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Issue Archive

Volume 8, Issue 21
November 12 2024
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Cytopenias in BCMA CAR T: unraveling inflammatory mechanisms
Adam S. Sperling
View Articletitled, Cytopenias in BCMA CAR T: unraveling inflammatory mechanisms
Btk inhibition: the importance of being selective
Robert Flaumenhaft
View Articletitled, Btk inhibition: the importance of being selective
Where there is smoke, there is fire: afib in SCD
Jonathan Uniat,John C. Wood
View Articletitled, Where there is smoke, there is fire: afib in SCD
Deferiprone and idiosyncrasic neutropenia: light and shadow
Francesca Fioredda,Gian Luca Forni
View Articletitled, Deferiprone and idiosyncrasic neutropenia: light and shadow

CLINICAL TRIALS AND OBSERVATIONS

Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction
Clinical Trials & Observations
Marcel Benkhoff,Karin Alde,Vincent Ehreiser,Jana Dahlmanns,Daniel Metzen,Jean M. Haurand,Dragos Andrei Duse,Christian Jung,Malte Kelm,Tobias Petzold,Amin Polzin
View Articletitled, Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction
Supplemental data
Outcomes with single-agent gilteritinib for relapsed or refractory FLT3-mutant AML after contemporary induction therapy
Clinical Trials & Observations
Jad Othman,Angela Hwang,Maximillian Brodermann,Islam Abdallah,Kayleigh McCloskey,Paolo Gallipoli,Georgina Clarke,Raymond Dang,Jennifer Vidler,Pramila Krishnamurthy,Faisal Basheer,Anne-Louise Latif,Renuka Palanicawandar,Tom Taylor,Asra Khan,Victoria Campbell,Francesca Hogan,Alex Kanellopoulos,Kathryn Fleming,Angela Collins,Chris Dalley,Justin Loke,Scott Marshall,David Taussig,Sreetharan Munisamy,Eleana Loizou,Heba Yassin,Mike Dennis,Rui Zhao,Edward Belsham,Duncan Murray,Nicole Fowler,Jenny O'Nions,Anjum Khan,Rob Sellar,Richard Dillon
View Articletitled, Outcomes with single-agent gilteritinib for relapsed or refractory <em>FLT3</em>-mutant AML after contemporary induction therapy
Supplemental data
Asymptomatic multicentric Castleman disease: a potential early stage of idiopathic MCD
Clinical Trials & Observations
Lu Zhang,Qin-hua Liu,Hui Zhou,Hui-lai Zhang,Yu-jun Dong,Xiao-bo Wang,Lu-qun Wang,Li-ping Su,Xiao-jing Yan,Yan Li,Ming-zhi Zhang,Kai-yang Ding,Hui-han Wang,Hong-ling Peng,Li-ye Zhong,Lin Yang,Lin-tao Bi,Da Gao,Guang-xun Gao,Liang Huang,Chun-yan Sun,Jia Song,Wen-bin Qian,Wen-rong Huang,Zhen-ling Li,Yao Liu,Jian Li
View Articletitled, Asymptomatic multicentric Castleman disease: a potential early stage of idiopathic MCD
Supplemental data
Rates of severe neutropenia and infection risk in patients treated with deferiprone: 28 years of data
Clinical Trials & Observations
Sherif M. Badawy,Jan Palmblad,Fernando Tricta,Noemi Toiber Temin,Caroline Fradette,Leo Lin,Anna Rozova,Sujit Sheth
View Articletitled, Rates of severe neutropenia and infection risk in patients treated with deferiprone: 28 years of data
Ibrutinib plus rituximab and mini-CHOP in older patients with newly diagnosed DLBCL: a phase 2 ALLG study
Clinical Trials & Observations
Emma Verner,Amanda Johnston,Nalini Pati,Eliza A. Hawkes,Hui-Peng Lee,Tara Cochrane,Chan Yoon Cheah,Robin Filshie,Duncan Purtill,Hanlon Sia,Anoop K. Enjeti,Christina Brown,Nicholas Murphy,Jennifer Curnow,Kenneth Lee,Maher K. Gandhi,Mannu Walia,Belinda E. Butcher,Judith Trotman,on behalf of the Australasian Leukaemia & Lymphoma Group
View Articletitled, Ibrutinib plus rituximab and mini-CHOP in older patients with newly diagnosed DLBCL: a phase 2 ALLG study
Supplemental data
The impact of different doses of oral iron supplementation during pregnancy: a pilot randomized trial
Clinical Trials & Observations
Simon J. Stanworth,David Churchill,Samaher Sweity,Tom Holmes,Cara Hudson,Rosemary Brown,Stephanie J. Lax,Joanne Murray,Helen Spiby,Noemi Roy,Andrew Farmer,Chris Gale,Elise Crayton,Fabiana Lorencatto,James Griffiths,Joanne Mullings,Sara Last,Marian Knight,On behalf of the PANDA Collaborator Group
View Articletitled, The impact of different doses of oral iron supplementation during pregnancy: a pilot randomized trial
Supplemental data

