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Journal Articles

DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia

Yonghan He, MD, Raphael Koch, Vivekananda Budamagunta, Dongwen Lv, Sajid Khan, Xuan Zhang, Janet S Wiegand, Guangrong Zheng, David M. Weinstock, MD, Daohong Zhou

Blood (2019) 134 (Supplement_1): 303.

https://doi.org/10.1182/blood-2019-125820

Published: 2019

Journal Articles

Targeting BCL-XL By Protac DT2216 Effectively Eliminates Leukemia Cells in T-ALL Pre-Clinical Models

Qi Zhang, PhD, Sajid Khan, PhD, Xuan Zhang, Vinitha Mary Kuruvilla, MSc, Sanaz Ghotbaldini, Julia Wells, PhD, Natalia Baran, PhDMD, Tianyu Cai, PhD, Lina Han, PhD, Adolfo Ferrando, MD, PhD, Yong-Mi Kim, MD MPH, PhD, Guangrong Zheng, Daohong Zhou, Marina Y Konopleva, MD PhD

Blood (2019) 134 (Supplement_1): 3870.

https://doi.org/10.1182/blood-2019-124744

Published: 2019

Journal Articles

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

Judith Lind, PhD, Felix Czernilofsky, Sonia Vallet, MD, Fengjuan Fan, PhD, Martin Sattler, PhD, Latifa Bakiri, Erwin F Wagner, PhD, Martin Percherstorfer, MD, Klaus Podar, MD PhD

Blood (2019) 134 (Supplement_1): 4415.

https://doi.org/10.1182/blood-2019-125202

Published: 2019

Journal Articles

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Sajid Khan, PhD, Xuan Zhang, BMBS, Dongwen Lv, PhD, Yonghan He, MD, Peiyi Zhang, MS, Xingui Liu, PhD, Dinesh Thummuri, PhD, Qi Zhang, PhD, Marina Y. Konopleva, MD PhD, Robert A. Hromas, MD, Guangrong Zheng, Daohong Zhou, MD

Blood (2018) 132 (Supplement 1): 2698.

https://doi.org/10.1182/blood-2018-99-114762

Published: 2018

Journal Articles

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Brandi Reeves, MD, Soo Jin Kim, MS, Jihyun Song, PhD, Radhika Gangaraju, MD, Rafal Pawlinski, PhD, Perumal Thiagarajan, MD, Victor R. Gordeuk, MD, Nigel S. Key, MBChB, FRCP, Josef T. Prchal, MD

Blood (2018) 132 (Supplement 1): 2513.

https://doi.org/10.1182/blood-2018-99-117812

Published: 2018

Journal Articles

A Hitherto Undescribed Von Hippel Lindau Polymorphism Induced/Related Polycythemia Entity, Clinical Features, Cancer Association and Familiar Characteristics, Preliminary Data

Udvardy Miklos, Miklos Egyed, MD PhD, Imre Bodó, MD PhD, Gyula Remenyi, MD PhD, Zsuzsanna Bereczky, MD PhD, Aniko Ujfalusi, PhD, Arpad Illes, MD

Blood (2018) 132 (Supplement 1): 4884.

https://doi.org/10.1182/blood-2018-99-114080

Published: 2018

Journal Articles

Identification of a new VHL exon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease

Marion Lenglet, Florence Robriquet, Klaus Schwarz, Carme Camps, Anne Couturier, David Hoogewijs, Alexandre Buffet, Samantha J. L. Knight, Sophie Gad, Sophie Couvé, Franck Chesnel, Mathilde Pacault, Pierre Lindenbaum, Sylvie Job, Solenne Dumont, Thomas Besnard, Marine Cornec, Helene Dreau, Melissa Pentony, Erika Kvikstad, Sophie Deveaux, Nelly Burnichon, Sophie Ferlicot, Mathias Vilaine, Jean-Michaël Mazzella, Fabrice Airaud, Céline Garrec, Laurence Heidet, Sabine Irtan, Elpis Mantadakis, Karim Bouchireb, Klaus-Michael Debatin, Richard Redon, Stéphane Bezieau, Brigitte Bressac-de Paillerets, Bin Tean Teh, François Girodon, Maria-Luigia Randi, Maria Caterina Putti, Vincent Bours, Richard Van Wijk, Joachim R. Göthert, Antonis Kattamis, Nicolas Janin, Celeste Bento, Jenny C. Taylor, Yannick Arlot-Bonnemains, Stéphane Richard, Anne-Paule Gimenez-Roqueplo, Holger Cario, Betty Gardie

Blood (2018) 132 (5): 469–483.

