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Letter to Blood| December 14, 2023

Epidemiology and geographic clustering of Erdheim-Chester disease in Italy and France

Clinical Trials & Observations

Francesco Peyronel,

Francesco Peyronel

1Nephrology and Dialysis Unit, Meyer Children’s University Hospital—Istituto di Ricovero e Cura a Carattere Scientifico, Florence, Italy

2Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

https://orcid.org/0000-0001-8470-1952

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Julien Haroche,

Julien Haroche

3Sorbonne University, Assistance Publique—Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Internal Medicine Department 2, French National Referral Center for Rare Systemic Diseases and Histiocytoses, Centre d’immunologie et des maladies infectieuses (Cimi INSERM Unité Mixte de Recherche Scientifique—1135), Paris, France

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Corrado Campochiaro,

Corrado Campochiaro

4Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy

5Vita-Salute San Raffaele University, Milan, Italy

https://orcid.org/0000-0001-6806-3794

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Francesco Pegoraro,

Francesco Pegoraro

6Department of Health Science, University of Florence, Florence, Italy

https://orcid.org/0000-0002-4954-5744

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Zahir Amoura,

Zahir Amoura

3Sorbonne University, Assistance Publique—Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Internal Medicine Department 2, French National Referral Center for Rare Systemic Diseases and Histiocytoses, Centre d’immunologie et des maladies infectieuses (Cimi INSERM Unité Mixte de Recherche Scientifique—1135), Paris, France

https://orcid.org/0000-0003-0292-9043

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Alessandro Tomelleri,

Alessandro Tomelleri

4Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy

5Vita-Salute San Raffaele University, Milan, Italy

https://orcid.org/0000-0002-5440-2078

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Martina Mazzariol,

Martina Mazzariol

7Department of Medical Sciences, University of Turin, Turin, Italy

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Matthias Papo,

Matthias Papo

3Sorbonne University, Assistance Publique—Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Internal Medicine Department 2, French National Referral Center for Rare Systemic Diseases and Histiocytoses, Centre d’immunologie et des maladies infectieuses (Cimi INSERM Unité Mixte de Recherche Scientifique—1135), Paris, France

https://orcid.org/0000-0003-3389-9473

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Giulio Cavalli,

Giulio Cavalli

4Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy

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Giuseppe D. Benigno,

Giuseppe D. Benigno

8Renal Unit, Parma University Hospital, Parma, Italy

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Paride Fenaroli,

Paride Fenaroli

9Nephrology and Dialysis Unit, Azienda Unità Sanitaria Locale—Istituto di Ricovero e Cura a Carattere Scientifico Reggio Emilia, Reggio Emilia, Italy

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Chrysanthos Grigoratos,

Chrysanthos Grigoratos

10Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy

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Maria C. Mengoli,

Maria C. Mengoli

11Operative Unit of Pathology, Azienda Unità Sanitaria Locale—Istituto di Ricovero e Cura a Carattere Scientifico Reggio Emilia, Reggio Emilia, Italy

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Arturo Bonometti,

Arturo Bonometti

12Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Humanitas Clinical and Research Hospital, Rozzano, Italy

13Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy

https://orcid.org/0000-0003-3258-0727

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Emilio Berti,

Emilio Berti

14Dermatology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

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Gustavo Savino,

Gustavo Savino

15Ocular Oncology Unit, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

16Università Cattolica del Sacro Cuore, UCSC, Rome, Italy

https://orcid.org/0000-0002-9993-5986

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Mauro Cives,

Mauro Cives

17Division of Medical Oncology, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy

18Department of Interdisciplinary Medicine, University of Bari “Aldo Moro,” Bari, Italy

https://orcid.org/0000-0002-3013-1816

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Iria Neri,

Iria Neri

19Dermatology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy

https://orcid.org/0000-0002-8552-0771

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Gaetano Pacinella,

Gaetano Pacinella

20Internal Medicine and Stroke Care Ward, Department of Promoting Health, Maternal-Infant, Excellence and Internal and Specialized Medicine G. D’Alessandro, University of Palermo, Palermo, Italy

https://orcid.org/0000-0001-6135-3721

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Antonino Tuttolomondo,

Antonino Tuttolomondo

20Internal Medicine and Stroke Care Ward, Department of Promoting Health, Maternal-Infant, Excellence and Internal and Specialized Medicine G. D’Alessandro, University of Palermo, Palermo, Italy

