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Volume 87, Issue 6

March 15 1996

In this Issue

PHOTOGRAPHS
REVIEW
ARTICLES
RANDOMIZED CONTROLLED TRIAL
LETTER

PHOTOGRAPHS

Photograph

A. M. Dvorak

View Articletitled, Photograph

REVIEW

Biologic basis for interleukin-1 in disease

CA Dinarello

View Articletitled, Biologic basis for interleukin-1 in disease

ARTICLES

Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G- CSF-mediated activation of signaling complexes of the p21ras route

RM Barge,JP de Koning,K Pouwels,F Dong,B Lowenberg,IP Touw

View Articletitled, Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G- CSF-mediated activation of signaling complexes of the p21ras route

Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets

PJ Fielder,AL Gurney,E Stefanich,M Marian,MW Moore,K Carver-Moore,FJ de Sauvage

View Articletitled, Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

WS Alexander,AW Roberts,NA Nicola,R Li,D Metcalf

View Articletitled, Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

Mutations in the Wilms' tumor gene WT1 in leukemias

L King-Underwood,J Renshaw,K Pritchard-Jones

View Articletitled, Mutations in the Wilms' tumor gene WT1 in leukemias

Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia

JM Cayuela,A Madani,L Sanhes,MH Stern,F Sigaux

View Articletitled, Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia

Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia

W Terpstra,A Prins,RE Ploemacher,BW Wognum,G Wagemaker,B Lowenberg,JJ Wielenga

View Articletitled, Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia

Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation

S Slavin,E Naparstek,A Nagler,A Ackerstein,S Samuel,J Kapelushnik,C Brautbar,R Or

View Articletitled, Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation

The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells

P Batard,P Sansilvestri,C Scheinecker,W Knapp,N Debili,W Vainchenker,HJ Buhring,MN Monier,E Kukk,J Partanen,MT Matikainen,R Alitalo,J Hatzfeld,K Alitalo

View Articletitled, The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells

Induction of hematopoietic commitment and erythromyeloid differentiation in embryonal stem cells constitutively expressing c-myb

P Melotti,B Calabretta

View Articletitled, Induction of hematopoietic commitment and erythromyeloid differentiation in embryonal stem cells constitutively expressing c-myb

Immobilized anti-KIT monoclonal antibody induces ligand-independent dimerization and activation of Steel factor receptor: biologic similarity with membrane-bound form of Steel factor rather than its soluble form

K Kurosawa,K Miyazawa,A Gotoh,T Katagiri,J Nishimaki,LK Ashman,K Toyama

View Articletitled, Immobilized anti-KIT monoclonal antibody induces ligand-independent dimerization and activation of Steel factor receptor: biologic similarity with membrane-bound form of Steel factor rather than its soluble form

The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

NJ Philpott,AJ Turner,J Scopes,M Westby,JC Marsh,EC Gordon-Smith,AG Dalgleish,FM Gibson

View Articletitled, The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

Antibody ligation of CD9 modifies production of myeloid cells in long- term cultures

K Oritani,X Wu,K Medina,J Hudson,K Miyake,JM Gimble,SA Burstein,PW Kincade

View Articletitled, Antibody ligation of CD9 modifies production of myeloid cells in long- term cultures

The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation

NW Lukacs,SL Kunkel,RM Strieter,HL Evanoff,RG Kunkel,ML Key,DD Taub

View Articletitled, The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation

Association of the expression of an SR-cyclophilin with myeloid cell differentiation

SL Giardina,JD Coffman,HA Young,SJ Potter,JL Frey,JR Ortaldo,SK Anderson

View Articletitled, Association of the expression of an SR-cyclophilin with myeloid cell differentiation

CD4 Expression by erythroid precursor cells in human bone marrow

RP Cleveland,YC Liu

View Articletitled, CD4 Expression by erythroid precursor cells in human bone marrow

A hematopoietic organ-specific 49-kD nuclear antigen: predominance in immature normal and tumor granulocytes and detection in hematopoietic precursor cells

BC Lee,Y Shav-Tal,A Peled,Y Gothelf,W Jiang,J Toledo,RE Ploemacher,N Haran-Ghera,D Zipori

View Articletitled, A hematopoietic organ-specific 49-kD nuclear antigen: predominance in immature normal and tumor granulocytes and detection in hematopoietic precursor cells

