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Journal Articles

Defective neutrophil clearance in JAK2 V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24

Available to Purchase
Eman Khatib-Massalha, Christian A. Di Buduo, Agathe L. Chédeville, Ya-Hsuan Ho, Yexuan Zhu, Elodie Grockowiak, Yuki Date, Lam T. Khuat, Zijian Fang, José Quesada-Salas, Eva Carrillo Félez, Matteo Migliavacca, Isabel Montero, José A. Pérez-Simón, Alessandra Balduini, Simón Méndez-Ferrer
Journal: Blood
Blood (2025) 146 (6): 717–731.
https://doi.org/10.1182/blood.2024027455
Published: 2025
Includes: Supplemental data
Journal Articles

Atypical cytoplasmic inclusions and erythrophagocytosis in acute myeloid leukemia with KMT2A :: MLLT3 and U2AF1 mutation

Free
Shuying Chen, Zhijian Xiao
Journal: Blood
Blood (2025) 146 (6): 765.
https://doi.org/10.1182/blood.2025029617
Published: 2025
Journal Articles

Induction chemotherapy and molecular MRD influence outcomes in KMT2A-rearranged AML

Available to Purchase
Jad Othman, Nicola Potter, Sylvie D Freeman, Nicholas McCarthy, Jelena Jovanovic, Manohursingh Runglall, Joanna Canham, Ian Thomas, Sean Johnson, Amanda Frances Gilkes, James Durrell Cavenagh, Panagiotis Kottaridis, David C Taussig, Claire Arnold, Claire Jane Hemmaway, Dr, Dominic Culligan, Ulrik Malthe Overgaard, Mike Dennis, Alan K Burnett, Nigel H. Russell, Richard James Dillon
Journal: Blood
Blood blood.2025029556.
https://doi.org/10.1182/blood.2025029556
Published: 2025
Includes: Supplemental data
Journal Articles

How I Manage Chronic Myeloid Leukemia During Pregnancy

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Elisabetta Abruzzese, Ekaterina Chelysheva
Journal: Blood
Blood blood.2024026513.
https://doi.org/10.1182/blood.2024026513
Published: 2025
Journal Articles

A precision medicine approach to the myelodysplastic syndrome with isolated deletion 5q 50 years after its discovery

Free
Marco Roncador, Elsa Bernard, Robert P Hasserjian, Jacqueline Boultwood, Chiara Elena, Anna Galli, Carmelo Gurnari, Cristina Mecucci, Lucienne Michaux, Moshe Mittelman, Martina Sarchi, Erica Travaglino, Donal P McLornan, Seishi Ogawa, Elli Papaemmanuil, Eva S Hellstrom-Lindberg, Luca Malcovati, Mario Cazzola
Journal: Blood
Blood blood.2025028619.
https://doi.org/10.1182/blood.2025028619
Published: 2025
Includes: Supplemental data
Journal Articles

Disrupting tRNA modifications to target mitochondrial vulnerabilities in drug-resistant leukemia cells

Open Access
Cornelius Pauli, Michael Kienhöfer, Maximilian Felix Blank, Oguzhan Begik, Christian Rohde, Sarah MN Zimmermann, Laura Werner, Daniel Heid, Fu Xu, Katharina Weidenauer, Sylvain Delaunay, Nadja Krall, Katrin Trunk, Duoduo Zhao, Fengbiao Zhou, Laia Llovera, Ollivier Alexane, Anke Heit-Mondrzyk, Uwe Platzbecker, Claudia D. Baldus, Hubert Serve, Martin Bornhäuser, Cathrine B Vågbø, Salvador Aznar Benitah, Jeroen Krijgsveld, Eva Maria Novoa, Carsten Müller-Tidow, Michaela Frye
Journal: Blood
Blood blood.2024027822.
https://doi.org/10.1182/blood.2024027822
Published: 2025
Includes: Supplemental data
Journal Articles

Magrolimab plus azacitidine vs physician’s choice for untreated TP53 -mutated acute myeloid leukemia: the ENHANCE-2 study

Open Access
Clinical Trials & Observations
Joshua F. Zeidner, David A. Sallman, Christian Récher, Naval G. Daver, Anskar Y. H. Leung, Devendra K. Hiwase, Marion Subklewe, Thomas Pabst, Pau Montesinos, Richard A. Larson, Lindsay Wilde, Anoop K. Enjeti, Ichiro Kawashima, Cristina Papayannidis, Jenny O’Nions, Lisa Johnson, Mei Dong, Julie Huang, Taravat Bagheri, Gal Hacohen Kleiman, Calvin Lee, Paresh Vyas
Journal: Blood
Blood (2025) 146 (5): 590–600.
https://doi.org/10.1182/blood.2024027408
Published: 2025
Includes: Supplemental data
Journal Articles

