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Issue Archive

Volume 9, Issue 2
January 28 2025
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Predicting CAR T-cell toxicity: insurance for CAR crashes
Clinical Trials & Observations
Sanam Shahid,Kevin J. Curran
View Articletitled, Predicting CAR T-cell toxicity: insurance for CAR crashes
Things (like AML salvage) go better with VEN(etoclax)
Clinical Trials & Observations
Eric S. Winer,Richard M. Stone
View Articletitled, Things (like AML salvage) go better with VEN(etoclax)
Receiving CAR T-cells gets faster, but not for all in need
Clinical Trials & Observations
Kristie N. Ramos,Jeffery J. Auletta
View Articletitled, Receiving CAR T-cells gets faster, but not for all in need

ADVANCES VIEWPOINT

Induction of factor VIII tolerance by hemophilia gene transfer to eradicate factor VIII inhibitors
Guy Young
View Articletitled, Induction of factor VIII tolerance by hemophilia gene transfer to eradicate factor VIII inhibitors

REVIEW ARTICLE

CHIP away at the marrow-clot connection: inflammation, clonal hematopoiesis, and thromboembolic disease
Angela Todorovski,Tzu-Fei Wang,Marc Carrier,Yan Xu
View Articletitled, CHIP away at the marrow-clot connection: inflammation, clonal hematopoiesis, and thromboembolic disease

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 multicenter trial of ruxolitinib to treat bronchiolitis obliterans syndrome after allogeneic HCT
Clinical Trials & Observations
Zachariah DeFilipp,Haesook T. Kim,Guang-Shing Cheng,Betty K. Hamilton,Saurabh Chhabra,Mehdi Hamadani,Karamjeet S. Sandhu,Lia Perez,Catherine J. Lee,Timothy L. Brennan,Cassandra Garrelts,Bergin M. Brown,Kathleen Gallagher,Richard A. Newcomb,Areej El-Jawahri,Yi-Bin Chen
View Articletitled, A phase 2 multicenter trial of ruxolitinib to treat bronchiolitis obliterans syndrome after allogeneic HCT
Supplemental data
Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era
Clinical Trials & Observations
Ayotola Fatola,Michael D. Evans,Jenna Brown,Elizabeth Davis,Andrew Johnson,Ana G. Antun,Andrew M. Farland,Ryan Woods,Ara Metjian,Yara A. Park,Gustaaf de Ridder,Briana Gibson,Raj S. Kasthuri,Darla K. Liles,Susan Eubanks,Frank Akwaa,Todd Clover,Lisa Baumann Kreuziger,J. Evan Sadler,Meera Sridharan,Ronald S. Go,Keith R. McCrae,Harsh Vardhan Upreti,Ming Y. Lim,Nicole K. Kocher,Radhika Gangaraju,X. Long Zheng,Jay S. Raval,Camila Masias,Spero R. Cataland,Marshall Mazepa,Shruti Chaturvedi,on behalf of the USTMA Consortium
View Articletitled, Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era
Supplemental data

