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Journal Articles

YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma

Yan Xu, Mariateresa Fulciniti, Mehmet K. Samur, Matthew Ho, Shuhui Deng, Lanting Liu, Kenneth Wen, Tengteng Yu, Zuzana Chyra, Sanika Dereibal, Li Zhang, Yao Yao, Chandraditya Chakraborty, Eugenio Morelli, Na Li, Michael A. Lopez, Tommaso Perini, Shidai Mu, Gang An, Rafael Alonso, Giada Bianchi, Yu-Tzu Tai, Kenneth C. Anderson, Lugui Qiu, Nikhil C. Munshi
Journal: Blood
Blood (2020) 136 (4): 468–479.
https://doi.org/10.1182/blood.2019004147
Published: 2020
Includes: Supplemental data
Journal Articles

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Gang Lu, Christine Surka, Chin-Chun Lu, In Sock Jang, PhD, Kai Wang, PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 405.
https://doi.org/10.1182/blood-2019-125492
Published: 2019
Journal Articles

Identification of an Immune Risk Score to Predict the Prognosis of Acute Myeloid Leukemia

Yang Liang, PhD, Yun Wang, Yan-Yu Cai, Siliang Chen, Run-Cong Nie, Zhe-Yuan Qin, PhD, Fang Hu, Weida Wang, MD, Yu-Jun Dai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 708.
https://doi.org/10.1182/blood-2019-126733
Published: 2019
Journal Articles

FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim

Ayako Nogami, MD PhD BPharm, Daisuke Watanabe, MD, Keigo Okada, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Toshikage Nagao, MD, PhD, Shuji Tohda, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1425.
https://doi.org/10.1182/blood-2019-123183
Published: 2019
Journal Articles

Genome-Wide CRISPR Screening Identifies MAPK and Mtorc Pathways As Regulators of Sorafenib Resistance in Acute Myeloid Leukemia

Alisa Damnernsawad, PhD, Tamilla Nechiporuk, PhD, Daniel Bottomly, MS, Stephen E Kurtz, PhD, Christopher A. Eide, Shannon K. McWeeney, PhD, Jeffrey W. Tyner
Journal: Blood
Blood (2019) 134 (Supplement_1): 2557.
https://doi.org/10.1182/blood-2019-128877
Published: 2019
Journal Articles

Ywhae/14-3-3ε Expression Promotes Translation Initiation and Protein Synthesis in Multiple Myeloma Regulating Proteasome Load and Contributing to Proteasome Inhibitor Sensitivity/Resistance

Yan Xu, MD, Matthew Ho, PhD, Mehmet Kemal Samur, PhD, Kenneth Wen, Shuhui Deng, MD, Lanting Liu, MD, Tengteng Yu, MD PhD, Zuzana Chyra, PhD, Sanika Derebail, Kenneth C. Anderson, MD, Lugui Qiu, MD PhD, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5539.
https://doi.org/10.1182/blood-2019-130902
Published: 2019
Journal Articles

Dysregulated Translational Control Is a Central Feature of MM Mediated By 14-3-3ε Interactome Promoting Multiple Myeloma Cell Growth and Viability

Yan Xu, MD, Mariateresa Fulciniti, PhD, Matthew Ho, Mehmet Kemal Samur, PhD, Michael A Lopez, Na Li, MD, Giada Bianchi, MD, Raphael Szalat, MD, Jianhong Lin, MD MSc, Tommaso Perini, MD, Srikanth Talluri, PhD, Tengteng Yu, MD, Kenneth Wen, BS, Jiye Liu, PhD, Li Zhang, MD, Liang Lin, PhD, Lijie Xing, MD, Gang An, MD, Yu-Tzu Tai, PhD, Kenneth Anderson, MD, Lugui Qiu, MD PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3176.
https://doi.org/10.1182/blood-2018-99-118994
Published: 2018
Journal Articles

A Potential Role for Genes within the mTORC1 Pathway in the Regulation of Embryonic Globin Expression Revealed By ChIP-Seq, RNA-Seq and eQTL Mapping in the Nan Anemia Mouse Model

Danitza M. Nebor, PhD, Joel H. Graber, PhD, Kevin R. Gillinder, PhD, Melissa D. Ilsley, BSc, Raymond F. Robledo, PhD, Steven L. Ciciotte, MS, Vivek Philip, PhD, James J. Bieker, PhD, Andrew C Perkins, PhD, Luanne L. Peters, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2203.
https://doi.org/10.1182/blood.V130.Suppl_1.2203.2203
Published: 2017
Journal Articles

