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Journal Articles

Antithrombin Reduction Corrected Thrombin Generation in Samples from Hemophilia A and B Patients with Inhibitors

Gili Kenet, Tami Livnat, Emma Fosbury, Pratima Chowdary, Alfica Sehgal, Akin Akinc, Benny Sorensen
Journal: Blood
Blood (2015) 126 (23): 552.
https://doi.org/10.1182/blood.V126.23.552.552
Published: 2015
Journal Articles

A Subcutaneously Administered RNAi Therapeutic (ALN-AT3) Targeting Antithrombin for Treatment of Hemophilia: Interim Phase 1 Study Results in Healthy Volunteers and Patients with Hemophilia a or B

Benny Sorensen, MD PhD, Tim Mant, MD, Akin Akinc, PhD, Amy Simon, MD, Lauren Melton, Christian Lynam, Andrew Strahs, PhD, Alfica Sehgal, PhD, Renta Hutabarat, PhD, Prasoon Chaturvedi, PhD, Scott Barros, PhD, Akshay Vaishnaw, MD PhD, Aln-AT Investigators
Journal: Blood
Blood (2014) 124 (21): 693.
https://doi.org/10.1182/blood.V124.21.693.693
Published: 2014
Journal Articles

Expanded Therapeutic Index Of Antithrombin Silencing and Correction Of Aptt In a Hemophilia A Mouse Model

Scott A Barros, PhD, DABT, Mary Carioto, Julia Hettinger, Yongfeng Jiang, June Qin, Harsha Prabhala, Alfica Sehgal, PhD, Akin Akinc, PhD
Journal: Blood
Blood (2013) 122 (21): 3585.
https://doi.org/10.1182/blood.V122.21.3585.3585
Published: 2013
Journal Articles

An RNAi Therapeutic Targeting Antithrombin Increases Thrombin Generation in Nonhuman Primates

Akin Akinc, PhD, Alfica Sehgal, PhD, Scott Barros, PhD, Julia Hettinger, Klaus Charisse, PhD, Josh Brodsky, June Qin, Tim Racie
Journal: Blood
Blood (2012) 120 (21): 3370.
https://doi.org/10.1182/blood.V120.21.3370.3370
Published: 2012
Journal Articles

Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia

Akin Akinc, PhD, Amy Chan-Daniels, PhD, Alfica Sehgal, PhD, Don Foster, Brian R Bettencourt, PhD, Julia Hettinger, Tim Racie, Justin Aubin, Satya Kuchimanchi, PhD, Hila Epstein-Barash, PhD, Tomoko Nakayama, PhD
Journal: Blood
Blood (2011) 118 (21): 688.
https://doi.org/10.1182/blood.V118.21.688.688
Published: 2011