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Issue Archive

Volume 9, Issue 9
May 13 2025
In Progress
Blood Advances Cover Image for Volume 9, Issue 9
In this Issue

Table of Contents

Feasibility and favorable responses after investigational CAR T-cell therapy for relapsed and refractory infant ALL
Clinical Trials & Observations
Colleen Annesley,Adam Lamble,Corinne Summers,Michael A. Pulsipher,Alan S. Wayne,Julie Rivers,Wenjun Huang,Ashley Wilson,Qian Vicky Wu,Kristy Seidel,Stephanie Mgebroff,Christopher Brown,Catherine Lindgren,Julie R. Park,Michael Jensen,Rebecca Gardner
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Supplemental data
Maximum tumor diameter is associated with relapse risk in limited-stage Hodgkin lymphoma: an international study
Clinical Trials & Observations
Elizabeth H. Phillips,Nicholas Counsell,Tim Illidge,Marc Andre,Igor Aurer,Valeria Fiaccadori,Catherine Fortpied,Anouk Neven,Massimo Federico,Sally F. Barrington,John Raemaekers,John Radford
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Supplemental data
Treatment holidays in patients with Erdheim-Chester disease receiving vemurafenib: a prospective pilot study
Francesco Pegoraro,Francesco Catamerò,Federica Allegretta,Giulia Palazzini,Francesco Peyronel,Eli L. Diamond,Augusto Vaglio
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Supplemental data
TP53 mutations are associated with CD19− relapse and inferior outcomes after blinatumomab in adults with ALL
Ibrahim Aldoss,Shanpeng Li,Jianying Zhang,Mary C. Clark,Vaibhav Agrawal,Hoda Pourhassan,Paul Koller,Ahmed Aribi,Haris Ali,Amanda Blackmon,Salman Otoukesh,Karamjeet Sandhu,Brian Ball,Shukaib Arslan,Andrew Artz,Idoroenyi Amanam,Monzr M. Al Malki,Amandeep Salhotra,Tibor Kovacsovics,Lindsey Murphy,Michelle Afkhami,Dat Ngo,Jose Tinajero,Zhaohui Gu,Pamela S. Becker,Ryotaro Nakamura,Anthony Stein,Guido Marcucci,Stephen J. Forman,Vinod Pullarkat
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Supplemental data
Definitions and use of tumor bulk in phase 3 lymphoma trials: a comprehensive literature review
Clinical Trials & Observations
Luke Wang,Eliza Chung,Cameron Wellard,Allison Barraclough,Belinda A. Campbell,Geoffrey Chong,Pietro R. Di Ciaccio,Gareth P. Gregory,Greg Hapgood,Anna M. Johnston,Constantine Tam,Stephen Opat,Erica M. Wood,Zoe K. McQuilten,Eliza A. Hawkes
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Supplemental data
Cutaneous dysbiosis characterizes the post–allogeneic hematopoietic stem cell transplantation period
Clinical Trials & Observations
Adela R. Cardones,Akintunde Emiola,Russell P. Hall, III,Anthony D. Sung,Jennifer Zhang,Amy J. Petty,Charles Puza,Lauren M. Bohannon,Amy T. Bush,Meagan V. Lew,Elizabeth Fleming,Yingai J. Jin,Krista Rowe Nichols,Vaibhav Jain,Simon G. Gregory,Keith M. Sullivan,Nelson J. Chao,Julia Oh
