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Journal Articles

Adverse Events, Patterns of Tumor Lysis Syndrome Prophylaxis and Management, and Dosing Patterns in a Large Cohort of Venetoclax Treated CLL Patients in Community and Academic Settings

Lindsey E. Roeker, MD, Christopher P. Fox, MD PhD, Toby A. Eyre, John N. Allan, MD, Stephen J. Schuster, MD, Chadi Nabhan, MD, Brian T. Hill, MD PhD, Nirav N Shah, MD, Frederick Lansigan, MD, Maryam Yazdy, MD, Nicole Lamanna, MD, Bruce Cheson, MD, Arun K Singavi, MD, Catherine C. Coombs, MD, Paul Barr, MD, Alan P Skarbnik, MD, Mazyar Shadman, MD MPH, Hande H. Tuncer, MD, Chaitra S. Ujjani, MD, Allison M. Winter, MD, Joanna Rhodes, MD, Colleen Dorsey, BSN, RN, Hannah Morse, BSN, John M. Pagel, MD PhD, Annalynn M Williams, MS, Ryan Jacobs, MD, Andre Goy, MD, Sivraj Muralikrishnan, MD, Laurie Pearson, MD, Andrea Sitlinger, MD, Neil Bailey, MSc, Anna Schuh, MD PhD, Danielle M. Brander, MD, Amy A Kirkwood, MSc, Anthony R Mato, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4410.
https://doi.org/10.1182/blood-2018-99-118159
Published: 2018
Journal Articles

Treatment Patterns and Outcomes of Patients with CLL Treated with Chemoimmuno- and Novel Agent-Based Therapy: A Multicenter Study

Anthony R Mato, MD, Maryam Sarraf Yazdy, MD, Brian T. Hill, MD PhD, Mazyar Shadman, Hande Tuncer, MD, Allison M. Winter, MD, Kaitlin Kennard, RN, BSN, John N. Allan, MD, Chaitra S. Ujjani, MD, Danielle M. Brander, MD, Chadi Nabhan, MD, Paul Barr, MD, Jennifer R. Brown, MD PhD, Christopher P. Fox, MD PhD, Joanna Rhodes, MD, Anna Schuh, MD PhD, Toby A. Eyre, MD, Nicole Lamanna, MD, Nitin Jain, MD, William G. Wierda, MD PhD, Alan P Skarbnik, MD, Lindsey E. Roeker, MD, Rajat Bannerji, MD PhD, Andrew M. Evens, MD, Frederick Lansigan, MD, Jennifer C. Samp, MS, PharmD, Jacqueline Nielsen, PhD, James M. Pauff, Thomas J. Kipps, MD PhD, Stephen J. Schuster, MD, George A Follows, MD PhD, Bruce Cheson, MD, Barbara Eichhorst
Journal: Blood
Blood (2018) 132 (Supplement 1): 4759.
https://doi.org/10.1182/blood-2018-99-119015
Published: 2018
Journal Articles

Ibrutinib Plus Venetoclax in Relapsed/Refractory CLL: Results of the Bloodwise TAP Clarity Study

Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Andy Rawstron, BSc, PhD, Kristian Brock, MSc, BSc, Samuel Munoz Vicente, MSc, Francesca Yates, PhD, Rebecca Bishop, BSc, Donald Macdonald, Christopher Fegan, MD, Alison McCaig, PhD, Anna Schuh, MD PhD, Andrew Pettitt, FRCPath, PhD, John G. Gribben, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Stephen Devereux, PhD, Adrian Bloor, MA MB BChir PhDFCRP FRCPath, Christopher P. Fox, MD PhD, Francesco Forconi, MD DM, PhD FRCPath, Talha Munir
Journal: Blood
Blood (2018) 132 (Supplement 1): 182.
https://doi.org/10.1182/blood-2018-182
Published: 2018
Journal Articles

Highly Comprehensive Genomic Testing for CLL: WGS, One Key to CLL Patient Stratification

Kate E Ridout, PhD, Pauline Robbe, MSc, PhD, Doriane Cavalieri, MSc, Jennifer Becq, PhD, Miao He, PhD, Ruth Clifford, FRCPath, PhD, Niamh Appleby, FRCPath, MD, Reem Alsolami, PhD, Adam Burns, BSc, PhD, Melanie Oates, PhD, Basile Stamatopoulos, PhD, Samantha Knight, PhD, Alona Sosinsky, PhD, Pavlos Antoniou, PhD, Mark Ross, PhD, David Bentley, PhD, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Mark Caulfield, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3115.
https://doi.org/10.1182/blood-2018-99-115935
Published: 2018
Journal Articles