Requirements of von Willebrand factor to protect factor VIII from inactivation by activated protein C

SJ Koppelman,M van Hoeij,T Vink,H Lankhof,ME Schiphorst,C Damas,AJ Vlot,R Wise,BN Bouma,JJ Sixma

View Articletitled, Requirements of von Willebrand factor to protect factor VIII from inactivation by activated protein C

Initiation of the tissue factor pathway of coagulation in the presence of heparin: control by antithrombin III and tissue factor pathway inhibitor

J Jesty,A Lorenz,J Rodriguez,TC Wun

View Articletitled, Initiation of the tissue factor pathway of coagulation in the presence of heparin: control by antithrombin III and tissue factor pathway inhibitor

Expression of cyclic ADP-ribose-synthetizing CD38 molecule on human platelet membrane

G Ramaschi,M Torti,ET Festetics,F Sinigaglia,F Malavasi,C Balduini

View Articletitled, Expression of cyclic ADP-ribose-synthetizing CD38 molecule on human platelet membrane

Hemodynamic forces modulate the effects of cytokines on fibrinolytic activity of endothelial cells

Y Kawai,Y Matsumoto,K Watanabe,H Yamamoto,K Satoh,M Murata,M Handa,Y Ikeda

View Articletitled, Hemodynamic forces modulate the effects of cytokines on fibrinolytic activity of endothelial cells

Comparative analysis of type 2b von Willebrand disease mutations: implications for the mechanism of von Willebrand factor binding to platelets

KA Cooney,D Ginsburg

View Articletitled, Comparative analysis of type 2b von Willebrand disease mutations: implications for the mechanism of von Willebrand factor binding to platelets

Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120

C Susal,M Kirschfink,M Kropelin,V Daniel,G Opelz

View Articletitled, Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120

Inhibition of factor XII in septic baboons attenuates the activation of complement and fibrinolytic systems and reduces the release of interleukin-6 and neutrophil elastase

PM Jansen,RA Pixley,M Brouwer,IW de Jong,AC Chang,CE Hack,FB Jr Taylor,RW Colman

View Articletitled, Inhibition of factor XII in septic baboons attenuates the activation of complement and fibrinolytic systems and reduces the release of interleukin-6 and neutrophil elastase

HLA-target antigens and T-cell receptor diversity of activated T cells invading the skin during acute graft-versus-host disease

J Gaschet,MA Trevino,M Cherel,R Vivien,A Garcia-Sahuquillo,MM Hallet,M Bonneville,JL Harrousseau,R Bragado,N Milpied,H Vie

View Articletitled, HLA-target antigens and T-cell receptor diversity of activated T cells invading the skin during acute graft-versus-host disease

Eosinophils express a functional receptor for interferon alpha: inhibitory role of interferon alpha on the release of mediators

D Aldebert,B Lamkhioued,C Desaint,AS Gounni,M Goldman,A Capron,L Prin,M Capron

View Articletitled, Eosinophils express a functional receptor for interferon alpha: inhibitory role of interferon alpha on the release of mediators

Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion

N Oyaizu,TW McCloskey,S Than,S Pahwa

View Articletitled, Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion

The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function

A Cambiaggi,AM Orengo,R Meazza,S Sforzini,PL Tazzari,F Lauria,D Raspadori,R Zambello,G Semenzato,L Moretta,S Ferrini

View Articletitled, The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function

Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells from cord blood CD34+ hematopoietic progenitor cells

C Caux,B Vanbervliet,C Massacrier,I Durand,J Banchereau

View Articletitled, Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells from cord blood CD34+ hematopoietic progenitor cells

Decreased inducible expression of CD80 and CD86 in human monocytes after ultraviolet-B irradiation: its involvement in inactivation of allogenecity

M Fujihara,TA Takahashi,M Azuma,C Ogiso,TL Maekawa,H Yagita,K Okumura,S Sekiguchi

View Articletitled, Decreased inducible expression of CD80 and CD86 in human monocytes after ultraviolet-B irradiation: its involvement in inactivation of allogenecity

Natural killer cell precursors in the CD44neg/dim T-cell receptor population of mouse bone marrow

