D., R.N., Lindsey Hageman, M.P.H., Heeyoung Kim, M.S., Cara Hanby, B.S., Kornegay Nancy, M.S., Bruce C. Bostrom, MD, Jacqueline Casillas, M.D., M.S.H.S., David S Dickens, M.D., Kelly W. Maloney, MD, Leo Mascarenhas, Jane Meza, Ph.D., Arthur Kim Ritchey, MD, Amanda M Termuhlen, M.D., William L. Carroll, MD, F. Lennie Wong, PhD, Mary V. Relling, PharmD

Blood (2012) 120 (21): 882.

https://doi.org/10.1182/blood.V120.21.882.882

Published: 2012

Journal Articles

Characterizing Rare Variants in Drug Metabolism Genes in Refractory Pediatric High-Risk Pre-B ALL

Andrew Hughes, Joseph Giacalone, Todd E Druley, MD, PhD

Blood (2012) 120 (21): 879.

https://doi.org/10.1182/blood.V120.21.879.879

Published: 2012

Journal Articles

Non-Adherence to Oral 6-Mercaptopurine (6MP) Explains Ethnic Differences In Disease-Free Survival In Children with Acute Lymphoblastic Leukemia (ALL) – a Children's Oncology Group (COG) Study (AALL03N1)

Smita Bhatia, Wendy Landier, R.N., M.S.N., C.P.N.P., Muyun Shangguan, M.S., Lindsey Hageman, M.P.H., Wendy Leisenring, Sc.D., Nancy Kornegay, M.S., Mary V. Relling, PharmD, F. Lennie Wong, Ph.D.

Blood (2010) 116 (21): 7.

https://doi.org/10.1182/blood.V116.21.7.7

Published: 2010

Journal Articles

Thiopurine Methyltransferase Genetics Is Associated with Treatment Outcome and Hepatic Toxicity in Pediatric Patients with Acute Lymphoblastic Leukemia: a Report From the ALL-BFM Study Group.

Martin Stanulla, MD, Elke Schäffeler, PhD, Silke Pohlschmidt, Martin Zimmermann, PhD, Anja Möricke, MD, Gunnar Cario, MD, Andre Schrauder, MD, Karl Welte, MD, Jochen Harbott, PhD, Wolf-Dieter Ludwig, MD, Alfred Reiter, MD, Michel Eichelbaum, MD, Martin Schrappe, MD, Matthias Schwab, MD

Blood (2009) 114 (22): 2625.

https://doi.org/10.1182/blood.V114.22.2625.2625

Published: 2009

Journal Articles

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols

Martin Stanulla, Elke Schaeffeler, Anja Möricke, Sally A. Coulthard, Gunnar Cario, André Schrauder, Peter Kaatsch, Michael Dördelmann, Karl Welte, Martin Zimmermann, Alfred Reiter, Michel Eichelbaum, Hansjörg Riehm, Martin Schrappe, Matthias Schwab

Blood (2009) 114 (7): 1314–1318.

https://doi.org/10.1182/blood-2008-12-193250

Published: 2009

Journal Articles

Maintenance loses its innocence

Michael A. Pulsipher

Blood (2009) 113 (24): 6041–6042.

https://doi.org/10.1182/blood-2009-03-210500

Published: 2009

Journal Articles

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Kjeld Schmiegelow, Ibrahim Al-Modhwahi, Mette Klarskov Andersen, Mikael Behrendtz, Erik Forestier, Henrik Hasle, Mats Heyman, Jon Kristinsson, Jacob Nersting, Randi Nygaard, Anne Louise Svendsen, Kim Vettenranta, Richard Weinshilboum

Blood (2009) 113 (24): 6077–6084.

https://doi.org/10.1182/blood-2008-11-187880

Published: 2009

Journal Articles

Importance of the Polymorphisms of the Thiopurine S-Methyltransferase Gene (TMPT) Determination in Mexican Mestizo Patients with Acute Lymphoblastic Leukemia (ALL).

Myrna Candelaria, MD, Lucia Taja-Chayeb, PhD, Silvia Vidal, MD, Olga Gutierrez, MD, Alfonso Dueñas-Gonzalez, PhD

Blood (2007) 110 (11): 4222.

https://doi.org/10.1182/blood.V110.11.4222.4222

Published: 2007

Journal Articles

Inosine-Triphosphate-Pyrophosphatase Genotype Is a Determinant of Severe Fever with Neutropenia Following Treatment of Acute Lymphoblastic Leukemia with Combination Chemotherapy That Includes Mercaptopurine Adjusted for Thiopurine-S-Methyltransferase Genotype.

Gabriele Stocco, PhD, Meyling Cheok, PhD, Wenjian Yang, PhD, Thierry Dervieux, PharmD/PhD, Kristine Crews, PharmD, Deqing Pei, Cheng Cheng, PhD, Ching-Hon Pui, MD, Mary V. Relling, PharmD, William E. Evans, PharmD

Blood (2007) 110 (11): 2827.

https://doi.org/10.1182/blood.V110.11.2827.2827

Published: 2007

Journal Articles

Risk of Second Malignant Neoplasm Is Related to TPMT Activity and Duration of MTX/6MP Maintenance Therapy of ALL.

Kjeld Schmiegelow, MD, Ibrahim Al-Modhawi, M.D., Mikael Berendtz, M.D., Erik Forestier, M.D., Henrik Hasle, M.D., Mats Heyman, M.D., Jon Kristinsson, M.D., Randi Nygaard, M.D., Kim Vettenranta, M.D.