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Supplemental data
Systemic mastocytosis: current status and challenges in 2024
Celalettin Ustun,Fatma Keklik Karadag,Michael A. Linden,Peter Valent,Cem Akin
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Supernumerary ring chromosome 1 syndrome leads to fusion-driven B-cell acute lymphoblastic leukemia in monozygotic twins
Jesús Gutiérrez-Abril,Gunes Gundem,Elise Fiala,Konstantinos Liosis,Noushin Farnoud,Dan Leongamornlert,Anu Amallraja,Juan E. Arango-Ossa,Dylan Domenico,Max Levine,Juan S. Medina-Martínez,Emily Stockfisch,Daoqi You,Mike Walsh,Sylwia Jasinski,Andrew L. Kung,Neerav N. Shukla,William L. Carroll,Elli Papaemmanuil
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Supplemental data
Factors associated with early quality-of-life response to palliative care during hematopoietic cell transplantation
Richard Newcomb,Hermioni L. Amonoo,Alison R. Kavanaugh,Kristin C. Wharton,Michaela Rowland,James Fausto,Jason Webb,Vicki Jackson,Joseph A. Greer,Jennifer S. Temel,Porsha Lark,Dustin J. Rabideau,Karen O’Brien,Thomas W. LeBlanc,Stephanie J. Lee,Areej El-Jawahri
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Supplemental data
Metabolically aberrant extracellular mitochondria induce oxidative endotheliopathy in traumatic brain injury
Xiaoxi Lu,Lujia Tang,Yingang Wu,Tristan Hilton,Xin Chen,Katie Houck,Sarah Fulton,Cha Han,Sophia Romero,Yi Wang,Rosemary Kozar,Jessica C. Cardenas,Xiaoyun Fu,Jianning Zhang,Zilong Zhao,Jing-fei Dong
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Supplemental data
Diagnosis, management, and outcomes of drug-induced erythrocytosis: a systematic review
Jessica Liu,Benjamin Chin-Yee,Jenny Ho,Alejandro Lazo-Langner,Ian H. Chin-Yee,Alla Iansavitchene,Cyrus C. Hsia
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Supplemental data
Fitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Adriano Venditti,Raffaele Palmieri,Luca Maurillo,Christoph Röllig,Agnieszka Wierzbowska,David de Leeuw,Fabio Efficace,Antonio Curti,Lok Lam Ngai,Jesse Tettero,Lionel Adès,Antonio Almeida,Lars Bullinger,Mike Dennis,Jordi Esteve,Felicetto Ferrara,Michael Heuser,Gerwin Huls,Michael Lübbert,Priyanka Mehta,Pau Montesinos,Thomas Pabst,Christian Récher,Giuseppe Rossi,Nigel Russell,Jorge Sierra,Reinhard Stauder,Norbert Vey,Roland B. Walter,Eunice Wang,Samantha Nier,Carolina Garcez Martins,Gert Ossenkoppele
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Supplemental data
Single-cell dynamics of breakthrough toxicities after anakinra prophylaxis for axicabtagene ciloleucel in lymphoma
Clinical Trials & Observations
