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Martina Seiffert
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Journal Articles

CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models

Brief Report
Berit J. Brinkmann, Alessia Floerchinger, Christina Schniederjohann, Tobias Roider, Mariana Coelho, Norman Mack, Peter-Martin Bruch, Nora Liebers, Sarah Dötsch, Dirk H. Busch, Michael Schmitt, Frank Neumann, Philipp M. Roessner, Martina Seiffert, Sascha Dietrich
Journal: Blood
Blood (2024) 144 (7): 784–789.
https://doi.org/10.1182/blood.2023022682
Published: 2024
Includes: Supplemental data
Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood
Blood (2024) 144 (5): 510–524.
https://doi.org/10.1182/blood.2023021990
Published: 2024
Includes: Supplemental data
Journal Articles

Longitudinal Omics Data Followed By Preclinical Treatment Studies Identify Proteasome Inhibition As Effective Therapy for Ibrutinib-Resistant Chronic Lymphocytic Leukemia

Lavinia Arseni, Gianluca Sigismondo, Johanne U Hermansen, Sigrid S Skånland, Eugen Tausch, Stephan Stilgenbauer, Jeroen Krijgsveld, Peter Lichter, Marc Zapatka, Martina Seiffert
Journal: Blood
Blood (2022) 140 (Supplement 1): 4107–4108.
https://doi.org/10.1182/blood-2022-166999
Published: 2022
Journal Articles

Single-Cell Omics Analyses Identify the TIM-3 Ligand Galectin-9 As Novel Immunotherapy Target for Chronic Lymphocytic Leukemia

Laura Llaó Cid, John KL Wong, Marina Wierz, Yashna Paul, Tobias Roider, Iria Fernandez Botana, Susanne Gonder, Alessia Floerchinger, Dolors Colomer, Elías Campo, Sascha Dietrich, Peter Lichter, Marc Zapatka, Etienne Moussay, Jérôme Paggetti, Martina Seiffert
Journal: Blood
Blood (2022) 140 (Supplement 1): 1805–1806.
https://doi.org/10.1182/blood-2022-167183
Published: 2022
Journal Articles

Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia

Billy Michael Chelliah Jebaraj, Annika Müller, Rashmi Priyadharshini Dheenadayalan, Sascha Endres, Philipp M. Roessner, Felix Seyfried, Claudia Walliser, Martin Wist, Jialei Qi, Eugen Tausch, Daniel Mertens, Judith A. Fox, Klaus-Michael Debatin, Lüder Hinrich Meyer, Pietro Taverna, Martina Seiffert, Peter Gierschik, Stephan Stilgenbauer
Journal: Blood
Blood (2022) 139 (6): 859–875.
https://doi.org/10.1182/blood.2021011516
Published: 2022
Includes: Supplemental data
Journal Articles

TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target

Emma Kennedy, Eve Coulter, Emma Halliwell, Nuria Profitos-Peleja, Elisabeth Walsby, Barnaby Clark, Elizabeth H. Phillips, Thomas A. Burley, Simon Mitchell, Stephen Devereux, Christopher D. Fegan, Christopher I. Jones, Rosalynd Johnston, Tim Chevassut, Ralph Schulz, Martina Seiffert, Angelo Agathanggelou, Ceri Oldreive, Nicholas Davies, Tatjana Stankovic, Triantafillos Liloglou, Chris Pepper, Andrea G. S. Pepper
Journal: Blood
Blood (2021) 137 (22): 3064–3078.
https://doi.org/10.1182/blood.2020005964
Published: 2021
Includes: Supplemental data
Journal Articles

Immune Suppression in CLL Is Mediated By the L-Amino Acid Oxidase IL4I1, a Reason for the Treatment Failure of IDO1 Inhibitors

Selcen Öztürk, PhD, Murat Iskar, PhD, Murat Sunbul, PhD, Philipp M Rößner, MD, Marc Zapatka, PhD, Martina Seiffert
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141317
Published: 2020
Journal Articles

Eomes and IL-10 Regulate Anti-Tumor Activity of T Cells in Chronic Lymphocytic Leukemia

Laura Llaó Cid, M.Sc, Philipp M Rößner, MD, Ekaterina Lupar, PhD, Bola S Hanna, PhD, Jérôme Paggetti, PhD, Etienne Moussay, PhD, Dolors Colomer, PhD, Sascha Dietrich, MD, Stephan Stilgenbauer, MD, Ana Izcue, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4288.
https://doi.org/10.1182/blood-2019-128465
Published: 2019
Journal Articles

IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia

Annika Scheffold, Billy Michael Chelliah Jebaraj, Eugen Tausch, Johannes Bloehdorn, Paolo Ghia, Anella Yahiaoui, Anna Dolnik, Tamara Jacqueline Blätte, Lars Bullinger, Rashmi Priyadharshini Dheenadayalan, Li Li, Christof Schneider, Shih-Shih Chen, Nicholas Chiorazzi, Sascha Dietrich, Martina Seiffert, Stacey Tannheimer, Hartmut Döhner, Daniel Mertens, Stephan Stilgenbauer
Journal: Blood
Blood (2019) 134 (6): 534–547.
https://doi.org/10.1182/blood.2018881029
Published: 2019
Includes: Supplemental data
Journal Articles

Targeting IRAK4 Disrupts Inflammatory Pathways and Delays Tumor Development in Chronic Lymphocytic Leukemia

