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Journal Articles

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Ramasamy Jagadeeswaran, PhD MSc, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Filippo Ciceri, PhD, Fernando Cavalcanti, PhD, Robert E. Molokie, MD, Donald Lavelle, PhD

Blood (2017) 130 (Supplement 1): 356.

https://doi.org/10.1182/blood.V130.Suppl_1.356.356

Published: 2017

Journal Articles

The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease

Ramasamy Jagadeeswaran, PhD MSc, Hong Lenny, PhD, Benjamin Vazquez, BA, Joshua Muniz, BS, Aimee Schad, Shivi Jain, MD, Michel Gowhari, DO, Donald Lavelle, PhD, Alan Diamond, PhD, Robert E. Molokie, MD, Angela Rivers, MD PhD

Blood (2017) 130 (Supplement 1): 2237.

https://doi.org/10.1182/blood.V130.Suppl_1.2237.2237

Published: 2017

Journal Articles

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Kestis Vaitkus, Vinzon Ibanez, Robert E Molokie, MD, Angela Rivers, MD PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2016) 128 (22): 324.

https://doi.org/10.1182/blood.V128.22.324.324

Published: 2016

Journal Articles

History of Asthma is Associated with Albuminuria within an International Pediatric Cohort of Sickle Cell Disease Patients: A Casire Group Analysis

Immacolata Tartaglione, MD, Baba PD Inusa, MBBS, FMCPaed, FRCPCH, MRCP, DCP, Raffaella Colombatti, MD PhD, Deepa Manwani, MD, Silverio Perrotta, Eugenia Vicky Naa Kwarley Asare, MBChB, BSc, Connie M. Piccone, MD, Fredericka Sey, MB ChB, Charles Antwi-Boasiako, PhD, Laura Sainati, MD, Adetola A. Kassim, MD MS, Donna Boruchov, MD, Angela Rivers, MD PhD, William Zempsky, MD, Crawford John Strunk, MD, Biree Andemariam, MD, Andrew D. Campbell, MD

Blood (2016) 128 (22): 3668.

https://doi.org/10.1182/blood.V128.22.3668.3668

Published: 2016

Journal Articles

Mitophagy Induction Is a Potential Therapeutic Approach for Sickle Cell Disease

Ramasamy Jagadeeswaran, PhD, Benjamin Alejandro Vazquez, BS, Vinzon Ibanez, Maria A Ruiz, Robert E Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2016) 128 (22): 267.

https://doi.org/10.1182/blood.V128.22.267.267

Published: 2016

Journal Articles

Hydroxyurea Shows Clinical Benefit without Alteration of Fetal Hemoglobin, MCV, or Hemoglobin in Unselected Adult and Pediatric Patients with Sickle Cell Anemia

Crawford John Strunk, MD, Biree Andemariam, MD, Fredericka Sey, MB ChB, Fatimah Farooq, BS, Rebekah Urbonya, BS, Charles Antwi-Boasiako, PhD, Adetola A. Kassim, MD MS, Onike Rodrigues, MD, Connie M. Piccone, MD, Angela Rivers, MD PhD, Deepa Manwani, MD, Imma Tartaglione, MD, Laura Sainati, MD, Raffaella Colombatti, MDPhD, Andrew D. Campbell, MD

Blood (2015) 126 (23): 2187.

https://doi.org/10.1182/blood.V126.23.2187.2187

Published: 2015

Journal Articles

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

Ramasamy Jagadeeswaran, PhD, Yash Agarwal, Vinzon Ibanez, Maria Armila Ruiz, Kestis Vaitkus, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2015) 126 (23): 3386.

https://doi.org/10.1182/blood.V126.23.3386.3386

Published: 2015

Journal Articles

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramaswamy Jagadeeswaran, PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2015) 126 (23): 642.

https://doi.org/10.1182/blood.V126.23.642.642

Published: 2015

Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 334.

https://doi.org/10.1182/blood.V124.21.334.334

Published: 2014

Journal Articles

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Angela Rivers, MD PhD, Kestis Vaitkus, Maria Armila Ruiz, B.S., Vinzon Ibanez, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 336.

https://doi.org/10.1182/blood.V124.21.336.336

Published: 2014

Journal Articles

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Maria Armila Ruiz, BS, Angela Rivers, MD, PhD, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Nadim Mahmud, MD, PhD, Joseph DeSimone, PhD, Donald Lavelle, PH.D.

Blood (2013) 122 (21): 438.

https://doi.org/10.1182/blood.V122.21.438.438

Published: 2013

Journal Articles

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Angela Rivers, MD, PhD, Maria Armila Ruiz, BS, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, Ph.D.

Blood (2013) 122 (21): 561.

https://doi.org/10.1182/blood.V122.21.561.561

Published: 2013

Journal Articles

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Maria Armila Ruiz, B.S., Kestis Vaitkus, Aparna Vasanthakumar, PhD, Angela Rivers, MD, PhD, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Lucy A. Godley, MD, PhD, Donald Lavelle, Ph.D.

Blood (2012) 120 (21): 824.

https://doi.org/10.1182/blood.V120.21.824.824

Published: 2012

Journal Articles

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Donald Lavelle, Ph.D., Kestis Vaitkus, Maria Armila Ruiz, B.S., Angela Rivers, MD, PhD, James D. Engel, PhD, Joseph DeSimone, PhD

Blood (2012) 120 (21): 249.

https://doi.org/10.1182/blood.V120.21.249.249

Published: 2012

NARROW

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

History of Asthma is Associated with Albuminuria within an International Pediatric Cohort of Sickle Cell Disease Patients: A Casire Group Analysis

Mitophagy Induction Is a Potential Therapeutic Approach for Sickle Cell Disease

Hydroxyurea Shows Clinical Benefit without Alteration of Fetal Hemoglobin, MCV, or Hemoglobin in Unselected Adult and Pediatric Patients with Sickle Cell Anemia

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

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American Society of Hematology

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American Society of Hematology

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