Matthew J. Frigault,Ning Yao,Trisha R. Berger,Marc Wehrli,Kathleen M. E. Gallagher,Nora Horick,Charlotte E. Graham,Caron A. Jacobson,Yi-Bin Chen,Mark B. Leick,Zachariah DeFilipp,Areej R. El-Jawahri,P. Connor Johnson,Maria Dolaher,Katelin Katsis,Austin I. Kim,Jennifer Crombie,Reid W. Merryman,Daniella Cook,Michael Trailor,Hana Cho,Richard Jeffrey, III,Rhine Shen,Simone Filosto,Jenny Nater,Gad Getz,Nicholas J. Haradhvala,Marcela V. Maus
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Supplemental data
Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia
Clinical Trials & Observations
Athalia R. Pyzer,Laura W. Dillon,Elad Sharon,Theodore G. Karrison,Yuanyuan Zha,Noreen Fulton,Gege Gui,Georgia Andrew,Howard Streicher,Kendra Sweet,George Yaghmour,Jane Jijun Liu,Brian A. Jonas,Aaron D. Schimmer,Steven Grant,Amer M. Zeidan,Gerhard C. Hildebrandt,Christopher H. Lowrey,Ryan J. Mattison,Neil Palmisiano,Amandeep Salhotra,Dimitrios Tzachanis,Maria R. Baer,Tara L. Lin,Prapti Patel,Helen Chen,Walter M. Stadler,Olatoyosi Odenike,Richard A. Larson,Thomas F. Gajewski,Christopher S. Hourigan,Wendy Stock,Hongtao Liu
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Supplemental data
Cellular and biochemical heterogeneity contributes to the phenotypic diversity of transfusion-dependent β-thalassemia
Konstantina Theocharaki,Alkmini T. Anastasiadi,Sophia Delicou,Vassilis L. Tzounakas,Ioanna Barla,Stella Rouvela,Evgenia Kazolia,Georgia Tzafa,George Mpekoulis,Theodore Gousdovas,Efthymia Pavlou,Ioannis V. Kostopoulos,Athanassios D. Velentzas,Nikolaos Simantiris,Aikaterini Xydaki,Niki Vassilaki,Ersi Voskaridou,Ioanna-Katerina Aggeli,Efrosyni Nomikou,Ourania Tsitsilonis,Efstathia Papageorgiou,Nikolaos Thomaidis,Evangelos Gikas,Marianna Politou,Veroniki Komninaka,Marianna H. Antonelou
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Supplemental data
Late-onset telomere biology disorders in adults: clinical insights and treatment outcomes from a retrospective registry cohort
Mareike Tometten,Fabian Beier,Martin Kirschner,Yannic Schumacher,Jeanette Walter,Margherita Vieri,Kim Kricheldorf,Alexander Röth,Uwe Platzbecker,Markus Radsak,Philippe Schafhausen,Selim Corbacioglu,Britta Höchsmann,Stefan Balabanov,Claas Hinze,Jörg Chromik,Michael Heuser,Michael Kreuter,Marcin W. Wlodarski,Miriam Elbracht,Ingo Kurth,Steffen Koschmieder,Jens Panse,Susanne Isfort,Robert Meyer,Tim H. Brümmendorf
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Supplemental data
Prior exposure to belantamab mafodotin influences outcomes with idecabtagene vicleucel in patients with multiple myeloma
Bhavesh Mohan Lal,Marah Alzubi,Jawad Alrawabdeh,John D. Shaughnessy, Jr.,Fenghuang Zhan,Eric R. Siegel,Carolina Schinke,Sharmilan Thanendrarajan,Maurizio Zangari,Frits van Rhee,Samer Al Hadidi
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T cell exhaustion and an immunosuppressive microenvironment is a hallmark of CTCL. Durvalumab combined with lenalidomide has the potential to enhance anti-tumor immunity in CTCL.

