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Dimitar G. Efremov
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Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood
Blood (2024) 144 (5): 510–524.
https://doi.org/10.1182/blood.2023021990
Published: 2024
Includes: Supplemental data
Journal Articles

CXCR4 Loss Reduces the Local Growth of Richter Syndrome Murine and Patient-Derived Xenograft Models and Impairs BCR and VLA-4 Activation

Claudio Martines, Supriya Chakraborty, Antonella Zucchetto, Erika Tissino, Vincenzo Guastafierro, Marija Vujovikj, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J Dimovski, Valter Gattei, Dimitar G Efremov
Journal: Blood
Blood (2023) 142 (Supplement 1): 80.
https://doi.org/10.1182/blood-2023-179183
Published: 2023
Journal Articles

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Anne Largeot, Vanessa Klapp, Elodie Viry, Susanne Gonder, Iria Fernandez Botana, Arnaud Blomme, Mohaned Benzarti, Sandrine Pierson, Chloé Duculty, Petra Marttila, Marina Wierz, Ernesto Gargiulo, Giulia Pagano, Ning An, Najla El Hachem, Daniel Perez Hernandez, Supriya Chakraborty, Loïc Ysebaert, Jean-Hugues François, Susan Cortez Clemente, Guy Berchem, Dimitar G. Efremov, Gunnar Dittmar, Martyna Szpakowska, Andy Chevigné, Petr V. Nazarov, Thomas Helleday, Pierre Close, Johannes Meiser, Basile Stamatopoulos, Laurent Désaubry, Jérôme Paggetti, Etienne Moussay
Journal: Blood
Blood (2023) 141 (26): 3166–3183.
https://doi.org/10.1182/blood.2022017839
Published: 2023
Includes: Supplemental data
Journal Articles

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Claudio Martines, Supriya Chakraborty, Marija Vujovikj, Stefania Gobessi, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J. Dimovski, Dimitar G. Efremov
Journal: Blood
Blood (2022) 140 (22): 2335–2347.
https://doi.org/10.1182/blood.2022016272
Published: 2022
Includes: Supplemental data
Journal Articles

Rapid Generation of Murine CLL/Richter Syndrome Models By Multiplexed CRISPR/Cas9 Editing of Common CLL Driver Genes

Supriya Chakraborty, Giulia Felician, Claudio Martines, Alice Bonato, Ana Colado, Marija Vujovic, Aleksandar J. Dimovski, Dimitar G Efremov
Journal: Blood
Blood (2022) 140 (Supplement 1): 1536–1537.
https://doi.org/10.1182/blood-2022-163067
Published: 2022
Journal Articles

VEGF and IL-6 As Markers of Severity and Response to Treatment in Waldenstrom Macroglobulinemia and IgM-Monoclonal Gammopathy of Undetermined Significance: A Monocentric Experience

Annamaria Tomasso, Idanna Innocenti, Giulia Benintende, Francesco Autore, Alberto Fresa, Florenzia Vuono, Luca Stirparo, Antonio Mosca, Claudia Giannotta, Dimitar G Efremov, Marco Luigetti, Silvia Baroni, Luca Laurenti
Journal: Blood
Blood (2022) 140 (Supplement 1): 12498–12500.
https://doi.org/10.1182/blood-2022-165487
Published: 2022
Journal Articles

Predictive and Prognostic Molecular Biomarkers in Familial Chronic Lymphocytic Leukemia: A Pilot Monocentric Study

Giulia Benintende, Idanna Innocenti, Alberto Fresa, Francesco Autore, Annamaria Tomasso, Florenzia Vuono, Luca Stirparo, Antonio Mosca, Dimitar G Efremov, Andrea Bacigalupo, Luca Laurenti
Journal: Blood
Blood (2022) 140 (Supplement 1): 7018–7019.
https://doi.org/10.1182/blood-2022-169897
Published: 2022
Journal Articles

Chronic Lymphocytic Leukemia Cells with Mutated Nfkbie Are Positively Selected By Microenvironmental Signals and Display Reduced Sensitivity to Ibrutinib Treatment

Alice Bonato, Riccardo Bomben, Supriya Chakraborty, Giulia Felician, Claudio Martines, Antonella Zucchetto, Annalisa Chiarenza, Giovanni Del Poeta, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Aleksandar J. Dimovski, Valter Gattei, Dimitar G Efremov
Journal: Blood
Blood (2021) 138 (Supplement 1): 248.
https://doi.org/10.1182/blood-2021-149442
Published: 2021
Journal Articles

Prevalence of Allelic Variants and Clonality of IGHV1-69 Expressing B-Cells in Patients with Different Severity of COVID 19 Disease

Irina Panovska-Stavridis, Nevenka Ridova, Simona Stojanovska, Milena Stevanovic, Tatjana Stojanoska, Ilir Demiri, Nadica Matevska-Geshkovska, Marija Vujovic, Hristina Markoska, Venko Filipce, Aleksandar J. Dimovski, Dimitar G Efremov
Journal: Blood
Blood (2021) 138 (Supplement 1): 994.
https://doi.org/10.1182/blood-2021-153487
Published: 2021
Journal Articles