https://doi.org/10.1182/blood-2018-03-838235

Published: 2018

Includes: Supplemental data

Journal Articles

Targeted Therapy with BET Protein and β Catenin Antagonists Against Ruxolitinib Resistant Post-Myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells

Dyana T. Saenz, PhD, Warren Fiskus, BSc,PhD, Taghi Manshouri, Yimin Qian, PhD, Kanak Raina, PhD, David N Saenz, Christopher Peter Mill, PhD BA, Agnieszka J Nowak, Baohua Sun, MD PhD, Srdan Verstovsek, MD PhD, Craig M Crews, PhD, Kapil N. Bhalla, MD

Blood (2017) 130 (Supplement 1): 1239.

https://doi.org/10.1182/blood.V130.Suppl_1.1239.1239

Published: 2017

Journal Articles

Chuvash Polycythemia Patients from Afghanistan and Southern India Share a Common VHL Gene Haplotype. Support for Its Origin before Asians and Europeans Diverged

Christine Min, Jihyun Song, PhD, Joachim R. Goethert, MD, Soo Jin Kim, MS, Victor R. Gordeuk, MD, Josef T. Prchal, MD, Alan Lubin, MD

Blood (2017) 130 (Supplement 1): 930.

https://doi.org/10.1182/blood.V130.Suppl_1.930.930

Published: 2017

Journal Articles

The Role of Egln2/Proline Hydroxylase 1 in Regulation of Cyclin D1 in Mantle Cell Lymphoma

Olga Babosova, M.Sc., Lucie Lanikova, PhD, Katarina Kapralova, MSc, Vladimir Divoky, PhD, Vladimir Korinek, PhD, Josef T. Prchal, MD

Blood (2017) 130 (Supplement 1): 5141.

https://doi.org/10.1182/blood.V130.Suppl_1.5141.5141

Published: 2017

Journal Articles

Spectrum of Mutations Associated with Hereditary Erythrocytosis

Jennifer L Oliveira, MD, Lori A Frederick, BS, Lea M Coon, MS, Molly Susan Hein, BS, Mrinal M Patnaik, MBBS, Ayalew Tefferi, MD, Animesh Pardanani, MBBS, PhD, Stefan K Grebe, MD, PhD, David S Viswanatha, MD, James D Hoyer, MD

Blood (2015) 126 (23): 2140.

https://doi.org/10.1182/blood.V126.23.2140.2140

Published: 2015

Journal Articles

Prevalence of Extramedullary Hematopoiesis, Vertebral, Hepatic and Splenic Hemangioma and Renal Cyst Among Thalassaemic Patients: A Retrospective Study from the Myocardial Iron in Thalassemia (MIOT) Network

Alessia Pepe, Antonella Meloni, Alessandra Briatico Vangosa, Fabrizia Terrazzino, Maria Giovanna Neri, Domenico Maddaloni, Gaetano Roccamo, Sabrina Armari, Aurelio Maggio, MD, Cristina Salvatori, Vincenzo Positano, Paolo Ricchi

Blood (2015) 126 (23): 2154.

https://doi.org/10.1182/blood.V126.23.2154.2154

Published: 2015

Journal Articles

Microenvironmental Stromal Cells Rescue CLL Cells from Apoptosis Via Hypoxia That Can be Targeted Therapeutically

Irina Idler, PhD, Deyan Yosifov, PhD, Nupur Bhattacharya, PhD, Michaela Reichenzeller, PhD, Viola Meyer-Pannwitt, Daria Ezerina, Annika Scheffold, M.Sc., Sabrina Kugler, PhD, Tobias Dick, PhD, Hartmut Dohner, MD, Stephan Stilgenbauer, MD, Daniel Mertens, PhD

Blood (2015) 126 (23): 4140.

https://doi.org/10.1182/blood.V126.23.4140.4140

Published: 2015

Journal Articles

Proteolytic Targeting Chimeric Molecules (PROTACs) Specific for Bromodomain-Containing Protein (BRD) 4 Are Active Against Pre-Clinical Models of Multiple Myeloma

Xiaohui Zhang, MD, PhD, Jing Lu, PhD, Yimin Qian, PhD, Robert Z. Orlowski, PhD, MD

Blood (2015) 126 (23): 917.

https://doi.org/10.1182/blood.V126.23.917.917

Published: 2015

Journal Articles

A Comprehensive Study of the VHL -R200W Chuvash Polycythemia Mutation Reveals a Gradual Dysregulation of the Hypoxia Pathway in Oncogenesis

Blood (2014) 124 (21): 4020.

