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Andrew G. Polson
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Journal Articles

Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas

Clinical Trials & Observations
Stephen J. Schuster, Ling-Yuh Huw, Christopher R. Bolen, Victor Maximov, Andrew G. Polson, Katerina Hatzi, Elisabeth A. Lasater, Sarit E. Assouline, Nancy L. Bartlett, L. Elizabeth Budde, Matthew J. Matasar, Hartmut Koeppen, Emily C. Piccione, Deanna Wilson, Michael C. Wei, Shen Yin, Elicia Penuel
Journal: Blood
Blood (2024) 143 (9): 822–832.
https://doi.org/10.1182/blood.2023022348
Published: 2024
Includes: Supplemental data
Journal Articles

Novel CD20 Mutations As a Mechanism of Resistance to CD20-CD3 Targeted Therapies in Non-Hodgkin's Lymphoma

Victor Maximov, Christopher R. Bolen, Andrew G. Polson, Elicia Penuel, Elisabeth A. Lasater
Journal: Blood
Blood (2023) 142 (Supplement 1): 2808.
https://doi.org/10.1182/blood-2023-187696
Published: 2023
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 547.
https://doi.org/10.1182/blood-2018-99-116956
Published: 2018
Journal Articles

A Phase I Study of the Anti-CD79b THIOMAB TM -Drug Conjugate DCDS0780A in Patients (pts) with Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL)

Alex F. Herrera, MD, Manish R Patel, MD, John M. Burke, MD, Ranjana H. Advani, MD, Bruce D. Cheson, MD, Jeffrey P. Sharman, MD, Elicia Penuel, Andrew G. Polson, PhD, Ning Leng, PhD, Chunze Li, PhD, Eva Schuth, PhD, Anjali Vaze, PhD, Divya Samineni, PhD, Rebecca Elstrom, MDMA, Catherine S Diefenbach
Journal: Blood
Blood (2017) 130 (Supplement 1): 4129.
https://doi.org/10.1182/blood.V130.Suppl_1.4129.4129
Published: 2017
Journal Articles

An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia

Steven R. Leong, Siddharth Sukumaran, Maria Hristopoulos, Klara Totpal, Shannon Stainton, Elizabeth Lu, Alfred Wong, Lucinda Tam, Robert Newman, Brian R. Vuillemenot, Diego Ellerman, Chen Gu, Mary Mathieu, Mark S. Dennis, Allen Nguyen, Bing Zheng, Crystal Zhang, Genee Lee, Yu-Waye Chu, Rodney A. Prell, Kedan Lin, Steven T. Laing, Andrew G. Polson
Journal: Blood
Blood (2017) 129 (5): 609–618.
https://doi.org/10.1182/blood-2016-08-735365
Published: 2017
Includes: Supplemental data
Journal Articles

Preclinical Characterization of Combinability and Potential Synergy of Anti-CD20/CD3 T-Cell Dependent Bispecific Antibody with Chemotherapy and PD-1/PD-L1 Blockade

Liping Laura Sun, PhD, Peiyin Wang, Robyn Clark, Maria Hristopoulos, Diego Ellerman, PhD, Mary Mathieu, Yu-Waye Chu, Hong Wang, PhD, Klara Totpal, PhD, Allen J. Ebens, PhD, Andrew G. Polson, PhD, Stephen Gould, PhD
Journal: Blood
Blood (2016) 128 (22): 4168.
https://doi.org/10.1182/blood.V128.22.4168.4168
Published: 2016
Journal Articles

Pre-Clinical Characterization of T Cell-Dependent Bispecific Antibody Anti-CD79b/CD3 As a Potential Therapy for B Cell Malignancies

L. Laura Sun, PhD, Xiaocheng Chen, Yvonne Chen, Mark S. Dennis, Diego Ellerman, PhD, Clarissa Johnson, Mary Mathieu, Amy Oldendorp, Andrew G. Polson, PhD, Arthur Reyes, Eric Stefanich, Hong Wang, PhD, Peiyin Wang, Bing Zheng, Allen J. Ebens, PhD
Journal: Blood
Blood (2014) 124 (21): 4507.
https://doi.org/10.1182/blood.V124.21.4507.4507
Published: 2014
Journal Articles

FcRL5 as a Target of Antibody-Drug Conjugates for the Treatment of Multiple Myeloma.

Andrew G. Polson, Bing Zheng, Kristi Elkins, Jeffery Lau, Mary Ann T. Go, Suzie J. Scales, Shang-Fan Yu, Marta Chesi, P. Leif Bergsagel, MD, Allen J. Ebens, PhD
Journal: Blood
Blood (2009) 114 (22): 3836.
https://doi.org/10.1182/blood.V114.22.3836.3836
Published: 2009
Journal Articles

CD40 Pathway Activation Status Predicts Response to CD40 Targeted Therapy in Diffuse Large b-Cell Lymphoma.