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Supriya Chakraborty, Claudio Martines, Fabiola Porro, Ilaria Fortunati, Alice Bonato, Marija Dimishkovska, Silvano Piazza, Brijesh S. Yadav, Idanna Innocenti, Rosa Fazio, Tiziana Vaisitti, Silvia Deaglio, Alberto Zamò, Aleksandar J. Dimovski, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2021) 138 (12): 1053–1066.
https://doi.org/10.1182/blood.2020008276
Published: 2021
Includes: Supplemental data
Journal Articles

Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome

Supriya Chakraborty, PhD, Claudio Martines, MS, Fabiola Porro, MS, Ilaria Fortunati, BS, Alice Bonato, BA, Marija Dimishkovska, PhD, Brijesh Yadav, PhD, Idanna Innocenti, MDPhD, Rosa Fazio, BA, Tizianna Vaisitti, PhD, Silvia Deaglio, MD, Alberto Zamò, MD PhD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136668
Published: 2020
Journal Articles

A CRISPR/Cas9-Generated Murine Model Reveals Cooperation between BCR Signaling and CDKN2A/2B and TP53 Disruption in Richter Syndrome

Supriya Chakraborty, PhD, Ilaria Fortunati, BS, Claudio Martines, MS, Brijesh Yadav, PhD, Marija Dimishkovska, PhD, Idanna Innocenti, MD PhD, Rosa Fazio, BS, Giovanni D'Arena, MD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4278.
https://doi.org/10.1182/blood-2019-128425
Published: 2019
Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4409.
https://doi.org/10.1182/blood-2018-99-118562
Published: 2018
Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 240.
https://doi.org/10.1182/blood-2018-99-118057
Published: 2018
Journal Articles

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Binu K Sasi, PhD, Sven Turkalj, BS, Hilal Kalkan, BS, Fabiola Porro, MS, Engin Bojnik, PhD, Beata Pyrzynska, PhD, Abdessamad Zerrouqi, PhD, Malgorzata Bobrowicz, PhD, Magdalena Winiarska, PhD, Valdemar Priebe, MS, Francesco Bertoni, MD, Larry Mansouri, PhD, Richard Rosenquist, MD PhD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2860.
https://doi.org/10.1182/blood-2018-99-118120
Published: 2018
Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1721.
https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721
Published: 2017
Journal Articles

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Malgorzata Bobrowicz, Michal Dwojak, Beata Pyrzynska, Joanna Stachura, Angelika Muchowicz, Elise Berthel, Nicole Dalla-Venezia, Mieszko Kozikowski, Marta Siernicka, Nina Miazek, Piotr Zapala, Antoni Domagala, Kamil Bojarczuk, Agata Malenda, Joanna Barankiewicz, Agnieszka Graczyk-Jarzynka, Agnieszka Zagozdzon, Magdalena Gabrysiak, Jean-Jacques Diaz, Marta Karp, Ewa Lech-Maranda, Malgorzata Firczuk, Krzysztof Giannopoulos, Dimitar G. Efremov, Luca Laurenti, Dunja Baatout, Lukas Frenzel, Agata Malinowska, Mikolaj Slabicki, Thorsten Zenz, Abdessamad Zerrouqi, Jakub Golab, Magdalena Winiarska
Journal: Blood
Blood (2017) 130 (14): 1628–1638.
https://doi.org/10.1182/blood-2016-08-736066
Published: 2017
Includes: Supplemental data
Journal Articles

Chlorambucil PLUS Rituximab As FRONT-LINE Therapy for Elderly and/or Unfit CLL Patients. LONG-TERM Follow-up and Correlation with Biologic-Based Risk Stratification

Luca Laurenti, Idanna Innocenti, MD, Francesco Autore, MD, Raffaella Pasquale, Barbara Vannata, MD, Stefania Ciolli, Francesca Romana Mauro, MD PhD, Donato Mannina, MD, Giovanni Del Poeta, MD, Giovanni D'Arena, MD, Massimo Massaia, MD, Marta Coscia, MD PhD, Stefano Molica, MD, Gabriele Pozzato, MD, Dimitar G Efremov, MD PhD, Roberto Marasca, MD, Piero Galieni, Antonio Cuneo, MD, Sonia Orlando, Alfonso Piciocchi, BS, Riccardo Boncompagni, Donatella Iolanda Vincelli, MD, Anna Marina Liberati, MD, Filomena Russo, Robin Foa
Journal: Blood
Blood (2016) 128 (22): 3240.
https://doi.org/10.1182/blood.V128.22.3240.3240
Published: 2016
Journal Articles

The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism

Binu K Sasi, PhD, Tamara Vervloessem, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, Geert Bultynck, PhD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2014.
https://doi.org/10.1182/blood.V128.22.2014.2014
Published: 2016
Journal Articles

FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Gabriele Pozzato, MD, Idanna Innocenti, MD, Luca Laurenti, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2015.
https://doi.org/10.1182/blood.V128.22.2015.2015
Published: 2016