Phase 1 trial of durvalumab (anti–PD-L1) combined with lenalidomide in relapsed/refractory cutaneous T-cell lymphoma
Clinical Trials & Observations
Christiane Querfeld,Joycelynne Palmer,Zhen Han,Xiwei Wu,Yate-Ching Yuan,Min-Hsuan Chen,Chingyu Su,Ni-Chun Tsai,D. Lynne Smith,Samantha N. Hammond,Liliana Crisan,Joo Y. Song,Raju Pillai,Steven T. Rosen,Jasmine Zain
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Supplemental data
In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands
Christian A. Di Buduo,Francesca Careddu,Samuele Metti,Marco Lunghi,Santo Diprima,Virginia Camilotto,Giovanna Bruni,Umberto Gianelli,Delfina Tosi,Cesare Perotti,Claudia Del Fante,Mario Cazzola,Paola Braghetta,David L. Kaplan,Giampaolo Minetti,Luca Malcovati,Alessandra Balduini
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Supplemental data
Presentation of CXCL12γ by heparan sulfate proteoglycans activates CXCR4 without desensitization in normal and malignant B cells
Hildo C. Lantermans,Fangxue Ma,Annemieke Kuil,Martin F. M. de Rooij,Nick D. Bergkamp,Werner van der Meer,Jaap D. van Buul,Martine J. Smit,Marie José Kersten,Marcel Spaargaren,Steven T. Pals
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Supplemental data
Diffuse lung involvement as a rare presentation of systemic AL amyloidosis: a retrospective cohort study
Amy Song,George Mellgard,Claudia Bellofiore,Marco Basset,Mario Nuvolone,Andrea Foli,Giampaolo Merlini,Mathew S. Maurer,Markus Y. Mapara,Divaya Bhutani,Suzanne Lentzsch,Hiram Shaish,Giovanni Palladini,Rajshekhar Chakraborty,Paolo Milani
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Supplemental data
BR or R-CHOP induction with rituximab maintenance in untreated, transplant-ineligible patients with mantle cell lymphoma
Clinical Trials & Observations
Katja Gutmair,Diego Villa,Nicholas Cunningham,Elisabeth Silkenstedt,Lisa Rimsza,Colleen Ramsower,David W. Scott,Alina S. Gerrie,Hanneke C. Kluin-Nelemans,Martin Dreyling,Eva Hoster
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Supplemental data
Long-term efficacy of immune checkpoint inhibitors for relapsed primary mediastinal B-cell lymphoma: a real-world study
Beatrice Casadei,Lisa Argnani,Alessandro Broccoli,Martina Cantelli,Gabriele Gugliotta,Marianna Gentilini,Matteo Carella,Vittorio Stefoni,Cinzia Pellegrini,Nicole Fabbri,Giulia Gabrielli,Camilla Mazzoni,Pierluca Maglio,Gianmarco Bagnato,Pier Luigi Zinzani
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A pharmacokinetic and safety study of oral arsenic trioxide in patients with acute promyelocytic leukemia
Farhad Ravandi,Sravanti Rangaraju,Hagop Kantarjian,Guillermo Garcia-Manero,Musa Yilmaz,Kristen Baker,Terence Hall,Joy Grabenstein,Pourab Roy,Beth A. Zamboni,William C. Zamboni,Erica Warlick,Michael Kelly,David A. Roth,Gabriel Ghiaur
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Supplemental data
Interim PET after 4 cycles predicts outcome in histomolecularly confirmed primary mediastinal B-cell lymphoma
Clinical Trials & Observations
Vincent Camus,Thierry Molina,Fabienne Desmots,Paul Blanc-Durand,Salim Kanoun,Amine Moslemi,Philippe Ruminy,Steven Le Gouill,Hervé Ghesquières,Lucie Oberic,Franck Morschhauser,Hervé Tilly,Vincent Ribrag,Roch Houot,Catherine Thieblemont,Hervé Maisonneuve,Fabien Claves,Krimo Bouabdallah,Corinne Haioun,Gandhi Laurent Damaj,Luc-Matthieu Fornecker,Robin Noel,Pierre Feugier,David Sibon,Guillaume Cartron,Christophe Bonnet,Wivine Bernard,Françoise Kraeber-Bodéré,Caroline Bodet-Milin,Jean-Philippe Jais,Josette Brière,Cedric Rossi,Mad-Hélénie Elsensohn,Loïc Chartier,Emmanuel Itti,Fabrice Jardin,Thierry Fest
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Supplemental data
Interplay between iron metabolism, inflammation, and EPO-ERFE-hepcidin axis in RDEB-associated chronic anemia