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Massimo Marano,

Massimo Marano

21Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy

22Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy

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Francesco Muratore,

Francesco Muratore

23Rheumatology Unit, Azienda Unità Sanitaria Locale—Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, University of Modena and Reggio Emilia, Reggio Emilia, Italy

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Andreina Manfredi,

Andreina Manfredi

24Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Policlinico of Modena, Modena, Italy

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Alessandro Broccoli,

Alessandro Broccoli

25Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia “Seràgnoli”, Bologna, Italy

26Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy

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Pier L. Zinzani,

Pier L. Zinzani

25Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia “Seràgnoli”, Bologna, Italy

26Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy

https://orcid.org/0000-0002-2112-2651

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Biagio Didona,

Biagio Didona

27Istituto Dermopatico dell'Immacolata—Istituto di Ricovero e Cura a Carattere Scientifico Rare Disease Center, Rome, Italy

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Chiara Massaccesi,

Chiara Massaccesi

28Pulmonology Unit, “C. & G. Mazzoni” Hospital, Ascoli Piceno, Italy

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Andrea Buono,

Andrea Buono

29De Gasperis Cardio Center, Transplant Center, Niguarda Hospital, Milan, Italy

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Enrico Ammirati,

Enrico Ammirati

29De Gasperis Cardio Center, Transplant Center, Niguarda Hospital, Milan, Italy

30Department of Health Sciences, University of Milan-Bicocca, Monza, Italy

https://orcid.org/0000-0002-1676-5257

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Vito Di Lernia,

Vito Di Lernia

31Dermatology Unit, S. Maria Nuova, Azienda Unità Sanitaria Locale—Istituto di Ricovero e Cura a Carattere Scientifico Reggio Emilia, Italy

https://orcid.org/0000-0002-8961-7108

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Lorenzo Dagna,

Lorenzo Dagna

4Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy

5Vita-Salute San Raffaele University, Milan, Italy

https://orcid.org/0000-0002-7428-315X

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Augusto Vaglio,

Augusto Vaglio

1Nephrology and Dialysis Unit, Meyer Children’s University Hospital—Istituto di Ricovero e Cura a Carattere Scientifico, Florence, Italy

32Department of Biomedical, Experimental and Clinical Sciences “Mario Serio,” University of Florence, Florence, Italy

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Fleur Cohen-Aubart

Fleur Cohen-Aubart

3Sorbonne University, Assistance Publique—Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Internal Medicine Department 2, French National Referral Center for Rare Systemic Diseases and Histiocytoses, Centre d’immunologie et des maladies infectieuses (Cimi INSERM Unité Mixte de Recherche Scientifique—1135), Paris, France

https://orcid.org/0000-0002-7610-4995

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Blood (2023) 142 (24): 2119–2123.

https://doi.org/10.1182/blood.2023021670

Article history

Submitted:

June 29, 2023

Accepted:

September 24, 2023

First Edition:

October 23, 2023

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Citation

Francesco Peyronel, Julien Haroche, Corrado Campochiaro, Francesco Pegoraro, Zahir Amoura, Alessandro Tomelleri, Martina Mazzariol, Matthias Papo, Giulio Cavalli, Giuseppe D. Benigno, Paride Fenaroli, Chrysanthos Grigoratos, Maria C. Mengoli, Arturo Bonometti, Emilio Berti, Gustavo Savino, Mauro Cives, Iria Neri, Gaetano Pacinella, Antonino Tuttolomondo, Massimo Marano, Francesco Muratore, Andreina Manfredi, Alessandro Broccoli, Pier L. Zinzani, Biagio Didona, Chiara Massaccesi, Andrea Buono, Enrico Ammirati, Vito Di Lernia, Lorenzo Dagna, Augusto Vaglio, Fleur Cohen-Aubart; Epidemiology and geographic clustering of Erdheim-Chester disease in Italy and France. Blood 2023; 142 (24): 2119–2123. doi: https://doi.org/10.1182/blood.2023021670

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Abstract

This geoepidemiological study, performed in Italy and France, shows that Erdheim-Chester disease is increasingly diagnosed and cases cluster in specific geographic areas, namely southern Italy and central France. Disease frequency inversely correlates with the Human Development Index.

Subjects:

Clinical Trials and Observations, Myeloid Neoplasia

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© 2023 by The American Society of Hematology

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December 14 2023

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