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Brian Groff
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Journal Articles

Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia

Frank Cichocki, Jodie P. Goodridge, Ryan Bjordahl, Sajid Mahmood, Zachary B. Davis, Svetlana Gaidarova, Ramzey Abujarour, Brian Groff, Alec Witty, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T. Lee, Bruce Walcheck, Bahram Valamehr, Jeffrey S. Miller
Journal: Blood
Blood (2022) 140 (23): 2451–2462.
https://doi.org/10.1182/blood.2021015184
Published: 2022
Includes: Supplemental data
Journal Articles

iPSC-Derived CD38-Null NK Cells in Combination with CD38-Targeted Antibody: A Dual Therapeutic Strategy to Enable ADCC and Eliminate Host Immune Cells in Multiple Myeloma

Rina M Mbofung, Xingyue Zong, Erika Varady, Alan M Williams, Ken L Hayama, Yijia Pan, Sushil Devkota, Brian Groff, Miguel Meza, Thomas Dailey, Tom Lee, Lilly Wong, Sarah Cooley, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 7388–7389.
https://doi.org/10.1182/blood-2022-169817
Published: 2022
Journal Articles

Combined Genetic Ablation of CD54 and CD58 in CAR Engineered Cytotoxic Lymphocytes Effectively Averts Allogeneic Immune Cell Rejection

Quirin Hammer, Karlo Perica, Rina M Mbofung, Hanna van Ooijen, Erika Varady, Mark Jelcic, Yijia Pan, Pouria Momayyezi, Brian Groff, Ramzey Abujarour, Silje Zandstra Krokeide, Tom Lee, Alan M Williams, Jode P Goodridge, Bahram Valamehr, Bjorn Onfelt, Michel Sadelain, Karl-Johan Malmberg
Journal: Blood
Blood (2022) 140 (Supplement 1): 1165–1166.
https://doi.org/10.1182/blood-2022-163086
Published: 2022
Journal Articles

Alloimmune Defense Receptor Harnesses Host Immune Cell Activation to Potentiate Functional Persistence and Anti-Tumor Activity of Off-the-Shelf, Cell-Based Cancer Therapy

Alan M Williams, Ken L Hayama, Yijia Pan, Brian Groff, Rina M Mbofung, Amber Chang, Christine Chen, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Maksim Mamonkin, Raedun Clarke, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 4547–4548.
https://doi.org/10.1182/blood-2022-167139
Published: 2022
Journal Articles

A Novel Stealth Strategy That Activates Adoptively Transferred Allogeneic Immune Cells and Avoids Rejection for Off-the-Shelf Cell-Based Cancer Therapy

Alan M Williams, Ken Hayama, Yijia Pan, Brian Groff, Rina M Mbofung, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Quirin Hammer, Karl-Johan Malmberg, Maksim Mamonkin, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 4800.
https://doi.org/10.1182/blood-2021-153614
Published: 2021
Journal Articles

Off-the-Shelf, iPSC-Derived CAR-NK Cells Multiplexed-Engineered for the Avoidance of Allogeneic Host Immune Cell Rejection

Rina M Mbofung, Alan M Williams, Ken Hayama, Yijia Pan, Brian Groff, Thomas Dailey, Sonia Reyes, Sajid Mahmood, Ketan Mathavan, Greg Bonello, Quirin Hammer, Karl-Johan Malmberg, Tom Lee, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 2795.
https://doi.org/10.1182/blood-2021-153484
Published: 2021
Journal Articles

CAR19 iPSC-Derived NK Cells Utilize the Innate Functional Potential Mediated through NKG2A-Driven Education and Override the HLA-E Check Point to Effectively Target B Cell Lymphoma

Minoru Kanaya, PhD, Camille Philippon, MSc, Artur Cieslar-Pobuda, PhD, Frank Cichocki, PhD, Michelle Saetersmoen, MSc, Sajid Mahmood, PhD, Quirin Hammer, PhD, Marianna Vincenti, MD, Merete Thune Wiiger, PhD, Hanna Julie Hoel, MSc, Lise Kveberg, PhD, Svetlana Gaidarova, MS, Ryan Bjordahl, PhD, Hui-yi Chu, PhD, Brian Groff, Matthew Denholtz, PhD, Jeffrey S. Miller, MD, Tom Lee, PhD, Dan S Kaufman, MDPhD, Jode P Goodridge, PhD, Bahram Valamehr, PhD, Karl-Johan Malmberg, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-138527
Published: 2020
Journal Articles

FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma

Jode P Goodridge, PhD, Ryan Bjordahl, PhD, Sajid Mahmood, PhD, John Reiser, PhD, Svetlana Gaidarova, MS, Robert Blum, MS, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Yu-Waye Chu, MD, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Armin Rehm, Uta Hopken, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-142750
Published: 2020
Journal Articles

FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Jode P Goodridge, PhD, Sajid Mahmood, PhD, Huang Zhu, PhD, Svetlana Gaidarova, MS, Robert Blum, Ryan Bjordahl, PhD, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Dan S Kaufman, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 301.
https://doi.org/10.1182/blood-2019-129319
Published: 2019
Journal Articles

