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Raedun Clarke
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Journal Articles

Alloimmune Defense Receptor Harnesses Host Immune Cell Activation to Potentiate Functional Persistence and Anti-Tumor Activity of Off-the-Shelf, Cell-Based Cancer Therapy

Alan M Williams, Ken L Hayama, Yijia Pan, Brian Groff, Rina M Mbofung, Amber Chang, Christine Chen, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Maksim Mamonkin, Raedun Clarke, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 4547–4548.
https://doi.org/10.1182/blood-2022-167139
Published: 2022
Journal Articles

The Development of Allogeneic Tips-Derived TCR - CAR + CD8αβ T Cells

Sjoukje J.C. van der Stegen, Roseanna M. Petrovic, Pieter L. Lindenbergh, Mame P. Diop, Vera Alexeeva, Hongyao Xie, Raedun Clarke, Bahram Valamehr, Isabelle Rivière, Michel Sadelain
Journal: Blood
Blood (2022) 140 (Supplement 1): 10290–10291.
https://doi.org/10.1182/blood-2022-169375
Published: 2022
Journal Articles

High-Density Cryopreservation of Off-the-Shelf CAR-NK Cells Facilitates On-demand Treatment Access

Ya-Ju Chang, Niancao Chen, Christine Chen, Tingxia Guo, Jaslem Herrera Valdez, Svetlana Gaidarova, Bryan Hancock, Betsy Rezner, Yvonne Lentz, Mark Plavsic, Richard Anderson, Raedun Clarke, Bahram Valamehr
Journal: Blood
Blood (2022) 140 (Supplement 1): 4693–4694.
https://doi.org/10.1182/blood-2022-162712
Published: 2022
Journal Articles

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Xu Yuan, Raedun Clarke, Yi-Shin Lai, Chia-Wei Chang, Bi-Huei Yang, Gloria Hsia, Ramzey Abujarour, Tom Lee, Sjoukje van der Stegen, Helena Shaked, Abubakar Jalloh, Stephanie Moreno, Jason ORourke, Eric Sung, Alma Gutierrez, Betsy Rezner, Meghan Eberhart, Rebecca Magdaleno, Xiuyan Wang, Brigitte Senechal, Devanjan S. Sikder, Dell Farnan, Mark Plavsic, Jerome Bressi, Isabelle Rivière, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1766.
https://doi.org/10.1182/blood-2021-152985
Published: 2021
Journal Articles

NOTCH and CAR Signaling Control T Cell Lineage Commitment from Pluripotent Stem Cells

Sjoukje van der Stegen, PhD, Pieter Lindenbergh, Roseanna Petrovic, PhD, Benjamin Whitlock, PhD, Raedun Clarke, PhD, Bahram Valamehr, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30.
https://doi.org/10.1182/blood-2020-142894
Published: 2020
Journal Articles

Generation of Multiplexed Engineered, Off-the-Shelf CAR T Cells Uniformly Carrying Multiple Anti-Tumor Modalities to Prevent Tumor Relapse

Chiawei Chang, Eigen Peralta, PhD, Gloria Hsia, PhD, Bi-Huei Yang, PhD, Wen-I Yeh, PhD, Raedun Clarke, PhD, Mandal Mili, PhD, Tom Lee, PhD, Mochtar Pribadi, PhD, Ramzey Abujarour, PhD, Yi-Shin Lai, PhD, David Robbins, BS, Matthew Denholtz, PhD, Sandeep Kothapally Hanok, Emily Driver, BS, Emily Carron, PhD, Natalie Navarrete, BS, May Sumi, Amit Mehta, Philip Chu, Jason ORourke, PhD, Alma Gutierrez, Eric Sung, Suzanna Gasparian, Angela Gentile, Alec Witty, PhD, Amanda Yzaguirre, Samuel LaBarge, Cokey Nguyen, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-138930
Published: 2020
Journal Articles

FT819: Translation of Off-the-Shelf TCR-Less Trac-1XX CAR-T Cells in Support of First-of-Kind Phase I Clinical Trial

