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Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Blood (2018) 132 (Supplement 1): 1339.

https://doi.org/10.1182/blood-2018-99-111015

Published: 2018

Journal Articles

Patients Who Are Refractory to Ida-FLAG As Initial Induction Chemotherapy for AML Have Persistence of the Dominant Genetic Mutations and a Poor Clinical Outcome

Blood (2017) 130 (Supplement 1): 2596.

https://doi.org/10.1182/blood.V130.Suppl_1.2596.2596

Published: 2017

Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD

Blood (2017) 130 (Supplement 1): 2524.

https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524

Published: 2017

Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 881.

https://doi.org/10.1182/blood.V130.Suppl_1.881.881

Published: 2017

Journal Articles

Burkitt Lymphoma Genome Sequencing Project (BLGSP): Introduction

Daniela S Gerhard, PhD, Bruno Grande, B. Sc., Nicholas Griner, PhD, Corey Casper, MD, Sarah E. Gerdts, MPH, Abraham Omoding, MD, Jackson Orem, MD, Sam M Mbulaiteye, MD, Martin D. Ogwang, MD, Steven J. Reynolds, MD MPH, Kishor Bhatia, PhD, Leona Ayers, MD, John K Choi, MD, Charles G. Mullighan, MBBS, MSc, PhD, John T. Sandlund, MD, Thomas B. Alexander, MD MPH, Jeremy S. Abramson, MD, Thomas G. Gross, MD PhD, Ariela Noy, MD PhD, Jeffrey Bethony, PhD, Fabio Leal, MD, PhD, Timothy C Greiner, MS, MD, Elaine S. Jaffe, MD, Nancy Lee Harris, MD, Julie M. Gastier-Foster, PhD, Jay Bowen, MS, Benjamin Hanf, Roland Schmitz, PhD, Jean-Paul Martin, MD, Marie-Reine Martin, MD, John D. Irvin, MD PhD, Ellen Miller, MS, Patee Gesuwan, Leandro C. Hermida, Tanja M. Davidsen, PhD, Andrew J. Mungall, Yussanne Ma, PhD, Marco A. Marra, PhD, Ryan D. Morin, Louis M. Staudt, MD PhD

Blood (2016) 128 (22): 1760.

https://doi.org/10.1182/blood.V128.22.1760.1760

Published: 2016

Journal Articles

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Sanduni U. Liyanage, Hon. B. Sc., Rose Hurren, Veronique Voisin, Wang Xiaoming, Gaëlle Bridon, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Aisha Shamas-Din, PhD, Shrivani Sriskanthadevan, Mark D. Minden, MD PhD, Gary D Bader, Rebecca Laposa, Aaron D. Schimmer, MD PhD

Blood (2016) 128 (22): 1573.

https://doi.org/10.1182/blood.V128.22.1573.1573

Published: 2016

Journal Articles

Mutations in the Second Linker of KLF1 Cause Congenital Non-Spherocytic Hemolytic Anemia Due to Global Reduction of In Vivo DNA-Binding Affinity

Stephen Huang, B Sc (Hons), Kevin R. Gillinder, PhD, Annabel Sorolla, PhD, Emma Whitelaw, BSc PhD, Andrew C Perkins, PhD

Blood (2016) 128 (22): 1246.

https://doi.org/10.1182/blood.V128.22.1246.1246

Published: 2016

Journal Articles

Direct Targets of Epo Receptor-JAK2-pSTAT5 Signalling in Erythropoiesis

Kevin R. Gillinder, PhD, Hugh Tuckey, BSc (Hons), Charles Bell, BSc, Stephen Huang, B Sc (Hons), Melissa Ilsley, BSc, Graham Magor, MB BS (Hons), Andrew C Perkins, PhD

Blood (2016) 128 (22): 3881.

https://doi.org/10.1182/blood.V128.22.3881.3881

Published: 2016

Journal Articles

A Randomized, Phase II Study with Biomarker Analysis of Panobinostat with or without Rituximab in Relapsed Diffuse Large B Cell Lymphoma

Sarit Assouline, Michael Crump, MD, Torsten Holm Nielsen, Miguel Alcaide, B. Sc., Ph. D., David Macdonald, MD FRCPC, Axel Tosikyan, Tina Haliotis, Celia Greenwood, Kathleen Klein Oros, Ryan Morin, PhD, Nathalie Johnson, MD PhD, Koren Kathleen Mann, PhD