Venetoclax As Monotherapy or in Combination: Patterns of Use and Predictors of Outcomes in an International Multicenter Study of CLL Patients

Anthony R. Mato, MD MSCE, Lindsey E. Roeker, MD, Toby A. Eyre, Chadi Nabhan, MD, Nicole Lamanna, MD, Brian T. Hill, MD PhD, Danielle M. Brander, MD, Paul Barr, MD, Frederick Lansigan, MD, Bruce Cheson, MD, Arun K Singavi, MD, Maryam Yazdy, MD, Nirav N Shah, MD, John N. Allan, MD, Erica B Bhavsar, BS, Joanna Rhodes, MD, Kaitlin Kennard, RN, BSN, Stephen J. Schuster, MD, Annalynn M Williams, MS, Alan P Skarbnik, MD, Andre Goy, MD, Catherine C. Coombs, MD, Hande H. Tuncer, MD, Chaitra S. Ujjani, MD, Ryan Jacobs, MD, Allison M. Winter, MD, John M. Pagel, MD PhD, Neil Bailey, MSc, Anna Schuh, MD PhD, Mazyar Shadman, MD MPH, Andrea Sitlinger, MD, Hanna Weissbrot, BS, Sivraj Muralikrishnan, MD, Amy A Kirkwood, MSc, Christopher P. Fox, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3142.
https://doi.org/10.1182/blood-2018-99-114840
Published: 2018
Journal Articles

p53 Functional Assessment and Correlation with 17p Deletion and/or TP53 Mutation Status: Final Report of the ICLL001 Bomp Trial

Magali Le Garff-Tavernier, Claire Quiney, Lauren Veronese, MD PhD, Florence Nguyen-Khac, MD PhD, Pauline Robbe, MSc, PhD, Patricia Combes, Marie-Sarah Dilhuydy, MD, Pierre Feugier, Beatrice Mahe, MD, Laurence Sanhes, MD, Alain Jacques Delmer, MD, Loic Ysebaert, MD PhD, Malgorzata Truchan-Graczyk, Brigitte Dreyfus, MD, Choquet Sylvain, MD, Thérèse Aurran, MD, Emmanuelle Ferrant, MD, Caroline Dartigeas, MD, Stéphane Leprêtre, MD, Gian Matteo Pica, MD, Frederic Davi, MD PhD, Bruno Pereira, Roselyne Delepine, Anna Schuh, MD PhD, Romain Guieze, MD, Jacques-Olivier Bay, MD PhD, Véronique Leblond, MD PhD, Helene Merle-Beral, MD PhD, Sophie de Guibert, MD, Olivier Tournilhac, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3127.
https://doi.org/10.1182/blood-2018-99-116722
Published: 2018
Journal Articles

Detection of Clinically Relevant Molecular Alterations in Chronic Lymphocytic Leukemia (CLL) By Nanopore Sequencing

Adam Burns, BSc, PhD, David Robert Bruce, MRCP, Pauline Robbe, MSc, PhD, Adele Timbs, Basile Stamatopoulos, PhD, Ruth Clifford, FRCPath, PhD, Maria Lopopolo, Duncan Parkes, Kate E Ridout, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2018-99-110948
Published: 2018
Journal Articles

Initial Results of Ibrutinib Plus Venetoclax in Relapsed, Refractory CLL (Bloodwise TAP CLARITY Study): High Rates of Overall Response, Complete Remission and MRD Eradication after 6 Months of Combination Therapy

Peter Hillmen, MBChB, PhD, Talha Munir, Andy Rawstron, PhD, Kristian Brock, MSc, BSc, Samuel Munoz Vicente, MSc, Francesca Yates, PhD, Rebecca Bishop, BSc, Christopher Fegan, MD, Donald Macdonald, Alison McCaig, PhD, Anna Schuh, MD PhD, Andrew Pettitt, FRCPath, PhD, John G. Gribben, MDDSc FMedSci, Stephen Devereux, FRCP, FRCPath, PhD, Adrian Bloor, Christopher P Fox, MBChB PhD, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 428.
https://doi.org/10.1182/blood.V130.Suppl_1.428.428
Published: 2017
Journal Articles

Idelalisib-Rituximab Results in Considerable Toxicity but Induces Durable Clinical Remissions in Patients with TP53 Disrupted B Cell Prolymphocytic Leukemia

