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Volume 2, Issue 4
November 2025
In Progress
Blood Neoplasia Cover Image for Volume 2, Issue 4

Volume 2 Issue 4 | Blood Neoplasia | American Society of Hematology

BASIC MECHANISMS OF NEOPLASIA

Olfactory receptors as tumor suppressors in cutaneous T-cell lymphoma via p38γ pathway modulation
Xu Hannah Zhang,Hongzhi Li,Jack Hsiang,Chih-Hong Chen,Sangkil Nam,Henry Wong,Xiwei Wu,Weidong Hu,Jack Shively,Steven T. Rosen
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Azanucleoside treatment leads to B-cell precursor acute lymphoblastic leukemia
Vijay Negi,Ryan Bertoli,Olivia Tuckey,Yuelin Jack Zhu,Robert L. Walker,Michael J. Difilippantonio,James H. Doroshow,Paul S. Meltzer,Peter D. Aplan
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CLINICAL TRIALS AND OBSERVATIONS

Tagraxofusp, a CD123-targeted therapy, for chronic myelomonocytic leukemia: final results of a phase 1/2 study
Clinical Trials & Observations
Mrinal M. Patnaik,Haris Ali,Eunice S. Wang,Abdulraheem Yacoub,James M. Foran,Vikas Gupta,Gary J. Schiller,Don Ambrose Stevens,Moshe Talpaz,Sarah Wall,Terra L. Lasho,Abhishek A. Mangaonkar,Talha Badar,Ross Lindsay,Antonio Galleu,Ira Gupta,Naveen Pemmaraju,Guillermo Garcia-Manero
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Minimal residual disease measurement in blood by mass spectrometry identifies long-term responders in multiple myeloma
Clinical Trials & Observations
Tadeusz Kubicki,Benjamin A. Derman,Jennifer H. Cooperrider,Anna Puła,David Barnidge,Dominik Dytfeld,Ken Jiang,Andrzej J. Jakubowiak
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A phase 1 study of IO-202, an anti-LILRB4 antibody, in chronic myelomonocytic leukemia and acute myeloid leukemia
Clinical Trials & Observations
Ahmed Aribi,Gabriel N. Mannis,Yazan F. Madanat,Brian A. Jonas,Neil Dunavin,Gail J. Roboz,Deepa Jeyakumar,Guillermo Garcia-Manero,Hongtao Liu,Hetty E. Carraway,Jennifer N. Saultz,William Blum,Gary Schiller,Tao Huang,Paul Woodard,Barbara Klencke,X. Charlene Liao,Hong Xiang,Daniel A. Pollyea,Courtney D. DiNardo
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Final safety and efficacy results from a phase 1/2 study of tagraxofusp, a CD123-targeted therapy, for myelofibrosis
Clinical Trials & Observations
Abdulraheem Yacoub,Haris Ali,Vikas Gupta,Eunice S. Wang,Mrinal M. Patnaik,Gary J. Schiller,Minakshi Taparia,Tariq I. Mughal,Ross Lindsay,Antonio Galleu,Ira Gupta,Naveen Pemmaraju
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Analyses of transplantation outcomes for adult patients with mixed-phenotype acute leukemia
Clinical Trials & Observations
Tomoyasu Jo,Tadakazu Kondo,Shohei Mizuno,Shinichi Kako,Noriko Doki,Naoyuki Uchida,Masatsugu Tanaka,Tetsuya Nishida,Takahiro Fukuda,Masashi Sawa,Yoshinobu Kanda,Satoru Takada,Yuta Hasegawa,Yuta Katayama,Satoshi Yoshihara,Koji Kawamura,Marie Ohbiki,Yoshiko Atsuta,Masamitsu Yanada,Yasuyuki Arai
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MYELOID NEOPLASIA