Blood (2015) 126 (23): 2719.

https://doi.org/10.1182/blood.V126.23.2719.2719

Published: 2015

Journal Articles

Characterisation of Novel Hypomorphic and Null Mutations in Klf1 Derived from a Genetic Screen for Modifiers of a -Globin Transgene Variegation

Stephen Huang, B Sc (Hons), Kevin R. Gillinder, PhD, Melissa Ilsley, BSc, Graham Magor, MB BS (Hons), Michael Tallack, MDPhD, Anabel Sorolla, B Sc PhD, Harald Oey, BSc PhD, Sarah Harten, BSc PhD, Lucia Clemens-Daxinger, BSc PhD, Emma Whitelaw, BSc PhD, Andrew C Perkins, MDPhD

Blood (2015) 126 (23): 3329.

https://doi.org/10.1182/blood.V126.23.3329.3329

Published: 2015

Journal Articles

Recipient CD8 + DC Delete Alloreactive Donor CTL and Promote Leukemic Relapse after Allogeneic BMT

Kate A Markey, MBBS, PhD, Rachel D Kuns, BSc, Renee J Robb, PhD, Motoko Koyama, MDPhD, Kate Helen Gartlan, PhD, Andrea S Henden, MBBS, Simone A Minnie, B Sc, Kelli P A Macdonald, PhD, Thomas Brocker, PhD, Gabrielle T Belz, PhD, Steven W. Lane, MD, Geoff R Hill, MD

Blood (2015) 126 (23): 4279.

https://doi.org/10.1182/blood.V126.23.4279.4279

Published: 2015

Journal Articles

NFAT2 Regulates Anergy Induction in CLL through Lck

Melanie Märklin, M. Sc., Jonas S. Heitmann, B. Sc., Alexandra Poljak, B. Sc., Stefanie Bugl, PhD, Hans-Georg Kopp, MD, Michael Haap, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R. Müller, MD PhD

Blood (2014) 124 (21): 720.

https://doi.org/10.1182/blood.V124.21.720.720

Published: 2014

Journal Articles

C-CBL Is a Critical Negative Regulator of Megakaryopoesis

Sebastian J. Saur, MD, Melanie Märklin, M. Sc., Alexandra Poljak, B. Sc., Manuela Ganser, B. Sc., David E. James, PhD, Kyle Hoehn, PhD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Martin R. Müller, MD PhD

Blood (2014) 124 (21): 1581.

https://doi.org/10.1182/blood.V124.21.1581.1581

Published: 2014

Journal Articles

Final Report Of a Phase II Clinical Trial Of Lenalidomide Monotherapy For T-Cell Lymphoma

Ethan Toumishey, B. Sc, Angeli Prasad, CCRP, Gregory S. Dueck, MD, MSc, BSc, FRCPC, Neil Chua, MD, FRCPC, Daygen Finch, MD, Douglas A. Stewart, MD, FRCPC, Darrell J. White, MD, Richard H. van der Jagt, MD, FRCPC, James B Johnston, MD, Andrew R Belch, MD, Tony Reiman, MD

Blood (2013) 122 (21): 4376.

https://doi.org/10.1182/blood.V122.21.4376.4376

Published: 2013

Journal Articles

NFAT2 Is a Critical Regulator Of Anergy Induction In CLL

Melanie Märklin, M. Sc., Jonas S. Heitmann, B. Sc., David Worbs, B. Sc., Alexandra Poljak, B. Sc., Claude Evouna, MD, Hans-Georg Kopp, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2013) 122 (21): 869.

https://doi.org/10.1182/blood.V122.21.869.869

Published: 2013

Journal Articles

Transcriptional Mistargeting Of NFAT2 In CLL

Blood (2013) 122 (21): 4122.

https://doi.org/10.1182/blood.V122.21.4122.4122

Published: 2013

Journal Articles

A Retrospective Single-Centre Cohort Study Comparing Lower-Dose Intravenous Immune Globulin (IVIg) (1 g/kg) to Higher-Dose Ivig (2 g/kg) in Adult Immune Thrombocytopenia

