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Journal Articles

CXCR4 Loss Reduces the Local Growth of Richter Syndrome Murine and Patient-Derived Xenograft Models and Impairs BCR and VLA-4 Activation

Claudio Martines, Supriya Chakraborty, Antonella Zucchetto, Erika Tissino, Vincenzo Guastafierro, Marija Vujovikj, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J Dimovski, Valter Gattei, Dimitar G Efremov

Blood (2023) 142 (Supplement 1): 80.

https://doi.org/10.1182/blood-2023-179183

Published: 2023

Journal Articles

The Characterization of Metabolic Profile and Substrates Dependencies of Richter's Syndrome Cells Open for Translational Opportunities

Matilde Micillo, Lorenzo Brandimarte, Giulia Omezzolli, Nadia Bertola, Francesco Edoardo Vallone, Andrea Iannello, Chiara Lavarello, Nicole Grinovero, Giulio Ferrero, Kevin Mellert, Peter Moller, Nicoletta Vitale, Silvia Bruno, Richard R. Furman, John N. Allan, Andrea Petretto, Silvia Deaglio, Silvia Ravera, Tiziana Vaisitti

Blood (2023) 142 (Supplement 1): 6115.

https://doi.org/10.1182/blood-2023-179164

Published: 2023

Journal Articles

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Claudio Martines, Supriya Chakraborty, Marija Vujovikj, Stefania Gobessi, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J. Dimovski, Dimitar G. Efremov

Blood (2022) 140 (22): 2335–2347.

https://doi.org/10.1182/blood.2022016272

Published: 2022

Includes: Supplemental data

Journal Articles

Decreased Apoptotic Priming and Loss of Bcl-2 Dependence Are Functional Hallmarks of Richter's Syndrome

Antonella Rigo, Tiziana Vaisitti, Carlo Laudanna, Matilde Micillo, Flavia Merigo, Alessio Montresor, Andrea Sbarbati, Kevin Mellert, Peter Moeller, Fabrizio Vinante, Silvia Deaglio, Isacco Ferrarini

Blood (2022) 140 (Supplement 1): 1809–1810.

https://doi.org/10.1182/blood-2022-160380

Published: 2022

Journal Articles

Anti-CD37 α-amanitin–conjugated antibodies as potential therapeutic weapons for Richter syndrome

Tiziana Vaisitti, Nicoletta Vitale, Matilde Micillo, Lorenzo Brandimarte, Andrea Iannello, Mauro Giulio Papotti, Ozren Jaksic, Gianluca Lopez, Arianna Di Napoli, Juan Carlos Cutrin, Christian Orlik, Michael Kulke, Andreas Pahl, Silvia Deaglio

Blood (2022) 140 (13): 1565–1569.

https://doi.org/10.1182/blood.2022016211

Published: 2022

Includes: Supplemental data

Journal Articles

A new taxonomy for splenic marginal zone lymphoma

Silvia Deaglio, Tiziana Vaisitti

Blood (2022) 139 (5): 644–645.

https://doi.org/10.1182/blood.2021014198

Published: 2022

Journal Articles

The Tigit/CD226/CD155 Immunomodulatory Axis Is Deregulated in CLL and Contributes to B-Cell Anergy

Francesca Arruga, Andrea Iannello, Nikolaos Ioannou, Alberto Maria Todesco, Marta Coscia, Riccardo Moia, Gianluca Gaidano, John N. Allan, Richard Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

Blood (2021) 138 (Supplement 1): 3718.

https://doi.org/10.1182/blood-2021-150183

Published: 2021

Journal Articles

Evidence of a Synergistic Cross-Talk between the B Cell Receptor (BCR) and Nicotinamide Phosphoribosyl Transferase (NAMPT) in Richter's Syndrome Patient-Derived Xenograft Models: Therapeutic Implications

Vincenzo Gianluca Messana, Nicoletta Vitale, Matteo Rovere, Lucia Renzullo, Francesca Arruga, Tiziana Vaisitti, Silvia Deaglio

Blood (2021) 138 (Supplement 1): 250.

https://doi.org/10.1182/blood-2021-150238

Published: 2021

Journal Articles

Anti-CD37 Alpha-Amanitin Conjugated Antibodies As Therapeutic Weapons for Richter's Syndrome

Tiziana Vaisitti, Nicoletta Vitale, Andrea Iannello, Lorenzo Brandimarte, Matilde Micillo, Mauro Giulio Papotti, Arianna Di Napoli, Christian Orlik, Michael Kulke, Andreas Pahl, Silvia Deaglio

Blood (2021) 138 (Supplement 1): 791.

https://doi.org/10.1182/blood-2021-150280

Published: 2021

Journal Articles

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Supriya Chakraborty, Claudio Martines, Fabiola Porro, Ilaria Fortunati, Alice Bonato, Marija Dimishkovska, Silvano Piazza, Brijesh S. Yadav, Idanna Innocenti, Rosa Fazio, Tiziana Vaisitti, Silvia Deaglio, Alberto Zamò, Aleksandar J. Dimovski, Luca Laurenti, Dimitar G. Efremov

