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Journal Articles

An Unsupervised Machine Learning Method Stratifies Chronic Lymphocytic Leukemia Patients into Novel Categories with Different Risk of Early Treatment

Federico Pozzo, Francesca Cuturello, Edith Villegas Garcia, Francesca Rossi, Massimo Degan, Paola Nanni, Ilaria Cattarossi, Eva Zaina, Paola Varaschin, Alessandra Braida, Michele Berton, Laura Zannier, Filippo Vit, Erika Tissino, Tamara Bittolo, Roberta Laureana, Giovanni Francesco D'Arena, Luca Laurenti, Agostino Tafuri, Jacopo Olivieri, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Maria Ilaria Del Principe, Riccardo Bomben, Antonella Zucchetto, Alessio Ansuini, Chris Fegan, Chris Pepper, Andrea Pepper, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Alberto Cazzaniga, Valter Gattei
Journal: Blood
Blood (2023) 142 (Supplement 1): 1892.
https://doi.org/10.1182/blood-2023-177884
Published: 2023
Journal Articles

Telomere Length and DNA Methylation Epitype Both Provide Independent Prognostic Information in CLL Patients; Data from the UK CLL4, Arctic and Admire Clinical Trials

Louise J. Carr, Kevin Norris, Helen Parker, Anna Nilsson-Takeuchi, Dean J. Bryant, Harindra Eranthi Amarasinghe, Latha Kadalayil, Monica Else, Tomasz Wojdacz, Andrew Pettitt, Peter Hillmen, Anna Schuh, Renata Walewska, Duncan M. Baird, David Graham Oscier, Christopher C. Oakes, Jane Gibson, Chris Pepper, Jonathan C. Strefford
Journal: Blood
Blood (2023) 142 (Supplement 1): 6514.
https://doi.org/10.1182/blood-2023-177575
Published: 2023
Journal Articles

TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target

Emma Kennedy, Eve Coulter, Emma Halliwell, Nuria Profitos-Peleja, Elisabeth Walsby, Barnaby Clark, Elizabeth H. Phillips, Thomas A. Burley, Simon Mitchell, Stephen Devereux, Christopher D. Fegan, Christopher I. Jones, Rosalynd Johnston, Tim Chevassut, Ralph Schulz, Martina Seiffert, Angelo Agathanggelou, Ceri Oldreive, Nicholas Davies, Tatjana Stankovic, Triantafillos Liloglou, Chris Pepper, Andrea G. S. Pepper
Journal: Blood
Blood (2021) 137 (22): 3064–3078.
https://doi.org/10.1182/blood.2020005964
Published: 2021
Includes: Supplemental data
Journal Articles

Telomere Length and CD49d Cooperate with IGHV Gene Status As Predictors of Long-Term Progression-Free Survival in CLL Patients Treated with FCR-Based Regimens

Andrea GS Pepper, PhD, Antonella Zucchetto, PhD, Kevin Norris, PhD, Erika Tissino, PhD, Jerry Polesel, Zarni Soe, David Allsup, Anna Hockaday, Pei Loo Ow, Peter Hillmen, MBChB, PhD, Andrew Rawstron, PhD, Daniel Catovsky, MD FRCP, Riccardo Bomben, PhD, Duncan M Baird, PhD, Christopher Fegan, Valter Gattei, MD, Chris Pepper, BSc, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–47.
https://doi.org/10.1182/blood-2020-141279
Published: 2020
Journal Articles

CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression

Erika Tissino, Federico Pozzo, Dania Benedetti, Chiara Caldana, Tamara Bittolo, Francesca Maria Rossi, Riccardo Bomben, Paola Nanni, Hillarj Chivilò, Ilaria Cattarossi, Eva Zaina, Kevin Norris, Jerry Polesel, Massimo Gentile, Giovanni Tripepi, Riccardo Moia, Enrico Santinelli, Idanna Innocenti, Jacopo Olivieri, Giovanni D’Arena, Luca Laurenti, Francesco Zaja, Gabriele Pozzato, Annalisa Chiarenza, Francesco Di Raimondo, Davide Rossi, Chris Pepper, Tanja Nicole Hartmann, Gianluca Gaidano, Giovanni Del Poeta, Valter Gattei, Antonella Zucchetto
Journal: Blood
Blood (2020) 135 (15): 1244–1254.
https://doi.org/10.1182/blood.2019003179
Published: 2020
Includes: Supplemental data
Journal Articles

Multicentre Genome Wide Association Study Identifies Risk Alleles for Progressive Chronic Lymphocytic Leukaemia

