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Journal Articles

Longitudinal Single Cell Analyses Reveal the Co-Evolutionary Dynamics of the Tumor and Microenvironment Accompanying Follicular Lymphoma Transformation

Megan Perrett, Lucy Pickard, Emil Kumar, Giuseppe Palladino, Faraz Khan, Carina Edmondson, Connor Knight, Edward Poynton, Janet Matthews, Shamzah Araf, Andrew James Clear, Maria Calaminici, John G. Gribben, Hamish King, Mirjana Efremova, Jun Wang, Jessica Okosun
Journal: Blood
Blood (2022) 140 (Supplement 1): 748–749.
https://doi.org/10.1182/blood-2022-159995
Published: 2022
Journal Articles

The MYC/MIZ1 Complexes Are Required for Germinal Center B Cell Lymphomagenesis

Arief Suryono Gunawan, Amparo Toboso-Navasa, Probir Chakravarty, Andrew James Clear, Maria Calaminici, Dinis Pedro Calado
Journal: Blood
Blood (2021) 138 (Supplement 1): 1141.
https://doi.org/10.1182/blood-2021-150489
Published: 2021
Journal Articles

Phosphoglycerate Dehydrogenase Is Required for Germinal Center Formation and Is a Therapeutic Target in MYC- driven Lymphoma

Annalisa D'Avola, Nathalie Legrave, Mylene Tajan, Probir Chakravarty, Ryan Shearer, Hamish King, Eric Cheung, Andrew James Clear, Arief Suryono Gunawan, Lingling Zhang, Louisa James, James MacRae, John Gribben, Dinis Pedro Calado, Karen Vousden, John C. Riches
Journal: Blood
Blood (2021) 138 (Supplement 1): 717.
https://doi.org/10.1182/blood-2021-150442
Published: 2021
Journal Articles

Immune System Deregulation Predicts Outcome in Diffuse Large B Cell Lymphoma (DLBCL)

Edward Truelove, MBBS, BSc, MRCP, FRCPath, Joseph G Taylor, MBBS, BSc, Andrew James Clear, BSc, Mariarita Calaminici, Professor John G. Gribben, MD DSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-143104
Published: 2020
Journal Articles

Beyond Exhaustion: The PDL1-PD1 Axis Shapes the Classical Hodgkin Lymphoma Microenvironment

Joseph G Taylor, MBBS, BSc, Andrew James Clear, BSc, Edward Truelove, MBBS, BSc, MRCP, FRCPath, Mariarita Calaminici, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 658.
https://doi.org/10.1182/blood-2019-125247
Published: 2019
Journal Articles

The Immune Micro-Environment in Diffuse Large B Cell Lymphoma Is Characterised By an Immunosuppressive Shift in T Cell Subsets

Edward Truelove, MBBS, BSc, MRCP, FRCPath, Frances Seymour, MRCP, BSc, MBBS, Joseph G Taylor, MBBS, BSc, Mariarita Calaminici, Andrew James Clear, BSc, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 5240.
https://doi.org/10.1182/blood-2019-130712
Published: 2019
Journal Articles

Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel

Findlay Bewicke-Copley, PhD MSc, BSc, Koorosh Korfi, PhD BSc, Shamzah Araf, MRCP, MBBS, PhD, Emil Arjun Kumar, BCh,BM, Thomas E C Cummin, MRCP MBBCh BSc, Margaret Ashton-Key, MD, Sharon Barrans, Suzan Van Hoppe, Cathy Burton, Mohamed Elshiekh, Simon Rule, Nicola Crosbie, Andrew James Clear, BSc, Maria Calaminici, MD PhD, David W. Scott, MBChB, PhD, Lisa M. Rimsza, MD, Menon Geetha, Chulin Sha, Michael A Bentley, Ai Nagano, PhD, Andrew Davies, MD PhD, Daniel Painter, BSc, Alexandra Smith, PhD, John G. Gribben, MD DSc, Kikkeri Naresh, David R Westhead, Jessica Okosun, MD PhD, Peter Johnson, MDFRCP, Jun Wang, PhD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2769.
https://doi.org/10.1182/blood-2019-124352
Published: 2019
Journal Articles

B-Cell Receptor Signaling Drives Glycolysis in Chronic Lymphocytic Leukemia Cells

Andrew James Clear, BSc, Annalisa D'Avola, PhD, Samir G. Agrawal, BSc, PhD MBChB, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, John G. Gribben, John Riches, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3121.
https://doi.org/10.1182/blood-2018-99-112860
Published: 2018
Journal Articles

The Treg/Th17 Axis Is Skewed in Classical Hodgkin Lymphoma By PDL1+Ve but Not PDL1-Ve Lymphoma Cells and By Lymphoma MHC Class 2 Expression.