HEALTH SERVICES AND OUTCOMES

Medicaid coverage continuity is associated with lymphoma stage among children and adolescents/young adults
Xinyue Elyse Zhang,Sharon M. Castellino,K. Robin Yabroff,Wendy Stock,Patricia Cornwell,Shasha Bai,Ann C. Mertens,Joseph Lipscomb,Xu Ji
View Articletitled, Medicaid coverage continuity is associated with lymphoma stage among children and adolescents/young adults
Supplemental data
Access barriers to anti-CD19+ CART therapy for NHL across a community transplant and cellular therapy network
Clinical Trials & Observations
Minoo Battiwalla,Michael Tees,Ian Flinn,Jeremy Pantin,Jesus Berdeja,Tara Gregory,Michael Maris,Vikas Bhushan,Estil Vance,John Mathews,Carlos Bachier,Paul Shaughnessy,Aravind Ramakrishnan,Shahbaz Malik,Shahram Mori,Casey Martin,Rocky Billups,Betsy Blunk,Charles F. LeMaistre,Navneet S. Majhail
View Articletitled, Access barriers to anti-CD19<sup>+</sup> CART therapy for NHL across a community transplant and cellular therapy network
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition
Matthew J. Williams,Xiaonan Wang,Hugo P. Bastos,Gabriela Grondys-Kotarba,Qin Wu,Shucheng Jin,Carys Johnson,Nicole Mende,Emily Calderbank,Michelle Wantoch,Hyun Jung Park,Giovanna Mantica,Rebecca Hannah,Nicola K. Wilson,Dean C. Pask,Tina L. Hamilton,Sarah J. Kinston,Ryan Asby,Rachel Sneade,E. Joanna Baxter,Peter Campbell,George S. Vassiliou,Elisa Laurenti,Juan Li,Berthold Göttgens,Anthony R. Green
View Articletitled, Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition
Supplemental data
Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response
Wazim Mohammed Ismail,Jenna A. Fernandez,Moritz Binder,Terra L. Lasho,Minsuk Kim,Susan M. Geyer,Amelia Mazzone,Christy M. Finke,Abhishek A. Mangaonkar,Jeong-Heon Lee,Liguo Wang,Kwan Hyun Kim,Vernadette A. Simon,Fariborz Rakhshan Rohakthar,Amik Munankarmy,Seul Kee Byeon,Susan M. Schwager,Jonathan J. Harrington,Melissa R. Snyder,Keith D. Robertson,Akhilesh Pandey,Eric D. Wieben,Nicholas Chia,Alexandre Gaspar-Maia,Mrinal M. Patnaik
View Articletitled, Single-cell multiomics reveal divergent effects of <em>DNMT3A-</em> and <em>TET2-</em>mutant clonal hematopoiesis in inflammatory response
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Universal protection of allogeneic T-cell therapies from natural killer cells via CD300a agonism
Shu-Qi Zhang,Faith Thomas,Justin Fang,Kathryn Austgen,Chad Cowan,G. Grant Welstead
View Articletitled, Universal protection of allogeneic T-cell therapies from natural killer cells via CD300a agonism
Supplemental data
EASIX and m-EASIX predict CRS and ICANS in pediatric and AYA patients after CD19-CAR T-cell therapy
Clinical Trials & Observations
Dua’a Zandaki,Subodh Selukar,Yu Bi,Ying Li,Megan Zinsky,Challice L. Bonifant,Rebecca Epperly,Dinesh Keerthi,Brandon M. Triplett,Stephen Gottschalk,Swati Naik,Aimee C. Talleur
View Articletitled, EASIX and m-EASIX predict CRS and ICANS in pediatric and AYA patients after CD19-CAR T-cell therapy
Supplemental data

MYELOID NEOPLASIA

Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia
Romane Joudinaud,Augustin Boudry,Laurène Fenwarth,Sandrine Geffroy,Mikaël Salson,Hervé Dombret,Céline Berthon,Arnaud Pigneux,Delphine Lebon,Pierre Peterlin,Simon Bouzy,Pascale Flandrin-Gresta,Emmanuelle Tavernier,Martin Carre,Sylvie Tondeur,Lamya Haddaoui,Raphael Itzykson,Sarah Bertoli,Audrey Bidet,Eric Delabesse,Mathilde Hunault,Christian Récher,Claude Preudhomme,Nicolas Duployez,Pierre-Yves Dumas
View Articletitled, Midostaurin shapes macroclonal and microclonal evolution of <em>FLT3</em>-mutated acute myeloid leukemia
Supplemental data
Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML
Clinical Trials & Observations
Julia M. Unglaub,Richard F. Schlenk,Jan Moritz Middeke,Stefan W. Krause,Sabrina Kraus,Hermann Einsele,Michael Kramer,Sven Zukunft,Joseph Kauer,Simon Renders,Elena Katelari,Christoph Schliemann,Caroline Pabst,Thomas Luft,Peter Dreger,Christoph Röllig,Martin Bornhäuser,Carsten Müller-Tidow,Tim Sauer,for the Study Alliance Leukemia
View Articletitled, Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Increased exercise tolerance in humanized G6PD-deficient mice
Francesca I. Cendali,Christina Lisk,Monika Dzieciatkowska,Ian S. LaCroix,Julie A. Reisz,Julie Harral,Daniel Stephenson,Ariel M. Hay,Eric P. Wartchow,Anza Darehshouri,Karolina H. Dziewulska-Cronk,Paul W. Buehler,Philip J. Norris,Xutao Deng,Michael P. Busch,Eric J. Earley,Grier P. Page,Kirk C. Hansen,James C. Zimring,David C. Irwin,Travis Nemkov,Angelo D’Alessandro
View Articletitled, Increased exercise tolerance in humanized G6PD-deficient mice
Supplemental data

