Risk stratification and prognostication are crucial for the appropriate management of patients with myelodysplastic syndromes (MDSs) or myelodysplastic neoplasms, for whom the expected survival can vary from a few months to >10 years. For the past 5 decades, patients with MDS have been classified into higher-risk vs lower-risk disease phenotypes using sequentially developed clinical prognostic scoring systems. Factors such as morphologic dysplasia, clinical hematologic parameters, cytogenetics, and, more recently, mutational information have been captured in prognostic scoring systems that refine risk stratification and guide therapeutic management in patients with MDS. This review describes the progressive evolution and improvement of these systems which has led to the current Molecular International Prognostic Scoring System.
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MYELODYSPLASTIC SYNDROMES IN THE AGE OF GENOMIC MEDICINE|
December 28, 2023
The trajectory of prognostication and risk stratification for patients with myelodysplastic syndromes
Amy E. DeZern,
Amy E. DeZern
1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
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Peter L. Greenberg
Peter L. Greenberg
2Hematology Division, Department of Medicine, Stanford University School of Medicine, Stanford, CA
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Blood (2023) 142 (26): 2258–2267.
Article history
Submitted:
June 1, 2023
Accepted:
August 4, 2023
First Edition:
August 10, 2023
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Citation
Amy E. DeZern, Peter L. Greenberg; The trajectory of prognostication and risk stratification for patients with myelodysplastic syndromes. Blood 2023; 142 (26): 2258–2267. doi: https://doi.org/10.1182/blood.2023020081
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December 28 2023
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