Neus Giménez Carabaza, B.Pharm, Rosich Laia, PhD, Schulz Ralph, MS, Higashi Morihiro, MD, Marta Aymerich, Neus Villamor, PhD, Julio Delgado, MD, Manel Juan, MD, Monica Lopez-Guerra, PhD, Elias Campo, Martina Seiffert, PhD, Dolors Colomer, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2650.
https://doi.org/10.1182/blood-2018-99-115999
Published: 2018
Journal Articles

IL-10 Receptor Deficiency Aggravates Exhaustion of CD8 + T-Cells and Impedes Their Control of Chronic Lymphocytic Leukemia

Bola S Hanna, PhD, Philipp M Röβner, Murat Iskar, PhD, Norman Mack, Verena Kalter, Manfred Schmidt, PhD, Marc Zapatka, PhD, Markus Feuerer, MD, Richard Gabriel, PhD, Peter Lichter, PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 385.
https://doi.org/10.1182/blood.V130.Suppl_1.385.385
Published: 2017
Journal Articles

Exhausted PD-1 hi T-Cells Are Enriched in Secondary Lymphoid Organs of CLL Patients

Philipp M Rößner, Bola S Hanna, PhD, Colomer Dolors, PhD, Elias Campo, MD PhD, Stephan Stilgenbauer, MD PhD, Peter Lichter, PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 4281.
https://doi.org/10.1182/blood.V130.Suppl_1.4281.4281
Published: 2017
Journal Articles

PI3K-δ Inhibition Influences T-Cell Populations and Anti-Tumoral Immune Function in Preclinical Models

Annika Scheffold, Bola S Hanna, PhD, Philipp Roeßner, Yasmin Demerdash, Billy Michael Chelliah Jebaraj, PhD, Peter Lichter, PhD, Stephan Stilgenbauer, MD PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 2998.
https://doi.org/10.1182/blood.V130.Suppl_1.2998.2998
Published: 2017
Journal Articles

CLL Exosome-Derived Y RNA hY4 Induces TLR7/8-Mediated Inflammation and PD-L1 Expression in Monocytes

Franziska Haderk, MSc, Laura Llao Cid, MSc, Murat Iskar, PhD, Ralph Schulz, MSc, Maria Goebel, MD, Jan Duerig, MD, Stephan Stilgenbauer, Marc Zapatka, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2016) 128 (22): 3217.
https://doi.org/10.1182/blood.V128.22.3217.3217
Published: 2016
Journal Articles

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

Clinical Trials & Observations
Sascha Dietrich, Andreas Pircher, Volker Endris, Frédéric Peyrade, Clemens-Martin Wendtner, George A. Follows, Jennifer Hüllein, Alexander Jethwa, Elena Ellert, Tatjana Walther, Xiyang Liu, Martin J. S. Dyer, Thomas Elter, Tilman Brummer, Robert Zeiser, Michael Hermann, Michael Herold, Wilko Weichert, Claire Dearden, Torsten Haferlach, Martina Seiffert, Michael Hallek, Christof von Kalle, Anthony D. Ho, Anita Gaehler, Mindaugas Andrulis, Michael Steurer, Thorsten Zenz
Journal: Blood
Blood (2016) 127 (23): 2847–2855.
https://doi.org/10.1182/blood-2015-11-680074
Published: 2016
Includes: Supplemental data
Journal Articles

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Jerome Paggetti, Franziska Haderk, Martina Seiffert, Bassam Janji, Ute Distler, Wim Ammerlaan, Yeoun Jin Kim, Julien Adam, Peter Lichter, Eric Solary, Guy Berchem, Etienne Moussay
Journal: Blood
Blood (2015) 126 (9): 1106–1117.
https://doi.org/10.1182/blood-2014-12-618025
Published: 2015
Includes: Supplemental data
Journal Articles

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Fabienne McClanahan, Bola Hanna, Shaun Miller, Andrew James Clear, Peter Lichter, John G. Gribben, Martina Seiffert
Journal: Blood
Blood (2015) 126 (2): 203–211.
https://doi.org/10.1182/blood-2015-01-622936
Published: 2015
Includes: Supplemental data
Journal Articles

Immune Checkpoint Blockade with Anti-PD-L1 Prevents Immune Dysfuntion and CLL Development in the TCL1 Adoptive Transfer Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Shaun Miller, Peter Lichter, PhD, Martina Seiffert, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2014) 124 (21): 717.
https://doi.org/10.1182/blood.V124.21.717.717
Published: 2014
Journal Articles

The Flavonoid Wogonin Reduces CLL Cell Survival in Vitro and Leukemia Development in Eµ-TCL1 Mice By Targeting Aberrant TNF Receptor Signaling

Claudia Dürr, Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, John G. Gribben, MD DSc, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2014) 124 (21): 1966.
https://doi.org/10.1182/blood.V124.21.1966.1966
Published: 2014
Journal Articles

Chronic Lymphocytic Leukemia-Derived Extracellular Vesicles Contain a Distinctive Proteome, As Well As Specific Micro RNAs and Y RNAs

Franziska Haderk, Etienne Moussay, Jerome Paggetti, Maria Göbel, Jan Dürig, MD, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2014) 124 (21): 1968.
https://doi.org/10.1182/blood.V124.21.1968.1968
Published: 2014