Blood (2021) 138 (12): 1053–1066.

https://doi.org/10.1182/blood.2020008276

Published: 2021

Includes: Supplemental data

Journal Articles

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

Andrea Iannello, Nicoletta Vitale, Silvia Coma, Francesca Arruga, Amy Chadburn, Arianna Di Napoli, Carlo Laudanna, John N. Allan, Richard R. Furman, Jonathan A. Pachter, Silvia Deaglio, Tiziana Vaisitti

Blood (2021) 137 (24): 3378–3389.

https://doi.org/10.1182/blood.2020010187

Published: 2021

Includes: Supplemental data

Journal Articles

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models

Tiziana Vaisitti, Francesca Arruga, Nicoletta Vitale, Thanh-Trang Lee, Mira Ko, Amy Chadburn, Esteban Braggio, Arianna Di Napoli, Andrea Iannello, John N. Allan, Langdon L. Miller, Brian J. Lannutti, Richard R. Furman, Katti A. Jessen, Silvia Deaglio

Blood (2021) 137 (24): 3365–3377.

https://doi.org/10.1182/blood.2020008404

Published: 2021

Includes: Supplemental data

Journal Articles

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

Tiziana Vaisitti, PhD, Katti Jessen, PhD, Thanh-Trang Vo, PhD, Mira Ko, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Esteban Braggio, PhD, Arianna Di Napoli, Amy Chadburn, MD, John N. Allan, MD, Richard R. Furman, MD, Langdon L. Miller, Brian J Lanutti, PhD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 2856.

https://doi.org/10.1182/blood-2019-126827

Published: 2019

Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD

Blood (2019) 134 (Supplement_1): 2862.

https://doi.org/10.1182/blood-2019-125754

Published: 2019

Journal Articles

CD79b Expression in Richter's Transformation

John N. Allan, MD, Erica B Bhavsar, BS, Tiziana Vaisitti, PhD, Vincent Sarno, Yifang Liu, Francesca Arruga, PhD, Maureen Joyce, Mathias Schulz, MD MBA, Silvia Deaglio, MD PhD, Richard R. Furman, MD, Amy Chadburn, MD

Blood (2019) 134 (Supplement_1): 4279.

https://doi.org/10.1182/blood-2019-128305

Published: 2019

Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD

Blood (2018) 132 (Supplement 1): 240.

https://doi.org/10.1182/blood-2018-99-118057

Published: 2018

Journal Articles

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Tiziana Vaisitti, PhD, John N. Allan, MD, Esteban Braggio, PhD, Francesca Arruga, PhD, Amy Chadburn, MD, Richard R. Furman, MD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 4297.

https://doi.org/10.1182/blood.V130.Suppl_1.4297.4297

Published: 2017

Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 1721.

https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721

Published: 2017

Journal Articles

Targeting Cellular Metabolism and Survival in Chronic Lymphocytic Leukemia and Richter Syndrome Cells By a Novel NF-Kb Inhibitor

Tiziana Vaisitti, PhD, Federica Gaudino, Samedy Ouk, Sara Serra, PhD, Johannes L. Zakrzewski, MD, Erica B. Bhavsar, John N. Allan, MD, Hsiou-Chi Liou, PhD, Richard R. Furman, Silvia Deaglio, MD PhD

Blood (2016) 128 (22): 304.

https://doi.org/10.1182/blood.V128.22.304.304

Published: 2016

Journal Articles

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Blood (2016) 128 (22): 969.

https://doi.org/10.1182/blood.V128.22.969.969

Published: 2016

NARROW

CXCR4 Loss Reduces the Local Growth of Richter Syndrome Murine and Patient-Derived Xenograft Models and Impairs BCR and VLA-4 Activation

The Characterization of Metabolic Profile and Substrates Dependencies of Richter's Syndrome Cells Open for Translational Opportunities

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Decreased Apoptotic Priming and Loss of Bcl-2 Dependence Are Functional Hallmarks of Richter's Syndrome

Anti-CD37 α-amanitin–conjugated antibodies as potential therapeutic weapons for Richter syndrome

A new taxonomy for splenic marginal zone lymphoma

The Tigit/CD226/CD155 Immunomodulatory Axis Is Deregulated in CLL and Contributes to B-Cell Anergy

Evidence of a Synergistic Cross-Talk between the B Cell Receptor (BCR) and Nicotinamide Phosphoribosyl Transferase (NAMPT) in Richter's Syndrome Patient-Derived Xenograft Models: Therapeutic Implications

Anti-CD37 Alpha-Amanitin Conjugated Antibodies As Therapeutic Weapons for Richter's Syndrome

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

CD79b Expression in Richter's Transformation

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Targeting Cellular Metabolism and Survival in Chronic Lymphocytic Leukemia and Richter Syndrome Cells By a Novel NF-Kb Inhibitor

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

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American Society of Hematology

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American Society of Hematology

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