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Journal Articles

In silico Modeling of the Impact of Antithrombin Lowering on Thrombin Generation in Rare Bleeding Disorders

Gautham Sridharan, PhD, Jingxuan Liu, PhD, Kun Qian, M.S., Varun Goel, PhD, Stephen Huang, MD, Akin Akinc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3659.
https://doi.org/10.1182/blood.V130.Suppl_1.3659.3659
Published: 2017
Journal Articles

Fitusiran, an Investigational RNAi Therapeutic Targeting Antithrombin for the Treatment of Hemophilia: Updated Results from a Phase 1 and Phase 1/2 Extension Study in Patients without Inhibitors

Margaret V. Ragni, MD, Pencho Georgiev, Tim Mant, Michael Desmond Creagh, Toshko Lissitchkov, David Bevan, Steve Austin, Charles R Hay, Inga Hegemann, Rashid Kazmi, Pratima Chowdary, Savita Rangarajan, Chang-Heok Soh, Akin Akinc, Angela M. Partisano, Benny Sorenson, K John Pasi
Journal: Blood
Blood (2016) 128 (22): 2572.
https://doi.org/10.1182/blood.V128.22.2572.2572
Published: 2016
Journal Articles

Fitusiran, an Investigational RNAi Therapeutic Targeting Antithrombin for the Treatment of Hemophilia: Updated Results from a Phase 1 and Phase 1/2 Extension Study in Patients with Inhibitors

K John Pasi, Pencho Georgiev, Tim Mant, Toshko Lissitchkov, Michael Desmond Creagh, David Bevan, Steve Austin, Charles R Hay, Inga Hegemann, Rashid Kazmi, Pratima Chowdary, Margaret V. Ragni, MD, Chang-Heok Soh, Akin Akinc, Angela M. Partisano, Benny Sorenson, Savita Rangarajan
Journal: Blood
Blood (2016) 128 (22): 1397.
https://doi.org/10.1182/blood.V128.22.1397.1397
Published: 2016
Journal Articles

A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-AT3) Targeting Antithrombin for Treatment of Hemophilia: Interim Weekly and Monthly Dosing Results in Patients with Hemophilia A or B

K John Pasi, Pencho Georgiev, Tim Mant, Michael Desmond Creagh, Toshko Lissitchkov, MD, David Bevan, Steve Austin, Charles R Hay, Brigit Brand, Rashid Kazmi, Pratima Chowdary, Margaret V Ragni, Jihong Chen, Akin Akinc, Benny Sorensen, Savita Rangarajan
Journal: Blood
Blood (2015) 126 (23): 551.
https://doi.org/10.1182/blood.V126.23.551.551
Published: 2015
Journal Articles

Antithrombin Reduction Corrected Thrombin Generation in Samples from Hemophilia A and B Patients with Inhibitors

Gili Kenet, Tami Livnat, Emma Fosbury, Pratima Chowdary, Alfica Sehgal, Akin Akinc, Benny Sorensen
Journal: Blood
Blood (2015) 126 (23): 552.
https://doi.org/10.1182/blood.V126.23.552.552
Published: 2015
Journal Articles

A Subcutaneously Administered RNAi Therapeutic (ALN-AT3) Targeting Antithrombin for Treatment of Hemophilia: Interim Phase 1 Study Results in Healthy Volunteers and Patients with Hemophilia a or B

Benny Sorensen, MD PhD, Tim Mant, MD, Akin Akinc, PhD, Amy Simon, MD, Lauren Melton, Christian Lynam, Andrew Strahs, PhD, Alfica Sehgal, PhD, Renta Hutabarat, PhD, Prasoon Chaturvedi, PhD, Scott Barros, PhD, Akshay Vaishnaw, MD PhD, Aln-AT Investigators
Journal: Blood
Blood (2014) 124 (21): 693.
https://doi.org/10.1182/blood.V124.21.693.693
Published: 2014
Journal Articles

Expanded Therapeutic Index Of Antithrombin Silencing and Correction Of Aptt In a Hemophilia A Mouse Model

Scott A Barros, PhD, DABT, Mary Carioto, Julia Hettinger, Yongfeng Jiang, June Qin, Harsha Prabhala, Alfica Sehgal, PhD, Akin Akinc, PhD
Journal: Blood
Blood (2013) 122 (21): 3585.
https://doi.org/10.1182/blood.V122.21.3585.3585
Published: 2013
Journal Articles

An RNAi Therapeutic Targeting Antithrombin Increases Thrombin Generation in Nonhuman Primates

Akin Akinc, PhD, Alfica Sehgal, PhD, Scott Barros, PhD, Julia Hettinger, Klaus Charisse, PhD, Josh Brodsky, June Qin, Tim Racie
Journal: Blood
Blood (2012) 120 (21): 3370.
https://doi.org/10.1182/blood.V120.21.3370.3370
Published: 2012
Journal Articles

Treatment of erythropoietin deficiency in mice with systemically administered siRNA

William Querbes, Roman L. Bogorad, Javid Moslehi, Jamie Wong, Amy Y. Chan, Elena Bulgakova, Satya Kuchimanchi, Akin Akinc, Kevin Fitzgerald, Victor Koteliansky, William G. Kaelin, Jr
Journal: Blood
Blood (2012) 120 (9): 1916–1922.
https://doi.org/10.1182/blood-2012-04-423715
Published: 2012
Includes: Supplemental data
Journal Articles

Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia

Akin Akinc, PhD, Amy Chan-Daniels, PhD, Alfica Sehgal, PhD, Don Foster, Brian R Bettencourt, PhD, Julia Hettinger, Tim Racie, Justin Aubin, Satya Kuchimanchi, PhD, Hila Epstein-Barash, PhD, Tomoko Nakayama, PhD
Journal: Blood
Blood (2011) 118 (21): 688.
https://doi.org/10.1182/blood.V118.21.688.688
Published: 2011
Journal Articles

Liver Specific Delivery of siRNA Targeting EGLN Prolyl Hydroxylases Activates Hepatic Erythropoietin Production and Stimulates Erythropoiesis,

William Querbes, PhD, Roman Bogorad, PhD, Javid Moslehi, MD, Akin Akinc, PhD, Jamie Wong, PhD, Chris Zurenko, June Qin, Julia Hettinger, Satya Kuchimanchi, PhD, Klaus Charisse, PhD, Dinah WY Sah, PhD, Kevin Fitzgerald, PhD, Victor Kotelianski, MD, PhD, William G. Kaelin, Jr., MD
Journal: Blood
Blood (2011) 118 (21): 3161.
https://doi.org/10.1182/blood.V118.21.3161.3161
Published: 2011