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Journal Articles

IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB– and caspase-8–dependent mechanisms

Liang Zhou, Yu Zhang, Mark B. Meads, Yun Dai, Yanxia Ning, Xiaoyan Hu, Lin Li, Kanika Sharma, Jewel Nkwocha, Rebecca Parker, Danny Bui, Jacquelyn McCarter, Lora Kramer, Cullen Purcell, Praneeth R. Sudalagunta, Rafael R. Canevarolo, Maria D. Coelho Siqueira Silva, Gabriel De Avila, Raghunandan Reddy Alugubelli, Ariosto S. Silva, Maciej Kmeiciak, Andrea Ferreira-Gonzalez, Kenneth H. Shain, Steven Grant
Journal: Blood Advances
Blood Adv (2021) 5 (19): 3776–3788.
https://doi.org/10.1182/bloodadvances.2020003597
Published: 2021
Includes: Supplemental data
Journal Articles

Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted

Clinical Trials & Observations
Jeremy D. Rubinstein, Xiang Zhu, Thomas Leemhuis, Giang Pham, Lorraine Ray, Sana Emberesh, Sonata Jodele, Shawn Thomas, Jose A. Cancelas, Catherine M. Bollard, Patrick J. Hanley, Michael D. Keller, Olivia Grimley, Diana Clark, Teri Clark, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Stella M. Davies, Adam S. Nelson, Michael S. Grimley, Carolyn Lutzko
Journal: Blood Advances
Blood Adv (2021) 5 (17): 3309–3321.
https://doi.org/10.1182/bloodadvances.2021004456
Published: 2021
Includes: Supplemental data
Journal Articles

Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL

Burcu Aslan, Gorkem Kismali, Lisa S. Chen, LaKesla R. Iles, Mikhila Mahendra, Michael Peoples, Mihai Gagea, Natalie W. Fowlkes, Xiaofeng Zheng, Jing Wang, Christopher P. Vellano, Joseph R. Marszalek, Maria Teresa Sabrina Bertilaccio, Varsha Gandhi
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3134–3146.
https://doi.org/10.1182/bloodadvances.2020003821
Published: 2021
Includes: Supplemental data
Journal Articles

Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis

Kang Le, Jing Sun, Hunain Khawaja, Maho Shibata, Sanjay B. Maggirwar, Mitchell R. Smith, Mamta Gupta
Journal: Blood Advances
Blood Adv (2021) 5 (14): 2863–2878.
https://doi.org/10.1182/bloodadvances.2020003871
Published: 2021
Includes: Supplemental data
Journal Articles

RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia

Stavroula Ntoufa, Marina Gerousi, Stamatia Laidou, Fotis Psomopoulos, Georgios Tsiolas, Theodoros Moysiadis, Nikos Papakonstantinou, Larry Mansouri, Achilles Anagnostopoulos, Niki Stavrogianni, Sarka Pospisilova, Karla Plevova, Antonios M. Makris, Richard Rosenquist, Kostas Stamatopoulos
Journal: Blood Advances
Blood Adv (2021) 5 (13): 2788–2792.
https://doi.org/10.1182/bloodadvances.2020001717
Published: 2021
Includes: Supplemental data
Journal Articles

Study of the antilymphoma activity of pracinostat reveals different sensitivities of DLBCL cells to HDAC inhibitors

Afua Adjeiwaa Mensah, Filippo Spriano, Giulio Sartori, Valdemar Priebe, Luciano Cascione, Eugenio Gaudio, Chiara Tarantelli, Elisa Civanelli, Luca Aresu, Andrea Rinaldi, Giovanna Damia, Emanuela Lovati, Emanuele Zucca, Anastasios Stathis, Claudio Pietra, Francesco Bertoni
Journal: Blood Advances
Blood Adv (2021) 5 (10): 2467–2480.
https://doi.org/10.1182/bloodadvances.2020003566
Published: 2021
Includes: Supplemental data
Journal Articles

G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor–mediated cell death

Eva De Smedt, Julie Devin, Catharina Muylaert, Nicolas Robert, Guilhem Requirand, Philip Vlummens, Laure Vincent, Guillaume Cartron, Ken Maes, Jerome Moreaux, Elke De Bruyne
Journal: Blood Advances
Blood Adv (2021) 5 (9): 2325–2338.
https://doi.org/10.1182/bloodadvances.2020003217
Published: 2021
Includes: Supplemental data
Journal Articles

LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBPα

Kensaku Kohrogi, Shinjiro Hino, Akihisa Sakamoto, Kotaro Anan, Ryuta Takase, Hirotaka Araki, Yuko Hino, Kazutaka Araki, Tetsuya Sato, Kimitoshi Nakamura, Mitsuyoshi Nakao
Journal: Blood Advances
Blood Adv (2021) 5 (9): 2305–2318.
https://doi.org/10.1182/bloodadvances.2020003521
Published: 2021
Includes: Supplemental data
Journal Articles

Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma

Christie P. M. Verkleij, Marloes E. C. Broekmans, Mark van Duin, Kristine A. Frerichs, Rowan Kuiper, A. Vera de Jonge, Martin Kaiser, Gareth Morgan, Amy Axel, Rengasamy Boominathan, Jocelyn Sendecki, Amy Wong, Raluca I. Verona, Pieter Sonneveld, Sonja Zweegman, Homer C. Adams, III, Tuna Mutis, Niels W. C. J. van de Donk
Journal: Blood Advances
Blood Adv (2021) 5 (8): 2196–2215.
https://doi.org/10.1182/bloodadvances.2020003805
Published: 2021
Includes: Supplemental data
Journal Articles