HEALTH SERVICES AND OUTCOMES

Ancestry-independent risk of venous thromboembolism in individuals with sickle cell trait vs factor V Leiden
Keng-Han Lin,Julie M. Granka,Anjali J. Shastri,Vence L. Bonham,Rakhi P. Naik,the 23andMe Research Team
View Articletitled, Ancestry-independent risk of venous thromboembolism in individuals with sickle cell trait vs factor V Leiden
Supplemental data

HEMATOPOIESIS AND STEM CELLS

NFAT5 counters long-term IFN-1 responses in hematopoietic stem cells to preserve reconstitution potential
Laia Traveset,Víctor Cerdán Porqueras,Hector Huerga Encabo,Silvia Avalle,Anna Esteve-Codina,Oscar Fornas,Jose Aramburu,Cristina Lopez-Rodriguez
View Articletitled, NFAT5 counters long-term IFN-1 responses in hematopoietic stem cells to preserve reconstitution potential
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Molecular mechanisms promoting long-term cytopenia after BCMA CAR-T therapy in multiple myeloma
Maria Luisa Palacios-Berraquero,Paula Rodriguez-Marquez,Maria Erendira Calleja-Cervantes,Nerea Berastegui,Aintzane Zabaleta,Leire Burgos,Diego Alignani,Patxi San Martin-Uriz,Amaia Vilas-Zornoza,Saray Rodriguez-Diaz,Susana Inoges,Ascensión Lopez-Diaz de Cerio,Sofia Huerga,Esteban Tamariz,Jose Rifon,Ana Alfonso-Pierola,Juan Jose Lasarte,Bruno Paiva,Mikel Hernaez,Paula Rodriguez-Otero,Jesus San-Miguel,Teresa Ezponda,Juan Roberto Rodriguez-Madoz,Felipe Prosper
View Articletitled, Molecular mechanisms promoting long-term cytopenia after BCMA CAR-T therapy in multiple myeloma
Supplemental data

