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Klaus-Michael Debatin
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Journal Articles

Acquired Venetoclax Resistance in an In Vivo Model of B-Cell Precursor Acute Lymphoblastic Leukemia Is Characterized By Altered Functions of Apoptosis Regulators

Stefanie Enzenmüller, Alexandra Niedermayer, Felix Seyfried, Alexander Groß, Klaus-Michael Debatin, Lüder Hinrich Meyer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1446.
https://doi.org/10.1182/blood-2023-185621
Published: 2023
Journal Articles

Identification of vulnerabilities for targeting BCL-2 family members in T-Cell Acute Lymphoblastic Leukemia

Colin Fortner, Maren Wichert, Alexandra Niedermayer, Klaus-Michael Debatin, Lüder Hinrich Meyer, Felix Seyfried
Journal: Blood
Blood (2023) 142 (Supplement 1): 1608.
https://doi.org/10.1182/blood-2023-177613
Published: 2023
Journal Articles

Identification of Mir-532-5p As a Reliable miRNA Reference in Acute Lymphoblastic Leukemia

Teresa Mack, Klaus-Michael Debatin, Lueder Hinrich Meyer, Vera Münch
Journal: Blood
Blood (2023) 142 (Supplement 1): 5735.
https://doi.org/10.1182/blood-2023-179236
Published: 2023
Journal Articles

Venetoclax Resistance in B-Cell Precursor Acute Lymphoblastic Leukemia Is Characterized By Increased Mitochondrial Metabolism and Can be Overcome By Co-Targeting Oxidative Phosphorylation

Alexandra Niedermayer, Stefanie Enzenmüller, Felix Seyfried, Daniel Tews, Pamela Fischer-Posovszky, Ulrich Rupp, Paul Walther, Klaus-Michael Debatin, Lüder Hinrich Meyer
Journal: Blood
Blood (2022) 140 (Supplement 1): 6358–6359.
https://doi.org/10.1182/blood-2022-166223
Published: 2022
Journal Articles

Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia

Billy Michael Chelliah Jebaraj, Annika Müller, Rashmi Priyadharshini Dheenadayalan, Sascha Endres, Philipp M. Roessner, Felix Seyfried, Claudia Walliser, Martin Wist, Jialei Qi, Eugen Tausch, Daniel Mertens, Judith A. Fox, Klaus-Michael Debatin, Lüder Hinrich Meyer, Pietro Taverna, Martina Seiffert, Peter Gierschik, Stephan Stilgenbauer
Journal: Blood
Blood (2022) 139 (6): 859–875.
https://doi.org/10.1182/blood.2021011516
Published: 2022
Includes: Supplemental data
Journal Articles

MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemia

Elena Boldrin, Enrico Gaffo, Alexandra Niedermayer, Judith M. Boer, Martin Zimmermann, Dieter Weichenhan, Rainer Claus, Vera Münch, Qian Sun, Stefanie Enzenmüller, Felix Seyfried, Salih Demir, Julia Zinngrebe, Gunnar Cario, Martin Schrappe, Monique L. Den Boer, Christoph Plass, Klaus-Michael Debatin, Geertruij te Kronnie, Stefania Bortoluzzi, Lüder Hinrich Meyer
Journal: Blood
Blood (2021) 138 (20): 1953–1965.
https://doi.org/10.1182/blood.2020007591
Published: 2021
Includes: Supplemental data
Journal Articles

Synergistic Activity of BH3-Mimetics By Combined Targeting of Anti-Apoptotic Regulators in B-Cell Precursor ALL

Felix Seyfried, Felix Stirnweiß, Alexandra Niedermayer, Stefanie Enzenmüller, Rebecca Hörl, Stefan Köhrer, Klaus-Michael Debatin, Lüder Hinrich Meyer
Journal: Blood
Blood (2021) 138 (Supplement 1): 706.
https://doi.org/10.1182/blood-2021-150162
Published: 2021
Journal Articles

Characterization of Mechanisms of Acquired Venetoclax-Insensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia

Alexandra Niedermayer, MSc, Stefanie Enzenmüller, PhD, Eugen Tausch, Stephan Stilgenbauer, MD, Felix Seyfried, MD, Klaus-Michael Debatin, MD, Lüder Hinrich Meyer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3954.
https://doi.org/10.1182/blood-2019-126582
Published: 2019
Journal Articles

Urine Proteomic Analysis Reveals Disease-Specific Patterns in Pediatric Patients with Classical Hodgkin's Disease(HD). an Addon Study to the Euronet-PHL-C2 Trial

Karl-Walter Sykora, MD, Jochen Metzger, PhD, Dieter Körholz, MD PhD, Michael Frühwald, MD, Gabriele Strauss, MD, Norbert Jorch, MD, Jozef Zlocha, MD PhD, Thomas Wiesel, MD, Axel Sauerbrey, MD, Monika Streiter, MD, Rhoikos Furtwaengler, MD, Gunnar Cario, MD PhD, Thorsten Simon, MD PhD, Holger Christiansen, MD, Peter Vorwerk, MD, Angela Wawer, MD, Wolfram Scheurlen, MD, Hermann Müller, MD, Stefan Bielack, MD, Martin Ebinger, PD Dr. MD, Klaus-Michael Debatin, MD, Oliver Andres, MD, Christine Mauz-Körholz, Anja Troeger, MD, Dominik Schneider, MD, Eva M Weissinger, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2804.
https://doi.org/10.1182/blood-2019-125611
Published: 2019
Journal Articles

Biomarker Profile for Prediction of Patient Response to Smac Mimetic Monotherapy in Pediatric Precursor B-Cell Acute Lymphoblastic Leukemia

Julia Zinngrebe, MD, Ferdinand Schlichtig, Malcolm Meyer, Johann M. Kraus, Elena Boldrin, PhD, Hans A. Kestler, Lüder Hinrich Meyer, MD, Pamela Fischer-Posovszky, Klaus-Michael Debatin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2082.
https://doi.org/10.1182/blood-2019-130967
Published: 2019
Journal Articles

Venetoclax Resistance in Mantle Cell Lymphoma Is Mediated By BCL-XL and Can be Circumvent By Inhibiting the BH4 Domain of BCL-2

Daniela Steinbrecher, PhD, Felix Seyfried, MD, Eugen Tausch, Johannes Bloehdorn, MD, Billy Michael Chelliah Jebaraj, PhD, Klaus-Michael Debatin, MD, Lüder Hinrich Meyer, MD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD, Christof Schneider, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1507.
https://doi.org/10.1182/blood-2019-127931
Published: 2019
Journal Articles

Synergistic Activity of the MCL-1-Specific Inhibitor S63845 with Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia

Felix Seyfried, Felix Stirnweiß, Stefan Köhrer, MD, Klaus-Michael Debatin, MD, Lüder Hinrich Meyer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1416.
https://doi.org/10.1182/blood-2018-99-117139
Published: 2018
Journal Articles

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Ameera Alsadeq, Lennart Lenk, Anila Vadakumchery, Antony Cousins, Christian Vokuhl, Ahmad Khadour, Fotini Vogiatzi, Felix Seyfried, Lueder-Hinrich Meyer, Gunnar Cario, Elias Hobeika, Klaus-Michael Debatin, Christina Halsey, Martin Schrappe, Denis M. Schewe, Hassan Jumaa
Journal: Blood
Blood (2018) 132 (15): 1614–1617.
https://doi.org/10.1182/blood-2018-04-844209
Published: 2018
Includes: Supplemental data
Journal Articles

Identification of a new VHL exon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease

