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Journal Articles

Venetoclax plus gilteritinib is effective in preclinical models of FLT3 -mutant BCL11B-a lineage-ambiguous leukemia

Available to Purchase
Brief Report
Lindsey E. Montefiori, Ilaria Iacobucci, Qingsong Gao, Jamila Moore, William C. Wright, Huimei Wei, Pradyumna Baviskar, Surbhi Sona, Hongjian Jin, Amit Budhraja, Josi Lott, Qi Zhang Tatarata, Zhongshan Cheng, Tanya Khan, Emily A. Backhaus Wagner, Melissa Johnson, Cyrus M. Mehr, Burgess Freeman, Laura Janke, Torsten Haferlach, Paul Geeleher, Paul E. Mead, Marina Konopleva, Joseph T. Opferman, Charles G. Mullighan
Journal: Blood
Blood (2025) 146 (19): 2350–2356.
https://doi.org/10.1182/blood.2025028985
Published: 2025
Includes: Supplemental data
Journal Articles

Disease risk but not remission status determines transplant outcomes in AML: long-term outcomes of the ASAP trial

Open Access
Clinical Trials & Observations
Matthias Stelljes, Jan Moritz Middeke, Gesine Bug, Eva-Maria Wagner-Drouet, Lutz P. Müller, Christoph Schmid, Stefan W. Krause, Wolfgang Bethge, Edgar Jost, Uwe Platzbecker, Stefan A. Klein, Judith Niederland, Martin Kaufmann, Kerstin Schäfer-Eckart, Henning Baldauf, Friedrich Stölzel, Sarah Trost, Christoph Röllig, Malte von Bonin, Katharina Egger-Heidrich, Desiree Kunadt, Björn Steffen, Beate Hauptrock, Christoph Schliemann, Katja Sockel, Fabian Lang, Oliver Kriege, Judith Schaffrath, Christian Reicherts, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Alexander H. Schmidt, Jan-Henrik Mikesch, Martin Bornhäuser, Johannes Schetelig
Journal: Blood
Blood (2025) 146 (19): 2293–2305.
https://doi.org/10.1182/blood.2025028730
Published: 2025
Includes: Supplemental data
Journal Articles

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

Available to Purchase
Sven Turkalj, Felix A. Radtke, Bilyana Stoilova, Rabea Mecklenbrauck, Angus J. Groom, Niels Asger Jakobsen, Curtis A. Lachowiez, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Zhihong Zeng, Sanam Loghavi, Jennifer Marvin-Peek, Verena Körber, Farhad Ravandi, Ghayas C. Issa, Tapan M. Kadia, Vasiliki Symeonidou, Anne P. de Groot, Hagop M Kantarjian, Koichi Takahashi, Marina Konopleva, Courtney D. DiNardo, Paresh Vyas
Journal: Blood
Blood blood.2024027948.
https://doi.org/10.1182/blood.2024027948
Published: 2025
Includes: Supplemental data
Journal Articles

Guanine nucleotides drive ribosome biogenesis and glycolytic reprogramming in acute myeloid leukemia stem cells

Open Access
Gentaro Kawano, Riichiro Ikeda, Daisuke Ishihara, Takahiro Shima, Teppei Sakoda, Shunsuke Yamamoto, Yu Kochi, Yuichiro Semba, Sanae Ashitani, Yasuo Mori, Koji Kato, Takahiro Maeda, Toshihiro Miyamoto, Tomoyoshi Soga, Koichi Akashi, Yoshikane Kikushige
Journal: Blood
Blood blood.2025030209.
https://doi.org/10.1182/blood.2025030209
Published: 2025
Includes: Supplemental data
Journal Articles

A clinical guide to TP53 mutations in myeloid neoplasms

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Samuel Urrutia, Terrence N. Wong, Daniel C. Link
Journal: Blood
Blood (2025) 146 (18): 2157–2167.
https://doi.org/10.1182/blood.2025029691
Published: 2025
Journal Articles

XPO1 drives resistance to eprenetapopt and azacitidine and can be targeted in TP53 -mutated myeloid malignancies

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Traci L. Kruer, Ariel Quintana, Hannah Newman, Meghan Ferrall-Fairbanks, Ling Zhang, Amy McLemore, Surendra Neupane, Qin Yang, Nana Adjoa Ben-Crentsil, Maria E. Balasis, Christopher Letson, Rami Komrokji, Sana Chaudhry, Tulasigeri M. Totiger, Joshua Traina, Maria E. Figueroa, Christopher B. Ryder, Thomas Cluzeau, Justin Taylor, David A. Sallman, Eric Padron
Journal: Blood
Blood (2025) 146 (18): 2244–2258.
https://doi.org/10.1182/blood.2025028803
Published: 2025
Includes: Supplemental data
Journal Articles

Epidemiology, clinical features, and molecular basis of TTMV :: RARA -driven acute promyelocytic leukemia