LYMPHOID NEOPLASIA

Evaluation of prognostic factors in patients with high-risk classical Hodgkin lymphoma undergoing autologous transplantation
Narendranath Epperla,Ying Huang,Amanda F. Cashen,John L. Vaughn,Walter Hanel,Talha Badar,Stefan K. Barta,Paolo F. Caimi,Tarsheen K. Sethi,Nishitha Reddy,Reem Karmali,Celeste Bello,Julio C. Chavez,Shalin K. Kothari,Francisco J. Hernandez-Ilizaliturri,Jakub Svoboda,Frederick Lansigan,Martha J. Glenn,Jonathon B. Cohen,Caryn Sorge,Beth Christian,Alex F. Herrera,Mehdi Hamadani,Luciano J. Costa,Ana C. Xavier
View Articletitled, Evaluation of prognostic factors in patients with high-risk classical Hodgkin lymphoma undergoing autologous transplantation
Supplemental data
Autologous stem cell transplantation in T-cell/histiocyte-rich large B-cell lymphoma: EBMT Lymphoma Working Party study
Clinical Trials & Observations
Simon Renders,Maud Ngoya,Herve Finel,Marie-Thérèse Rubio,William Townsend,Roland Schroers,Urban Novak,Nicolaas Schaap,Mahmoud Aljurf,Grzegorz Helbig,Matthew Collin,Guido Kobbe,Anne Huynh,José Antonio Pérez-Simón,Adrian Bloor,Hervé Ghesquieres,Anna Sureda,Norbert Schmitz,Bertram Glass,Peter Dreger
View Articletitled, Autologous stem cell transplantation in T-cell/histiocyte-rich large B-cell lymphoma: EBMT Lymphoma Working Party study
Supplemental data
Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer-associated fibroblasts
Richard J. Burt,Aditi Dey,Ayse Akarca,Hermione Allen,Rodothea Amerikanou,Samantha Atkinson,David Auty,Jenny Chatzigerou,Emily Cutler,Jose Afonso Guerra-Assuncao,Kristina Kirschner,Ruchi Kumari,Jiten Manji,Teresa Marafioti,Juma Ward,Adele K. Fielding
View Articletitled, Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer-associated fibroblasts
Supplemental data

PLATELETS AND THROMBOPOIESIS

Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia
Taylor Olmsted Kim,Jennifer M. Geris,Jonathan M. Flanagan,Rachael F. Grace,Michele P. Lambert,Candelaria O’Farrell,Melissa J. Rose,Kristin A. Shimano,Omar Niss,Cindy Neunert,Taizo A. Nakano,Derek MacMath,Bogdan Dinu,Susan E. Kirk,Ellis J. Neufeld,Jenny M. Despotovic,Michael E. Scheurer,Amanda B. Grimes
View Articletitled, Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia
Supplemental data
Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function
Simone A. Brysland,Dipti Talaulikar,Sarah M. Hicks,James I. Hearn,Sidra A. Ali,Muhammad Gohar Maqbool,Mridula Mokoonlall,Vijay Bhoopalan,Amandeep Kaur,Yee Lin Thong,Robert K. Andrews,James C. Whisstock,Philip J. Crispin,Elizabeth E. Gardiner
View Articletitled, Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function
Supplemental data
Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice
Christopher W. Smith,Joana Campos,Helena C. Brown,Natalie J. Jooss,Vanesa-Sindi Ivanova,Maan Harbi,Lourdes Garcia-Quintanilla,Sian Jossi,Marisol Perez-Toledo,Kieran Rookes,Alexander Brill,Lindsay N. Theodore,Tim Owens,Jacob LaStant,Matthew C. Foulke,Shin Mukai,Michelle Francesco,Michael Storek,Alexandra Hicks,Claire Langrish,Philip A. Nunn,Adam F. Cunningham,Abhi Chauhan,Mark R. Thomas,Steve P. Watson,Phillip L. R. Nicolson
View Articletitled, Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Impact of iron overload on incidence of diabetes mellitus, cardiac disease, and death in congenital hemolytic anemias
Aaron N. Cheng,Hanny Al-Samkari
View Articletitled, Impact of iron overload on incidence of diabetes mellitus, cardiac disease, and death in congenital hemolytic anemias
Atrial arrhythmia in adults with sickle cell anemia: a missing link toward understanding and preventing strokes
Thomas d’Humières,Zineb Sadraoui,Laurent Savale,Laurent Boyer,Henri Guillet,Lara Alassaad,Gonzalo de Luna,Sihem Iles,Paul Balfanz,Anoosha Habibi,Suella Martino,Ziana Amorouayeche,Thuy Linh Dang,Anne Laure Pham Hung d'Alexandry d'Orengiani,Dominique Rideau,Laura Train,Theo Simon,Christine Ibrahim,Laurent A. Messonnier,Etienne Audureau,Haytham Derbel,David Calvet,Nicolas Lellouche,Geneviève Derumeaux,Pablo Bartolucci
View Articletitled, Atrial arrhythmia in adults with sickle cell anemia: a missing link toward understanding and preventing strokes
Supplemental data
Activating pyruvate kinase improves red blood cell integrity by reducing band 3 tyrosine phosphorylation
Kang Le,Xunde Wang,Jonathan Chu,Maureen Lundt,Yuan Yee Lee,Anna Conrey,Ingrid Frey,Silvia Giannini,Penelope A. Kosinski,John M. Hausman,Philip S. Low,Neal Jeffries,Sanjay A. Desai,Swee Lay Thein
View Articletitled, Activating pyruvate kinase improves red blood cell integrity by reducing band 3 tyrosine phosphorylation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Thrombomodulin (p.Cys537Stop) is released from cells by an unusual membrane insertion/leakage mechanism
Clara Bernard,Andréa Pin,Nathalie Hézard,Vincent Ernest,Céline Falaise,Camille Roze,Stéphanie Simoncini,Romaric Lacroix,Pierre-Emmanuel Morange,Franck Peiretti
View Articletitled, Thrombomodulin (p.Cys537Stop) is released from cells by an unusual membrane insertion/leakage mechanism
Supplemental data
Plasmin generation analysis in patients with bleeding disorder of unknown cause
Clinical Trials & Observations
Dino Mehic,Stéphanie E. Reitsma,Claire de Moreuil,Helmuth Haslacher,Maximilian C. Koeller,Bas de Laat,Cihan Ay,Ingrid Pabinger,Alisa S. Wolberg,Johanna Gebhart
View Articletitled, Plasmin generation analysis in patients with bleeding disorder of unknown cause
Supplemental data