The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma

Brittany C. Lipchick, Adam Utley, Zhannan Han, Sudha Moparthy, Dong Hyun Yun, Anna Bianchi-Smiraglia, David W. Wolff, Emily Fink, Liang Liu, Cristina M. Furdui, Jingyun Lee, Kelvin P. Lee, Mikhail A. Nikiforov
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1933–1946.
https://doi.org/10.1182/bloodadvances.2020002578
Published: 2021
Includes: Supplemental data
Journal Articles

Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells

Elina Parri, Heikki Kuusanmäki, Daria Bulanova, Satu Mustjoki, Krister Wennerberg
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1862–1875.
https://doi.org/10.1182/bloodadvances.2020003300
Published: 2021
Includes: Supplemental data
Journal Articles

Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax

Blake S. Moses, Samantha McCullough, Jennifer M. Fox, Bryan T. Mott, Søren M. Bentzen, MinJung Kim, Jeffrey W. Tyner, Rena G. Lapidus, Ashkan Emadi, Michelle A. Rudek, Tami J. Kingsbury, Curt I. Civin
Journal: Blood Advances
Blood Adv (2021) 5 (3): 711–724.
https://doi.org/10.1182/bloodadvances.2020003429
Published: 2021
Includes: Supplemental data
Journal Articles

Adenylate kinase 2 expression and addiction in T-ALL

Nabih Maslah, Mehdi Latiri, Vahid Asnafi, Mélanie Féroul, Nawel Bedjaoui, Thomas Steimlé, Emmanuelle Six, Els Verhoyen, Elizabeth Macintyre, Chantal Lagresle-Peyrou, Ludovic Lhermitte, Guillaume P. Andrieu
Journal: Blood Advances
Blood Adv (2021) 5 (3): 700–710.
https://doi.org/10.1182/bloodadvances.2020002700
Published: 2021
Includes: Supplemental data
Journal Articles

Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

Kodandaram Pillarisetti, Gordon Powers, Leopoldo Luistro, Alexander Babich, Eric Baldwin, Yingzhe Li, Xiaochun Zhang, Mark Mendonça, Nate Majewski, Rupesh Nanjunda, Diana Chin, Kathryn Packman, Yusri Elsayed, Ricardo Attar, François Gaudet
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4538–4549.
https://doi.org/10.1182/bloodadvances.2020002393
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma

Neeraj Jain, Satishkumar Singh, Georgios Laliotis, Amber Hart, Elizabeth Muhowski, Kristyna Kupcova, Tereza Chrbolkova, Tamer Khashab, Sayan Mullick Chowdhury, Anuvrat Sircar, Fazal Shirazi, Ram Kumar Singh, Lapo Alinari, Jiangjiang Zhu, Ondrej Havranek, Philip Tsichlis, Jennifer Woyach, Robert Baiocchi, Felipe Samaniego, Lalit Sehgal
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4382–4392.
https://doi.org/10.1182/bloodadvances.2020001685
Published: 2020
Includes: Supplemental data
Journal Articles

Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734

Filippo Spriano, Eugenio Gaudio, Luciano Cascione, Chiara Tarantelli, Federica Melle, Giovanna Motta, Valdemar Priebe, Andrea Rinaldi, Gaetanina Golino, Afua Adjeiwaa Mensah, Luca Aresu, Emanuele Zucca, Stefano Pileri, Michael Witcher, Bill Brown, Claes Wahlestedt, Francis Giles, Anastasios Stathis, Francesco Bertoni
Journal: Blood Advances
Blood Adv (2020) 4 (17): 4124–4135.
https://doi.org/10.1182/bloodadvances.2020001879
Published: 2020
Includes: Supplemental data
Journal Articles

BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression

Thomas E. C. Cummin, Kerry L. Cox, Tom D. Murray, Anna H. Turaj, Lisa Dunning, Vikki L. English, Rachel Fell, Graham Packham, Yan Ma, Ben Powell, Peter W. M. Johnson, Mark S. Cragg, Matthew J. Carter
Journal: Blood Advances
Blood Adv (2020) 4 (14): 3316–3328.
https://doi.org/10.1182/bloodadvances.2020002231
Published: 2020
Includes: Supplemental data
Journal Articles

Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML

Molly C. Kingsley, Hongbo M. Xie, Bo-Rui Chen, Simone S. Riedel, Taylor Pastuer, Madelyn K. Bollig, Tyler Shank, Clara Libbrecht, Sally P. Stabler, Aniruddha J. Deshpande, Andrew M. Intlekofer, Kathrin M. Bernt
Journal: Blood Advances
Blood Adv (2020) 4 (13): 3109–3122.
https://doi.org/10.1182/bloodadvances.2020001922
Published: 2020
Includes: Supplemental data
Journal Articles

JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL

Sara Yumeen, Fatima N. Mirza, Julia M. Lewis, Amber Loren O. King, Sa Rang Kim, Kacie R. Carlson, Sheila R. Umlauf, Yulia V. Surovtseva, Francine M. Foss, Michael Girardi
Journal: Blood Advances
Blood Adv (2020) 4 (10): 2213–2226.
https://doi.org/10.1182/bloodadvances.2020001756
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting CD300f to enhance hematopoietic stem cell transplantation in acute myeloid leukemia

Edward Abadir, Pablo A. Silveira, Robin E. Gasiorowski, Murari Ramesh, Adelina Romano, Ahmed H. Mekkawy, Tsun-Ho Lo, Karieshma Kabani, Sarah Sutherland, Geoffrey A. Pietersz, P. Joy Ho, Christian E. Bryant, Stephen R. Larsen, Georgina J. Clark
Journal: Blood Advances
Blood Adv (2020) 4 (7): 1206–1216.
https://doi.org/10.1182/bloodadvances.2019001289
Published: 2020
Includes: Supplemental data