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Xiaosu Zhou, Jiaqi Chen, Yan-Lai Tang, Haibo Sun, Qihui Chen, Xue Chen, Yang Zhang, Jiancheng Fang, Panxiang Cao, Xiaoli Ma, Li Chen, Yangyang Xie, Lijun Wen, Li-Bin Huang, Zhong Fan, Jiacheng Lou, Wenning Xu, Nan Zhang, Jing Li, Yu Luo, Yan Dai, Huan Du, Kun Yang, Zhixu He, Xiaoyan Yang, Linya Wang, Bing Liu, Danna Lin, Yajie Zhang, Fang Xu, Min Zhang, Yang Wang, Shu Yan, Hua Nan, Jing Zhang, Li Xu, Xiujuan Ma, Ruijie Tang, Fang Wang, Lili Yuan, Ming Liu, Lei Wang, Qisheng Wu, Lina Zhang, Siyuan Liu, Chengcheng Yan, Jianfeng Zhou, Fanyong Lyu, Ping Wu, Tong Wang, Xian Zhang, Yue Lu, Deyan Liu, Junfang Yang, Min Xiong, Yanli Zhao, Gaowei Fan, Xia Xiao, Futian Ma, Lihua Yang, Xue-Qun Luo, Junmin Li, Shuhong Shen, Huyong Zheng, Suning Chen, Hongwei Chen, Jianhong Zhao, Zhanglin Zhang, Kankan Wang, Peihua Lu, Hongxing Liu
Journal: Blood
Blood (2025) 146 (18): 2229–2243.
https://doi.org/10.1182/blood.2025028674
Published: 2025
Includes: Supplemental data
Journal Articles

The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia

Open Access
Yuichiro Semba, Takuji Yamauchi, Daniel E. Bauer, Seishi Ogawa, Koichi Akashi, Takahiro Maeda
Journal: Blood
Blood blood.2025028918.
https://doi.org/10.1182/blood.2025028918
Published: 2025
Includes: Supplemental data
Journal Articles

Multiselective RAS(ON) inhibition targets oncogenic RAS and overcomes RAS-mediated resistance to FLT3i and BCL2i in AML

Open Access
Bogdan Popescu, Matthew F Jones, Madison Piao, Elaine Tran, Andrew Koh, Isabelle Lomeli, Cheryl A. C. Peretz, Natalia Murad, Sydney Abelson, Carolina E. Morales, Jose M Rivera, Alexa Rane Batingana, Jeevitha D'Souza, Yana Pikman, Michael L. Cheng, Aaron C Logan, Benjamin J. Huang, Elliot Stieglitz, Catherine C. Smith
Journal: Blood
Blood blood.2025030558.
https://doi.org/10.1182/blood.2025030558
Published: 2025
Includes: Supplemental data
Journal Articles

Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98 -rearranged leukemia

Open Access
Masayuki Umeda, Ryan Hiltenbrand, Nicole L. Michmerhuizen, Juan M. Barajas, Melvin E. Thomas III, Bright Arthur, Michael P. Walsh, Guangchun Song, Jing Ma, Tamara Westover, Amit Kumar, Petri Pölönen, Cristina Mecucci, Danika Di Giacomo, Franco Locatelli, Riccardo Masetti, Salvatore N. Bertuccio, Martina Pigazzi, Shondra M. Pruett-Miller, Stanley Pounds, Jeffrey Rubnitz, Hiroto Inaba, Kyriakos P. Papadopoulos, Michael J. Wick, Ilaria Iacobucci, Charles G. Mullighan, Jeffery M. Klco
Journal: Blood
Blood (2025) 146 (17): 2102–2118.
https://doi.org/10.1182/blood.2025028993
Published: 2025
Includes: Supplemental data
Journal Articles

Preclinical characterization of TGRX-678, a brain-penetrant allosteric inhibitor of BCR::ABL1

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Yanxia Shi, Qian Jiang, Linxin Li, Yingying Zuo, Shuzhen Jiang, Tingting Yan, Cuifang Zheng, Shuo Zhang, Nannan Yu, Jingrong Cao, Yun Liu, Yixin Ai, Yihan Wang
Journal: Blood
Blood (2025) 146 (17): 2088–2101.
https://doi.org/10.1182/blood.2025028539
Published: 2025
Includes: Supplemental data
Journal Articles

The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia

Open Access
Kentson Lam, Yoon Joon Kim, Evelyn Li-Ting Tan, Carlo Miguel Ong, Andrea Zoey Liu, Fanny Jiahua Zhou, Mary Jean Sunshine, Bernadette Chua, Silvia Vicenzi, Katelyn Zhining Chen, Helena Yu, Pierce Ford, Jie-Hua Zhou, Yuning Hong, Eric J Bennett, Leslie A Crews, Edward D. Ball, Robert Signer
Journal: Blood
Blood blood.2024026749.
https://doi.org/10.1182/blood.2024026749
Published: 2025
Includes: Supplemental data
Journal Articles

