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Letter| September 24, 2024

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Sun Loo,

Sun Loo

Peter MacCallum Cancer Centre and Royal Melbourne Hospital, 3052, Australia

https://orcid.org/0000-0001-6294-2691

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Nicola Potter,

Nicola Potter

King's College, London, United Kingdom

https://orcid.org/0000-0002-8256-9350

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Adam Ivey,

Adam Ivey

The Alfred Hospital, Melbourne, Australia

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Jenny O'Nions, Dr,

Jenny O'Nions, Dr

University College London Hospitals NHS Foundation Trust, London, United Kingdom

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Roderick Moon,

Roderick Moon

Alfred Health, Melbourne, Australia

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Jelena Jovanovic,

Jelena Jovanovic

King's College London, London, United Kingdom

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Chun Yew Fong,

Chun Yew Fong

Austin Health, Heidelberg, Australia

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Natasha S Anstee,

Natasha S Anstee

Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

https://orcid.org/0000-0003-2093-1403

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Ing S Tiong,

Ing S Tiong

Peter MacCallum Cancer Centre, Melbourne, Australia

https://orcid.org/0000-0001-7417-4343

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Jad Othman,

Jad Othman

Kings College London, London, United Kingdom

https://orcid.org/0000-0002-4971-3576

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Chong Chyn Chua,

Chong Chyn Chua

2. The Walter and Eliza Hall Institute of Medical Research, Australia

https://orcid.org/0000-0002-2162-3288

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Hannah Renshaw,

Hannah Renshaw

UCLH, London, United Kingdom

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Robert Baker,

Robert Baker

Health Services Laboratories, London, United Kingdom

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Shaun Fleming,

Shaun Fleming

Alfred Health, Ashwood, Australia

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Nigel H. Russell,

Nigel H. Russell

Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

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David Ritchie,

David Ritchie

Peter MacCallum Cancer Centre and Royal Melboure Hospital, Melbourne, Australia

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Ashish Bajel,

Ashish Bajel

Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia

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Hsin-An Hou,

Hsin-An Hou

National Taiwan University Hospital, Taipei, Taiwan

https://orcid.org/0000-0003-2780-4845

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Richard James Dillon,

Richard James Dillon

King's College, London, London, United Kingdom

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Andrew H. Wei

Andrew H. Wei

Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia

* Corresponding Author; email: Andrew.Wei@petermac.org

https://orcid.org/0000-0002-7514-3298

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Blood blood.2024026605.

https://doi.org/10.1182/blood.2024026605

Pre-transplant detection of KMT2Ar MRD ≥0.001% by quantitative PCR was associated with significantly inferior post-transplant survival (2-year RFS 17% vs 59%; p=0.001) and increased cumulative incidence of relapse (2-year CIR 75% vs 25%, p=0.0004).

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Copyright © 2024 American Society of Hematology

2024

Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

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