TRANSPLANTATION

Cardiac events after allo-HCT in patients with acute myeloid leukemia
María Queralt Salas,Enric Cascos,Alberto López-García,Estefanía Pérez,Mónica Baile-González,Carlos Martín Rodríguez,María Jesús Pascual Cascón,Marta Luque,Albert Esquirol,Inmaculada Heras Fernando,Felipe Peña-Muñóz,Itziar Oiartzabal Ormtegi,Adolfo Jesús Sáez Marín,Sara Fernández-Luis,Juan José Domínguez-García,Sara Villar Fernández,Miguel Fernández de Sanmamed Girón,Leslie González Pinedo,Lucía García,Ana Pilar González-Rodríguez,Tamara Torrado,Silvia Filaferro,Ángel Cedillo,Guillermo Ortí,Manuel Jurado Chacón,on behalf of the GETH-TC
View Articletitled, Cardiac events after allo-HCT in patients with acute myeloid leukemia
Supplemental data
Artificial intelligence enabled interpretation of ECG images to predict hematopoietic cell transplantation toxicity
Brian C. Shaffer,Samantha Brown,Stephanie Chinapen,Kathryn E. Mangold,Oscar Lahoud,Francisco Lopez-Jimenez,Wendy Schaffer,Jennifer Liu,Sergio Giralt,Sean Devlin,Gunjan Shah,Michael Scordo,Esperanza Papadopoulos,Heather Landau,Saad Usmani,Miguel-Angel Perales,Paul A. Friedman,Bernard J. Gersh,Itzhak Zachi Attia,Peter A. Noseworthy,Ioanna Kosmidou
View Articletitled, Artificial intelligence enabled interpretation of ECG images to predict hematopoietic cell transplantation toxicity
Supplemental data
NK- and T-cell repertoire is established early after allogeneic HSCT and is imprinted by CMV reactivation
Antonia Schäfer,Zuleika Calderin Sollet,Marie-Priscille Hervé,Stéphane Buhler,Sylvie Ferrari-Lacraz,Paul J. Norman,Katherine M. Kichula,Ticiana D. J. Farias,Stavroula Masouridi-Levrat,Anne-Claire Mamez,Amandine Pradier,Federico Simonetta,Yves Chalandon,Jean Villard
View Articletitled, NK- and T-cell repertoire is established early after allogeneic HSCT and is imprinted by CMV reactivation
Supplemental data

