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Journal Articles

Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors

Manuela Albuquerque de Melo, Brunno Gilberto Santos Macedo, Natasha Peixoto Fonseca, Priscila Santos Scheucher, Diego A Pereira-Martins, João Agostinho Machado-Neto, Fabiola Traina

Blood (2023) 142 (Supplement 1): 5752.

https://doi.org/10.1182/blood-2023-190724

Published: 2023

Journal Articles

Jak2V617F Bone Marrow Exposure Leads to Dysfunction of Normal NK Cells

Izabela Aparecida Lopes, Camila Araújo Bernardino Garcia, Leticia Olops Marini, Amanda Fernandes Oliveira Costa, Larissa Sarri Binelli, Mariana Medeiros, Josiane Lillian Schiavinato, Priscila Santos Scheucher, Cleide Lúcia Araújo Silva, Lorena Lobo Figueiredo-Pontes

Blood (2023) 142 (Supplement 1): 3153.

https://doi.org/10.1182/blood-2023-189920

Published: 2023

Journal Articles

Eltrombopag Specifically Expands Hematopoietic Multipotent Progenitors in Human Aplastic Anemia

Bruno Quintino Oliveira, brunoqolvr@gmail.com, Bárbara Santana, PhD, Luiz Fernando Bazzo Catto, MDPhD, Maria Florencia Tellechea, PhD, Priscila Santos Scheucher, PhD, Phillip Scheinberg, MD, Rodrigo T. Calado, MD PhD

Blood (2020) 136 (Supplement 1): 23.

https://doi.org/10.1182/blood-2020-142746

Published: 2020

Journal Articles

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Thiago Mantello Bianco, MSc, Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Priscila Santos Scheucher, PhD, Isabel Weinhäuser, MSc, Antonio Bruno Alves Silva, BSc, Cleide Lucia Silva, MSc, Ann Mullally, MD, Susumu S Kobayashi, MD PhD, Eduardo M Rego, MD PhD, Fabiola Traina, MD PhD, Lorena Lobo Figueiredo-Pontes, MD PhD

Blood (2019) 134 (Supplement_1): 2977.

https://doi.org/10.1182/blood-2019-131023

Published: 2019

Journal Articles

Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

João Agostinho Machado-Neto, BSc, Juan Luiz Coelho-Silva, BSc, MSc, Fábio Pires de Souza Santos, MD PhD, Priscila Santos Scheucher, PhD, Paulo Vidal Campregher, MD PhD, Nelson Hamerschlak, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2018) 132 (Supplement 1): 1788.

https://doi.org/10.1182/blood-2018-99-119651

Published: 2018

Journal Articles

C/Ebpg (CCAAT/Enhancer Binding Protein Gamma) Balances Cytotoxic and Secretory Potential of Natural Killer Cells

Izabela Aparecida Lopes, MSc, Miroslava Kardosova, MSc, Thiago Mantello Bianco, MSc, Adriana Queiroz Arantes, MD, Cleide Araújo Silva, MSc, Priscila Santos Scheucher, PhD, Daniel G. Tenen, MD, Sanghoon Lee, PhD, Eduardo Magalhães Rego, MD PhD, Robert S. Welner, PhD, Meritxell Alberich-Jorda, Lorena Lobo Figueiredo-Pontes, MD PhD

Blood (2018) 132 (Supplement 1): 3721.

https://doi.org/10.1182/blood-2018-99-119389

Published: 2018

Journal Articles

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

Bruna Alves Fenerich, BSc, João Agostinho Machado-Neto, BSc, Ana Paula Nunes Rodrigues Alves, MSc, Paula De Melo Campos, MD PhD, Jaqueline Cristina Fernandes, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Renata Scopim Ribeiro, BSc, MSc, Fernanda B da Silva, BSc and MSc, Priscila Santos Scheucher, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 1253.

https://doi.org/10.1182/blood.V130.Suppl_1.1253.1253

Published: 2017

Journal Articles

IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia

Juan Luiz Coelho-Silva, BSc, MSc, João Agostinho Machado-Neto, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Ana Silvia G de Lima, PhD, Priscila Santos Scheucher, PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 3966.

https://doi.org/10.1182/blood.V130.Suppl_1.3966.3966

Published: 2017

Journal Articles

Imbalance between Tolerant and Cytotoxic Functional Subsets of NK Cells in a JAK2 V617F Myeloproliferative Neoplasm Model

Thiago Mantello Bianco, MSc, Adriana Queiroz Arantes, MD, Izabela Aparecida Lopes, MSc, Priscila Santos Scheucher, PhD, Cleide Araújo Silva, MSc, Ann Mullally, MD, Susumu S Kobayashi, MD PhD, Eduardo Magalhães Rego, MDPhD, Lorena Lobo Figueiredo-Pontes, MD PhD

Blood (2017) 130 (Supplement 1): 4221.

https://doi.org/10.1182/blood.V130.Suppl_1.4221.4221

Published: 2017

Journal Articles

Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells

Ana Paula Nunes Rodrigues Alves, M.Sc., João Agostinho Machado-Neto, PhD, Jaqueline Cristina Fernandes, B.Sc., Bruna Alves Fenerich, B.Sc., Fernanda Borges da Silva, B.Sc., Priscila Santos Scheucher, PhD, Belinda Pinto Simões, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD

