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Journal Articles

Potency and Efficacy of Pharmacological PIP4K2 Inhibitors in Acute Lymphoblastic Leukemia

Keli Lima, Maria Fernanda Lopes Carvalho, Diego A. Pereira-Martins, Wellington F Silva, Mariane Cristina do Nascimento, Lívia Bassani Lins de Miranda, Rita de Cássia Cavaglieri Medeiros, Luciana Nardinelli, Aline de Medeiros Leal, Elvira Deolinda Rodrigues Pereira Velloso, Israel Bendit, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

Blood (2023) 142 (Supplement 1): 5786.

https://doi.org/10.1182/blood-2023-189786

Published: 2023

Journal Articles

Identification of Vulnerabilities for Pharmacological Inhibition of PIP4K2s in Acute Myeloid Leukemia

Keli Lima, Maria Fernanda Lopes Carvalho, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Mariane Cristina do Nascimento, Frederico Lisboa Nogueira, Rita de Cássia Cavaglieri Medeiros, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

Blood (2023) 142 (Supplement 1): 5774.

https://doi.org/10.1182/blood-2023-189998

Published: 2023

Journal Articles

Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors

Manuela Albuquerque de Melo, Brunno Gilberto Santos Macedo, Natasha Peixoto Fonseca, Priscila Santos Scheucher, Diego A Pereira-Martins, João Agostinho Machado-Neto, Fabiola Traina

Blood (2023) 142 (Supplement 1): 5752.

https://doi.org/10.1182/blood-2023-190724

Published: 2023

Journal Articles

Cephalochromin-Induced Mitochondrial Damage Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia Models

Mariane Cristina Do Nascimento, Diego A Pereira-Martins, Guilherme Augusto Sousa Alcântara, Keli Lima, Hugo Passos Vicari, Marcelo José Pena Ferreira, Leticia Veras Costa-Lotufo, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

Blood (2023) 142 (Supplement 1): 5751.

https://doi.org/10.1182/blood-2023-189814

Published: 2023

Journal Articles

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Keli Lima, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Juan L Coelho-Silva, Giovana da Silva Leandro, Isabel Weinhäuser, Rita de Cassia Cavaglieri, Wellington F Silva, Aline Medeiros Leal, Ana Paula Alencar de Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger, Jacobien R Hilberink, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo M Rego

Blood (2022) 140 (Supplement 1): 5965–5966.

https://doi.org/10.1182/blood-2022-165172

Published: 2022

Journal Articles

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

Natasha Peixoto Fonseca, Bruna Alves Fenerich, Diego A Pereira-Martins, Pedro Manoel Marques Garibaldi, Juan L Coelho-Silva, Antonio Bruno Alves Silva, Jaqueline Cristina Fernandes, Cleide Lucia Silva, Eduardo M Rego, João Agostinho Machado-Neto, Fabiola Traina

Blood (2022) 140 (Supplement 1): 12153–12154.

https://doi.org/10.1182/blood-2022-167392

Published: 2022

Journal Articles

IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia

Juan L Coelho-Silva, Diego A Pereira-Martins, Virginia Campos Silvestrini, João Agostinho Machado-Neto, Eduardo M Rego, Marcus Smolka, Vitor Marcel Faca, Fabiola Traina

Blood (2021) 138 (Supplement 1): 1869.

https://doi.org/10.1182/blood-2021-153105

Published: 2021

Journal Articles

Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia

Antonio R. Lucena-Araujo, Diego A Pereira-Martins, Juan L Coelho-Silva, Isabel Weinhäuser, Pedro Luis Franca-Neto, Douglas RA Silveira, Marinus M Lima, Jan Jacob Schuringa, Luisa C Koury, Raul Antônio Morais Melo, Rosane Bittencourt, Katia B Pagnano, Elenaide C. Nunes, Evandro Maranhão Fagundes, Fabio R. Kerbauy, Lorena Figueredo-Pontes, Eduardo M Rego

Blood (2021) 138 (Supplement 1): 3474.

https://doi.org/10.1182/blood-2021-151265

Published: 2021

Journal Articles

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

Isabel Weinhäuser, Diego A Pereira-Martins, Jacobien R Hilberink, Luciana Yamamoto Almeida, Douglas RA Silveira, Lynn Quek, Shanna M Hogeling, Jose Mauricio Mota, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Gerwin A. Huls, Jan Jacob Schuringa, Eduardo M Rego

Blood (2021) 138 (Supplement 1): 3472.

https://doi.org/10.1182/blood-2021-150699

Published: 2021

Journal Articles

Treatment with the Recombinant SLIT2 Protein Delays AML Leukemogenesis In Vivo

Luise A de Albuquerque Simoes, Isabel Weinhäuser, Diego A Pereira-Martins, César Alexander Ortiz Rojas, Thiago Mantello Bianco, Rita de Cassia Cavaglieri, Eduardo M Rego

Blood (2021) 138 (Supplement 1): 2368.

https://doi.org/10.1182/blood-2021-151069

Published: 2021

Journal Articles

Co-occurrence of DNMT3A , NPM1 , FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Blood (2020) 135 (11): 870–875.

https://doi.org/10.1182/blood.2019003339

Published: 2020

Includes: Supplemental data

Journal Articles

Up-Regulation of Mir-21 and Mir-130a and Serum Leptin Levels on Leg Ulcers Development in Sickle Cell Anemia