DV Delfino,KD Patrene,J Lu,A Deleo,R Deleo,RB Herberman,SS Boggs

View Articletitled, Natural killer cell precursors in the CD44neg/dim T-cell receptor population of mouse bone marrow

Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines

L Jia,SM Kelsey,MF Grahn,XR Jiang,AC Newland

View Articletitled, Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines

Target-induced death by apoptosis in human lymphokine-activated natural killer cells

K Taga,A Yamauchi,K Kabashima,ET Bloom,J Muller,G Tosato

View Articletitled, Target-induced death by apoptosis in human lymphokine-activated natural killer cells

Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells

RR Schumann,T Nakarai,HJ Gruss,MA Brach,U von Arnim,C Kirschning,L Karawajew,WD Ludwig,JC Renauld,J Ritz,F Herrmann

View Articletitled, Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells

Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder?

LX Pan,TC Diss,HZ Peng,AJ Norton,PG Isaacson

View Articletitled, Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder?

Epstein-Barr virus (EBV)-associated lymphoproliferations in severe combined immunodeficient mice transplanted with Hodgkin's disease lymph nodes: implications of EBV-positive bystander B lymphocytes rather than EBV-infected Reed-Sternberg cells

F Meggetto,C Muller,S Henry,J Selves,B Mariame,P Brousset,TA Saati,G Delsol

View Articletitled, Epstein-Barr virus (EBV)-associated lymphoproliferations in severe combined immunodeficient mice transplanted with Hodgkin's disease lymph nodes: implications of EBV-positive bystander B lymphocytes rather than EBV-infected Reed-Sternberg cells

Activation of Hodgkin cells via the CD30 receptor induces autocrine secretion of interleukin-6 engaging the NF-kappabeta transcription factor

HJ Gruss,D Ulrich,SK Dower,F Herrmann,MA Brach

View Articletitled, Activation of Hodgkin cells via the CD30 receptor induces autocrine secretion of interleukin-6 engaging the NF-kappabeta transcription factor

Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells

BI Lundell,JB McCarthy,NL Kovach,CM Verfaillie

View Articletitled, Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells

The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grunwald- Giemsa staining and fluorescence in situ hybridization

T Haferlach,M Winkemann,H Loffler,R Schoch,W Gassmann,C Fonatsch,C Schoch,M Poetsch,K Weber-Matthiesen,B Schlegelberger

View Articletitled, The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grunwald- Giemsa staining and fluorescence in situ hybridization

Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia

AF List,CS Spier,TM Grogan,C Johnson,DJ Roe,JP Greer,SN Wolff,HJ Broxterman,GL Scheffer,RJ Scheper,WS Dalton

View Articletitled, Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia

Frequent expression of the cell death-inducing gene Bax in Reed- Sternberg cells of Hodgkin's disease

F Rigal-Huguet,J Gopas,I Prinsloo,J Pris,G Delsol,JC Reed,D Schlaifer,P Brousset,D Benharroch,S Krajewski,G Laurent,F Meggetto

View Articletitled, Frequent expression of the cell death-inducing gene Bax in Reed- Sternberg cells of Hodgkin's disease

Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture

F Cervantes,BA Pierson,PB McGlave,CM Verfaillie,JS Miller

View Articletitled, Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture

Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect

A Gillio Tos,A Cignetti,G Rovera,R Foa

View Articletitled, Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect

Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5

H Poirel,K Rack,E Delabesse,I Radford-Weiss,X Troussard,C Debert,D Leboeuf,C Bastard,F Picard,A Veil-Buzyn,G Flandrin,O Bernard,E Macintyre

View Articletitled, Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5

Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements

Y Choi,SJ Greenberg,TL Du,PM Ward,PM Overturf,ML Brecher,M Ballow

View Articletitled, Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements

A critical role of VLA-4 in erythropoiesis in vivo

K Hamamura,H Matsuda,Y Takeuchi,S Habu,H Yagita,K Okumura

View Articletitled, A critical role of VLA-4 in erythropoiesis in vivo

Production of genetically stable high-titer retroviral vectors that carry a human gamma-globin gene under the control of the alpha-globin locus control region

S Ren,BY Wong,J Li,XN Luo,PM Wong,GF Atweh

View Articletitled, Production of genetically stable high-titer retroviral vectors that carry a human gamma-globin gene under the control of the alpha-globin locus control region