Chiawei Chang, Sjoukje Van Der Stegen, PhD, Mandal Mili, PhD, Raedun Clarke, PhD, Yi-Shin Lai, PhD, Alec Witty, PhD, Pieter Lindenbergh, Bi-Huei Yang, PhD, Mushtaq Husain, PhD, Helena Shaked, PhD, Brian Groff, Laurel Stokely, Ramzey Abujarour, PhD, Tom Lee, PhD, Hui-Yi Chu, PhD, Mochtar Pribadi, PhD, Jason ORourke, PhD, Alma Gutierrez, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4434.
https://doi.org/10.1182/blood-2019-130584
Published: 2019
Journal Articles

Pluripotent Cell-Derived Off-the-Shelf TCR-Less CAR-Targeted Cytotoxic T Cell Therapeutic for the Allogeneic Treatment of B Cell Malignancies

Raedun Clarke, PhD, Sjoukje Van Der Stegen, PhD, Chia-Wei Chang, PhD, Mushtaq Husain, PhD, Yi-Shin Lai, PhD, Eigen Peralta, PhD, Laurel Stokely, Ramzey Abujarour, PhD, Jason Dinella, PhD, Tom Lee, PhD, Mochtar Pribadi, PhD, Helen Chu, PhD, Chris Truong, Mohsen Sabouri-Ghomi, PhD, Miguel Meza, BS, Judith Feucht, MD, Justin Eyquem, PhD, Jorge Mansilla-Soto, PhD, Isabelle Riviere, PhD, Michel Sadelain, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4546.
https://doi.org/10.1182/blood-2018-99-116843
Published: 2018
Journal Articles

Multi-Functional Genetic Engineering of Pluripotent Cell Lines for Universal Off-the-Shelf Natural Killer Cell Cancer Immunotherapy

Ryan Bjordahl, PhD, Raedun Clarke, PhD, Svetlana Gaidarova, Matthieu Bauer, PhD, Jeff Sasaki, Brian Groff, Tom Lee, PhD, Weijie Lan, PhD, Ramzey Abujarour, PhD, Greg Bonello, PhD, Megan Robinson, Ian Hardy, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3187.
https://doi.org/10.1182/blood.V130.Suppl_1.3187.3187
Published: 2017
Journal Articles

Clinical Translation of Pluripotent Cell-Derived Off-the-Shelf Natural Killer Cell Cancer Immunotherapy

Frank Cichocki, Ryan Bjordahl, PhD, Svetlana Gaidarova, Paul Rogers, Raedun Clarke, PhD, Brian Groff, Stacey Moreno, Ramzey Abujarour, PhD, Megan Robinson, Greg Bonello, PhD, Tom Lee, PhD, Weijie Lan, PhD, Betsy Rezner, BS, Stewart Abbot, Darin Sumstad, MLS, Bruce Blazar, MD, Daniel Shoemaker, PhD, Scott Wolchko, Dan Kaufman, MD, David H. McKenna, MD, Bahram Valamehr, PhD, Sarah Cooley, MD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 656.
https://doi.org/10.1182/blood.V130.Suppl_1.656.656
Published: 2017
Journal Articles

Generation of Clonal Antigen Specific CD8αβ + Cytotoxic T Lymphocytes from Renewable Pluripotent Stem Cells for Off-the-Shelf T Cell Therapeutics

Sjoukje Van Der Stegen, PhD, Raedun Clarke, PhD, Jorge Mansilla - Soto, PhD, Edwin Ortiz, Chia-Wei Chang, Jeff Sasaki, Tom Lee, PhD, Weijie Lan, PhD, Daniel Shoemaker, PhD, Isabelle Riviere, PhD, Bahram Valamehr, PhD, Michel Sadelain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 163.
https://doi.org/10.1182/blood.V130.Suppl_1.163.163
Published: 2017
Journal Articles

Efficient Site-Specific Multi-Gene Engineering of Renewable Pluripotent Cells for Generation of Off-the-Shelf Hematopoietic Immunotherapeutics