Personalized Therapy Design for Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Using Computational Biology Modeling with in Vitro Validation

Madeleine Turcotte, MS, Raphael Charles Bosse, BS, MD PhD, Kimberly E. Hawkins, PhD BS, Amy Meacham, MS, Vindhya Vijay, MS, Girish Chinnaswamy, MD MRCP, Manju Sengar, MD DM, Ansu Kumar, MS, Shwetha K, BE, Anisha Kamath, BT, Anjana T. Nair, MS, Karthik S. Raju, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1448.
https://doi.org/10.1182/blood.V130.Suppl_1.1448.1448
Published: 2017
Journal Articles

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Cuiqing Fan, PhD, Chuntao Zhao, PhD, Feng Zhang, Xiongwei Cai, PhD, Lingli Xu, Shan Lin, PhD, Xiaoyi Chen, PhD, Fukun Guo, PhD, Richard Q Lu, PhD, Weidong Tian, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2416.
https://doi.org/10.1182/blood.V130.Suppl_1.2416.2416
Published: 2017
Journal Articles

Whole-Exome Sequencing of Paroxysmal Nocturnal Hemoglobinuria

Rong Fu, PhD, Liyan LI, Hui Liu, Yun Liu, PhD, Lijuan Li, MD, Kai Ding, MD, Zonghong Shao, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3475.
https://doi.org/10.1182/blood.V130.Suppl_1.3475.3475
Published: 2017
Journal Articles

Microenvironment-Induced Expression of PIM Kinases Supports Chronic Lymphocytic Leukemia Cells Survival and Promotes CXCR4-mTOR Pathway Dependent Migration

Emilia Bialopiotrowicz, PhD, Patryk Gorniak, PhD, Bartosz Pula, MD PhD, Monika Noyszewska-Kania, MSc, Hanna Makuch-Lasica, MSc, Grazyna Nowak, MSc, Maciej Szydlowski, PhD, Ewa Jablonska, PhD, Tomasz Sewastianik, PhD, Anna Polak, PhD, Ewa Lech-Maranda, MD PhD, Bozena Katarzyna Budziszewska, MD PhD, Maja Wasylecka, MD, Katarzyna Borg, PhD, Krzysztof Warzocha, Wojciech Czardybon, PhD, Michal Galezowski, PhD, Renata Windak, PhD, Krzysztof Brzozka, PhD, Przemyslaw Juszczynski, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3239.
https://doi.org/10.1182/blood.V128.22.3239.3239
Published: 2016
Journal Articles

Functional Proteomic Profiling of Myelodysplastic Syndromes Reveals Distinct Protein Expression Signatures and Identifies Candidate Therapeutic Targets

Brittany Knick Ragon, MD, Fieke W Hoff, Chenyue W Hu, Yihua Qiu, MD, Suk-Young Yoo, Amina Qutub, Steven M. Kornblau, MD
Journal: Blood
Blood (2016) 128 (22): 1975.
https://doi.org/10.1182/blood.V128.22.1975.1975
Published: 2016
Journal Articles

MYC-Dependent PI3K and MCL-1 Feedbacks Attenuate BET Inhibitors Activity in Diffuse Large B-Cell Lymphoma

Enrico Derenzini, MD PhD, Patrizia Mondello, MD MSc, Yuxuan Liu, PhD, Mary Scallion, Zahra Asgari, John Philip, Patrick Hilden, MS, Hakim Djaballah, PhD, Ouathek Ouerfelli, PhD, Elisa de Stanchina, PhD, Venkatraman Seshan, PhD, Ronald Hendrickson, PhD, Andrew D. Zelenetz, Anas Younes, MD
Journal: Blood
Blood (2016) 128 (22): 294.
https://doi.org/10.1182/blood.V128.22.294.294
Published: 2016
Journal Articles

Activity of PIM Kinases in Chronic Lymphocytic Leukemia Modulates Tumor Cell Survival and Stromal Interactions through a Pleiotropic Mechanism Involving Modulation of CXCR4 - mTOR Pathway