Joseph G Taylor, MBBS, BSc, Andrew James Clear, BSc, Janet Matthews, Mariarita Calaminici, John G. Gribben
Journal: Blood
Blood (2018) 132 (Supplement 1): 4124.
https://doi.org/10.1182/blood-2018-99-119126
Published: 2018
Journal Articles

Human Gastro-Intestinal Graft-Versus-Host Disease Is Mediated By Retinoic Acid-Responsive CD8 + Effector T-Cells Under IL-23 Polarising Conditions

Jennifer A Ball, PhD, Andrew James Clear, BSc, Maria Calaminici, MD PhD, Andrew Stagg, BSc (Hons), PhD, James Lindsay, FRCP PhDBM BCh, John G. Gribben, MDDSc FMedSci, Jeff Davies, MBBS, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 77.
https://doi.org/10.1182/blood.V130.Suppl_1.77.77
Published: 2017
Journal Articles

Integrative Analysis of 1001 Diffuse Large B Cell Lymphoma Identifies Novel Oncogenic Roles for Rhoa

Jenny Zhang, BSc, Anupama Reddy, PhD, Nicholas Davis, BSc, Andrea Moffitt, PhD, Cassandra Love, Alexander Waldrop, PhD, Sirpa Leppa, MD, Annika Pasanen, MD, Leo Meriranta, MS, Marja-Liisa Karjalainen-Lindsberg, Peter H. Norgaard, MDPhD, Mette Ø Pedersen, MD, Anne Ortved Gang, Estrid Hogdall, PhD, Tayla Heavican, Waseem Lone, PhD, Javeed Iqbal, MSc, PhD, Guojie Li, PhD, So Young Kim, PhD, Jane Healy, MD PhD, Kristy L. Richards, MD PhD, Yuri Fedoriw, MD, Leon Bernal-Mizrachi, MD, Jean L. Koff, MD, Ashley D. Staton, MD, Christopher Flowers, MD, Ora Paltiel-Clarfield, Neta Goldschmidt, MD, Maria Calaminici, MD PhD, Andrew James Clear, BSc, John G. Gribben, MDDSc FMedSci, Evelyn Nguyen, Magdalena Czader, MD PhD, Sarah L. Ondrejka, MD, Angela Collie, MD PhD, Eric D. Hsi, MD, Eric Tse, MBBS, PhD FRCP, FRCPath, Rex Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, William Choi, MBBS,MRCP, Andrew M Evens, DO,MSc, Monika Pilichowska, MD PhD, Manju Sengar, MD DM, Nishitha Reddy, MD MSCI, MBBS, Shaoying Li, MD, Amy Chadburn, MD, Leo I. Gordon, MD, Elaine S. Jaffe, MD, Rachel Rempel, Tiffany Tzeng, Tushar Dave, Lanie Happ, Deepthi Rajagopalan, Jyotishka Datta, David Dunson, Sandeep Dave, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 37.
https://doi.org/10.1182/blood.V130.Suppl_1.37.37
Published: 2017
Journal Articles

Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma

Shamzah Araf, MRCP, MBBS, Jun Wang, PhD, Koorosh Korfi, PhD BSc, Celine Pangault, PhD, Eleni Kotsiou, PhD, Ana Rio-Machin, PhD, Tahrima Rahim, BSc, James Andrew Heward, PhD BSc, Andrew James Clear, BSc, Sameena Iqbal, Jeff Davies, MBBS, PhD, Peter Johnson, MD FRCP, Maria Calaminici, MD PhD, Silvia Montoto, Rebecca Auer, MD PhD, Claude Chelala, PhD, John G. Gribben, MDDSc FMedSci, Trevor Graham, PhD, Thierry Fest, MD PhD, Jude Fitzgibbon, PhD, Jessica Okosun, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2730.
https://doi.org/10.1182/blood.V130.Suppl_1.2730.2730
Published: 2017
Journal Articles

Longitudinal Analyses of the Genomic, Transcriptomic, and T Cell Repertoire in Diffuse Large B Cell Lymphoma Demonstrates Changes in Signaling and Immune Recognition at Relapse

Shamzah Araf, MRCP, MBBS, Koorosh Korfi, PhD BSc, Ai Nagano, PhD, Thomas E C Cummin, MRCP MBBCh BSc, Michael Bentley, PhD, Aaron R. Thorner, PhD, Margaret Ashton-Key, MD, Maria Calaminici, MD PhD, Andrew James Clear, BSc, Andrew Davies, PhD, Sharon Barrans, Suzan Van Hoppe, Cathy Burton, Simon Rule, MD, Nicola Crosbie, Daniel Painter, BSc, Alexandra Smith, PhD, David M. Weinstock, MD, David R Westhead, Jessica Okosun, MD PhD, John G. Gribben, MDDSc FMedSci, Peter Johnson, MD FRCP, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2734.
https://doi.org/10.1182/blood.V130.Suppl_1.2734.2734
Published: 2017
Journal Articles