https://doi.org/10.1182/blood.V124.21.4020.4020

Published: 2014

Journal Articles

Tibetan PHD2 D4E High Altitude Adapted Gene Can be Rapidly Detected By High Resolution Melting Assay

Anna Shestakova, PhD, Felipe Lorenzo, MD/PhD, Tsewang Tashi, MD, Lucie Lanikova, PhD, Carl T Wittwer, MD/PhD, Josef T. Prchal, MD

Blood (2014) 124 (21): 4875.

https://doi.org/10.1182/blood.V124.21.4875.4875

Published: 2014

Journal Articles

Activation of the Hypoxia-Inducible Factor Pathway Expands Early Thymic Progenitors

Anita Hollenbeck, Stefanie Weber, Kathrin Händschke, PhD, Mandy Necke, Bertram Opalka, PhD, Ulrich Dührsen, MD, Joachim Rudolf Göthert, MD

Blood (2014) 124 (21): 2896.

https://doi.org/10.1182/blood.V124.21.2896.2896

Published: 2014

Journal Articles

The Clinical Utility Of Next-Generation Sequencing In The Diagnosis Of Polycythemia

Roberto H Nussenzveig, PhD, Mohamed E Salama, MD, Sherrie L. Perkins, MD, PhD, Josef Prchal, MD, Archana M Agarwal, MD

Blood (2013) 122 (21): 2185.

https://doi.org/10.1182/blood.V122.21.2185.2185

Published: 2013

Journal Articles

Convergence Of Hypoxia and TGFβ Pathways On Cell Cycle Regulation In Human Hematopoietic Stem/Progenitor Cells

Albertus T.J. Wierenga, PhD, Edo Vellenga, MD, PhD, Jan Jacob Schuringa, PhD

Blood (2013) 122 (21): 3694.

https://doi.org/10.1182/blood.V122.21.3694.3694

Published: 2013

Journal Articles

Deletion Of The Von Hippel-Lindau Gene Interferes With The Development Of Peripheral B-Cell Subsets

Kathrin Händschke, Stefanie Weber, Mandy Necke, Anita Hollenbeck, Bertram Opalka, PhD, Ulrich Dührsen, MD, Joachim Rudolf Göthert, MD

Blood (2013) 122 (21): 3666.

https://doi.org/10.1182/blood.V122.21.3666.3666

Published: 2013

NARROW

DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia

Targeting BCL-XL By Protac DT2216 Effectively Eliminates Leukemia Cells in T-ALL Pre-Clinical Models

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy

DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-X L for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

A Hitherto Undescribed Von Hippel Lindau Polymorphism Induced/Related Polycythemia Entity, Clinical Features, Cancer Association and Familiar Characteristics, Preliminary Data

Identification of a new VHL exon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease

Targeted Therapy with BET Protein and β Catenin Antagonists Against Ruxolitinib Resistant Post-Myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells

Chuvash Polycythemia Patients from Afghanistan and Southern India Share a Common VHL Gene Haplotype. Support for Its Origin before Asians and Europeans Diverged

The Role of Egln2/Proline Hydroxylase 1 in Regulation of Cyclin D1 in Mantle Cell Lymphoma

Spectrum of Mutations Associated with Hereditary Erythrocytosis

Prevalence of Extramedullary Hematopoiesis, Vertebral, Hepatic and Splenic Hemangioma and Renal Cyst Among Thalassaemic Patients: A Retrospective Study from the Myocardial Iron in Thalassemia (MIOT) Network

Microenvironmental Stromal Cells Rescue CLL Cells from Apoptosis Via Hypoxia That Can be Targeted Therapeutically

Proteolytic Targeting Chimeric Molecules (PROTACs) Specific for Bromodomain-Containing Protein (BRD) 4 Are Active Against Pre-Clinical Models of Multiple Myeloma

A Comprehensive Study of the VHL -R200W Chuvash Polycythemia Mutation Reveals a Gradual Dysregulation of the Hypoxia Pathway in Oncogenesis

Tibetan PHD2 D4E High Altitude Adapted Gene Can be Rapidly Detected By High Resolution Melting Assay

Activation of the Hypoxia-Inducible Factor Pathway Expands Early Thymic Progenitors

The Clinical Utility Of Next-Generation Sequencing In The Diagnosis Of Polycythemia

Convergence Of Hypoxia and TGFβ Pathways On Cell Cycle Regulation In Human Hematopoietic Stem/Progenitor Cells

Deletion Of The Von Hippel-Lindau Gene Interferes With The Development Of Peripheral B-Cell Subsets

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American Society of Hematology

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American Society of Hematology

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