Emilia Bialopiotrowicz, PhD, Patryk Gorniak, PhD, Maciej Szydlowski, PhD, Tomasz Sewastianik, MSc, Przemyslaw Kiliszek, MSc, Anna Polak, MSc, Ewa Jablonska, PhD, Bozena Katarzyna Budziszewska, MD PhD, Bartosz Pula, MD, Maja Wasylecka, MD, Katarzyna Borg, PhD, Hanna Makuch-Lasica, MSc, Grazyna Nowak, MSc, Ewa Lech-Maranda, MD PhD, Krzysztof Warzocha, MD PhD, Wojciech Czardybon, PhD, Michal Galezowski, PhD, Renata Windak, PhD, Krzysztof Brzozka, PhD, Przemyslaw Juszczynski, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1549.
https://doi.org/10.1182/blood.V126.23.1549.1549
Published: 2015
Journal Articles

Optimizing Effects of mTOR Inhibition in Acute Myelogenous Leukemia

Joshua Acklin, Mitra Azadniv, PhD, Scott Portwood, MS, MBA, Kimberly Lacagnina, MA, Charlotte Beers, Eunice S. Wang, MD, Jane L. Liesveld, MD
Journal: Blood
Blood (2015) 126 (23): 4930.
https://doi.org/10.1182/blood.V126.23.4930.4930
Published: 2015
Journal Articles

Mutation Impact of Targeted Genes in Diffuse Large B-Cell Lymphoma Patients Treated with Ibrutinib

Leo WK Cheung, Karl J. Schweighofer, Shiquan Wu, Hsu-Ping Kuo, Karl Eckert, Sriram Balasubramanian, PhD, Deborah Ricci, Yu Liang, Darrin Beaupre, Betty Y. Chang
Journal: Blood
Blood (2015) 126 (23): 2642.
https://doi.org/10.1182/blood.V126.23.2642.2642
Published: 2015
Journal Articles

Co-Activation of AMPK and mTORC1 Is Synthetically Lethal in Acute Myeloid Leukemia

Pierre Sujobert, MD, Etienne Paubelle, Adrien Grenier, MD, Florence Zylbersztejn, Mireille Lambert, PhD, Laury Poulain, graduate student, Elizabeth Townsend, PhD, Jean-Marie Brusq, PhD, Edwige Nicodeme, PhD, Justine Decrooqc, MD, Ina Nepstad, graduate student, Alexa Green, Marie-Anne Hospital, MD, Nathalie Jacque, MD, Olivier Hermine, MD PhD, Marc Foretz, PhD, Benoit Viollet, PhD, Catherine Lacombe, David M. Weinstock, MD, Patrick Mayeux, PhD, Ivan C Moura, PhD, Didier Bouscary, MD, Jerome Tamburini, MD PhD
Journal: Blood
Blood (2014) 124 (21): 616.
https://doi.org/10.1182/blood.V124.21.616.616
Published: 2014
Journal Articles

Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation

Kristen A McEachern, PhD, Adriana E Tron, PhD, Greg O'Connor, Rachel DuPont, Francis D Gibbons, PhD, Lourdes Pablo, Karthick Vishwanathan, PhD, Patricia McCoon, PhD, Jorge E. Cortes, MD, Daniel J. DeAngelo, MDPhD, Mark D Minden, MDPhD, Geoffrey L. Uy, MD, Frank Neumann, MDPhD, Karen Keating, Dennis Huszar, PhD, J. Elizabeth Pease, PhD, Jeffrey Brown, PhD, J. Carl Barrett, PhD
Journal: Blood
Blood (2014) 124 (21): 906.
https://doi.org/10.1182/blood.V124.21.906.906
Published: 2014
Journal Articles

Significant Activity Of The mTOR Inhibitor Sirolimus and HDAC Inhibitor Vorinostat In Heavily Pretreated Refractory Hodgkin Lymphoma Patients

Filip Janku, MD, PhD, Ignacio Garrido-Laguna, MD, Vivianne Velez-Bravo, Gerald S. Falchook, MD, Vivek Subbiah, MD, David S. Hong, MD, Yasuhiro Oki, MD, Jason R. Westin, MD, Cesar A. Nunez, M.D., Luis E Fayad, Larry W. Kwak, MD, PhD, Elizabeth J Shpall, MD, Jennifer J. Wheler, MD, Winnie Liang, PhD, Bodour Salhia, PhD, Funda Meric-Bernstam, MD, Razelle Kurzrock, Michelle Fanale, MD
Journal: Blood
Blood (2013) 122 (21): 3048.
https://doi.org/10.1182/blood.V122.21.3048.3048
Published: 2013