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Journal Articles

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Stacy Cooper, MD, Hong Guo, MD PhD, Justin Thomas, Jay L. Hess, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Alan D. Friedman, MD

Blood (2016) 128 (22): 2691.

https://doi.org/10.1182/blood.V128.22.2691.2691

Published: 2016

Journal Articles

The Roles of RUNX1 in Human Hematopoiesis and Megakaryopoiesis Revealed By Genome-Targeted Human iPSCs and an Improved Hematopoietic Differentiation Model

Bin-Kuan Chou, PhD, Hao Bai, PhD, Yongxing Gao, Ying Wang, Zhaohui Ye, PhD, Erika Mijin Kwon, PhD, Pu Paul Liu, MD PhD, Alan D. Friedman, MD, Zack Z. Wang, PhD, Linzhao Cheng, PhD

Blood (2015) 126 (23): 1167.

https://doi.org/10.1182/blood.V126.23.1167.1167

Published: 2015

Journal Articles

In Vivo Deletion of the Cebpa +37 Kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

Alan D. Friedman, MD, Hong Guo, MD PhD, Stacy Cooper, MD

Blood (2015) 126 (23): 1178.

https://doi.org/10.1182/blood.V126.23.1178.1178

Published: 2015

Journal Articles

The Multimerization Domain of Cbfß-SMMHC Is Required for Leukemogenesis

Ling Zhao, MD PhD, Lemlem Alemu, Jun Cheng, Tao Zhen, PhD, Alan D. Friedman, MD, Pu Paul Liu, MD PhD

Blood (2015) 126 (23): 3666.

https://doi.org/10.1182/blood.V126.23.3666.3666

Published: 2015

Journal Articles

Loss of IKKβ Increases the Number and Self-Renewal Capacity of Hematopoietic Stem Cells

Jing Zhang, PhD, Li Li, PhD, Albert S. Baldwin, PhD, Alan D. Friedman, MD, Ido Paz-Priel, MD

Blood (2014) 124 (21): 4345.

https://doi.org/10.1182/blood.V124.21.4345.4345

Published: 2014

Journal Articles

Functional Dissection of the C Terminus of CBFβ-SMMHC Indicates a Critical Role of the Multimerization Domain during Hematopoiesis and Leukemogenesis

Ling Zhao, MD PhD, Lemlem Alemu, Jun Cheng, Tao Zhen, PhD, Alan D. Friedman, MD, Pu Paul Liu, MD PhD

Blood (2014) 124 (21): 2218.

https://doi.org/10.1182/blood.V124.21.2218.2218

Published: 2014

Journal Articles

The RUNX1-Regulated Cebpa +37 Kb Enhancer Directs Human CD4 Transgene Expression To Long-Term Hematopoietic Stem Cells and Preferentially To Myeloid Compared With Lymphoid Or Erythroid Progenitors

Alan D. Friedman, M.D., Hong Guo, M.D., Ph.D., Ou Ma, Ph.D., Leonard I. Zon, MD, Ilya Shestopalov, Ph.D., Dan S. Kaufman, M.D., Ph.D., Patrick I Ferrell, B.S.

Blood (2013) 122 (21): 2442.

https://doi.org/10.1182/blood.V122.21.2442.2442

Published: 2013

Journal Articles

Src Kinase Can Activate RUNX1 Activity Via Phosphorylation Of C-Terminal Tyrosines and Activated RUNX1 Stimulates Granulopoiesis

Alan D. Friedman, M.D., Wan Yee Leong, M.Sc., Hong Guo, M.D., Ph.D., Ou Ma, Ph.D., Alan B. Cantor, M.D., Ph.D., Hui Huang, Ph.D.

Blood (2013) 122 (21): 1210.

https://doi.org/10.1182/blood.V122.21.1210.1210

Published: 2013

Journal Articles

A Carboxy-Terminally Truncated G-CSF Receptor Abolishes Apoptosis Induction By Neutrophil Elastase G185R Mutant In Myeloid Cells,

Fan Dong, M.D., Ph.D., Yaling Qiu, M.D., Nan Hu, Alan D. Friedman, M.D.

Blood (2013) 122 (21): 443.

https://doi.org/10.1182/blood.V122.21.443.443

Published: 2013

Journal Articles

Canonical NF-κB Signalling Is a Potential Target in FLT3/ITD AML.

Jing Zhang, PhD, Li Li, PhD, Alan D. Friedman, M.D., Donald Small, MD, PhD, Ido Paz-Priel, M.D.

Blood (2012) 120 (21): 2447.

https://doi.org/10.1182/blood.V120.21.2447.2447

Published: 2012

Journal Articles

Reduced C/EBPα Expression Favors Monopoiesis Over Granulopoiesis

Alan D. Friedman, M.D., Ou Ma, Ph.D., SunHwa Hong, Ph.D.