Thais Helena Chaves Batista, Rodrigo Marcionilo Santana, Marcondes José de Vasconcelos Costa Sobreira, BSc, Gabriela da Silva Arcanjo, BSc, Diego Arruda Falcao, PhD, Diego A Pereira-Martins, MD, Aderson da Silva Araujo, MD PhD, Fernando Ferreira Costa, MD PhD, Mario José Abdalla Saad, PhD MD, Bruno de Melo Carvalho, PhD, Luydson Richardson Silva Vasconcelos, PhD, Antonio R. Lucena-Araujo, PhD, Marcos Andre Cavalcanti Bezerra, PhD

Blood (2019) 134 (Supplement_1): 975.

https://doi.org/10.1182/blood-2019-132043

Published: 2019

Journal Articles

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Thiago Mantello Bianco, MSc, Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Priscila Santos Scheucher, PhD, Isabel Weinhäuser, MSc, Antonio Bruno Alves Silva, BSc, Cleide Lucia Silva, MSc, Ann Mullally, MD, Susumu S Kobayashi, MD PhD, Eduardo M Rego, MD PhD, Fabiola Traina, MD PhD, Lorena Lobo Figueiredo-Pontes, MD PhD

Blood (2019) 134 (Supplement_1): 2977.

https://doi.org/10.1182/blood-2019-131023

Published: 2019

Journal Articles

Combining Clinical Features with Genetic Factors Improves Survival Prediction for Adults with Acute Myeloid Leukemia: Validation of a New Score System in 3 Cohorts

Douglas R. A. Silveira, Lynn Quek, MD PhD, Anna Corby, B.Sc., Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Grant Vallance, B.Sc., PhD, Benjamin Brown, B.Sc., PhD, Luciana Nardinelli, M.Sc, Wellington F Silva, MD, Elvira DRP Velloso, MD PhD, Fabiola Traina, MD PhD, Andy Peniket, MD, Paresh Vyas, MD PhD, Eduardo M Rego, MD PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD

Blood (2019) 134 (Supplement_1): 2602.

https://doi.org/10.1182/blood-2019-130726

Published: 2019

Journal Articles

Reduced SLIT2 Are Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in APL Cells

Isabel Weinhäuser, MSc, Diego A Pereira-Martins, MSc, Luíse A A Simões, BSc, César Alexander Ortiz Rojas, BSc, Thiago Mantello Bianco, MSc, Cleide Lucia Silva, MSc, Mariane Cristina Do Nascimento, BSc, Lorena Lobo Figueiredo-Pontes, MD PhD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD

Blood (2019) 134 (Supplement_1): 5165.

https://doi.org/10.1182/blood-2019-131496

Published: 2019

Journal Articles

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Blood (2019) 134 (Supplement_1): 5166.

https://doi.org/10.1182/blood-2019-131595

Published: 2019

Journal Articles

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Juan L Coelho-Silva, BSc, MSc, Douglas R. A. Silveira, Diego A Pereira-Martins, MSc, César Alexander Ortiz Rojas, BSc, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD, João Agostinho Machado-Neto, PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 4257.

https://doi.org/10.1182/blood-2019-132141

Published: 2019

Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 2689.

https://doi.org/10.1182/blood-2019-132129

Published: 2019

Journal Articles

Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia

Blood (2019) 134 (Supplement_1): 2719.

https://doi.org/10.1182/blood-2019-131211

Published: 2019

Journal Articles

MN1 Expression Is an Indepedent Prognostic Marker in FLT3-Mutated Acute Myeloid Leukemia and Is Involved in the Resistance to FLT3 Inhibitors

Diego A Pereira-Martins, MSc, Juan L Coelho-Silva, BSc, MSc, Isabel Weinhäuser, MSc, Carol Hassibe Thomé, César Alexander Ortiz Rojas, BSc, Luíse A A Simões, BSc, Fabiola Traina, MD PhD, Michael Heuser, MD, Arnold Ganser, MD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD

Blood (2019) 134 (Supplement_1): 1403.

https://doi.org/10.1182/blood-2019-131542

Published: 2019

NARROW

Potency and Efficacy of Pharmacological PIP4K2 Inhibitors in Acute Lymphoblastic Leukemia

Identification of Vulnerabilities for Pharmacological Inhibition of PIP4K2s in Acute Myeloid Leukemia

Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors

Cephalochromin-Induced Mitochondrial Damage Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia Models

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia

Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

Treatment with the Recombinant SLIT2 Protein Delays AML Leukemogenesis In Vivo

Co-occurrence of DNMT3A , NPM1 , FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Up-Regulation of Mir-21 and Mir-130a and Serum Leptin Levels on Leg Ulcers Development in Sickle Cell Anemia

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Combining Clinical Features with Genetic Factors Improves Survival Prediction for Adults with Acute Myeloid Leukemia: Validation of a New Score System in 3 Cohorts

Reduced SLIT2 Are Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in APL Cells

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia

MN1 Expression Is an Indepedent Prognostic Marker in FLT3-Mutated Acute Myeloid Leukemia and Is Involved in the Resistance to FLT3 Inhibitors

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American Society of Hematology

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ASH Publications

American Society of Hematology

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