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Adam Linley
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Journal Articles

Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders

Skye Montoya, Jessie Bourcier, Meghan C. Thompson, Mark Noviski, May Tan, Eric Wang, Xiaoli Mi, Nivetha Brathaban, Carla Barrientos Risso, Daniel Tsai, Jordan Ye, Jacob Jahn, Gabriel Pardo, Lee Cabuhat, Ryan Notti, Alejandro Pardo, Maurizio Affer, Stephanie Yung, James Luliano, Janine Powers, Daniel W Robbins, Vindhya Nawaratne, Tulasigeri M Totiger, Camila Pena-Velasquez, Joanna M. Rhodes, Andrew D. Zelenetz, Lindsey E. Roeker, Hao Lu, Adam Linley, Anthony R. Mato, Omar Abdel-Wahab, Justin Taylor
Journal: Blood
Blood (2022) 140 (Supplement 1): 1811–1813.
https://doi.org/10.1182/blood-2022-163268
Published: 2022
Journal Articles

Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9

Melanie Maerken, MS, BSc, David MacEwan, PhD, Nicholas Harper, PhD, Joseph R Slupsky, PhD, Adam Linley, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3952.
https://doi.org/10.1182/blood-2018-99-113804
Published: 2018
Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4290.
https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290
Published: 2017
Journal Articles

IL-4 enhances expression and function of surface IgM in CLL cells

Maria M. Aguilar-Hernandez, Matthew D. Blunt, Rachel Dobson, Alison Yeomans, Stephen Thirdborough, Marta Larrayoz, Lindsay D. Smith, Adam Linley, Jonathan C. Strefford, Andrew Davies, Peter M. W. Johnson, Natalia Savelyeva, Mark S. Cragg, Francesco Forconi, Graham Packham, Freda K. Stevenson, Andrew J. Steele
Journal: Blood
Blood (2016) 127 (24): 3015–3025.
https://doi.org/10.1182/blood-2015-11-682906
Published: 2016
Includes: Supplemental data
Journal Articles

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC -specific mRNA translation

Alison Yeomans, Stephen M. Thirdborough, Beatriz Valle-Argos, Adam Linley, Sergey Krysov, Marina Sanchez Hidalgo, Elodie Leonard, Muhammad Ishfaq, Simon D. Wagner, Anne E. Willis, Andrew J. Steele, Freda K. Stevenson, Francesco Forconi, Mark J. Coldwell, Graham Packham
Journal: Blood
Blood (2016) 127 (4): 449–457.
https://doi.org/10.1182/blood-2015-07-660969
Published: 2016
Includes: Supplemental data
Journal Articles

Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells

Adam Linley, Sergey Krysov, Maurilio Ponzoni, Peter W. Johnson, Graham Packham, Freda K. Stevenson
Journal: Blood
Blood (2015) 126 (16): 1902–1910.
https://doi.org/10.1182/blood-2015-04-640805
Published: 2015
Includes: Supplemental data
Journal Articles

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK

Sergey Krysov, Andrew J. Steele, Vania Coelho, Adam Linley, Marina Sanchez Hidalgo, Matthew Carter, Kathleen N. Potter, Benjamin Kennedy, Andrew S. Duncombe, Margaret Ashton-Key, Francesco Forconi, Freda K. Stevenson, Graham Packham
Journal: Blood
Blood (2014) 124 (20): 3101–3109.
https://doi.org/10.1182/blood-2014-04-567198
Published: 2014
Includes: Supplemental data