Lucía Quintana-Castanedo,Rocío Maseda,Isabel Pérez-Conde,Nora Butta,Elena Monzón-Manzano,Paula Acuña-Butta,María G. Crespo,Antonio Buño-Soto,Eva Jiménez,Jaris Valencia,María C. Arriba,Pilar Zuluaga,Raúl de Lucas,Marcela del Río,Ángeles Vicente,María J. Escámez,Rosa Sacedón
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Supplemental data
Neutrophil recruitment depends on platelet-derived leukotriene B4
Christian Hackenbroch,Tugce Cimen,Carina Gross,Stefanie Rubenzucker,Philipp Burkard,Niklas Groß,Robert Ahrends,Tamara Girbl,David Stegner
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Supplemental data
DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions
Sarah M. Waldvogel,Virginia Camacho,Dandan Fan,Anna G. Guzman,Alejandra Garcia-Martell,Elmira Khabusheva,Jacey Rodriguez Pridgen,Josephine De La Fuente,Rachel Rau,Ashlyn G. Laidman,Maria N. Barrachina,Estelle Carminita,Justin A. Courson,Michael R. Williamson,Joanne I. Hsu,Chun-Wei Chen,Jaime Reyes,Subhashree Pradhan,Rolando E. Rumbaut,Alan R. Burns,Benjamin Deneen,Jianzhong Su,Kellie R. Machlus,Margaret A. Goodell
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Supplemental data
Universal driving restrictions beyond 4 weeks appear unnecessary following CAR-T therapy in multiple myeloma
Rahul Banerjee,Alicia Richards,Shonali Midha,Aimaz Afrough,Faiz Anwer,Djordje Atanackovic,Shebli Atrash,Veronika Bachanova,Amer M. Beitinjaneh,Evguenia Bhurtel,Omar Castaneda Puglianini,Saurabh Chhabra,Kara I. Cicero,James A. Davis,Binod Dhakal,Danai Dima,Christopher J. Ferreri,Peter A. Forsberg,Ciara L. Freeman,Megan M. Herr,Tania Jain,Murali Janakiram,Jack Khouri,Mehmet H. Kocoglu,Anupama Kumar,Yuxin Liu,Frederick Locke,Joseph P. McGuirk,Lekha Mikkilineni,Omar Nadeem,Ricardo D. Parrondo,Oren Pasvolsky,Lauren C. Peres,Sneha Purvey,Shahzad Raza,Ran Reshef,Shambavi Richard,Adriana C. Rossi,Douglas W. Sborov,Leyla Shune,Charlotte B. Wagner,Saurabh S. Zanwar,Surbhi Sidana,Krina K. Patel,Doris K. Hansen,Shaji K. Kumar,Yi Lin,Thomas G. Martin,Peter M. Voorhees,Larry D. Anderson, Jr,Andrew J. Cowan,Gurbakhash Kaur
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Supplemental data
Key role of long-duration cardiac rhythm monitoring in patients with sickle cell disease with atrial hyperexcitability
Clinical Trials & Observations
Thuy Linh Dang,Thibaut Moulin,Gonzalo de Luna,Sihem Iles,Anaïs Lamadieu,David Calvet,Geneviève Derumeaux,Pablo Bartolucci,Nicolas Lellouche,Thomas d’Humières
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Taking a break: a therapeutic option for ECD?
Matthias Papo,Kenneth McClain
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Paudel BB, Tan S-F, Fox TE, et al. Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes. Blood Adv. 2024;8(5):1137-1142.
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Finding the right fit: assessment of fitness in AML
Clinical Trials & Observations
Nicholas Chornenki,Lee Mozessohn
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  • Cover Image

    Cover Image

    issue cover

    Histologic section of a bone marrow trephine core biopsy showing an atypical, partially paratrabecular mast cell aggregate, admixed with small nonneoplastic lymphoid cells. The atypical mast cell aggregate is composed of mast cells that are predominantly spindled. Bone marrow section stained with hematoxylin and eosin; photomicrograph captured using a 20× objective. See the article by Ustun et al.

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Taking a break: a therapeutic option for ECD?
Finding the right fit: assessment of fitness in AML
Universal driving restrictions beyond 4 weeks appear unnecessary following CAR-T therapy in multiple myeloma
Key role of long-duration cardiac rhythm monitoring in patients with sickle cell disease with atrial hyperexcitability
Paudel BB, Tan S-F, Fox TE, et al. Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes. Blood Adv. 2024;8(5):1137-1142.

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