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Journal Articles

TP-0184 Inhibits ALK2/ACVR1, Decreases Hepcidin Levels, and Demonstrates Activity in Preclinical Mouse Models of Functional Iron Deficiency

Peter Peterson, PhD, W K, Clifford Whatcott, PhD, Adam Siddiqui-Jain, PhD, Steven Weitman, MD PhD, Mark Kieran, MD PhD, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 937.
https://doi.org/10.1182/blood.V130.Suppl_1.937.937
Published: 2017
Journal Articles

The ALK-2 Inhibitor, TP-0184, Demonstrates High Distribution to the Liver Contributing to Significant Preclinical Efficacy in Mouse Models of Anemia of Chronic Disease

Peter Peterson, PhD, Wontak Kim, Hillary Haws, Clifford J. Whatcott, PhD, Adam Siddiqui-Jain, PhD, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2016) 128 (22): 263.
https://doi.org/10.1182/blood.V128.22.263.263
Published: 2016
Journal Articles

ALK2 Inhibition Via TP-0184 Abrogates Inflammation-Induced Hepcidin Expression and Is a Potential Therapeutic for Anemia of Chronic Disease

Peter Peterson, PhD, Katherine K. Soh, Ye Sol Lee, Wontak Kim, Clifford J. Whatcott, PhD, Adam Siddiqui-Jain, PhD, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2015) 126 (23): 273.
https://doi.org/10.1182/blood.V126.23.273.273
Published: 2015
Journal Articles

Novel Series of ALK2 Inhibitors That Alter Hepcidin Expression As Potential Therapeutics for Anemia of Chronic Disease

Wontak Kim, Kyle S. Maughan, Katherine K. Soh, Jeremiah J. Bearss, Brigham L. Bahr, David J. Bearss, PhD, Steven L. Warner, PhD
Journal: Blood
Blood (2014) 124 (21): 212.
https://doi.org/10.1182/blood.V124.21.212.212
Published: 2014
Journal Articles

Oral Administration Of a BMP Type I Receptor Inhibitor Prevents The Development Of Anemia Of Inflammation

Claire Mayeur, MD, Starsha A Kolodziej, Amy Wang, Xin Xu, Arthur Lee, Paul B. Yu, MD, PhD, John Shen, PhD, Kenneth D. Bloch, MD
Journal: Blood
Blood (2013) 122 (21): 2195.
https://doi.org/10.1182/blood.V122.21.2195.2195
Published: 2013
Journal Articles

Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia

Akin Akinc, PhD, Amy Chan-Daniels, PhD, Alfica Sehgal, PhD, Don Foster, Brian R Bettencourt, PhD, Julia Hettinger, Tim Racie, Justin Aubin, Satya Kuchimanchi, PhD, Hila Epstein-Barash, PhD, Tomoko Nakayama, PhD
Journal: Blood
Blood (2011) 118 (21): 688.
https://doi.org/10.1182/blood.V118.21.688.688
Published: 2011
Journal Articles

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

Andrea U. Steinbicker, Chetana Sachidanandan, Ashley J. Vonner, Rushdia Z. Yusuf, Donna Y. Deng, Carol S. Lai, Kristen M. Rauwerdink, Julia C. Winn, Borja Saez, Colleen M. Cook, Brian A. Szekely, Cindy N. Roy, Jasbir S. Seehra, Gregory D. Cuny, David T. Scadden, Randall T. Peterson, Kenneth D. Bloch, Paul B. Yu
Journal: Blood
Blood (2011) 117 (18): 4915–4923.
https://doi.org/10.1182/blood-2010-10-313064
Published: 2011
Includes: Supplemental data
Journal Articles

Shortened Erythrocyte Life Span and Increased Oxidative Stress In Erythroid Precursors Are Consistent with Normocytic Anemia In Mice with Chronic Inflammation

Andrew J. Layman, Jacqueline M. Langdon, Qilu Yu, Ph.D., Olivier D. Prince, M.D., Jeremy D. Walston, M.D., Curt I. Civin, MD, Cindy N. Roy, PhD
Journal: Blood
Blood (2010) 116 (21): 3205.
https://doi.org/10.1182/blood.V116.21.3205.3205
Published: 2010
Journal Articles

Role of BMP Signaling In the Anemia of Chronic Disease

Andrea U. Steinbicker, MD, MPH, Ashley J. Vonner, Chetana Sachidanandan, PhD, Lisa Lohmeyer, David T. Scadden, MD, Randall T. Peterson, PhD, Kenneth D. Bloch, MD, Paul B. Yu, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2043.
https://doi.org/10.1182/blood.V116.21.2043.2043
Published: 2010
Journal Articles

Targeting Hepcidin with Antisense Oligonucletides Improves Anemia Endpoints in Mice.

Jeffrey R. Crosby, PhD, William A. Gaarde, Jarrett Egerston, Robert McKay, Yingqing Sun, Susan Freier, Ph.D., Andy Watt, Gene P. Hung, MD, Bret P. Monia, PhD
Journal: Blood
Blood (2006) 108 (11): 269.
https://doi.org/10.1182/blood.V108.11.269.269
Published: 2006
Journal Articles

In Chronic Inflammation, There Exists an IL-6 Independent Pathway for the Induction of Hepcidin.

Seth Rivera, MD, Victoria Gabayan, Tomas Ganz, PhD, MD
Journal: Blood
Blood (2004) 104 (11): 3205.
https://doi.org/10.1182/blood.V104.11.3205.3205
Published: 2004
Journal Articles

Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules

Clinical Trials & Observations
Sharon S. Evans, Wan-Chao Wang, Mark D. Bain, Randy Burd, Julie R. Ostberg, Elizabeth A. Repasky
Journal: Blood
Blood (2001) 97 (9): 2727–2733.
https://doi.org/10.1182/blood.V97.9.2727
Published: 2001