David Dornan, Ph.D, Bart Burington, Ph.D, Peng Yue, Ph.D, Xiaoyan Shi, Ph.D, Ranjana Advani, MD, Nancy Yu, Jeffrey T Lau, Shang-Fan Yu, Sven De Vos, MD, PhD, Stephen M Ansell, Andres Forero-Torres, MD, Zora Modrusan, Hartmut Koeppen, Teddy Yang, Changchun Du, BM, BS, Kristi Elkins, Andrew G. Polson, Rienk Offringa, Nancy Whiting, PharmD, BCOP, Allen J. Ebens, PhD
Journal: Blood
Blood (2009) 114 (22): 2721.
https://doi.org/10.1182/blood.V114.22.2721.2721
Published: 2009
Journal Articles

Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

David Dornan, Fiona Bennett, Yvonne Chen, Mark Dennis, Dan Eaton, Kristi Elkins, Dorothy French, Mary Ann T. Go, Andrew Jack, Jagath R. Junutula, Hartmut Koeppen, Jeffrey Lau, Jacqueline McBride, Andy Rawstron, Xiaoyan Shi, Nancy Yu, Shang-Fan Yu, Peng Yue, Bing Zheng, Allen Ebens, Andrew G. Polson
Journal: Blood
Blood (2009) 114 (13): 2721–2729.
https://doi.org/10.1182/blood-2009-02-205500
Published: 2009
Includes: Supplemental data
Journal Articles

Development and Therapeutic Potential of an Anti-CD79b Antibody-Drug Conjugate, Anti-CD79b-Vc-MMAE, for the Treatment of Non-Hodgkin’s Lymphoma

Andrew G. Polson, Fiona L Bennett, Yvonne Chen, Mark Dennis, Dan Eaton, Allen Ebens, Kristi Elkins, Dorothy French, Mary Ann T. Go, Andrew S Jack, Jagath Junutula, Hartmut Koeppen, Jeffery Lau, Jacqueline McBride, Lily Shi, Andy Rawston, Shang-Fan Yu, Peng Yue, Bing Zheng, David Dornan
Journal: Blood
Blood (2008) 112 (11): 2618.
https://doi.org/10.1182/blood.V112.11.2618.2618
Published: 2008
Journal Articles

Pharmacodynamics, Pharmacokinetics, and Tolerability of a B-Cell Specific Antibody-Targeted Chemotherapeutic Agent, Anti-CD79b-MCC-DM1, in Cynomolgus Monkeys

Marna Williams, Dongwei Li, Reina Fuji, Franklin Fuh, Saileta Prabhu, Bing Zheng, Kristi Elkins, Shang-Fan Yu, Josefa Chuh, Christine Tan, Joanne Hongo, Helga Raab, Judy Young, Sarajane Ross, Katherine Kozak, Dan Eaton, Susan D. Spencer, Kirsten A Poon, Paul Fielder, Jay Tibbitts, Karen Berry, William Manning, Vanitha Ramakrishnan, Allen Ebens, Andrew G. Polson
Journal: Blood
Blood (2008) 112 (11): 4974.
https://doi.org/10.1182/blood.V112.11.4974.4974
Published: 2008
Journal Articles

Pharmacodynamic Effects of Administration of Maytansine Conjugated Anti-CD22 Monoclonal Antibodies to Cynomolgus Monkeys

Franklin Fuh, Reina Fuji, Kirsten A Poon, Dongwei Li, Clarissa David, Quyen Nguyen, Kathy Howell, Joseph Beyer, Paul Fielder, William Manning, Jr., Karen Berry, Vanitha Ramakrishnan, Andrew G. Polson, Allen Ebens, Saileta Prabhu, Marna Williams
Journal: Blood
Blood (2008) 112 (11): 4996.
https://doi.org/10.1182/blood.V112.11.4996.4996
Published: 2008
Journal Articles

Antibody-Drug Conjugates with Uncleavable Linkers for the Treatment of Non-Hodgkin Lymphoma.

Andrew G. Polson, PhD, Suzanna Clark, Changchun Du, Dan Eaton, Ph.D., Kristi Elkins, Reina N. Fuji, VMD, PhD, Mary Ann, Go, Alane Gray, Tom Januario, Hartmut Koeppen, M.D., Ph.D., Jeffery Lau, Will Leach, Elena McDorman, Ph.D., Kathleen McKeever, Ph.D., Saileta Prabhu, Ph.D., Suzie J. Scales, Ph.D., Dionysos Slaga, Susan Spencer, Marna Williams, Ph.D, David Xie, Shang-Fan Yu, Bing Zheng, Allen Ebens, PhD.
Journal: Blood
Blood (2007) 110 (11): 526.
https://doi.org/10.1182/blood.V110.11.526.526
Published: 2007
Journal Articles

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma

Andrew G. Polson, Shang-Fan Yu, Kristi Elkins, Bing Zheng, Suzanna Clark, Gladys S. Ingle, Dionysos S. Slaga, Lynne Giere, Changchun Du, Christine Tan, Jo-Anne Hongo, Alvin Gogineni, Mary J. Cole, Richard Vandlen, Jean-Philippe Stephan, Judy Young, Wesley Chang, Suzie J. Scales, Sarajane Ross, Dan Eaton, Allen Ebens
Journal: Blood
Blood (2007) 110 (2): 616–623.
https://doi.org/10.1182/blood-2007-01-066704
Published: 2007
Includes: Supplemental data
Journal Articles

Antibody-Drug Conjugates Targeted to CD79 for the Treatment of Non-Hodgkin’s Lymphoma.

Andrew G. Polson, Shang-Fan Yu, Kristi Elkins, Bing Zheng, Suzanna Clark, Gladys Ingle, Dion Slaga, Lynne Giere, Changchun Du, Jean-Philippe Stephan, Judy Young, Richard Vandlen, Wesley Chang, Suzie Scales, Sarajane Ross, Dan Eaton, Allen Ebens
Journal: Blood
Blood (2006) 108 (11): 2524.
https://doi.org/10.1182/blood.V108.11.2524.2524
Published: 2006