Ferritin translation by interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes

JT Rogers

View Articletitled, Ferritin translation by interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes

Hereditary spherocytosis with spectrin deficiency due to an unstable truncated beta spectrin

H Hassoun,JN Vassiliadis,J Murray,SJ Yi,M Hanspal,CA Johnson,J Palek

View Articletitled, Hereditary spherocytosis with spectrin deficiency due to an unstable truncated beta spectrin

Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria

M Endo,RE Ware,TM Vreeke,SP Singh,TA Howard,A Tomita,MH Holguin,CJ Parker

View Articletitled, Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria

Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction

J Yoo,LE Herman,C Li,SB Krantz,D Tuan

View Articletitled, Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction

Mutations in the erythropoietin receptor gene are not a common cause of Diamond-Blackfan anemia

I Dianzani,E Garelli,C Dompe,N Crescenzio,F Locatelli,G Schiliro,G Castaman,GP Bagnara,NF Olivieri,V Gabutti,U Ramenghi

View Articletitled, Mutations in the erythropoietin receptor gene are not a common cause of Diamond-Blackfan anemia

Phospholipase A2 levels in acute chest syndrome of sickle cell disease

LA Styles,CG Schalkwijk,AJ Aarsman,EP Vichinsky,BH Lubin,FA Kuypers

View Articletitled, Phospholipase A2 levels in acute chest syndrome of sickle cell disease

A gene transfer strategy for making bone marrow cells resistant to trimetrexate

HT Spencer,SE Sleep,JE Rehg,RL Blakley,BP Sorrentino

View Articletitled, A gene transfer strategy for making bone marrow cells resistant to trimetrexate

Comparison of genomic DNA and cDNA for detection of residual disease after treatment of chronic myeloid leukemia with allogeneic bone marrow transplantation

JG Zhang,F Lin,A Chase,JM Goldman,NC Cross

View Articletitled, Comparison of genomic DNA and cDNA for detection of residual disease after treatment of chronic myeloid leukemia with allogeneic bone marrow transplantation

The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation

KG Lucas,TN Small,G Heller,B Dupont,RJ O'Reilly

View Articletitled, The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation

RANDOMIZED CONTROLLED TRIAL

Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer

JA O'Shaughnessy,A Tolcher,D Riseberg,D Venzon,J Zujewski,M Noone,M Gossard,D Danforth,J Jacobson,V Chang,B Goldspiel,P Keegan,R Giusti,KH Cowan

View Articletitled, Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer

LETTER

The accurate definition of protein S deficiency may avoid the misestimation of the frequency of this defect [letter; comment]

L Falkon,M Gari,J Fontcuberta

View Articletitled, The accurate definition of protein S deficiency may avoid the misestimation of the frequency of this defect [letter; comment]

Novel CBFB-MYH11 fusion transcripts or reverse transcription-polymerase chain reaction artifacts? [letter; comment]

BA van der Reijden,A Hagemeijer,MH Breuning

View Articletitled, Novel CBFB-MYH11 fusion transcripts or reverse transcription-polymerase chain reaction artifacts? [letter; comment]

Reticuloendothelial origin and metastasis of Kaposi's sarcoma: historical update on the literature [letter; comment]

F Cottoni

View Articletitled, Reticuloendothelial origin and metastasis of Kaposi's sarcoma: historical update on the literature [letter; comment]

Variation of fetal hemoglobin and F-cell number with the LCR-HS2 polymorphism in nonanemic individuals [letter]

T Merghoub,M Maier-Redelsperger,D Labie,B Perichon,N Feingold,SP Dibenedetto,G Schiliro,P Samperi,r Ducrocq,J Elion,R Krishnamoorthy

View Articletitled, Variation of fetal hemoglobin and F-cell number with the LCR-HS2 polymorphism in nonanemic individuals [letter]

Visualization of IgG-binding loci on the surface of sickle erythrocytes [letter]

GA Green

View Articletitled, Visualization of IgG-binding loci on the surface of sickle erythrocytes [letter]

A genetic view on the etiology of the inhibitor complication [letter]

F Giannelli,PM Green,JA Naylor

View Articletitled, A genetic view on the etiology of the inhibitor complication [letter]

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