Blood (2006) 108 (11): 1853.

https://doi.org/10.1182/blood.V108.11.1853.1853

Published: 2006

Journal Articles

Thiopurine methyltransferase Genotype Is Not a Risk Factor for Secondary Malignant Neoplasias after Treatment for Childhood Acute Lymphoblastic Leukemia on Berlin-Frankfurt-Muenster Protocols.

Martin Stanulla, MD, Elke Schaeffeler, PhD, Anja Moericke, MD, Gunnar Cario, MD, Michel Eichelbaum, MD, Hansjoerg Riehm, MD, Karl Welte, MD, Martin Schrappe, MD, Matthias Schwab, MD

Blood (2006) 108 (11): 150.

https://doi.org/10.1182/blood.V108.11.150.150

Published: 2006

Journal Articles

Thiopurine methyltransferase in acute lymphoblastic leukemia

Mary V. Relling, Ching-Hon Pui, Cheng Cheng, William E. Evans

Blood (2006) 107 (2): 843–844.

https://doi.org/10.1182/blood-2005-08-3379

Published: 2006

Journal Articles

Different Prevalence of Drug Metabolism Gene Polymorphisms (GSTP and GSTT) in FA Patients Compared to a Normal Population.

Moema Nene Santos, MD, Vanderson Rocha, MD, PhD, Dalila Zanette, Pharm, Raphael Porcher, MS, Irina Ionescu, MD, Marli Tavela, Tech, Jean Soulier, MD, PhD, Thierry Leblanc, MD, Gustavo Fisher, MD, André Baruchel, MD, Marco Antonio Zago, MD, Eliane Gluckman, MD

Blood (2005) 106 (11): 106.

https://doi.org/10.1182/blood.V106.11.106.106

Published: 2005

Journal Articles

Thiopurine Methyltransferase Genotype Modulates Early Treatment Response to 6-Mercaptopurine as Measured by Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia.

Martin Stanulla, MD, Elke Schaffeler, PhD, Thomas Flohr, PhD, Gunnar Cario, MD, Karl Welte, MD, Bartram R. Claus, MD, Eichelbaum Michel, MD, Zanger Ulrich, PhD, Schrappe Martin, MD, Schwab Matthias, MD

Blood (2004) 104 (11): 321.

https://doi.org/10.1182/blood.V104.11.321.321

Published: 2004

NARROW

No Association between Relapse Risk and Thiopurine Methyltransferase Activity By Either Geno- or Phenotype in the NOPHO ALL-2008 Protocol

Thiopurine Methyl Transferase (TPMT) Activity and Erythrocyte Thioguanine Nucleotide Levels Are Reliable Markers of Tolerability to 6-Mercaptopurine in Adult Acute Lymphoblastic Leukemia

Tolerability of 6-Mercaptopurine (6MP) in Patients with Thiopurine Methyltransferase ( TPMT ) Heterozygosity in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia (ALL)

Impact of 6 Mercaptopurine (6MP) Pill-Taking Habits on Adherence, Thioguanine Nucleotide (TGN) Levels and Relapse Risk in Children with Acute Lymphoblastic Leukemia (ALL): Results from a Children’s Oncology Group (COG) Study (AALL03N1)

High Intra-Individual Variability In Systemic Exposure To 6 Mercaptopurine (6MP) In Children With Acute Lymphoblastic Leukemia (ALL) Contributes To ALL Relapse: Results From a Children’s Oncology Group (COG) Study (AALL03N1)

Host Thiopurine Methyltransferase Status Affects Mercaptopurine Antileukemic Effectiveness

Nonadherence to Oral 6-Mercaptopurine (6MP) in a Multi-Ethnic Cohort of Children with Acute Lymphoblastic Leukemia (ALL) and Its Impact On Relapse – a Children's Oncology Group (COG) Study (AALL03N1)

Characterizing Rare Variants in Drug Metabolism Genes in Refractory Pediatric High-Risk Pre-B ALL

Non-Adherence to Oral 6-Mercaptopurine (6MP) Explains Ethnic Differences In Disease-Free Survival In Children with Acute Lymphoblastic Leukemia (ALL) – a Children's Oncology Group (COG) Study (AALL03N1)

Thiopurine Methyltransferase Genetics Is Associated with Treatment Outcome and Hepatic Toxicity in Pediatric Patients with Acute Lymphoblastic Leukemia: a Report From the ALL-BFM Study Group.

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols

Maintenance loses its innocence

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Importance of the Polymorphisms of the Thiopurine S-Methyltransferase Gene (TMPT) Determination in Mexican Mestizo Patients with Acute Lymphoblastic Leukemia (ALL).

Inosine-Triphosphate-Pyrophosphatase Genotype Is a Determinant of Severe Fever with Neutropenia Following Treatment of Acute Lymphoblastic Leukemia with Combination Chemotherapy That Includes Mercaptopurine Adjusted for Thiopurine-S-Methyltransferase Genotype.

Risk of Second Malignant Neoplasm Is Related to TPMT Activity and Duration of MTX/6MP Maintenance Therapy of ALL.

Thiopurine methyltransferase Genotype Is Not a Risk Factor for Secondary Malignant Neoplasias after Treatment for Childhood Acute Lymphoblastic Leukemia on Berlin-Frankfurt-Muenster Protocols.

Thiopurine methyltransferase in acute lymphoblastic leukemia

Different Prevalence of Drug Metabolism Gene Polymorphisms (GSTP and GSTT) in FA Patients Compared to a Normal Population.

Thiopurine Methyltransferase Genotype Modulates Early Treatment Response to 6-Mercaptopurine as Measured by Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia.

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only