A comparative assessment of molecular-based prognostic models in CMML
Luis E. Aguirre,Najla Al Ali,Somedeb Ball,Akriti G. Jain,David A. Sallman,Andrew T. Kuykendall,Alison R. Walker,Kendra Sweet,Jeffrey E. Lancet,Eric Padron,Rami S. Komrokji
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Targeting scavenger receptor class B type 1 with a bioinspired ligand induces apoptosis or ferroptosis in AML
Adam Y. Lin,Jonathan S. Rink,Eva Yang,Sara Small,Jessica J. Gerber,Taylor J. Zak,Jessica Altman,Yasmin Abaza,Leonidas C. Platanias,Leo I. Gordon,C. Shad Thaxton
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V-FAST: a phase 1b master trial to investigate CPX-351 combined with targeted agents in adults with newly diagnosed AML
Vinod A. Pullarkat,Mark Levis,James McCloskey,Gabriel N. Mannis,Stephen A. Strickland,Amir T. Fathi,Tara L. Lin,Vijaya R. Bhatt,Thuva Vanniyasingam,Divya Chakravarthy,Yana Lutska,Stefan Faderl,Ronald S. Cheung,Harry P. Erba
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Correlates of organ damage in patients with advanced systemic mastocytosis enrolled in clinical trials of avapritinib
Emily C. Liang,Cecelia Perkins,Rong Lu,Hongliang Shi,Saša Dimitrijević,Justin Abuel,Cheryl Langford,Parveen Abidi,Lenn Fechter,William Shomali,Jason Gotlib
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Intensive chemotherapy vs venetoclax/hypomethylating agents for patients aged 60 to 75 years with favorable, NPM1-mutated AML
Andrew D Zale,Venkata Preetam Sandeep Kaduluri,Jonathan A Webster,Mark J Levis,Ivana Gojo,Amy E DeZern,Gabriel Ghiaur,Lukasz P Gondek,William Brian Dalton,Theodoros Karantanos,Tania Jain,Gabrielle T Prince,Richard J Jones,B. Douglas Smith,Alexander J Ambinder
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Juvenile myelomonocytic leukemia stem cells are sensitive to NK cell–mediated lysis and express targetable antigens
Shannalee Martinez,Vladimir V. Senyukov,Suheyla Hasgur,Arianexys Aquino-López,Peter D. Emanuel,Y. Lucy Liu,Elliot Stieglitz,Gregory Behbehani,Amanda R. Campbell,Dean A. Lee
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Omacetaxine and venetoclax in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome with mutant RUNX1
Courtney D. DiNardo,Wei-Ying Jen,Guillermo Montalban-Bravo,Xuemei Wang,Sanam Loghavi,Sravanthi Lavu,Nicholas J. Short,Kelly Chien,Ghayas C. Issa,Naveen Pemmaraju,Musa Yilmaz,Michael Andreeff,Gautam Borthakur,Tapan M. Kadia,Naval G. Daver,Guillermo Garcia-Manero,Christopher P. Mill,Xiaoping Su,Warren Fiskus,Kapil N. Bhalla
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MNT: a new target for AML
Karla C. Fischer,Veronique Litalien,Sarah T. Diepstraten,Michelle Jahja,Fiona C. Brown,Gemma L. Kelly,Andrew H. Wei,Suzanne Cory
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Ivosidenib or venetoclax combined with hypomethylating agents in IDH1-mutated acute myeloid leukemia: a real-world study
Curtis A. Lachowiez,B. Douglas Smith,Alexander Joseph Ambinder,Gary Binder,Anne Angiolillo,Ravi Potluri,Eros Papademetriou,Thomas W. LeBlanc
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Second malignancies among older patients with classical myeloproliferative neoplasms treated with ruxolitinib
Rong Wang,Jessica M. Stempel,Rory M. Shallis,Scott F. Huntington,Amer M. Zeidan,Natalia Neparidze,Mengyang Di,Jan Philipp Bewersdorf,Lourdes Mendez,Xiaomei Ma,Nikolai A. Podoltsev
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Application of the International Working Group MDS molecular taxonomy classes to a single institution cohort
Rohiverth Guarecuco,Lisa Yuen,Maxwell Roth,Brandon J. Aubrey,Andrew M. Brunner,Robert P. Hasserjian
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Predicting secondary myeloid neoplasms in acquired aplastic anemia using machine learning models
Ahmet Celal Toprak,Mutlu Mete,Julia J. Shi,Daria V. Babushok,Carmelo Gurnari,Jaroslaw P. Maciejewski,Zoe Bass,Zehra Tombul,Carlos. I. A. Santos,Munevver N. Duran,Hussein Awada,Ibrahim Ibrahim,Alper Olcal,Yusuf Ozcan,Leslie Guerrero,Julio Alvarenga Thiebaud,Taha Bat
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REVIEW ARTICLE

Current landscape of frontline and relapsed follicular lymphoma trials
Lawrence Cheng Kiat Ng,Carla Casulo
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How to drug a leukemic stem cell: deciphering heterogeneity for better specificity
Alice Worker,Nicholas Jinks,Peter Woodmancy,Claire Seedhouse,Sophie G. Kellaway
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RESEARCH LETTER