Ramzey Abujarour, PhD, Weijie Lan, PhD, Tom Tong Lee, PhD, Greg Bonello, Miguel Meza, MS, Megan Robinson, BS, Raedun Clarke, PhD, Christopher Truong, Chris Lynn, BS, David Robbins, BS, Betsy Rezner, BS, Stewart E. Abbot, PhD BSc, MSc, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 5887.
https://doi.org/10.1182/blood.V128.22.5887.5887
Published: 2016
Journal Articles

Genetically Enhanced Pluripotent Stem Cell-Derived T Lymphocytes for Off-the-Shelf Cellular Immunotherapy

Raedun Clarke, PhD, Brian Groff, B.S., Jeffrey Sasaki, B.S., Matthieu Bauer, PhD, Tom Tong Lee, PhD, Weijie Lan, PhD, Michelle Burrascano, Ramzey Abujarour, PhD, Greg Bonello, Megan Robinson, BS, Heather Foster, David Robbins, BS, Scott Wolchko, MS, Daniel Shoemaker, PhD, Stewart E. Abbot, PhD BSc, MSc, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 2164.
https://doi.org/10.1182/blood.V128.22.2164.2164
Published: 2016
Journal Articles

Genetic Engineering of Pluripotent Cells for the Continuous Derivation of Off-the-Shelf Effector Lymphocytes with Enhanced Therapeutic Persistence By Overcoming the Host Histocompatibility Barrier

Matthieu Bauer, PhD, Raedun Clarke, PhD, Jeffrey Sasaki, B.S., Brian Groff, B.S., Tom Tong Lee, PhD, Weijie Lan, PhD, Ramzey Abujarour, PhD, Greg Bonello, Michelle Burrascano, Megan Robinson, BS, Ryan Bjordahl, PhD, Svetlana Gaidarova, M.S., Stewart E. Abbot, PhD BSc, MSc, Scott Wolchko, MS, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 2165.
https://doi.org/10.1182/blood.V128.22.2165.2165
Published: 2016
Journal Articles

Off-the-Shelf Natural Killer Cell Immunotherapy for Enhanced Antibody Directed Cellular Cytotoxicity

Ryan Bjordahl, PhD, Raedun Clarke, PhD, Svetlana Gaidarova, M.S., Brian Groff, B.S., Paul Rogers, PhD, Stacey Moreno, Ramzey Abujarour, PhD, Greg Bonello, PhD, Tom Tong Lee, PhD, Weijie Lan, PhD, Michelle Burrascano, Matthieu Bauer, PhD, Megan Robinson, BS, Jeff Sasaki, William Kim, PhD, David Robbins, BS, Betsy Rezner, BS, Stewart E. Abbot, PhD BSc, MSc, Scott Wolchko, MS, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 3363.
https://doi.org/10.1182/blood.V128.22.3363.3363
Published: 2016
Journal Articles

A Platform for the Scalable Derivation of Genetically-Enhanced T and NK Lymphocytes from Naive Human Induced Pluripotent Stem Cells for Cancer Immunotherapy

Raedun Clarke, PhD, William Kim, PhD, Brian Groff, BS, Ramzey Abujarour, PhD, Megan Robinson, BS, Xiaosong Huang, PhD, Newsha Sahaf, Sarah Raynel, MS, Betsy Rezner, BS, David Robbins, BS, Lisa Guerrettaz, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2015) 126 (23): 2364.
https://doi.org/10.1182/blood.V126.23.2364.2364
Published: 2015
Journal Articles

Human Induced Pluripotent Stem Cells Incorporating Safe Harbor Loci Integrated Inducible Suicide Systems for Use in the Application of Cellular Therapeutics

Xiaosong Huang, PhD, Weijie Lan, PhD, Philippe Parone, PhD, Raedun Clarke, PhD, Ramzey Abujarour, PhD, Megan Robinson, BS, Miguel Meza, MS, Sarah Raynel, MS, Betsy Rezner, BS, David Robbins, BS, Tom Tong Lee, PhD, Daniel Shoemaker, PhD, Bahram Valamehr, PhD MBA
Journal: Blood
Blood (2015) 126 (23): 3237.
https://doi.org/10.1182/blood.V126.23.3237.3237
Published: 2015