Toby A. Eyre, MBBChir, MRCP, Christopher P. Fox, MBChB, PhD, Ali Boden, MRCP, Adrian Bloor, Moez Dungawalla, Paneesha Shankara, Richard Went, Anna Schuh, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4068.
https://doi.org/10.1182/blood.V130.Suppl_1.4068.4068
Published: 2017
Journal Articles

Dynamic of Telomeric Parameters in Relapsing or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL), an Analysis of the Filo ICLL001 Bomp Trial

Laura Bounaix, Andrei Tchirkov, MD PhD, Florence Nguyen-Khac, MD PhD, Patricia Combes, Pierre Feugier, MD, Laurence Sanhes, Marie-Sarah Dilhuydy, MD, Hussam Saad, MD, Loic Ysebaert, MD PhD, Choquet Sylvain, Jean-Pierre Vilque, Annie Brion, Carla Araujo, MD, Emmanuelle Ferrant, Brigitte Dreyfus, Alain Jacques Delmer, MD, Malgorzata Truchan-Graczyk, Stéphane Leprêtre, MD, Sophie de Guibert, Romain Guieze, MD PhD, Lauren Veronese, MD PhD, Richard Lemal, MD, Philippe Vago, Jacques-Olivier Bay, MD PhD, Marc G. Berger, MD PhD, Anna Schuh, MD PhD, Christophe Ferrand, PhD, Roselyne Delepine, Véronique Leblond, Olivier Tournilhac, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4285.
https://doi.org/10.1182/blood.V130.Suppl_1.4285.4285
Published: 2017
Journal Articles

The Bloodwise TAP Calibre Feasibility Study to Assess the Mechanism of Action of Idelalisib in B-Cell Receptor Pathway (BCR) Inhibition in Chronic Lymphocytic Leukaemia (CLL)

Talha Munir, Peter Hillmen, MBChB, PhD, Andy Rawstron, PhD, Kristian Brock, MSc, BSc, Samuel Munoz-Vicente, Francesca Yates, PhD, Surita Dalal, PhD, Ruth M de Tute, PhD FRCPath, Chris P Fox, Donald Macdonald, Christopher Fegan, MD, Adrian Bloor, Anna Schuh, MD PhD, Gina Doody
Journal: Blood
Blood (2017) 130 (Supplement 1): 3014.
https://doi.org/10.1182/blood.V130.Suppl_1.3014.3014
Published: 2017
Journal Articles

Acalabrutinib Monotherapy in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: Updated Results from the Phase 1/2 ACE-CL-001 Study

John C. Byrd, MD, William G Wierda, MD PhD, Anna Schuh, MD PhD, Stephen Devereux, FRCP, FRCPath, PhD, Jorge M. Chaves, MD, Jennifer R. Brown, MD PhD, Peter Hillmen, MBChB, PhD, Peter Martin, MD, Farrukh T. Awan, MD MS, Deborah M. Stephens, DO, Paolo Ghia, MD PhD, Jacqueline C. Barrientos, MD, John M. Pagel, MD PhD, Jennifer A. Woyach, MD, Prista Charuworn, MD, Ahmed Hamdy, MD, Raquel Izumi, PhD, Priti Patel, MD, Wayne M. Rothbaum, Min Hui Wang, PhD, Richard R. Furman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 498.
https://doi.org/10.1182/blood.V130.Suppl_1.498.498
Published: 2017
Journal Articles

The Contribution of Gene Mutations to Long-Term Clinical Outcomes: Data from the Randomised UK LRF CLL4 Trial

Stuart Blakemore, PhD, Ruth Clifford, Pavlos Antoniou, Helen Parker, PhD, Pauline Robbe, MSc, Marta Larrayoz, PhD, Zadie Davis, Latha Kadalyayil, Andrew Collins, Jade Forster, PhD, Monica Else, Andrew J Steele, PhD, Jacqueline Chan, PhD, Graham Speight, PhD, Mark Cragg, PhD, Matthew John Jerome Rose-Zerilli, PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Anna Schuh, MD PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 259.
https://doi.org/10.1182/blood.V130.Suppl_1.259.259
Published: 2017
Journal Articles

Clinical Importance of DNA Methylation Signatures in Chronic Lymphocytic Leukaemia Patients Treated with Chemo-Immunotherapy