Blood (2012) 120 (21): 1230.

https://doi.org/10.1182/blood.V120.21.1230.1230

Published: 2012

Journal Articles

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

Hong Guo, Ou Ma, Nancy A. Speck, Alan D. Friedman

Blood (2012) 119 (19): 4408–4418.

https://doi.org/10.1182/blood-2011-12-397091

Published: 2012

Includes: Supplemental data

Journal Articles

PU.1 Is a Downstream Target of C/EBPα in Normal Hematopoiesis and Acute Myeloid Leukemia

Christian Bach, Ph.D., Philipp B. Staber, M.D., Min Ye, Ph.D., Pu Zhang, M.D., Alan D. Friedman, M.D., Ruud Delwel, Ph.D., Daniel G. Tenen

Blood (2011) 118 (21): 1353.

https://doi.org/10.1182/blood.V118.21.1353.1353

Published: 2011

Journal Articles

Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression

Nauder Faraday, Lisa R. Yanek, Xiao Ping Yang, Rasika Mathias, J. Enrique Herrera-Galeano, Bhoom Suktitipat, Rehan Qayyum, Andrew D. Johnson, Ming-Huei Chen, Geoffrey H. Tofler, Ingo Ruczinski, Alan D. Friedman, Arnaldur Gylfason, Unnur Thorsteinsdottir, Paul F. Bray, Christopher J. O'Donnell, Diane M. Becker, Lewis C. Becker

Blood (2011) 118 (12): 3367–3375.

https://doi.org/10.1182/blood-2010-11-320788

Published: 2011

Includes: Supplemental data

Journal Articles

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis

Li Zhang, Alan D. Friedman

Blood (2011) 118 (8): 2266–2274.

https://doi.org/10.1182/blood-2011-01-331157

Published: 2011

Includes: Supplemental data

Journal Articles

C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes

Ido Paz-Priel, Simone Houng, Julia Dooher, Alan D. Friedman

Blood (2011) 117 (15): 4085–4094.

https://doi.org/10.1182/blood-2010-07-294470

Published: 2011

Journal Articles

C/EBPα, C/EBPα Oncoproteins, or C/EBPβ Preferentially Bind NF-κB p50 Compared with p65 Via Conserved Residues In the C/EBP Basic Region

Julia E. Dooher, Ph.D., Ido Paz-Priel, M.D., Simone Houng, Albert S. Baldwin, Jr., Ph.D., Alan D. Friedman, M.D.

Blood (2010) 116 (21): 708.

https://doi.org/10.1182/blood.V116.21.708.708

Published: 2010

Journal Articles

NF-κB Target Genes Activation Via Displacement of HDACs Bound to NF-κB p50 Homodimers by C/EBPα, Its AML Oncoproteins or C/EBPβ.

Ido Paz-Priel, M.D., Simone Houng, M.Eng., Julia E. Dooher, Ph.D., Alan D. Friedman, M.D.

Blood (2010) 116 (21): 3637.

https://doi.org/10.1182/blood.V116.21.3637.3637

Published: 2010

Journal Articles

SHP2 Tyrosine Phosphatase Enhances CEBPA Gene Expression, STAT3 Activation, and Cytokine-Dependent Granulopoiesis.

Li Zhang, Ph.D., Alan D. Friedman, M.D.

Blood (2010) 116 (21): 1550.

https://doi.org/10.1182/blood.V116.21.1550.1550

Published: 2010

Journal Articles

Myeloid Expansion In the Absence of RUNX1 Is Associated with Increased Monopoiesis, Reduced Granulopoiesis, and Diminished CEBPA Gene Expression, Effects of Potential Relevance to Myeloid Transformation

Hong Guo, M.D., Ph.D., Alan D. Friedman, M.D.

Blood (2010) 116 (21): 3147.

https://doi.org/10.1182/blood.V116.21.3147.3147

Published: 2010

NARROW

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

The Roles of RUNX1 in Human Hematopoiesis and Megakaryopoiesis Revealed By Genome-Targeted Human iPSCs and an Improved Hematopoietic Differentiation Model

In Vivo Deletion of the Cebpa +37 Kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

The Multimerization Domain of Cbfß-SMMHC Is Required for Leukemogenesis

Loss of IKKβ Increases the Number and Self-Renewal Capacity of Hematopoietic Stem Cells

Functional Dissection of the C Terminus of CBFβ-SMMHC Indicates a Critical Role of the Multimerization Domain during Hematopoiesis and Leukemogenesis

The RUNX1-Regulated Cebpa +37 Kb Enhancer Directs Human CD4 Transgene Expression To Long-Term Hematopoietic Stem Cells and Preferentially To Myeloid Compared With Lymphoid Or Erythroid Progenitors

Src Kinase Can Activate RUNX1 Activity Via Phosphorylation Of C-Terminal Tyrosines and Activated RUNX1 Stimulates Granulopoiesis

A Carboxy-Terminally Truncated G-CSF Receptor Abolishes Apoptosis Induction By Neutrophil Elastase G185R Mutant In Myeloid Cells,

Canonical NF-κB Signalling Is a Potential Target in FLT3/ITD AML.

Reduced C/EBPα Expression Favors Monopoiesis Over Granulopoiesis

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

PU.1 Is a Downstream Target of C/EBPα in Normal Hematopoiesis and Acute Myeloid Leukemia

Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis

C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes

C/EBPα, C/EBPα Oncoproteins, or C/EBPβ Preferentially Bind NF-κB p50 Compared with p65 Via Conserved Residues In the C/EBP Basic Region

NF-κB Target Genes Activation Via Displacement of HDACs Bound to NF-κB p50 Homodimers by C/EBPα, Its AML Oncoproteins or C/EBPβ.

SHP2 Tyrosine Phosphatase Enhances CEBPA Gene Expression, STAT3 Activation, and Cytokine-Dependent Granulopoiesis.

Myeloid Expansion In the Absence of RUNX1 Is Associated with Increased Monopoiesis, Reduced Granulopoiesis, and Diminished CEBPA Gene Expression, Effects of Potential Relevance to Myeloid Transformation

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American Society of Hematology

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American Society of Hematology

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