Posttranscriptional activity of eIF4E contributes to HoxA9-driven leukemogenesis
Fang Zhou,Biljana Culjkovic-Kraljacic,Christian Bach,Li Feng,Yuta Mishima,Katherine L. B. Borden,Daniel G. Tenen
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Do all patients with chronic phase CML require a diagnostic bone marrow biopsy in the modern TKI era?
Noel F. T. Fong,David M. Ross,David T. Yeung,Timothy P. Hughes,Naranie Shanmuganathan
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Deferring treatment in hairy cell leukemia: is active surveillance safe?
Victoria M. Rogness,Xuefei Jia,Wei Wei,Brian T. Hill
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IgA or IgM MGUS less than 1.0 g/dL is at low risk of progression to neoplasm
Ashok P. Pai,Lue-Yen Tucker,David M. Baer
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Supplemental data
Three-year follow-up of low-dose, early-start gilteritinib maintenance in posttransplant patients with R/R FLT3mut AML
Clinical Trials & Observations
Toshiki Terao,Ken-ichi Matsuoka,Takumi Kondo,Yoshinobu Maeda
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Eμ-TCL1 mice with conditional human BCL2 knockin as novel B-cell lymphoma model for studying venetoclax effects in vivo
Ismini Halmer,Daniela Asslaber,Laura Beckmann,Gero Knittel,Hans Christian Reinhardt,Hamid Kashkar,Michael Hallek,Jens Löber,Björn Chapuy,Alexander Egle,Günter Krause,Alexandra da Palma Guerreiro,Lukas P. Frenzel
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SRSF2 mutations in CCUS, MDS and AML: a cross-entity study
Sandra Huber,Sarah Ochmann,Stephan Hutter,Veronika Ecker,Manja Meggendorfer,Gregor Hoermann,Torsten Haferlach,Claudia Haferlach,Isolde Summerer
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A prospective study of prophylactic dexamethasone with glofitamab in relapsed/refractory large B-cell lymphoma
J. Erika Haydu,Matthew M. Lei,Robert A. Redd,Jeffrey A. Barnes,Elijah P. Darnell,Ephraim P. Hochberg,P. Connor Johnson,Ronald W. Takvorian,James I. Weitzman,Elliot C. Woods,Tiffany L. Hurvitz,Courtney D. Lafranchi,Patricia Livingstone,Julia M. Lynch,Emily N. Patterson,Jack E. Malespini,Brianne M. McGree,Alexa O. Santilli,Katherine A. Thorp,Maryanne M. Sherburne,Lindsey B. Wardrop,Uvette Y. Lou,Mark N. Sorial,Catherine Cho,Josie Ford,Ronnie Nemac,Jacob D. Soumerai,Jeremy S. Abramson
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Neutrophil-mediated trogocytosis as a new mechanism of action of daratumumab
Mauro Lorenzo-Mohamed,Carla Vicario-Bueno,Andrea Díaz-Tejedor,Marta González-Rodríguez,Bárbara Castellanos,Janet Sotolongo-Ravelo,Laura San-Segundo,Lorena González-Méndez,Montserrat Martín-Sánchez,Mercedes Garayoa,Teresa Paíno
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A single nucleotide polymorphism in the TCL1A promoter is not protective in patients with germ line RUNX1-FPD
Clinical Trials & Observations
Amra Kajdic,Natalie T. Deuitch,Ana Catarina Menezes,Martha Kirby,Ursula Harper,Shawn Chong,Kathleen Craft,Joie Davis,Raman Sood,David J. Young,Erica Bresciani,Paul P. Liu
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Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling
Bernhard Zdársky,Sophie Edtmayer,Agnieszka Witalisz-Siepracka,Stefanie Weiss,Stefanie Boigenzahn,Kerstin Heindl,Safia Zahma,Balázs Győrffy,Richard Moriggl,Dagmar Stoiber
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Real-world analysis of polycythemia vera treatment reveals nonadherence to NCCN guidelines in a large proportion of patients
Ghaith Abu-Zeinah,Anthony M. Hunter,Joseph J. Shatzel,Abdulraheem Yacoub,Albert Qin,Hung-Lun Chien,Ruben A. Mesa
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T-cell immune profile changes predict durable response to nivolumab-rituximab in treatment-naïve FL
Rachel M. Koldej,Allison Barraclough,Huw Morgan,Sze Ting Lee,Nicholas Holzwart,Minu Koshy,Charmaine Smith,Geoffrey Chong,Michael Gilbertson,Colm Keane,Denise Lee,Leonid Churilov,David S. Ritchie,Eliza A. Hawkes
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Luspatercept treatment affects immune-regulatory subsets in patients with MDS with ring sideroblasts
Stefania Leone,Francesco Grimaldi,Mara Memoli,Giulia Scalia,Annamaria Vincenzi,Maria Di Perna,Giuseppe Cerciello,Antonio Vassallo,Fabrizio Pane,Alessandra Picardi,Giuseppe Terrazzano,Giuseppina Ruggiero,Flavia Carriero,Valentina Rubino
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Lymphoid Neoplasia

