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Michael R. Savona
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Journal Articles

Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation

J. Brett Heimlich, Pawan Bhat, Alyssa C. Parker, Matthew T. Jenkins, Caitlyn Vlasschaert, Jessica Ulloa, Joseph C. Van Amburg, Chad R. Potts, Sydney Olson, Alexander J. Silver, Ayesha Ahmad, Brian Sharber, Donovan Brown, Ningning Hu, Peter van Galen, Michael R. Savona, Alexander G. Bick, P. Brent Ferrell
Journal: Blood Advances
Blood Adv (2024) 8 (14): 3665–3678.
https://doi.org/10.1182/bloodadvances.2023011445
Published: 2024
Includes: Supplemental data
Journal Articles

Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository

Clinical Trials & Observations
Morgan L. Shannon, J. Brett Heimlich, Sydney Olson, Ariana Debevec, Zachary Copeland, Ashwin Kishtagari, Caitlyn Vlasschaert, Christina Snider, Alexander J. Silver, Donovan Brown, Travis Spaulding, Manasa Bhatta, Kelly Pugh, Shannon S. Stockton, Jessica Ulloa, Yaomin Xu, Muhamed Baljevic, Javid Moslehi, Eiman Jahangir, P. Brent Ferrell, David Slosky, Alexander G. Bick, Michael R. Savona
Journal: Blood Advances
Blood Adv (2024) 8 (13): 3453–3463.
https://doi.org/10.1182/bloodadvances.2023011510
Published: 2024
Includes: Supplemental data
Journal Articles

An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS

Clinical Trials & Observations
Maximilian Stahl, Omar Abdel-Wahab, Andrew H. Wei, Michael R. Savona, Mina L. Xu, Zhuoer Xie, Justin Taylor, Daniel Starczynowski, Guillermo F. Sanz, David A. Sallman, Valeria Santini, Gail J. Roboz, Mrinal M. Patnaik, Eric Padron, Olatoyosi Odenike, Aziz Nazha, Stephen D. Nimer, Ravindra Majeti, Richard F. Little, Steven Gore, Alan F. List, Vijay Kutchroo, Rami S. Komrokji, Tae Kon Kim, Nina Kim, Christopher S. Hourigan, Robert P. Hasserjian, Stephanie Halene, Elizabeth A. Griffiths, Peter L. Greenberg, Maria Figueroa, Pierre Fenaux, Fabio Efficace, Amy E. DeZern, Matteo G. Della Porta, Naval G. Daver, Jane E. Churpek, Hetty E. Carraway, Andrew M. Brunner, Uma Borate, John M. Bennett, Rafael Bejar, Jacqueline Boultwood, Sanam Loghavi, Jan Philipp Bewersdorf, Uwe Platzbecker, David P. Steensma, Mikkael A. Sekeres, Rena J. Buckstein, Amer M. Zeidan
Journal: Blood Advances
Blood Adv (2023) 7 (12): 2709–2714.
https://doi.org/10.1182/bloodadvances.2022008747
Published: 2023
Journal Articles

Targeting RARA overexpression with tamibarotene, a potent and selective RARα agonist, is a novel approach in AML

Clinical Trials & Observations
Stéphane de Botton, Thomas Cluzeau, Carlos Vigil, Rachel J. Cook, Philippe Rousselot, David A. Rizzieri, Jane L. Liesveld, Pierre Fenaux, Thorsten Braun, Anne Banos, Joseph G. Jurcic, Mikkael A. Sekeres, Michael R. Savona, Gail J. Roboz, Dale Bixby, Kate Madigan, Angela Volkert, Kristin Stephens, Qing Kang-Fortner, Kristen Baker, Sofia Paul, Michael McKeown, John Carulli, Matthew Eaton, Graeme Hodgson, Christopher Fiore, Michael J. Kelly, David A. Roth, Eytan M. Stein
Journal: Blood Advances
Blood Adv (2023) 7 (9): 1858–1870.
https://doi.org/10.1182/bloodadvances.2022008806
Published: 2023
Includes: Supplemental data
Journal Articles