Integrative Genetic and Clinical Analysis through Whole Exome Sequencing in 1001 Diffuse Large B Cell Lymphoma (DLBCL) Patients Reveals Novel Disease Drivers and Risk Groups

Jenny Zhang, Anupama Reddy, Cassandra Love, Andrea B. Moffitt, Deepthi Rajagopalan, Sirpa Leppä, Annika Pasanen, MD PhD, Leo Meriranta, MS, Marja-Liisa Karjalainen-Lindsberg, Peter H Norgaard, MD PhD, Mette Pederson, Anne Ortved Gang, Estrid Hogdall, Kristy L. Richards, PhD MD, Yuri D. Fedoriw, MD, Leon Bernal-Mizrachi, MD, Jean L. Koff, MD, Ashley D. Staton, MD, Christopher Flowers, MDMS, Ora Paltiel-Clarfield, Neta Goldschmidt, MD, Maria Calaminici, Andrew James Clear, John Gribben, Evelyn Nguyen, Magdalena Czader, MD PhD, Sarah Lynn Ondrejka, DO, Angela Collie, MD PhD, Eric D Hsi, MD, Rex au-Yeung, Kwong Yok-Lam, Wai Lap Choi, MD, Gopesh Srivastava, Andrew M Evens, DO, MSc, FACP, Monika Pilichowska, MD PhD, Manju Sengar, Nishitha Reddy, MD MSCI, MBBS, Shaoying Li, MD, Elaine S. Jaffe, MD, Tiffany Tzeng, Jyotishka Datta, David Dunson, Sandeep Dave, MD
Journal: Blood
Blood (2016) 128 (22): 1087.
https://doi.org/10.1182/blood.V128.22.1087.1087
Published: 2016
Journal Articles

Overexpression of HMGB1 Receptor RAGE Is Associated with Worse Clinical Outcome in Patients with Chronic Lymphocytic Leukemia

Faith Norster, MBiochem, Andrew James Clear, BSc, Janet Matthews, Elena Hoxha, MSc, John Gribben, MDDSc, Li Jia, PhD MD
Journal: Blood
Blood (2015) 126 (23): 617.
https://doi.org/10.1182/blood.V126.23.617.617
Published: 2015
Journal Articles

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Fabienne McClanahan, Bola Hanna, Shaun Miller, Andrew James Clear, Peter Lichter, John G. Gribben, Martina Seiffert
Journal: Blood
Blood (2015) 126 (2): 203–211.
https://doi.org/10.1182/blood-2015-01-622936
Published: 2015
Includes: Supplemental data
Journal Articles

Immune Checkpoint Blockade with Anti-PD-L1 Prevents Immune Dysfuntion and CLL Development in the TCL1 Adoptive Transfer Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Shaun Miller, Peter Lichter, PhD, Martina Seiffert, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2014) 124 (21): 717.
https://doi.org/10.1182/blood.V124.21.717.717
Published: 2014
Journal Articles

The Flavonoid Wogonin Reduces CLL Cell Survival in Vitro and Leukemia Development in Eµ-TCL1 Mice By Targeting Aberrant TNF Receptor Signaling

Claudia Dürr, Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, John G. Gribben, MD DSc, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2014) 124 (21): 1966.
https://doi.org/10.1182/blood.V124.21.1966.1966
Published: 2014
Journal Articles

Overexpression of BCL-2 Does Not Inhibit Autophagy in Human Follicular and Diffuse Large B-Cell Lymphomas

Aine McCarthy, PhD, Andrew James Clear, BSc, Jacek Marzec, Rita Coutinho, MD, Robert D. Petty, PhD, Janet Matthews, Andrew Wilson, Sameena Iqbal, Maria Calaminici, MD PhD, John G. Gribben, MD DSc, Li Jia, PhD MD
Journal: Blood
Blood (2014) 124 (21): 3007.
https://doi.org/10.1182/blood.V124.21.3007.3007
Published: 2014
Journal Articles

TNFRSF14 aberrations in Follicular Lymphoma B Cells Result in Increased Alloresponses in Vitro and in Vivo

Eleni Kotsiou, PhD, Jessica Okosun, MD, Andrew James Clear, BSc, Sameena Iqbal, BSc, Jude Fitzgibbon, PhD, John G. Gribben, MD DSc, Jeff K. Davies, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2426.
https://doi.org/10.1182/blood.V124.21.2426.2426
Published: 2014