The ENHANCE-3 study: venetoclax and azacitidine plus magrolimab or placebo for untreated AML unfit for intensive therapy

Open Access
Clinical Trials & Observations
Naval Daver, Paresh Vyas, Gerwin Huls, Hartmut Döhner, Sébastien Maury, Jan Novak, Cristina Papayannidis, Carmen Martínez Chamorro, Pau Montesinos, Rabin Niroula, Pierre Fenaux, Jordi Esteve, Shang-Ju Wu, Adrien De Voeght, Jiri Mayer, Peter J. M. Valk, Lisa Johnson, Mei Dong, Ke Liu, Sowmya Kuwahara, Kenneth Caldwell, Guru Subramanian Guru Murthy
Journal: Blood
Blood (2025) 146 (5): 601–611.
https://doi.org/10.1182/blood.2024027506
Published: 2025
Includes: Supplemental data
Journal Articles

XPO1 Drives Resistance to Eprenetapopt and Azacitidine and Can Be Targeted in TP53-Mutated Myeloid Malignancies

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Traci L Kruer, Ariel Quintana-Gonzalez, Hannah L Newman, Meghan C. Ferrall-Fairbanks, Ling Zhang, Amy F McLemore, Surendra Neupane, Qin Yang, Nana Adjoa Ben-Crentsil, Maria E. Balasis, Christopher T Letson, Rami S Komrokji, Sana Chaudhry, Tulasigeri M Totiger, Joshua A Traina, Maria E Figueroa, Christopher B Ryder, Thomas Cluzeau, Justin Taylor, David A Sallman, Eric Padron
Journal: Blood
Blood blood.2025028803.
https://doi.org/10.1182/blood.2025028803
Published: 2025
Includes: Supplemental data
Journal Articles

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome

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Paul Breillat, Francesco Carbone, Emilie Lereclus, Quentin Riller, Thibaut d'Izarny-Gargas, Celine Posseme, Marie Templé, Lin-Pierre Zhao, Marine Luka, Estibaliz Lazaro, Pr, Roderau Outh, Guillaume Le Guenno, Francois Lifermann, Yannick Dieudonné, Marie Berleur, Cédric Lenormand, Karl Balabanian, Thierry Weitten, Vivien Guillotin, Marie Kostine, Barbara Burroni, Adrien Bigot, Alexandra Audemard-Verger, Aldric Manuel, Antoine Dossier, Cécile Golden, Jean-Philippe Martellosio, Benoit Faucher, Benjamin De Sainte Marie, Nadine Magy-Bertrand, Valentin Lacombe, Stéphane Vinzio, Sylvie Grosleron, Léa Dionet, Pierre-Louis Tharaux, Darragh Duffy, Mickaël Mathieu Ménager, Nicolas Dulphy, Olivier Kosmider, Benjamin Terrier
Journal: Blood
Blood blood.2024028216.
https://doi.org/10.1182/blood.2024028216
Published: 2025
Includes: Supplemental data
Journal Articles

Time to complete remission is an independent determinant of survival after intensive chemotherapy in AML

Available to Purchase
Rithin Nedumannil, Michael Ashby, James P Rowland, Dr, Jacques A J Malherbe, Jared Fairbank, Kelli Gray, Sun Loo, Matthew Wright, John Reynolds, Devendra K. Hiwase, Paula Marlton, Shaun A Fleming, Ashish Bajel, Andrew H Wei
Journal: Blood
Blood blood.2025028594.
https://doi.org/10.1182/blood.2025028594
Published: 2025
Includes: Supplemental data
Journal Articles

A clinical guide to TP53 mutations in myeloid neoplasms

Available to Purchase
Samuel Urrutia, Terrence N Wong, Daniel C. Link
Journal: Blood
Blood blood.2025029691.
https://doi.org/10.1182/blood.2025029691
Published: 2025
Journal Articles

HiJAKing the Hematopoietic System: A Low-Frequency JAK2V617F Clone Drives Myeloproliferative Neoplasm Pathology