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Chiawei Chang, Sjoukje Van Der Stegen, PhD, Mandal Mili, PhD, Raedun Clarke, PhD, Yi-Shin Lai, PhD, Alec Witty, PhD, Pieter Lindenbergh, Bi-Huei Yang, PhD, Mushtaq Husain, PhD, Helena Shaked, PhD, Brian Groff, Laurel Stokely, Ramzey Abujarour, PhD, Tom Lee, PhD, Hui-Yi Chu, PhD, Mochtar Pribadi, PhD, Jason ORourke, PhD, Alma Gutierrez, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4434.
https://doi.org/10.1182/blood-2019-130584
Published: 2019
Journal Articles

Clinical Translation of Pluripotent Cell-Derived Off-the-Shelf Natural Killer Cell Cancer Immunotherapy

Frank Cichocki, Ryan Bjordahl, PhD, Svetlana Gaidarova, Paul Rogers, Raedun Clarke, PhD, Brian Groff, Stacey Moreno, Ramzey Abujarour, PhD, Megan Robinson, Greg Bonello, PhD, Tom Lee, PhD, Weijie Lan, PhD, Betsy Rezner, BS, Stewart Abbot, Darin Sumstad, MLS, Bruce Blazar, MD, Daniel Shoemaker, PhD, Scott Wolchko, Dan Kaufman, MD, David H. McKenna, MD, Bahram Valamehr, PhD, Sarah Cooley, MD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 656.
https://doi.org/10.1182/blood.V130.Suppl_1.656.656
Published: 2017
Journal Articles

Multi-Functional Genetic Engineering of Pluripotent Cell Lines for Universal Off-the-Shelf Natural Killer Cell Cancer Immunotherapy

Ryan Bjordahl, PhD, Raedun Clarke, PhD, Svetlana Gaidarova, Matthieu Bauer, PhD, Jeff Sasaki, Brian Groff, Tom Lee, PhD, Weijie Lan, PhD, Ramzey Abujarour, PhD, Greg Bonello, PhD, Megan Robinson, Ian Hardy, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3187.
https://doi.org/10.1182/blood.V130.Suppl_1.3187.3187
Published: 2017
Journal Articles

Off-the-Shelf Natural Killer Cell Immunotherapy for Enhanced Antibody Directed Cellular Cytotoxicity

Ryan Bjordahl, PhD, Raedun Clarke, PhD, Svetlana Gaidarova, M.S., Brian Groff, B.S., Paul Rogers, PhD, Stacey Moreno, Ramzey Abujarour, PhD, Greg Bonello, PhD, Tom Tong Lee, PhD, Weijie Lan, PhD, Michelle Burrascano, Matthieu Bauer, PhD, Megan Robinson, BS, Jeff Sasaki, William Kim, PhD, David Robbins, BS, Betsy Rezner, BS, Stewart E. Abbot, PhD BSc, MSc, Scott Wolchko, MS, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 3363.
https://doi.org/10.1182/blood.V128.22.3363.3363
Published: 2016
Journal Articles

Genetically Enhanced Pluripotent Stem Cell-Derived T Lymphocytes for Off-the-Shelf Cellular Immunotherapy

Raedun Clarke, PhD, Brian Groff, B.S., Jeffrey Sasaki, B.S., Matthieu Bauer, PhD, Tom Tong Lee, PhD, Weijie Lan, PhD, Michelle Burrascano, Ramzey Abujarour, PhD, Greg Bonello, Megan Robinson, BS, Heather Foster, David Robbins, BS, Scott Wolchko, MS, Daniel Shoemaker, PhD, Stewart E. Abbot, PhD BSc, MSc, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 2164.
https://doi.org/10.1182/blood.V128.22.2164.2164
Published: 2016
Journal Articles

Genetic Engineering of Pluripotent Cells for the Continuous Derivation of Off-the-Shelf Effector Lymphocytes with Enhanced Therapeutic Persistence By Overcoming the Host Histocompatibility Barrier

Matthieu Bauer, PhD, Raedun Clarke, PhD, Jeffrey Sasaki, B.S., Brian Groff, B.S., Tom Tong Lee, PhD, Weijie Lan, PhD, Ramzey Abujarour, PhD, Greg Bonello, Michelle Burrascano, Megan Robinson, BS, Ryan Bjordahl, PhD, Svetlana Gaidarova, M.S., Stewart E. Abbot, PhD BSc, MSc, Scott Wolchko, MS, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 2165.
https://doi.org/10.1182/blood.V128.22.2165.2165
Published: 2016
Journal Articles

A Platform for the Scalable Derivation of Genetically-Enhanced T and NK Lymphocytes from Naive Human Induced Pluripotent Stem Cells for Cancer Immunotherapy

Raedun Clarke, PhD, William Kim, PhD, Brian Groff, BS, Ramzey Abujarour, PhD, Megan Robinson, BS, Xiaosong Huang, PhD, Newsha Sahaf, Sarah Raynel, MS, Betsy Rezner, BS, David Robbins, BS, Lisa Guerrettaz, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2015) 126 (23): 2364.
https://doi.org/10.1182/blood.V126.23.2364.2364
Published: 2015