Mikhyla J Richards, MD, Sophie Yu Wang, Ribeka Kim, B. Sc, Kate M Chipperfield, MD, FRCPC, David Pi, MBBS, FRCPC, Luke Y. C. Chen, MD, FRCPC

Blood (2012) 120 (21): 3324.

https://doi.org/10.1182/blood.V120.21.3324.3324

Published: 2012

Journal Articles

Genetic Loss of NFAT2 Induces Profound Acceleration of CLL in the TCL1 Mouse Model

Melanie Märklin, M. Sc., Stefanie Bugl, M. Sc., Jonas S. Heitmann, B. Sc., Alexandra Poljak, B. Sc., Bettina S, Hackl, B. Sc., Hans-Georg Kopp, MD, Lothar Kanz, MD, Anjana Rao, PhD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2012) 120 (21): 862.

https://doi.org/10.1182/blood.V120.21.862.862

Published: 2012

Journal Articles

Sustained Immune Competency and Long Term Molecular Remissions in FL Patients with FLIPI Risk Factors >1, Treated Front Line with R-CHOP Followed by Consolidative 90 Y-Radioimmunotherapy and Maintenance Rituximab

Neil L Berinstein, MD, FRCPC, Nancy M Pennell, B Sc, Mary-Anne Cussen, RN, BScN, CCRP, Kevin R Imrie, MD, Eugenia Piliotis, MD, FRCPC, Rena Buckstein, MD, Zeina Ghorab, MD, Ellen Anne Miles, MSc, Alden E. Chesney, MD, Matthew Cheung, MD

Blood (2012) 120 (21): 3681.

https://doi.org/10.1182/blood.V120.21.3681.3681

Published: 2012

Journal Articles

Overexpression and Aberrant Nuclear Translocation of NFAT2 in CLL

Jonas S. Heitmann, B. Sc., Melanie Märklin, M. Sc., Alexandra Poljak, B. Sc., Bettina S, Hackl, B. Sc., Juliane Sarah Stickel, MD, Lothar Kanz, MD, Hans-Georg Kopp, MD, Stefan Wirths, MD, Martin R Müller, MD, PhD

Blood (2012) 120 (21): 3909.

https://doi.org/10.1182/blood.V120.21.3909.3909

Published: 2012

NARROW

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Patients Who Are Refractory to Ida-FLAG As Initial Induction Chemotherapy for AML Have Persistence of the Dominant Genetic Mutations and a Poor Clinical Outcome

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Burkitt Lymphoma Genome Sequencing Project (BLGSP): Introduction

Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells

Mutations in the Second Linker of KLF1 Cause Congenital Non-Spherocytic Hemolytic Anemia Due to Global Reduction of In Vivo DNA-Binding Affinity

Direct Targets of Epo Receptor-JAK2-pSTAT5 Signalling in Erythropoiesis

A Randomized, Phase II Study with Biomarker Analysis of Panobinostat with or without Rituximab in Relapsed Diffuse Large B Cell Lymphoma

Characterisation of Novel Hypomorphic and Null Mutations in Klf1 Derived from a Genetic Screen for Modifiers of a -Globin Transgene Variegation

Recipient CD8 + DC Delete Alloreactive Donor CTL and Promote Leukemic Relapse after Allogeneic BMT

NFAT2 Regulates Anergy Induction in CLL through Lck

C-CBL Is a Critical Negative Regulator of Megakaryopoesis

Final Report Of a Phase II Clinical Trial Of Lenalidomide Monotherapy For T-Cell Lymphoma

NFAT2 Is a Critical Regulator Of Anergy Induction In CLL

Transcriptional Mistargeting Of NFAT2 In CLL

A Retrospective Single-Centre Cohort Study Comparing Lower-Dose Intravenous Immune Globulin (IVIg) (1 g/kg) to Higher-Dose Ivig (2 g/kg) in Adult Immune Thrombocytopenia

Genetic Loss of NFAT2 Induces Profound Acceleration of CLL in the TCL1 Mouse Model

Sustained Immune Competency and Long Term Molecular Remissions in FL Patients with FLIPI Risk Factors >1, Treated Front Line with R-CHOP Followed by Consolidative 90 Y-Radioimmunotherapy and Maintenance Rituximab

Overexpression and Aberrant Nuclear Translocation of NFAT2 in CLL

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American Society of Hematology

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American Society of Hematology

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