Open Access
Dennis M Bonal, Alissa Oakes, Anna Chorzalska, Makayla Pardo, Max Petersen, Michael Yeh Clarke, Seo-Ho Lee, Adam J Olszewski, Diana Olguta Treaba, John L Reagan, Mark S Dooner, John Morgan, Paul Bertone, Ting Zhao, Wentian Yang, Corey E. Ventetuolo, Gabriela S Hobbs, Joslyn Mills, Patrycja M. Dubielecka
Journal: Blood
Blood blood.2024027125.
https://doi.org/10.1182/blood.2024027125
Published: 2025
Includes: Supplemental data
Journal Articles

Delineating Mpl -dependent and -independent phenotypes of Jak2 V617F–positive MPNs in vivo

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Nicolas Papadopoulos, Audrey Nédélec, Yacine Rahmani, Hosuk Ryou, Jean-Philippe Defour, Jens Rittscher, Daniel Royston, Stefan N. Constantinescu
Journal: Blood
Blood (2025) 146 (4): 482–495.
https://doi.org/10.1182/blood.2024026711
Published: 2025
Includes: Supplemental data
Journal Articles

Preclinical characterization of TGRX-678, a brain-penetrant allosteric inhibitor of BCR::ABL1

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Yanxia Shi, Qian Jiang, Linxin Li, Yingying Zuo, Shuzhen Jiang, Tingting Yan, Cuifang Zheng, Shuo Zhang, Nannan Yu, Jingrong Cao, Yun Liu, Yixin Ai, Yihan Wang
Journal: Blood
Blood blood.2025028539.
https://doi.org/10.1182/blood.2025028539
Published: 2025
Includes: Supplemental data
Journal Articles

Fusion Oncoproteins and Cooperating Mutations Define Disease Phenotypes in NUP98-Rearranged Leukemia

Open Access
Masayuki Umeda, Ryan Lea Hiltenbrand, Nicole L Michmerhuizen, Juan M Barajas, Melvin E Thomas, III, Bright Arthur, Michael P Walsh, Guangchun Song, Jing J. Ma, Tamara Westover, Amit Kumar, Petri Pölönen, Cristina Mecucci, Danika Di Giacomo, Franco Locatelli, Riccardo Masetti, Salvatore Nicola Bertuccio, Martina Pigazzi, Shondra M Pruett-Miller, Stanley B Pounds, Jeffrey Rubnitz, Hiroto Inaba, Kyriakos P Papadopoulos, Michael J Wick, Ilaria Iacobucci, Charles G. Mullighan, Jeffery M Klco
Journal: Blood
Blood blood.2025028993.
https://doi.org/10.1182/blood.2025028993
Published: 2025
Includes: Supplemental data
Journal Articles

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2 -mutated post-MPN AML

Open Access
Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P. Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J. Mead, Raajit K. Rampal, Jeffrey W. Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2025) 146 (3): 341–355.
https://doi.org/10.1182/blood.2024027117
Published: 2025
Includes: Supplemental data
Journal Articles

Redefining risk stratification in pLCH

Free
Jithma P. Abeykoon, W. Oliver Tobin
Journal: Blood
Blood (2025) 146 (2): 136–138.
https://doi.org/10.1182/blood.2025029134
Published: 2025
Journal Articles

BRAF V600E -positive mononuclear cells in blood at diagnosis portend treatment failure and neurodegeneration in pediatric LCH

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Howard Lin, Akanksha Batajoo, Erin Peckham-Gregory, Daniel Zinn, Olive S. Eckstein, Nader Kim El-Mallawany, Nitya Gulati, Zachary D. Prudowsky, Brooks Scull, Jessica Velazquez, Harshal Abhyankar, Stephen J. Simko, Daria Vakula, Ryan Fleischmann, Vivekanudeep Karri, M. John Hicks, Kevin E. Fisher, Choladda V. Curry, Angshumoy Roy, Deborah Schiff, Kenneth M. Heym, Michael E. Scheurer, D. Williams Parsons, Miriam Merad, Tsz-Kwong Man, Kenneth L. McClain, Jennifer Picarsic, Carl E. Allen
Journal: Blood
Blood (2025) 146 (2): 206–218.
https://doi.org/10.1182/blood.2024026671
Published: 2025
Includes: Supplemental data
Journal Articles

Therapy-related juvenile myelomonocytic leukemia

Free
Ahmed Mohamed, Aida I. Richardson
Journal: Blood
Blood (2025) 146 (1): 127.
https://doi.org/10.1182/blood.2025028952
Published: 2025