RESEARCH LETTER

Efficacy and tolerance of brexucabtagene autoleucel in adults with R/R B-ALL: a GRAALL study from the DESCAR-T registry
Florence Rabian,David Beauvais,Tony Marchand,Sabine Fürst,Anne Huynh,Eolia Brissot,Sébastien Maury,Ludovic Gabellier,Patrice Chevallier,Michael Loschi,Stéphanie Nguyen,Marie Balsat,Ingrid Lafon,Amandine Fayard,Vincent Camus,Célestine Simand,Niels Moya,Cristina Castilla-Llorente,Magalie Joris,Ana Berceanu,Anne Thiebaut-Bertrand,Véronique Lhéritier,Eve Gehlkopf,Gabrielle Roth-Guépin,Thibaut Leguay,Nicolas Boissel
View Articletitled, Efficacy and tolerance of brexucabtagene autoleucel in adults with R/R B-ALL: a GRAALL study from the DESCAR-T registry
Supplemental data

COMMENTARIES

Comparison of patients with myeloma receiving zoledronic acid vs denosumab: a nationwide retrospective cohort study
Ghulam Rehman Mohyuddin,Jenny S. Guadamuz,Mustafa S. Ascha,Brian C.-H. Chiu,Pritesh R. Patel,Karen Sweiss,Rebecca Rohrer,Douglas Sborov,Gregory S. Calip
View Articletitled, Comparison of patients with myeloma receiving zoledronic acid vs denosumab: a nationwide retrospective cohort study
Supplemental data
Consensus recommendations for severe aplastic anemia
Phillip Scheinberg,Austin G. Kulasekararaj
View Articletitled, Consensus recommendations for severe aplastic anemia

RESPONSES

The critical role of symptom experience on risk tolerance for gene therapy
Juan Marcos Gonzalez Sepulveda,Shelby D. Reed,Marilyn Telen
View Articletitled, The critical role of symptom experience on risk tolerance for gene therapy
Listening to patients and parents with sickle cell disease: the totality of gene therapy risks may outweigh the perceived benefits
Liza-Marie Johnson,Akshay Sharma,Yvonne Carroll,Dominique Goodson,Belinda N. Mandrell,Jami Gattuso,Amanda Young,Jacklyn Boggs,Benjamin S. Wilfond,Yoram Unguru
View Articletitled, Listening to patients and parents with sickle cell disease: the totality of gene therapy risks may outweigh the perceived benefits

ERRATA

Taylor A, Keogh L, Dickens E, et al. Caplacizumab in pediatric immune thrombotic thrombocytopenic purpura: the UK TTP Registry experience. Blood Adv. 2024;8(17):4563-4567.
View Articletitled, Taylor A, Keogh L, Dickens E, et al. Caplacizumab in pediatric immune thrombotic thrombocytopenic purpura: the UK TTP Registry experience. <em>Blood Adv</em>. 2024;8(17):4563-4567.
Nording H, Baron L, Sauter M, et al. Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor–modulating factors. Blood Adv. 2023;7(21):6411-6427.
View Articletitled, Nording H, Baron L, Sauter M, et al. Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor–modulating factors. <em>Blood Adv.</em> 2023;7(21):6411-6427.
Sewastianik T, Guerrera ML, Adler K, et al. Human MYD88L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells. Blood Adv. 2019;3(21):3360-3374.
View Articletitled, Sewastianik T, Guerrera ML, Adler K, et al. Human <em>MYD88</em><sup>L265P</sup> is insufficient by itself to drive neoplastic transformation in mature mouse B cells. <em>Blood Adv.</em> 2019;3(21):3360-3374.
  • Cover Image

    Cover Image

    issue cover

    Healthy human collagen-adherent platelets, with red showing actin and green showing α-tubulin. See the article by Brysland et al.

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