Harindra Amarasinghe, PhD, Tomasz K Wojdacz, PhD MSc, Matthew John Jerome Rose-Zerilli, PhD, Alice Beattie, Jade Forster, PhD, Latha Kadalayil, Stuart Blakemore, PhD, Helen Parker, PhD, Marta Larrayoz, PhD, Ruth Clifford, Zadie Davis, Monica Else, Dena Cohen, Andrew J Steele, PhD, Richard Rosenquist, MD PhD, Andrew Collins, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MBChB, PhD, Pauline Robbe, MSc, Christopher Plass, Anna Schuh, MD PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Christopher C. Oakes, PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 56.
https://doi.org/10.1182/blood.V130.Suppl_1.56.56
Published: 2017
Journal Articles

Characterization of Recurrent Mutations in Patient with a Richter Syndrome By Targeted Next Generation Sequencing

Basile Stamatopoulos, PhD, Pavlos Antoniou, Dimitris Vavoulis, Toby A. Eyre, MD, Ruth Clifford, MD, Maité Cabes, Msc, Hélène Dreau, MSc, Anna Schuh, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3200.
https://doi.org/10.1182/blood.V128.22.3200.3200
Published: 2016
Journal Articles

Light Chain IgLV3-21 Is Associated with Poor Prognosis in Chronic Lymphocytic Leukemia Patients Independently of the Presence of Heavy Chain IgHV3-21

Basile Stamatopoulos, PhD, Thomas Smith, PhD, David Sims, PhD, Andreas Heger, PhD, Hélène Dreau, MSc, Anna Schuh, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3218.
https://doi.org/10.1182/blood.V128.22.3218.3218
Published: 2016
Journal Articles

Results of the Phase 3 Study of Lenalidomide Versus Placebo As Maintenance Therapy Following Second-Line Treatment for Patients with Chronic Lymphocytic Leukemia (the CONTINUUM Trial)

Robin Foà, MD, Anna Schuh, MD PhD, Andrey Zaritskey, MD, Sergey Semochkin, MD PhD, David Simpson, MBChB, FRACP, FRCPA, Miklos Egyed, Samuel Vokurka, MD PhD, Jeannine Kassis, MDFRCP, Jennie Zhang, PhD, Brendan Purse, BA, MBA, Asher A. Chanan-Khan, MD
Journal: Blood
Blood (2016) 128 (22): 230.
https://doi.org/10.1182/blood.V128.22.230.230
Published: 2016
Journal Articles

Acalabrutinib Monotherapy in Patients with Richter Transformation from the Phase 1/2 ACE-CL-001 Clinical Study

Peter Hillmen, Anna Schuh, MD PhD, Toby A. Eyre, MD, John M. Pagel, MD PhD, Jennifer R. Brown, MD PhD, Paolo Ghia, John N. Allan, MD, William Wierda, MDPhD, Ahmed Hamdy, MBBCh, Jane Huang, MD, Raquel Izumi, PhD, Priti Patel, Min Hui Wang, John C. Byrd, MD
Journal: Blood
Blood (2016) 128 (22): 60.
https://doi.org/10.1182/blood.V128.22.60.60
Published: 2016
Journal Articles

Identifying High-Risk CLL to Predict Early Relapse after FCR Based Treatment Using Whole Genome Sequencing: First Results from the Genomics England CLL Pilot

Pauline Robbe, Kate Ridout, Jennifer Becq, Miao He, Ruth Clifford, MD, Reem Alsolami, Adam Burns, Samantha JL Knight, Melanie Oates, Dena Howard, Andrew R. Pettitt, Augusto Rendon, Niko Popitsch, Peter Hillmen, Jenny C Taylor, Mark Caulfield, David Bentley, Clare Turnbull, Anna Schuh, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2022.
https://doi.org/10.1182/blood.V128.22.2022.2022
Published: 2016
Journal Articles

Acalabrutinib Monotherapy in Patients with Ibrutinib Intolerance: Results from the Phase 1/2 ACE-CL-001 Clinical Study

Farrukh T. Awan, Anna Schuh, MD PhD, Jennifer R. Brown, MD PhD, Richard R. Furman, John M. Pagel, MD PhD, Peter Hillmen, Deborah M. Stephens, DO, Ahmed Hamdy, MBBCh, Jane Huang, MD, Raquel Izumi, PhD, Priti Patel, Min Hui Wang, John C. Byrd, MD
Journal: Blood
Blood (2016) 128 (22): 638.
https://doi.org/10.1182/blood.V128.22.638.638
Published: 2016