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Journal Articles

Development and characterization of prototypes for in vitro and in vivo mouse models of ibrutinib-resistant CLL

Burcu Aslan, Gorkem Kismali, Lisa S. Chen, LaKesla R. Iles, Mikhila Mahendra, Michael Peoples, Mihai Gagea, Natalie W. Fowlkes, Xiaofeng Zheng, Jing Wang, Christopher P. Vellano, Joseph R. Marszalek, Maria Teresa Sabrina Bertilaccio, Varsha Gandhi
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3134–3146.
https://doi.org/10.1182/bloodadvances.2020003821
Published: 2021
Includes: Supplemental data
Journal Articles

Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis

Derek C. H. Chan, Joshua Xu, Ana Vujovic, Nicholas Wong, Victor Gordon, Laura P. M. H. de Rooij, Steven Moreira, Cailin E. Joyce, Jose La Rose, María-José Sandí, Bradley W. Doble, Carl D. Novina, Robert K. Rottapel, Kristin J. Hope
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3120–3133.
https://doi.org/10.1182/bloodadvances.2020002539
Published: 2021
Includes: Supplemental data
Journal Articles

Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis

Kang Le, Jing Sun, Hunain Khawaja, Maho Shibata, Sanjay B. Maggirwar, Mitchell R. Smith, Mamta Gupta
Journal: Blood Advances
Blood Adv (2021) 5 (14): 2863–2878.
https://doi.org/10.1182/bloodadvances.2020003871
Published: 2021
Includes: Supplemental data
Journal Articles

Study of the antilymphoma activity of pracinostat reveals different sensitivities of DLBCL cells to HDAC inhibitors

Afua Adjeiwaa Mensah, Filippo Spriano, Giulio Sartori, Valdemar Priebe, Luciano Cascione, Eugenio Gaudio, Chiara Tarantelli, Elisa Civanelli, Luca Aresu, Andrea Rinaldi, Giovanna Damia, Emanuela Lovati, Emanuele Zucca, Anastasios Stathis, Claudio Pietra, Francesco Bertoni
Journal: Blood Advances
Blood Adv (2021) 5 (10): 2467–2480.
https://doi.org/10.1182/bloodadvances.2020003566
Published: 2021
Includes: Supplemental data
Journal Articles

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Clinical Trials & Observations
Alessandra Di Grande, Sofie Peirs, Paul D. Donovan, Maaike Van Trimpont, Julie Morscio, Beatrice Lintermans, Lindy Reunes, Niels Vandamme, Steven Goossens, Hien Anh Nguyen, Arnon Lavie, Richard B. Lock, Jochen H. M. Prehn, Pieter Van Vlierberghe, Triona Ní Chonghaile
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1963–1976.
https://doi.org/10.1182/bloodadvances.2021004177
Published: 2021
Includes: Supplemental data
Journal Articles

The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma

Brittany C. Lipchick, Adam Utley, Zhannan Han, Sudha Moparthy, Dong Hyun Yun, Anna Bianchi-Smiraglia, David W. Wolff, Emily Fink, Liang Liu, Cristina M. Furdui, Jingyun Lee, Kelvin P. Lee, Mikhail A. Nikiforov
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1933–1946.
https://doi.org/10.1182/bloodadvances.2020002578
Published: 2021
Includes: Supplemental data
Journal Articles

Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection

Mayumi Yoshimori, Haruna Shibayama, Ken-Ichi Imadome, Fuyuko Kawano, Ayaka Ohashi, Miwako Nishio, Norio Shimizu, Morito Kurata, Shigeyoshi Fujiwara, Ayako Arai
Journal: Blood Advances
Blood Adv (2021) 5 (7): 1805–1815.
https://doi.org/10.1182/bloodadvances.2020002417
Published: 2021
Includes: Supplemental data
Journal Articles

Genome-wide interference of ZNF423 with B-lineage transcriptional circuitries in acute lymphoblastic leukemia

Pablo Iglesias, Ann-Christin Puller, Marcos Seoane, Michael Spohn, Sabine Raasch, Marianne Klokow, Jürgen Müller, Lia Burkhardt, Daniela Indenbirken, Martin A. Horstmann
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1209–1223.
https://doi.org/10.1182/bloodadvances.2020001844
Published: 2021
Includes: Supplemental data
Journal Articles

Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax

Blake S. Moses, Samantha McCullough, Jennifer M. Fox, Bryan T. Mott, Søren M. Bentzen, MinJung Kim, Jeffrey W. Tyner, Rena G. Lapidus, Ashkan Emadi, Michelle A. Rudek, Tami J. Kingsbury, Curt I. Civin
Journal: Blood Advances
Blood Adv (2021) 5 (3): 711–724.
https://doi.org/10.1182/bloodadvances.2020003429
Published: 2021
Includes: Supplemental data
Journal Articles

Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

Kodandaram Pillarisetti, Gordon Powers, Leopoldo Luistro, Alexander Babich, Eric Baldwin, Yingzhe Li, Xiaochun Zhang, Mark Mendonça, Nate Majewski, Rupesh Nanjunda, Diana Chin, Kathryn Packman, Yusri Elsayed, Ricardo Attar, François Gaudet
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4538–4549.
https://doi.org/10.1182/bloodadvances.2020002393
Published: 2020
Includes: Supplemental data
Journal Articles

CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia

Anthony Quagliano, Anilkumar Gopalakrishnapillai, E. Anders Kolb, Sonali P. Barwe
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4393–4405.
https://doi.org/10.1182/bloodadvances.2020001592
Published: 2020
Includes: Supplemental data
Journal Articles

AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys

Rebecca L. Goldstein, Ana Goyos, Chi-Ming Li, Petra Deegen, Pamela Bogner, Alexander Sternjak, Oliver Thomas, Matthias Klinger, Joachim Wahl, Matthias Friedrich, Benno Rattel, Edwin Lamas, Xiaoshan Min, Athena Sudom, Mozhgan Farshbaf, Angela Coxon, Mercedesz Balazs, Tara Arvedson
Journal: Blood Advances
Blood Adv (2020) 4 (17): 4180–4194.
https://doi.org/10.1182/bloodadvances.2020002565
Published: 2020
Includes: Supplemental data
Journal Articles

Inflammation-driven activation of JAK/STAT signaling reversibly accelerates acute myeloid leukemia in vitro

Jan Habbel, Lucas Arnold, Yiyang Chen, Michael Möllmann, Kirsten Bruderek, Sven Brandau, Ulrich Dührsen, Maher Hanoun
Journal: Blood Advances
Blood Adv (2020) 4 (13): 3000–3010.
https://doi.org/10.1182/bloodadvances.2019001292
Published: 2020
Includes: Supplemental data
Journal Articles

Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice

Veronika Lysenko, Nicole Wildner-Verhey van Wijk, Kathrin Zimmermann, Marie-Christine Weller, Marco Bühler, Mattheus H. E. Wildschut, Patrick Schürch, Christine Fritz, Ulrich Wagner, Laura Calabresi, Bethan Psaila, Richard A. Flavell, Alessandro M. Vannucchi, Adam J. Mead, Peter J. Wild, Stefan Dirnhofer, Markus G. Manz, Alexandre P. A. Theocharides
Journal: Blood Advances
Blood Adv (2020) 4 (11): 2477–2488.
https://doi.org/10.1182/bloodadvances.2019001364
Published: 2020
Includes: Supplemental data
Journal Articles

Quizartinib-resistant FLT3 -ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736

Andrew S. Moore, Amir Faisal, Grace W. Y. Mak, Farideh Miraki-Moud, Vassilios Bavetsias, Melanie Valenti, Gary Box, Albert Hallsworth, Alexis de Haven Brandon, Cristina P. R. Xavier, Randal Stronge, Andrew D. J. Pearson, Julian Blagg, Florence I. Raynaud, Rajesh Chopra, Suzanne A. Eccles, David C. Taussig, Spiros Linardopoulos
Journal: Blood Advances
Blood Adv (2020) 4 (7): 1478–1491.
https://doi.org/10.1182/bloodadvances.2019000986
Published: 2020
Includes: Supplemental data
Journal Articles

Chimeric antigen receptor–T cells with cytokine neutralizing capacity

Adrian H. J. Tan, Natasha Vinanica, Dario Campana
Journal: Blood Advances
Blood Adv (2020) 4 (7): 1419–1431.
https://doi.org/10.1182/bloodadvances.2019001287
Published: 2020
Includes: Supplemental data
Journal Articles

High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy

Lynn H. Lee, Christa Krupski, Jason Clark, Mark Wunderlich, Robert B. Lorsbach, Michael S. Grimley, Matthew Burwinkel, Adam Nelson, Ashish R. Kumar
Journal: Blood Advances
Blood Adv (2020) 4 (4): 717–727.
https://doi.org/10.1182/bloodadvances.2019032367
Published: 2020
Includes: Supplemental data
Journal Articles

Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies

Melissa A. Fischer, Sharon Y. Friedlander, Maria P. Arrate, Hua Chang, Agnieszka E. Gorska, Londa D. Fuller, Haley E. Ramsey, Trinayan Kashyap, Christian Argueta, Sophie Debler, Michael Byrne, Matthew T. Villaume, Aaron C. Shaver, William Senapedis, Yosef Landesman, Erkan Baloglu, Sharon Shacham, Michael R. Savona
Journal: Blood Advances
Blood Adv (2020) 4 (3): 586–598.
https://doi.org/10.1182/bloodadvances.2019000359
Published: 2020
Includes: Supplemental data
Journal Articles

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A -rearranged leukemia

Sina Al-Kershi, Raj Bhayadia, Michelle Ng, Lonneke Verboon, Stephan Emmrich, Lucie Gack, Adrian Schwarzer, Till Strowig, Dirk Heckl, Jan-Henning Klusmann
Journal: Blood Advances
Blood Adv (2019) 3 (24): 4252–4263.
https://doi.org/10.1182/bloodadvances.2019032029
Published: 2019
Includes: Supplemental data
Journal Articles

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

Jean-Yves Métais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, Stephanie C. Fowler, Matthew M. Hsieh, Varun Katta, Sagar Keriwala, Cicera R. Lazzarotto, Kevin Luk, Michael D. Neel, S. Scott Perry, Samuel T. Peters, Shaina N. Porter, Byoung Y. Ryu, Akshay Sharma, Devlin Shea, John F. Tisdale, Naoya Uchida, Scot A. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, Shondra Pruett-Miller, Shengdar Q. Tsai, Mitchell J. Weiss
Journal: Blood Advances
Blood Adv (2019) 3 (21): 3379–3392.
https://doi.org/10.1182/bloodadvances.2019000820
Published: 2019
Includes: Supplemental data