THROMBOSIS AND HEMOSTASIS

Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs
Noa A. Linthorst,Yvonne K. Jongejan,Richard J. Dirven,Sebastiaan N. J. Laan,Ruben Bierings,Caterina Casari,Robert A. Cordfunke,James E. Dahlman,Natasja Dolezal,Jan Wouter Drijfhout,Frank W. G. Leebeek,L. Renee Ruhaak,Elisa Schrader Echeverri,Jan Voorberg,Bart J. M. van Vlijmen,Cécile V. Denis,Jeroen C. J. Eikenboom
View Articletitled, Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs
Supplemental data

VASCULAR BIOLOGY

Cerebral vascular shunting and oxygen metabolism in sickle cell disease
Alexander K. Song,Wesley T. Richerson,Megan A. Aumann,Spencer L. Waddle,R. Sky Jones,Samantha Davis,Lauren Milner,Chelsea Custer,L. Taylor Davis,Sumit Pruthi,Dann Martin,Lori C. Jordan,Manus J. Donahue
View Articletitled, Cerebral vascular shunting and oxygen metabolism in sickle cell disease
Supplemental data

RESEARCH LETTERS

T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia
Clinical Trials & Observations
Talha Badar,Keith L. Knutson,James Foran,Naseema Gangat,Kevin D. Pavelko,Scott H. Kaufmann,Mark R. Litzow,Hemant Murthy,Davitte Cogen,Margaret Ushman,Arini Arsana,Aref Al-Kali,Hassan Alkhateeb,Ayalew Tefferi,Mrinal Patnaik,Mithun Shah
View Articletitled, T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia
Supplemental data
The E3 ubiquitin ligase MARCH5 promotes mitochondrial fusion and cell-cycle progression in acute myeloid leukemia
Clément Larrue,Sarah Mouche,Jerome Tamburini
View Articletitled, The E3 ubiquitin ligase MARCH5 promotes mitochondrial fusion and cell-cycle progression in acute myeloid leukemia
Supplemental data
Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy
Clinical Trials & Observations
Barbara D. Friedes,Amanda M. DiNofia,Emma Iannone,Yimei Li,Susan R. Rheingold,Allison Barz Leahy,Lisa Wray,Colleen Callahan,Diane Baniewicz,Lauren Vernau,Kelly D. Getz,Richard Aplenc,Shannon L. Maude,Stephan A. Grupp,Regina M. Myers
View Articletitled, Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy
Supplemental data
Optical genome mapping identified deletions, inversions, and insertions in hemophilia
Boyan Liu,Lu Zhou,Lijuan Cao,Haoning Liu,Laigen Tong,Zichan Zhang,Hongjie Shen,Changgeng Ruan,Yafeng Zhou,Miao Jiang
View Articletitled, Optical genome mapping identified deletions, inversions, and insertions in hemophilia
Supplemental data
Deficit accumulation frailty index and treatment tolerability in AML: data from CALGB 11001 and 11002 (Alliance)
Clinical Trials & Observations
Catherine Lai,Minji Lee,Olivia Bobek,Jennifer Le-Rademacher,Sumithra Mandrekar,Gail J. Roboz,Geoffrey L. Uy,Jeanne S. Mandelblatt,Heidi D. Klepin
View Articletitled, Deficit accumulation frailty index and treatment tolerability in AML: data from CALGB 11001 and 11002 (Alliance)

LETTER TO THE EDITOR

Is GPIbα really a master regulator of platelet activation?
Brianna E. Watson,Isabelle I. Salles-Crawley
View Articletitled, Is GPIbα really a master regulator of platelet activation?
  • Cover Image

    Cover Image

    issue cover

    Network analysis of significantly upregulated proteins in postexercise muscle tissues of humanized mice expressing the Mediterranean variant (S188F) of glucose-6-phosphate dehydrogenase, compared to nondeficient mice. Gene ontology enrichment for results in gastrocnemius and soleus identifies the upregulation of pathways related to mitochondrial protein translation, protein folding, mitochondrial biogenesis, intracellular transport, and cellular energy metabolism. See the article by Cendali et al.

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