David Allsup, BSc, MBBS, FRCP, FRCPath, PhD, Wei Yu Lin, PhD, Sarah Elizabeth Fordham, PhD BSc, Nicola Sunter, Claire Elstob, PhD, Thahira Rahman, PhD, Elaine Willmore, Colin Shepherd, Gordon Strathdee, BSc, PhD, Timothy Barrow, PhD, Tryfonia Mainou-Fowler, Rachel Piddock, Helen Marr, PhD, Jonathan Wallis, Scott R. Marshall, BSc,MDPhD, Geoffery Summerfield, Andrew Pettitt, FRCPath, PhD, Chris Pepper, BSc, PhD, Christopher Fegan, MB, MD FRCP, FRCPath, Francesco Forconi, MD DM, PhD FRCPath, Martin J.S. Dyer, Sandrine Jayne, PhD, April Sellors, Anna Schuh, PhD, Pauline Robbe, MSc, PhD, David Oscier, Richard S. Houlston, James Bailey, PhDFRCPath,MRCP,MD, Syed Ashar Rais, Alison Bentley, Lynn Cawkwell, Peter Hillmen, MD PhD, Guy Pratt, James M. Allan
Journal: Blood
Blood (2019) 134 (Supplement_1): 1740.
https://doi.org/10.1182/blood-2019-122037
Published: 2019
Journal Articles

Development and Characterisation of an in Vitro Model of Multiple Myeloma

Thomas Lewis, BSc, Elisabeth Jane Walsby, PhD, Stephen Man, Christopher Fegan, Chris Pepper, BSc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4505.
https://doi.org/10.1182/blood-2018-99-111842
Published: 2018
Journal Articles

A Laboratory Based Scoring System Predicts Early Treatment in Rai 0/Binet a CLL

Jared A Cohen, MD, Francesca Maria Rossi, PhD, Riccardo Bomben, PhD, Lodovico Terzi-di-Bergamo, Pietro Bulian, MD, Massimo Degan, PhD, Antonella Zucchetto, Giovanni Francesco D'Arena, MD, Enrico Santinelli, MD, Francesco Zaja, MD, Gabriele Pozzato, MD, Davide Rossi, MD PhD, Annalisa Chiarenza, MD PhD, Francesco Di Raimondo, MD, Luca Laurenti, MD, Idanna Innocenti, MD, Giovanni Del Poeta, MD, Christopher Fegan, MD, Chris Pepper, BSc, PhD, Kari G. Chaffee, MS, Sameer A. Parikh, MD, Neil E. Kay, MD, Valter Gattei, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4399.
https://doi.org/10.1182/blood-2018-99-112162
Published: 2018
Journal Articles

Telomere Length Predicts for Outcome to FCR Chemoimmunotherapy in CLL

Kevin Norris, PhD, Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Andy Rawstron, BSc, PhD, Robert K. Hills, MA, DPhil, MSc, Duncan M Baird, PhD, Chris Pepper, BSc, PhD, Christopher Fegan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1854.
https://doi.org/10.1182/blood-2018-99-114448
Published: 2018
Journal Articles

Telomere Length Is Associated with Epigenetic Programming in CLL and Is a Superior Predictor of Clinical Outcome with the Ability to Bifurcate Patients with the Same CLL-IPI Score

Kevin Norris, PhD, Christopher C. Oakes, Brian Giacopelli, BS, Tait D. Shanafelt, MD, Neil E. Kay, MD, Kari G. Chaffee, MS, Christopher Fegan, MD, Duncan M Baird, PhD, Chris Pepper, BSc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1833.
https://doi.org/10.1182/blood-2018-99-114488
Published: 2018
Journal Articles

Genetic Analysis of Distinct Phenotypic Subsets within MM1.S Multiple Myeloma Cell Line Reveals the Pre-Existence of MM.1R-like Glucocorticoid Resistance and a Sub-Clone with an Activating PI3-Kinase Delta Mutation That Is Preferentially Sensitive to the Selective PI3-Kinase Inhibitor, Idelalisib

James W Murray, MBBCh, Christopher Fegan, Chris Pepper, PhD
Journal: Blood
Blood (2016) 128 (22): 4449.
https://doi.org/10.1182/blood.V128.22.4449.4449
Published: 2016
Journal Articles

In Vitro Co-Culture of CLL-B Cells Reveals Long-Term Survival, Proliferation, and Maintenance of Telomere Length

Ceri H Jones, MBBCh, Thet Thet Lin, PhD, Elisabeth Jane Walsby, PhD, Guy E Pratt, MDFRCP FRCPath, Christopher Fegan, Duncan M Baird, PhD, Chris Pepper, PhD
Journal: Blood
Blood (2016) 128 (22): 350.
https://doi.org/10.1182/blood.V128.22.350.350
Published: 2016
Journal Articles