Marion Lenglet, Florence Robriquet, Klaus Schwarz, Carme Camps, Anne Couturier, David Hoogewijs, Alexandre Buffet, Samantha J. L. Knight, Sophie Gad, Sophie Couvé, Franck Chesnel, Mathilde Pacault, Pierre Lindenbaum, Sylvie Job, Solenne Dumont, Thomas Besnard, Marine Cornec, Helene Dreau, Melissa Pentony, Erika Kvikstad, Sophie Deveaux, Nelly Burnichon, Sophie Ferlicot, Mathias Vilaine, Jean-Michaël Mazzella, Fabrice Airaud, Céline Garrec, Laurence Heidet, Sabine Irtan, Elpis Mantadakis, Karim Bouchireb, Klaus-Michael Debatin, Richard Redon, Stéphane Bezieau, Brigitte Bressac-de Paillerets, Bin Tean Teh, François Girodon, Maria-Luigia Randi, Maria Caterina Putti, Vincent Bours, Richard Van Wijk, Joachim R. Göthert, Antonis Kattamis, Nicolas Janin, Celeste Bento, Jenny C. Taylor, Yannick Arlot-Bonnemains, Stéphane Richard, Anne-Paule Gimenez-Roqueplo, Holger Cario, Betty Gardie
Journal: Blood
Blood (2018) 132 (5): 469–483.
https://doi.org/10.1182/blood-2018-03-838235
Published: 2018
Includes: Supplemental data
Journal Articles

Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia

Fan Wang, Salih Demir, Franziska Gehringer, Clarissa D. Osswald, Felix Seyfried, Stefanie Enzenmüller, Sarah M. Eckhoff, Thomas Maier, Karlheinz Holzmann, Klaus-Michael Debatin, Thomas Wirth, Lüder H. Meyer, Alexey Ushmorov
Journal: Blood
Blood (2018) 131 (26): 2929–2942.
https://doi.org/10.1182/blood-2017-10-813576
Published: 2018
Includes: Supplemental data
Journal Articles

HSCT cures ADA2 deficiency

Klaus-Michael Debatin
Journal: Blood
Blood (2017) 130 (24): 2582–2583.
https://doi.org/10.1182/blood-2017-10-811125
Published: 2017
Journal Articles

Oncolytic Measles Virus MV-NIS Controls Relapsed ALL Patient-Derived Xenografts

Annika V. Goss, MSc, Chun Xu, BSc, Carmen Dorneburg, PhD, Christine Landthaler, MSc, Klaus-Michael Debatin, MD, Jiwu Wei, MD, Christian Beltinger, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3892.
https://doi.org/10.1182/blood.V130.Suppl_1.3892.3892
Published: 2017
Journal Articles

Targeting of the Interleukin-7 Receptor Alpha-Chain (IL-7Rα) Blocks B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Development and Reduces Leukemic Infiltration to the Central Nervous System (CNS)

Ameera Alsadeq, PhD, Anila George Vadakumchery, Ali Almasri, Hend Abdelrasoul, Markus Werner, PhD, Lennart Lenk, Felix Seyfried, Klaus-Michael Debatin, MD, Lueder-Hinrich Myer, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Denis Martin Schewe, MD, Hassan Jumaa, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 479.
https://doi.org/10.1182/blood.V130.Suppl_1.479.479
Published: 2017
Journal Articles

Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin

Clinical Trials & Observations
Aaron Seo, Miri Ben-Harosh, Mehtap Sirin, Jerry Stein, Orly Dgany, Joseph Kaplelushnik, Manfred Hoenig, Ulrich Pannicke, Myriam Lorenz, Klaus Schwarz, Clemens Stockklausner, Tom Walsh, Suleyman Gulsuner, Ming K. Lee, Anoop Sendamarai, Marilyn Sanchez-Bonilla, Mary-Claire King, Holger Cario, Andreas E. Kulozik, Klaus-Michael Debatin, Ansgar Schulz, Hannah Tamary, Akiko Shimamura
Journal: Blood
Blood (2017) 130 (7): 875–880.
https://doi.org/10.1182/blood-2017-02-768036
Published: 2017
Includes: Supplemental data
Journal Articles

Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor

Vera Münch, Luca Trentin, Julia Herzig, Salih Demir, Felix Seyfried, Johann M. Kraus, Hans A. Kestler, Rolf Köhler, Thomas F. E. Barth, Geertruy te Kronnie, Klaus-Michael Debatin, Lüder H. Meyer
Journal: Blood
Blood (2017) 130 (5): 643–654.
https://doi.org/10.1182/blood-2017-03-769315
Published: 2017
Includes: Supplemental data