Blood (2016) 128 (22): 3971.

https://doi.org/10.1182/blood.V128.22.3971.3971

Published: 2016

Journal Articles

Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1 T315I mutant Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Christopher A. Eide, Paula de Melo Campos, PhD, Priscila Santos Scheucher, PhD, Sara Teresinha Olalla Saad, MD PhD, Eduardo Magalhães Rego, MD, PhD, Cristina E. Tognon, Brian J. Druker, MD, Fabiola Traina, MD, PhD

Blood (2016) 128 (22): 1886.

https://doi.org/10.1182/blood.V128.22.1886.1886

Published: 2016

Journal Articles

Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity

João Agostinho Machado-Neto, PhD, Bruna Alves Fenerich, B.Sc., Renata Scopim-Ribeiro, M.Sc., Carlos Roberto Porto Dechandt, B.Sc., Ana Paula Nunes Rodrigues Alves, M.Sc., Jaqueline Cristina Fernandes, B.Sc., Priscila Santos Scheucher, PhD, Belinda Pinto Simões, MD, PhD, Luciane Carla Alberici, PhD, Lorena Lôbo de Figueiredo Pontes, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD

Blood (2016) 128 (22): 1960.

https://doi.org/10.1182/blood.V128.22.1960.1960

Published: 2016

Journal Articles

Decreased Activity of NK Cells in Myeloproliferative Neoplasms

Adriana Queiroz Arantes, MD, Cristina Tavares Leal, MD, Cleide Araújo Silva, Priscila Santos Scheucher, PhD, Aglair Bergamo, Robert S. Welner, PhD, Daniel G. Tenen, MD, Ann Mullally, MD, Susumu Kobayashi, MD PhD, Eduardo Magalhaes Rego, PhD, Lorena Lobo Figueiredo-Pontes, MD, PhD

Blood (2015) 126 (23): 1637.

https://doi.org/10.1182/blood.V126.23.1637.1637

Published: 2015

Journal Articles

Pharmacological IRS1/2 Inhibition Reduces Cell Viability in BCR-ABL1 Positive Cells

Renata Scopim-Ribeiro, M.Sc., João Agostinho Machado-Neto, PhD, Paula de Melo Campos, PhD, Adriana da Silva Santos Duarte, PhD, Priscila Santos Scheucher, PhD, Amélia Góes, PhD, Sara Teresinha Olalla Saad, MD, PhD, Belinda Pinto Simoes, MD, PhD, Eduardo Magalhães Rego, MD, PhD, Fabiola Traina, MD, PhD

Blood (2015) 126 (23): 2772.

https://doi.org/10.1182/blood.V126.23.2772.2772

Published: 2015

Journal Articles

LAT2, a Lipid Raft Protein That Participates in AKT Phosphorylation in Mantle Cell Lymphoma, Is a Target for Perifosine Chemotherapy

Germano A Ferreira, PhD, Carolina H Thomé, PhD, Priscila Santos Scheucher, PhD, Andréia M Leopoldino, Prof. PhD, Ana Maria Simão, PhD, Clarice Izumi, PhD, Pietro Ciancaglini, Prof. PhD, Vitor Marcel Faça, Prof, PhD, Lewis Joel Greene, Prof. PhD, Guilherme A Santos, MD PhD, Eduardo M Rego, Prof, MD PhD

Blood (2014) 124 (21): 923.

https://doi.org/10.1182/blood.V124.21.923.923

Published: 2014

Journal Articles

Better Performance of Flow-FISH in Comparison to qPCR As a Diagnostic Test for Telomere Diseases

Fernanda Gutierrez-Rodrigues, PhDstudent, Bárbara A Santana-Lemos, PhD, Priscila Santos Scheucher, PhD, Raquel M Alves-Paiva, PhD, Rodrigo T. Calado, MD PhD

Blood (2014) 124 (21): 1605.

https://doi.org/10.1182/blood.V124.21.1605.1605

Published: 2014

NARROW

Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors

Jak2V617F Bone Marrow Exposure Leads to Dysfunction of Normal NK Cells

Eltrombopag Specifically Expands Hematopoietic Multipotent Progenitors in Human Aplastic Anemia

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

C/Ebpg (CCAAT/Enhancer Binding Protein Gamma) Balances Cytotoxic and Secretory Potential of Natural Killer Cells

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia

Imbalance between Tolerant and Cytotoxic Functional Subsets of NK Cells in a JAK2 V617F Myeloproliferative Neoplasm Model

Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells

Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1 T315I mutant Cells

Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity

Decreased Activity of NK Cells in Myeloproliferative Neoplasms

Pharmacological IRS1/2 Inhibition Reduces Cell Viability in BCR-ABL1 Positive Cells

LAT2, a Lipid Raft Protein That Participates in AKT Phosphorylation in Mantle Cell Lymphoma, Is a Target for Perifosine Chemotherapy

Better Performance of Flow-FISH in Comparison to qPCR As a Diagnostic Test for Telomere Diseases

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American Society of Hematology

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ASH Publications

American Society of Hematology

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