Diagnosis and Management of AML in Pediatric Patients: Consensus Recommendations from an International Expert Panel

Free
C. Michel Zwaan, Sarah K Tasian, Richard Aplenc, Lisa Eidenschink Brodersen, Barbara Buldini, Barbara De Moerloose, Michael N Dworzak, Linda Fogelstrand, Brenda ES Gibson, Bianca F Goemans, Henrik Hasle, Betsy A Hirsch, Gertjan JL Kaspers, Jan-Henning Klusmann, Matthew A Kutny, Thomas Lehrnbecher, Franco Locatelli, Shoeil Meshinchi, Arnaud Petit, Martina Pigazzi, Anne Tierens, E Anders Kolb, Dirk Reinhardt, Daisuke Tomizawa, Todd M Cooper
Journal: Blood
Blood blood.2024027904.
https://doi.org/10.1182/blood.2024027904
Published: 2025
Includes: Supplemental data
Journal Articles

Insights from Single-cell Omics: Cellular Heterogeneity as a Foundation of Clinical Outcome in Chronic Myeloid Leukemia

Open Access
Ram Krishna Thakur, Göran Karlsson
Journal: Blood
Blood blood.2025029011.
https://doi.org/10.1182/blood.2025029011
Published: 2025
Journal Articles

Acute myeloid leukemia mimicking mature lymphoid morphology

Free
Radu Chiriac
Journal: Blood
Blood (2025) 146 (16): 2005.
https://doi.org/10.1182/blood.2025030253
Published: 2025
Journal Articles

CD99 promotes self-renewal in hematopoietic stem cells and leukemia stem cells by regulating protein synthesis

Open Access
Yuanyuan Ji, Yi Huang, Toby Thomas, Eda Gozel Kapti, Reiko Tachibana, Jacob Lark, Iryna Berezniuk, Liang Guo, Mohamed A. E. Ali, Karin Mims, Benjamin Kroger, Wenhuo Hu, Christopher Y. Park, Stephen S. Chung
Journal: Blood
Blood (2025) 146 (16): 1914–1928.
https://doi.org/10.1182/blood.2024026271
Published: 2025
Includes: Supplemental data
Journal Articles

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome

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Paul Breillat, Francesco Carbone, Emilie Lereclus, Quentin Riller, Thibaut d'Izarny-Gargas, Céline Posseme, Marie Templé, Lin-Pierre Zhao, Marine Luka, Estibaliz Lazaro, Rodérau Outh, Guillaume Le Guenno, François Lifermann, Yannick Dieudonné, Marie Berleur, Cédric Lenormand, Karl Balabanian, Thierry Weitten, Vivien Guillotin, Marie Kostine, Barbara Burroni, Adrien Bigot, Alexandra Audemard-Verger, Aldric Manuel, Antoine Dossier, Cécile Golden, Jean-Philippe Martellosio, Benoit Faucher, Benjamin De Sainte Marie, Nadine Magy-Bertrand, Valentin Lacombe, Stéphane Vinzio, Sylvie Grosleron, Léa Dionet, Pierre-Louis Tharaux, Darragh Duffy, Mickaël Ménager, Nicolas Dulphy, Olivier Kosmider, Benjamin Terrier
Journal: Blood
Blood (2025) 146 (16): 1950–1963.
https://doi.org/10.1182/blood.2024028216
Published: 2025
Includes: Supplemental data
Journal Articles

A precision medicine approach to the myelodysplastic syndrome with isolated deletion 5q, 50 years after its discovery

Free
Marco Roncador, Elsa Bernard, Robert Hasserjian, Jacqueline Boultwood, Chiara Elena, Anna Gallì, Carmelo Gurnari, Cristina Mecucci, Lucienne Michaux, Moshe Mittelman, Martina Sarchi, Erica Travaglino, Donal P. McLornan, Seishi Ogawa, Elli Papaemmanuil, Eva Hellström Lindberg, Luca Malcovati, Mario Cazzola
Journal: Blood
Blood (2025) 146 (16): 1883–1896.
https://doi.org/10.1182/blood.2025028619
Published: 2025
Includes: Supplemental data
Journal Articles

Modulators of the Hepcidin Pathway in Polycythemia Vera and Myelofibrosis

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Marina Kremyanskaya, Yelena Z Ginzburg, Ronald Hoffman
Journal: Blood
Blood blood.2025028643.
https://doi.org/10.1182/blood.2025028643
Published: 2025
Journal Articles

A rare case of epithelioid hemangioendothelioma involving bone marrow

Free
Vivian K. P. Yeung, Kate F. S. Leung
Journal: Blood
Blood (2025) 146 (15): 1869.
https://doi.org/10.1182/blood.2025030044
Published: 2025