Shelter in place: live CLL cells inside the bone marrow fibroblasts and its implication in residual disease persistence
Pin Lu,Carrie A Franzen,Aldana Vistarop,Andrey Efimov,SK Abrar Shahriyar,Shengchun Wang,Shilpa Rao,Marcus Messmer,Shazia Nakhoda,Edna Cukierman,Shuo Ma,Janusz Franco-Barraza,Juehua Gao,Y. Lynn Wang
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Targeting CDK9 inhibits the growth of KMT2A-rearranged infant leukemia and demonstrates synergy with menin inhibition
Ritul Sharma,Chunfen Zhang,Ravi Shah,Melanie M. Frigault,Amy J. Johnson,David Spencer Mangum,Luke D. Maese,Norman J. Lacayo,Aru Narendran
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Hypertension in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma in ALPINE: a secondary analysis
June-Wha Rhee,Nicole Lamanna,Wassim Aldairy,Lipeng Chen,Jun Zhang,Dulce Ramirez,William B. White
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Orally available decitabine prodrug OR-2100 induces mitotic perturbation for the treatment of double-hit lymphoma
Keisuke Kidoguchi,Hiroshi Ureshino,Yuta Yamamoto,Ryo Yanagiya,Yuki Kurahashi,Yuki Fukuda-Kurahasi,Yumeka Mine,Shigehisa Aoki,Kazutaka Nakashima,Hiroaki Miyoshi,Koichi Ohshima,Atsushi Kawaguchi,Shinya Kimura
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Bendamustine switches TNF receptor superfamily signal from a survival to a death signal in B-cell lymphomas
Kensuke Nakao,Hiroshi Arima,Yui Arakawa,Tomoyasu Jo,Yujuan Guo,Iroha Morita,Tomohiro Taya,Toshio Kitawaki,Akifumi Takaori-Kondo,Momoko Nishikori
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Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia
Evelyn H. Orlando,Patrick Gould,Brian Cuzzo,Maegan Ford,Yuxuan Chen,Alexander Sanjurjo,Saagar Jain,Benjamin May,Demetra Tsapepas,Rebecca J. Leeman-Neill,Govind Bhagat,Geoffrey K. Dube,Heather Morris,Selim Arcasoy,Farhana Latif,Ersilia M. DeFilippis,Mercedes Martinez,Gene Y. Im,Meaghan M. Phipps,Marcus R. Pereira,Paul K. Sue,Manuela Orjuela-Grimm,Andrew H. Lipsky,Ahmed Sawas,Ran Reshef,Barbara Pro,Hua-Jay J. Cherng,Jennifer E. Amengual
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Inferior survival in double refractory large B-cell lymphoma eligible for third-line CD19 CAR T-cell therapy
Chathuri Abeyakoon,Sita Bhella,Katrina Hueniken,Rachel Aitken,Carmel Waldron,Anca Prica,Vishal Kukreti,Robert Kridel,Abi Vijenthira,Christine Chen,Chloe Yang,Richard Tsang,David Hodgson,Danielle Rodin,Nauman Malik,Woodrow Wells,Michael Crump,John Kuruvilla
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TRANSLATIONAL RESEARCH

B-cell–specific Wwox deletion promotes plasmablastic tumor development and proinflammatory signatures in myeloma model
Tabish Hussain,Matthew D. Bramble,Bin Liu,Martin C. Abba,Marta Chesi,C. Marcelo Aldaz
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Disparities in real-world treatment patterns of hypomethylating agents among patients with MDS in the United States
Sudipto Mukherjee,Weichuan Dong,Aaron T. Gerds,Hetty E. Carraway,Abhay Singh,Anjali S. Advani,Moaath K. Mustafa Ali,John C. Molina,Sophia Balderman,Akriti Jain,Paolo Caimi,Faiz Anwer,Mikkael A. Sekeres,Siran M. Koroukian
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