Patient-specific comorbidities as prognostic variables for survival in myelofibrosis

Andrew L. Sochacki, Cosmin Adrian Bejan, Shilin Zhao, Ameet Patel, Ashwin Kishtagari, Travis P. Spaulding, Alexander J. Silver, Shannon S. Stockton, Kelly Pugh, R. Dixon Dorand, Manasa Bhatta, Nicholas Strayer, Siwei Zhang, Christina A. Snider, Thomas Stricker, Aziz Nazha, Alexander G. Bick, Yaomin Xu, Michael R. Savona
Journal: Blood Advances
Blood Adv (2023) 7 (5): 756–767.
https://doi.org/10.1182/bloodadvances.2021006318
Published: 2023
Includes: Supplemental data
Journal Articles

A geno-clinical decision model for the diagnosis of myelodysplastic syndromes

Clinical Trials & Observations
Nathan Radakovich, Manja Meggendorfer, Luca Malcovati, C. Beau Hilton, Mikkael A. Sekeres, Jacob Shreve, Yazan Rouphail, Wencke Walter, Stephan Hutter, Anna Galli, Sara Pozzi, Chiara Elena, Eric Padron, Michael R. Savona, Aaron T. Gerds, Sudipto Mukherjee, Yasunobu Nagata, Rami S. Komrokji, Babal K. Jha, Claudia Haferlach, Jaroslaw P. Maciejewski, Torsten Haferlach, Aziz Nazha
Journal: Blood Advances
Blood Adv (2021) 5 (21): 4361–4369.
https://doi.org/10.1182/bloodadvances.2021004755
Published: 2021
Includes: Supplemental data
Journal Articles

A novel differentiation response with combination IDH inhibitor and intensive induction therapy for AML

Clinical Trials & Observations
Emily F. Mason, Olga Pozdnyakova, Mikhail Roshal, Amir T. Fathi, Eytan M. Stein, P. Brent Ferrell, Aaron C. Shaver, Mark Frattini, Hongfang Wang, Lei Hua, Jimmy Mu, Sung Choe, Rengyi Xu, Caroline Almon, Michael Cooper, Richard M. Stone, Robert P. Hasserjian, Michael R. Savona
Journal: Blood Advances
Blood Adv (2021) 5 (8): 2279–2283.
https://doi.org/10.1182/bloodadvances.2020003685
Published: 2021
Includes: Supplemental data
Journal Articles

Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis

Clinical Trials & Observations
Aaron T. Gerds, Michael R. Savona, Bart L. Scott, Moshe Talpaz, Miklos Egyed, Claire N. Harrison, Abdulraheem Yacoub, Alessandro Vannucchi, Adam J. Mead, Jean-Jacques Kiladjian, Jennifer O’Sullivan, Valentin García-Gutiérrez, Prithviraj Bose, Raajit K. Rampal, Carole B. Miller, Jeanne Palmer, Stephen T. Oh, Sarah A. Buckley, Diane R. Mould, Kaori Ito, Shanthakumar Tyavanagimatt, Jennifer A. Smith, Karisse Roman-Torres, Sri Devineni, Adam R. Craig, John O. Mascarenhas
Journal: Blood Advances
Blood Adv (2020) 4 (22): 5825–5835.
https://doi.org/10.1182/bloodadvances.2020003314
Published: 2020
Includes: Supplemental data
Journal Articles

Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies

Melissa A. Fischer, Sharon Y. Friedlander, Maria P. Arrate, Hua Chang, Agnieszka E. Gorska, Londa D. Fuller, Haley E. Ramsey, Trinayan Kashyap, Christian Argueta, Sophie Debler, Michael Byrne, Matthew T. Villaume, Aaron C. Shaver, William Senapedis, Yosef Landesman, Erkan Baloglu, Sharon Shacham, Michael R. Savona
Journal: Blood Advances
Blood Adv (2020) 4 (3): 586–598.
https://doi.org/10.1182/bloodadvances.2019000359
Published: 2020
Includes: Supplemental data