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration

Marta Pasikowska, Elisabeth Walsby, Benedetta Apollonio, Kirsty Cuthill, Elizabeth Phillips, Eve Coulter, Maria Serena Longhi, Yun Ma, Deborah Yallop, Linda D. Barber, Piers Patten, Chris Fegan, Alan G. Ramsay, Chris Pepper, Stephen Devereux, Andrea G. S. Buggins
Journal: Blood
Blood (2016) 128 (4): 563–573.
https://doi.org/10.1182/blood-2016-01-683128
Published: 2016
Includes: Supplemental data
Journal Articles

CLL Is Associated with Development of Subclinical Cytomegalovirus Viraemia and Accumulation of Large Populations of “exhausted” CMV-Specific CD4+ T Cells

Helen M Parry, Natasha Cutmore, Nikhil Mirajkar, Annette Pachnio, Tina McSkeane, Miriam Ciaurriz, Duncan Baird, Chris Pepper, Mike Griffiths, Guy Pratt, Paul Moss, MDPhD
Journal: Blood
Blood (2014) 124 (21): 3290.
https://doi.org/10.1182/blood.V124.21.3290.3290
Published: 2014
Journal Articles

CXCL12 Enhances CLL Cell and T-Cell Migration in a Dynamic Circulating Model of CLL That Can be Abrogated By the CXCR4 Antagonist ONO-7161

Elisabeth J Walsby, Paul Brennan, Guy Pratt, Tanja Nicole Hartmann, PhD, Toshio Yoshizawa, Christopher Fegan, Chris Pepper
Journal: Blood
Blood (2014) 124 (21): 3293.
https://doi.org/10.1182/blood.V124.21.3293.3293
Published: 2014
Journal Articles

Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia

Elisabeth Walsby, Andrea Buggins, Stephen Devereux, Ceri Jones, Guy Pratt, Paul Brennan, Chris Fegan, Chris Pepper
Journal: Blood
Blood (2014) 123 (23): 3607–3617.
https://doi.org/10.1182/blood-2013-12-544569
Published: 2014
Includes: Supplemental data
Journal Articles

Longitudinal Analysis Reveals Telomere Length Maintenance In CLL B-Cells But Marked Erosion In CLL Patient T-Cells

Ceri Jones, Thet Lin, Guy Pratt, Chris Fegan, Duncan Baird, Chris Pepper
Journal: Blood
Blood (2013) 122 (21): 1617.
https://doi.org/10.1182/blood.V122.21.1617.1617
Published: 2013
Journal Articles

Characterization Of a Novel In Vitro Circulation System Designed To Model The Migration Of Primary CLL Cells Across The Vascular Endothelium

Elisabeth J Walsby, Andrea GS Buggins, Ph.D., Stephen Devereux, FRCP, FRCPath, PhD, Paul Brennan, Chris Fegan, Chris Pepper
Journal: Blood
Blood (2013) 122 (21): 667.
https://doi.org/10.1182/blood.V122.21.667.667
Published: 2013
Journal Articles

CD49d Is The Strongest Flow Cytometry-Based Predictor Of Overall Survival In Chronic Lymphocytic Leukemia

Pietro Bulian, MD, Tait D Shanafelt, MD, Chris Fegan, MBBS, Antonella Zucchetto, Lilla Cro, PhD, Holger Nuckel, MD, Luca Baldini, Antonina Kurtova, MS, Alessandra Ferrajoli, MD, Jan A. Burger, MD, PhD, Gianluca Gaidano, Giovanni Del Poeta, MD, Chris Pepper, Ph.D., Davide Rossi, Valter Gattei
Journal: Blood
Blood (2013) 122 (21): 672.
https://doi.org/10.1182/blood.V122.21.672.672
Published: 2013
Journal Articles

Lymph Node Derived CLL Cells Have a More Activated Phenotype and Better Antigen Presentation Capabilities Compared To Those From The Peripheral Blood

Andrea GS Buggins, Ph.D., Marta Pasikowska, Ph.D., Elisabeth J Walsby, Ph.D., Kirsty M Cuthill, MBBS, MRCP, FRCPath, Maria Longhi, Ph.D., Emma Hamilton, MBiochem, Linda Barber, Ph.D., Chris Fegan, MBBS, Chris Pepper, Ph.D., Stephen Devereux, FRCP, FRCPath, PhD
Journal: Blood
Blood (2013) 122 (21): 4119.
https://doi.org/10.1182/blood.V122.21.4119.4119
Published: 2013